Click here to switch to the map view.

The map label for this gene is hemL [H]

Identifier: 55980903

GI number: 55980903

Start: 882858

End: 884132

Strand: Reverse

Name: hemL [H]

Synonym: TTHA0934

Alternate gene names: 55980903

Gene position: 884132-882858 (Counterclockwise)

Preceding gene: 55980905

Following gene: 55980902

Centisome position: 47.8

GC content: 68.47

Gene sequence:

>1275_bases
ATGGAGCGGCCCATCTCCGAGGCCTACTTCCAGGAGGCGAAGCGGCACATCCCGGGCGGGGTGAGTAGCCCGGTCAGGGC
CTTCAAGGCCGTGGGCGGCACCCCCCCCTTCCTGGTGCGGGGCGAAGGGGCCTACGTCTGGGACGCGGACGGGAACCGCT
ACCTGGACTACGTGATGAGCTGGGGGCCCTTGATCCTGGGCCACGCCCACCCCAAGGTCCTCGCCCGGGTGCGGGAGACC
TTGGAAAGGGGCCTCACCTTCGGGGCGCCAAGCCCTCTGGAGGTGGCCCTGGCGAAGAAGGTCAAGCGGGCCTACCCCTT
TGTGGACCTGGTGCGCTTCGTGAACTCGGGGACCGAGGCCACCATGTCGGCCCTCCGCCTCGCCCGGGGGTATACGGGAA
GGCCCTACATCGTCAAGTTCCGGGGGAACTACCACGGCCACGCGGACGGCCTCCTGGTGGAGGCGGGCTCAGGGGCCCTC
ACCCTGGGCGTCCCCTCCTCCGCCGGGGTGCCCGAGGAATACGCCAAGCTCACCCTGGTCCTGGAGTACAACGACCCCGA
GGGCCTGCGGGAGGTGCTGAAGCGGCGGGGAGAGGAGATCGCCGCCATCATCTTTGAGCCCGTGGTCGGCAACGCCGGGG
TCCTGGTCCCCACGGAGGACTTCCTTAAGGCCCTCCACGAGGCCAAGGCCTACGGGGTCCTCCTCATCGCCGACGAGGTG
ATGACGGGCTTCCGCCTGGCCTTCGGCGGGGCCACGGAGCTTCTCGGCCTTAAGCCCGACCTCGTCACCCTGGGGAAGAT
CCTGGGCGGGGGGCTTCCCGCCGCGGCCTACGCGGGGAGGCGGGAGATCATGGAGAAGGTGGCCCCCCTGGGCCCCGTCT
ACCAGGCGGGGACGCTTTCCGGGAACCCCTTGGCCATGGCGGCGGGGCTCGCCACCCTGGAGCTCTTGGAGGAGAACCCC
GGCTACTACGCTTACCTAGAGGACCTGGGGGCCAGGCTGGAGGCGGGCCTGAAGGAGGTTCTCAAGGAGAAGGGGCTTCC
CCACACGGTGAACCGGGTGGGCTCCATGATCACCGTCTTCTTCACGGAAGGCCCCGTGGTCACCTTCCAGGACGCCAGGC
GCACGGACACGGAGCTCTTCAAGCGCTTCTTCCACGGCCTCTTGGACCGGGGTATTTACTGGCCTCCCTCCAACTTTGAG
GCGGCCTTCCTCTCCGTGGCCCACAGGGAGGAGGACGTGGAAAAGACCCTCGAGGCCCTGAGGAAGGCCTTGTAG

Upstream 100 bases:

>100_bases
AAGCCAGGATCTCGGAGAGGATGGCGAGGAAGAGGTAGGTCCACCCGCTCATCCCTCCAAGGCTACCCTTTCCCGGGGGA
AAGCCGCTAGAGTGGGGGGC

Downstream 100 bases:

>100_bases
AATGAAAGGGATGCGCTACACCGTCGTCTTACGCCCCGACCCGGAGACCCCAGGGGTGTGGCTTGCTGAGGTGCCCGCCC
TGCCCTGGTGCGCCACCTTC

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MERPISEAYFQEAKRHIPGGVSSPVRAFKAVGGTPPFLVRGEGAYVWDADGNRYLDYVMSWGPLILGHAHPKVLARVRET
LERGLTFGAPSPLEVALAKKVKRAYPFVDLVRFVNSGTEATMSALRLARGYTGRPYIVKFRGNYHGHADGLLVEAGSGAL
TLGVPSSAGVPEEYAKLTLVLEYNDPEGLREVLKRRGEEIAAIIFEPVVGNAGVLVPTEDFLKALHEAKAYGVLLIADEV
MTGFRLAFGGATELLGLKPDLVTLGKILGGGLPAAAYAGRREIMEKVAPLGPVYQAGTLSGNPLAMAAGLATLELLEENP
GYYAYLEDLGARLEAGLKEVLKEKGLPHTVNRVGSMITVFFTEGPVVTFQDARRTDTELFKRFFHGLLDRGIYWPPSNFE
AAFLSVAHREEDVEKTLEALRKAL

Sequences:

>Translated_424_residues
MERPISEAYFQEAKRHIPGGVSSPVRAFKAVGGTPPFLVRGEGAYVWDADGNRYLDYVMSWGPLILGHAHPKVLARVRET
LERGLTFGAPSPLEVALAKKVKRAYPFVDLVRFVNSGTEATMSALRLARGYTGRPYIVKFRGNYHGHADGLLVEAGSGAL
TLGVPSSAGVPEEYAKLTLVLEYNDPEGLREVLKRRGEEIAAIIFEPVVGNAGVLVPTEDFLKALHEAKAYGVLLIADEV
MTGFRLAFGGATELLGLKPDLVTLGKILGGGLPAAAYAGRREIMEKVAPLGPVYQAGTLSGNPLAMAAGLATLELLEENP
GYYAYLEDLGARLEAGLKEVLKEKGLPHTVNRVGSMITVFFTEGPVVTFQDARRTDTELFKRFFHGLLDRGIYWPPSNFE
AAFLSVAHREEDVEKTLEALRKAL
>Mature_424_residues
MERPISEAYFQEAKRHIPGGVSSPVRAFKAVGGTPPFLVRGEGAYVWDADGNRYLDYVMSWGPLILGHAHPKVLARVRET
LERGLTFGAPSPLEVALAKKVKRAYPFVDLVRFVNSGTEATMSALRLARGYTGRPYIVKFRGNYHGHADGLLVEAGSGAL
TLGVPSSAGVPEEYAKLTLVLEYNDPEGLREVLKRRGEEIAAIIFEPVVGNAGVLVPTEDFLKALHEAKAYGVLLIADEV
MTGFRLAFGGATELLGLKPDLVTLGKILGGGLPAAAYAGRREIMEKVAPLGPVYQAGTLSGNPLAMAAGLATLELLEENP
GYYAYLEDLGARLEAGLKEVLKEKGLPHTVNRVGSMITVFFTEGPVVTFQDARRTDTELFKRFFHGLLDRGIYWPPSNFE
AAFLSVAHREEDVEKTLEALRKAL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=303, Percent_Identity=31.3531353135314, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI37574042, Length=338, Percent_Identity=29.2899408284024, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI226442705, Length=335, Percent_Identity=28.6567164179104, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI226442709, Length=307, Percent_Identity=29.3159609120521, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI284507298, Length=222, Percent_Identity=33.7837837837838, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1786349, Length=421, Percent_Identity=54.6318289786223, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1789016, Length=378, Percent_Identity=32.2751322751323, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1787560, Length=341, Percent_Identity=31.3782991202346, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788044, Length=338, Percent_Identity=33.1360946745562, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI145693181, Length=318, Percent_Identity=31.1320754716981, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789759, Length=291, Percent_Identity=29.553264604811, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786991, Length=303, Percent_Identity=30.03300330033, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=300, Percent_Identity=31, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=338, Percent_Identity=28.4023668639053, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=334, Percent_Identity=29.0419161676647, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=143, Percent_Identity=34.965034965035, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=419, Percent_Identity=27.9236276849642, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324432, Length=382, Percent_Identity=26.7015706806283, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357415, Length=305, Percent_Identity=31.8032786885246, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI21356575, Length=306, Percent_Identity=29.0849673202614, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161085790, Length=362, Percent_Identity=29.2817679558011, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574759, Length=362, Percent_Identity=29.2817679558011, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46035; Mature: 46035

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERPISEAYFQEAKRHIPGGVSSPVRAFKAVGGTPPFLVRGEGAYVWDADGNRYLDYVMS
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCEEEECCCCCHHHHHHHH
WGPLILGHAHPKVLARVRETLERGLTFGAPSPLEVALAKKVKRAYPFVDLVRFVNSGTEA
CCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCHHH
TMSALRLARGYTGRPYIVKFRGNYHGHADGLLVEAGSGALTLGVPSSAGVPEEYAKLTLV
HHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHCEEEEE
LEYNDPEGLREVLKRRGEEIAAIIFEPVVGNAGVLVPTEDFLKALHEAKAYGVLLIADEV
EEECCCHHHHHHHHHCCCCEEEHEEECCCCCCCEEECCHHHHHHHHHHHHCEEEEEEHHH
MTGFRLAFGGATELLGLKPDLVTLGKILGGGLPAAAYAGRREIMEKVAPLGPVYQAGTLS
HHHHHHCCCCHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
GNPLAMAAGLATLELLEENPGYYAYLEDLGARLEAGLKEVLKEKGLPHTVNRVGSMITVF
CCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEE
FTEGPVVTFQDARRTDTELFKRFFHGLLDRGIYWPPSNFEAAFLSVAHREEDVEKTLEAL
EECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RKAL
HHCC
>Mature Secondary Structure
MERPISEAYFQEAKRHIPGGVSSPVRAFKAVGGTPPFLVRGEGAYVWDADGNRYLDYVMS
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCEEEECCCCCHHHHHHHH
WGPLILGHAHPKVLARVRETLERGLTFGAPSPLEVALAKKVKRAYPFVDLVRFVNSGTEA
CCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCHHH
TMSALRLARGYTGRPYIVKFRGNYHGHADGLLVEAGSGALTLGVPSSAGVPEEYAKLTLV
HHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHCEEEEE
LEYNDPEGLREVLKRRGEEIAAIIFEPVVGNAGVLVPTEDFLKALHEAKAYGVLLIADEV
EEECCCHHHHHHHHHCCCCEEEHEEECCCCCCCEEECCHHHHHHHHHHHHCEEEEEEHHH
MTGFRLAFGGATELLGLKPDLVTLGKILGGGLPAAAYAGRREIMEKVAPLGPVYQAGTLS
HHHHHHCCCCHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
GNPLAMAAGLATLELLEENPGYYAYLEDLGARLEAGLKEVLKEKGLPHTVNRVGSMITVF
CCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEE
FTEGPVVTFQDARRTDTELFKRFFHGLLDRGIYWPPSNFEAAFLSVAHREEDVEKTLEAL
EECCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RKAL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA