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The map label for this gene is gyaR [H]

Identifier: 55980755

GI number: 55980755

Start: 753370

End: 754305

Strand: Reverse

Name: gyaR [H]

Synonym: TTHA0786

Alternate gene names: 55980755

Gene position: 754305-753370 (Counterclockwise)

Preceding gene: 55980756

Following gene: 55980754

Centisome position: 40.78

GC content: 70.83

Gene sequence:

>936_bases
ATGAGGGTCCTCGTCACCCGCACCCTTCCCGGGAAGGCCCTGGACCGCCTGCGGGAAAGGGGCCTCGAGGTGGAGGTCCA
CCGGGGGCTCTTCCTCCCCAAAGCGGAACTCCTCAAGCGGGTGGAGGGGGCGGTGGGCCTCATCCCCACGGTGGAGGACC
GCATAGACGCCGAGGTGATGGACCGGGCCAAGGGCCTTAAGGTCATCGCCTGCTACAGCGTAGGGGTGGACCACGTGGAC
CTCGAGGCGGCCAGGGAGAGGGGCATCCGGGTCACGCACACCCCCGGGGTCCTCACCGAGGCCACCGCCGACCTCACCCT
CGCCCTCCTCCTCGCCGTGGCGAGGCGGGTGGTGGAGGGGGCGGCCTACGCCCGGGACGGGCTCTGGAAGGCCTGGCACC
CCGAGCTCCTTCTGGGCCTGGACCTCCAGGGCTTGACCCTCGGCCTCGTGGGCATGGGGCGGATCGGCCAGGCGGTGGCC
AAGAGGGCCCTGGCCTTCGGGATGCGGGTGGTCTACCACGCCCGCACCCCCAAGCCCCTCCCCTACCCCTTCCTCTCCCT
GGAGGAGCTCCTTAAAGAGGCGGACGTCGTCTCCCTCCACACCCCCCTCACCCCGGAAACCCATAGGCTCCTCAACCGGG
AAAGGCTCTTCGCCATGAAGCGGGGCGCCATCCTCCTCAACACCGCCCGGGGGGCCCTGGTGGACACCGAGGCCCTGGTG
GAGGCCTTAAGGGGCCACCTCTTCGGGGCGGGCCTGGACGTGACCGACCCCGAGCCCCTGCCCCCGGGCCATCCCCTCTA
CGCCCTTCCCAACGCCGTCATTACCCCCCACATCGGCTCGGCGGGGAGAACGACCCGGGAGCGCATGGCGGAGGTGGCGG
TGGAGAACCTCCTCGCCGTCCTGGAGGGGAGGGAGCCGCCAAACCCGGTAGTATAG

Upstream 100 bases:

>100_bases
TGGACTGGCTCCTCTTAAACGCGGCCTACGGGAGCCCCACCGTGGCGGTGGCCGAGCTCTCCTTCGCCGGGGCGTAACCT
CCCCCCGGTAAAAAAAGGGC

Downstream 100 bases:

>100_bases
GCGCCATGGGCCTTCTCATCGGCTTCCTCGGCGGGGTCTTCGGCGGCCTCGTAGGCCTAGGCGGCGGCACGGTGATGATC
CCCTTGATGGTGGGGCTTCT

Product: glycerate dehydrogenase/glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MRVLVTRTLPGKALDRLRERGLEVEVHRGLFLPKAELLKRVEGAVGLIPTVEDRIDAEVMDRAKGLKVIACYSVGVDHVD
LEAARERGIRVTHTPGVLTEATADLTLALLLAVARRVVEGAAYARDGLWKAWHPELLLGLDLQGLTLGLVGMGRIGQAVA
KRALAFGMRVVYHARTPKPLPYPFLSLEELLKEADVVSLHTPLTPETHRLLNRERLFAMKRGAILLNTARGALVDTEALV
EALRGHLFGAGLDVTDPEPLPPGHPLYALPNAVITPHIGSAGRTTRERMAEVAVENLLAVLEGREPPNPVV

Sequences:

>Translated_311_residues
MRVLVTRTLPGKALDRLRERGLEVEVHRGLFLPKAELLKRVEGAVGLIPTVEDRIDAEVMDRAKGLKVIACYSVGVDHVD
LEAARERGIRVTHTPGVLTEATADLTLALLLAVARRVVEGAAYARDGLWKAWHPELLLGLDLQGLTLGLVGMGRIGQAVA
KRALAFGMRVVYHARTPKPLPYPFLSLEELLKEADVVSLHTPLTPETHRLLNRERLFAMKRGAILLNTARGALVDTEALV
EALRGHLFGAGLDVTDPEPLPPGHPLYALPNAVITPHIGSAGRTTRERMAEVAVENLLAVLEGREPPNPVV
>Mature_311_residues
MRVLVTRTLPGKALDRLRERGLEVEVHRGLFLPKAELLKRVEGAVGLIPTVEDRIDAEVMDRAKGLKVIACYSVGVDHVD
LEAARERGIRVTHTPGVLTEATADLTLALLLAVARRVVEGAAYARDGLWKAWHPELLLGLDLQGLTLGLVGMGRIGQAVA
KRALAFGMRVVYHARTPKPLPYPFLSLEELLKEADVVSLHTPLTPETHRLLNRERLFAMKRGAILLNTARGALVDTEALV
EALRGHLFGAGLDVTDPEPLPPGHPLYALPNAVITPHIGSAGRTTRERMAEVAVENLLAVLEGREPPNPVV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=319, Percent_Identity=41.692789968652, Blast_Score=227, Evalue=9e-60,
Organism=Homo sapiens, GI23308577, Length=310, Percent_Identity=33.5483870967742, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI145580578, Length=270, Percent_Identity=35.5555555555556, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4557499, Length=270, Percent_Identity=35.5555555555556, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=35.5555555555556, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI61743967, Length=270, Percent_Identity=34.4444444444444, Blast_Score=134, Evalue=9e-32,
Organism=Homo sapiens, GI4557497, Length=270, Percent_Identity=34.4444444444444, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=39.2523364485981, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1787645, Length=332, Percent_Identity=30.7228915662651, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789279, Length=304, Percent_Identity=33.2236842105263, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87081824, Length=147, Percent_Identity=37.4149659863946, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788660, Length=266, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=32.9192546583851, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=274, Percent_Identity=30.2919708029197, Blast_Score=124, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6320925, Length=320, Percent_Identity=30, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=320, Percent_Identity=28.75, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324055, Length=257, Percent_Identity=35.0194552529183, Blast_Score=145, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6324964, Length=269, Percent_Identity=31.9702602230483, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=200, Percent_Identity=31, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=167, Percent_Identity=32.3353293413174, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=43.0868167202572, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI45552429, Length=316, Percent_Identity=38.9240506329114, Blast_Score=200, Evalue=9e-52,
Organism=Drosophila melanogaster, GI45551003, Length=316, Percent_Identity=38.9240506329114, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574284, Length=316, Percent_Identity=38.9240506329114, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24585514, Length=316, Percent_Identity=38.9240506329114, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574282, Length=316, Percent_Identity=38.9240506329114, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=38.2911392405063, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=34.9358974358974, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI19921140, Length=314, Percent_Identity=33.1210191082803, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646446, Length=262, Percent_Identity=36.6412213740458, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24646448, Length=262, Percent_Identity=36.6412213740458, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24646452, Length=262, Percent_Identity=36.6412213740458, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24646450, Length=262, Percent_Identity=36.6412213740458, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=36.6412213740458, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33823; Mature: 33823

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVTRTLPGKALDRLRERGLEVEVHRGLFLPKAELLKRVEGAVGLIPTVEDRIDAEVM
CEEEEEECCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHH
DRAKGLKVIACYSVGVDHVDLEAARERGIRVTHTPGVLTEATADLTLALLLAVARRVVEG
HHHCCCEEEEEEECCCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
AAYARDGLWKAWHPELLLGLDLQGLTLGLVGMGRIGQAVAKRALAFGMRVVYHARTPKPL
HHHHHCCCCCCCCCCEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCC
PYPFLSLEELLKEADVVSLHTPLTPETHRLLNRERLFAMKRGAILLNTARGALVDTEALV
CCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHH
EALRGHLFGAGLDVTDPEPLPPGHPLYALPNAVITPHIGSAGRTTRERMAEVAVENLLAV
HHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHHH
LEGREPPNPVV
HCCCCCCCCCC
>Mature Secondary Structure
MRVLVTRTLPGKALDRLRERGLEVEVHRGLFLPKAELLKRVEGAVGLIPTVEDRIDAEVM
CEEEEEECCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHH
DRAKGLKVIACYSVGVDHVDLEAARERGIRVTHTPGVLTEATADLTLALLLAVARRVVEG
HHHCCCEEEEEEECCCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
AAYARDGLWKAWHPELLLGLDLQGLTLGLVGMGRIGQAVAKRALAFGMRVVYHARTPKPL
HHHHHCCCCCCCCCCEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCC
PYPFLSLEELLKEADVVSLHTPLTPETHRLLNRERLFAMKRGAILLNTARGALVDTEALV
CCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHH
EALRGHLFGAGLDVTDPEPLPPGHPLYALPNAVITPHIGSAGRTTRERMAEVAVENLLAV
HHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHHH
LEGREPPNPVV
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA