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The map label for this gene is pyrC [H]

Identifier: 55980750

GI number: 55980750

Start: 749468

End: 750748

Strand: Reverse

Name: pyrC [H]

Synonym: TTHA0781

Alternate gene names: 55980750

Gene position: 750748-749468 (Counterclockwise)

Preceding gene: 55980751

Following gene: 55980749

Centisome position: 40.59

GC content: 71.19

Gene sequence:

>1281_bases
ATGATCTTGATCCGCAACGTCCGGCTGGTGGACGCCCGGGGCGAGCGGGGCCCCGCGGACGTCCTGATTGGCGAAGGGAG
GATCCTCTCCCTGGAAGGCGGTGAGGCGAAGCAGGTCGTGGACGGCACGGGGTGCTTCCTCGCCCCGGGGTTTTTAGACC
TCCACGCCCACCTGCGGGAGCCCGGGGAGGAGGTGAAGGAGGACCTCTTCTCGGGGCTTCTCGCGGCGGTGCGGGGAGGG
TACACCGACCTCGTCTCCATGCCCAACACCAAGCCCCCTGTGGACACCCCAGAGGCGGTGCGGGCCCTGAAGGAGAAGGC
CAAGGCCCTGGGCCTCGCAAGGCTCCACCCCGCGGCCGCCCTCACGGAAAAGCAGGAGGGGAAGACCCTAACGCCAGCGG
GGCTTCTCCGGGAGGCGGGGGCGGTCCTCCTCACCGACGACGGCCGCACCAACGAGGACGCCGGGGTCTTGGCGGCGGGG
CTCCTCATGGCCGCGCCTCTAGGCCTCCCCGTGGCGGTGCACGCGGAGGACGCGGGCCTAAGGCGAAATGGGGTCATGAA
CGATGGCCCCCTCGCCGACCTCTTGGGCCTGCCGGGCAACCCCCCCGAGGCCGAGGCCGCCCGCATCGCCCGGGACCTCG
AGGTCCTGCGCTACGCCTTAAGGCGAAGCCCGGCCACCCCCAGGCTCCACGTCCAACACCTTTCCACGAAGCGGGGCCTG
GAGCTCGTCCGGGAGGCGAAGCGCGCGGGCCTCCCCGTGACCGCGGAGGCCACCCCCCACCACCTCACCCTCACCGAGGA
GGCCCTGAGGACCTTTGACCCCCTCTTCAAGGTGGCCCCGCCCCTCAGGGGGGAAGAGGACCGGGAGGCCCTCCTGGAGG
GGCTTCTTGACGGCACCCTGGACGCCATCGCCACCGACCACGCCCCCCACACCCTGGCGGAGAAGGAAAAGGACCTCCTA
AGGGCCCCCTTCGGCATCCCGAGCCTCGAGGTGGCCTTCCCCCTCCTCTACACCGAGCTCCACCTGAAGCGGGGCTTTCC
CCTGCAAAGGCTCGTGGAGCTTTTCACCGACGGCCCCAGGCGGGTCCTGGGCCTTCCCCCCCTCCACCTGGAGGAGGGGG
CCGAGGCGAGCCTCGTCCTCCTCTCCCCCAAGGAGCGCCCCGTGGACCCCAGCGCCTTCGCCTCCAAGGCCCGCTACTCC
CCCTGGGCGGGGTGGGTCCTCGGGGGGTGGCCCGTTCTCACCCTGGTGGCGGGGCGGATCGTCCACGAAGCGCTAAAATA
G

Upstream 100 bases:

>100_bases
TGGCGGACTCGGCGAGGAGCCTGGTGAACCGACAGGTGCAAAACGGGGTGGCGGTGCGCATGGCGGTGCTCTACCACCTC
CTGGTGGGGAGGGAGAAAGC

Downstream 100 bases:

>100_bases
GGGGGTGCTGAAGAAGCTCCTGGAGGCAGATGCCATTGGCCTCAGGCTGGAGTGGGTGGGGGGGCTTCCCCTCTGGGAGG
CTCAACCCACCTACCGGCAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MILIRNVRLVDARGERGPADVLIGEGRILSLEGGEAKQVVDGTGCFLAPGFLDLHAHLREPGEEVKEDLFSGLLAAVRGG
YTDLVSMPNTKPPVDTPEAVRALKEKAKALGLARLHPAAALTEKQEGKTLTPAGLLREAGAVLLTDDGRTNEDAGVLAAG
LLMAAPLGLPVAVHAEDAGLRRNGVMNDGPLADLLGLPGNPPEAEAARIARDLEVLRYALRRSPATPRLHVQHLSTKRGL
ELVREAKRAGLPVTAEATPHHLTLTEEALRTFDPLFKVAPPLRGEEDREALLEGLLDGTLDAIATDHAPHTLAEKEKDLL
RAPFGIPSLEVAFPLLYTELHLKRGFPLQRLVELFTDGPRRVLGLPPLHLEEGAEASLVLLSPKERPVDPSAFASKARYS
PWAGWVLGGWPVLTLVAGRIVHEALK

Sequences:

>Translated_426_residues
MILIRNVRLVDARGERGPADVLIGEGRILSLEGGEAKQVVDGTGCFLAPGFLDLHAHLREPGEEVKEDLFSGLLAAVRGG
YTDLVSMPNTKPPVDTPEAVRALKEKAKALGLARLHPAAALTEKQEGKTLTPAGLLREAGAVLLTDDGRTNEDAGVLAAG
LLMAAPLGLPVAVHAEDAGLRRNGVMNDGPLADLLGLPGNPPEAEAARIARDLEVLRYALRRSPATPRLHVQHLSTKRGL
ELVREAKRAGLPVTAEATPHHLTLTEEALRTFDPLFKVAPPLRGEEDREALLEGLLDGTLDAIATDHAPHTLAEKEKDLL
RAPFGIPSLEVAFPLLYTELHLKRGFPLQRLVELFTDGPRRVLGLPPLHLEEGAEASLVLLSPKERPVDPSAFASKARYS
PWAGWVLGGWPVLTLVAGRIVHEALK
>Mature_426_residues
MILIRNVRLVDARGERGPADVLIGEGRILSLEGGEAKQVVDGTGCFLAPGFLDLHAHLREPGEEVKEDLFSGLLAAVRGG
YTDLVSMPNTKPPVDTPEAVRALKEKAKALGLARLHPAAALTEKQEGKTLTPAGLLREAGAVLLTDDGRTNEDAGVLAAG
LLMAAPLGLPVAVHAEDAGLRRNGVMNDGPLADLLGLPGNPPEAEAARIARDLEVLRYALRRSPATPRLHVQHLSTKRGL
ELVREAKRAGLPVTAEATPHHLTLTEEALRTFDPLFKVAPPLRGEEDREALLEGLLDGTLDAIATDHAPHTLAEKEKDLL
RAPFGIPSLEVAFPLLYTELHLKRGFPLQRLVELFTDGPRRVLGLPPLHLEEGAEASLVLLSPKERPVDPSAFASKARYS
PWAGWVLGGWPVLTLVAGRIVHEALK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=366, Percent_Identity=33.6065573770492, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=24.8898678414097, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786722, Length=443, Percent_Identity=25.9593679458239, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87082175, Length=445, Percent_Identity=28.5393258426966, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193204318, Length=367, Percent_Identity=31.3351498637602, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6322218, Length=232, Percent_Identity=27.5862068965517, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24642586, Length=364, Percent_Identity=30.2197802197802, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI18859883, Length=443, Percent_Identity=25.0564334085779, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45694; Mature: 45694

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIRNVRLVDARGERGPADVLIGEGRILSLEGGEAKQVVDGTGCFLAPGFLDLHAHLRE
CEEEEEEEEEECCCCCCCCCEEEECCEEEEECCCCCHHEECCCCCEECCCHHHHHHHHCC
PGEEVKEDLFSGLLAAVRGGYTDLVSMPNTKPPVDTPEAVRALKEKAKALGLARLHPAAA
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCHHHH
LTEKQEGKTLTPAGLLREAGAVLLTDDGRTNEDAGVLAAGLLMAAPLGLPVAVHAEDAGL
HHHHHCCCCCCHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCC
RRNGVMNDGPLADLLGLPGNPPEAEAARIARDLEVLRYALRRSPATPRLHVQHLSTKRGL
HHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
ELVREAKRAGLPVTAEATPHHLTLTEEALRTFDPLFKVAPPLRGEEDREALLEGLLDGTL
HHHHHHHHCCCCEEECCCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DAIATDHAPHTLAEKEKDLLRAPFGIPSLEVAFPLLYTELHLKRGFPLQRLVELFTDGPR
HHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
RVLGLPPLHLEEGAEASLVLLSPKERPVDPSAFASKARYSPWAGWVLGGWPVLTLVAGRI
CEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHH
VHEALK
HHHHHC
>Mature Secondary Structure
MILIRNVRLVDARGERGPADVLIGEGRILSLEGGEAKQVVDGTGCFLAPGFLDLHAHLRE
CEEEEEEEEEECCCCCCCCCEEEECCEEEEECCCCCHHEECCCCCEECCCHHHHHHHHCC
PGEEVKEDLFSGLLAAVRGGYTDLVSMPNTKPPVDTPEAVRALKEKAKALGLARLHPAAA
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCHHHH
LTEKQEGKTLTPAGLLREAGAVLLTDDGRTNEDAGVLAAGLLMAAPLGLPVAVHAEDAGL
HHHHHCCCCCCHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCC
RRNGVMNDGPLADLLGLPGNPPEAEAARIARDLEVLRYALRRSPATPRLHVQHLSTKRGL
HHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
ELVREAKRAGLPVTAEATPHHLTLTEEALRTFDPLFKVAPPLRGEEDREALLEGLLDGTL
HHHHHHHHCCCCEEECCCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DAIATDHAPHTLAEKEKDLLRAPFGIPSLEVAFPLLYTELHLKRGFPLQRLVELFTDGPR
HHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
RVLGLPPLHLEEGAEASLVLLSPKERPVDPSAFASKARYSPWAGWVLGGWPVLTLVAGRI
CEECCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHH
VHEALK
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171389 [H]