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The map label for this gene is lpxC [H]

Identifier: 54295445

GI number: 54295445

Start: 2887551

End: 2888465

Strand: Reverse

Name: lpxC [H]

Synonym: lpl2531

Alternate gene names: 54295445

Gene position: 2888465-2887551 (Counterclockwise)

Preceding gene: 54295446

Following gene: 54295444

Centisome position: 86.33

GC content: 39.02

Gene sequence:

>915_bases
ATGATAAAACAAAGAACTCCTAAAAAGGTAATCCAGGCTACTGGTGTTGGATTACATTCCGGTGAGAAAGTGCTTTTAAC
CTTAAGACCAGCTCCTGTAAACACAGGTATCGTTTTTAGACGCGTGGATTTGTCACCAGTTGTCGAAATACCTGCCTCCT
ACGAATACGTCGGAGATACCATGCTTTGCACCACCCTTCATCATGGCAAGGTGAAAATTGCAACGGTGGAACATTTATTA
TCTGCCTTGGCCGGGTTAGGAATTGATAACGCATATATAGATGTCAATGCTCCAGAGATTCCAATTATGGATGGAAGTGC
CGCCCCATTTGTATTTTTAATTCAATCAGCGGGCATAAGAGAGCAAAATGCAGCAAAAAGATATATCCGAATTCTTAAAC
CTATACGAGTCGAAGAAAATGGAAAGTATGTTCAGTTCCTTCCTCATAAAGGATATAAAATAACATTTACCATAGGTTTT
GAGCACCCGGTTTTTAATGATAGACCACAAACAGTAAGCTTTGATTTTTCTGGAACATCGTATGTCAAAGAAGTTTGTAG
AGCGAGAACTTTTGGTTTTCTTTCAGATTATGAAAAATTGAGAGAGTGCGACCTGGCAAAAGGCGGTAGTCTAGATAATG
CCATTGTAGTAGATGATTACCGTGTCCTTAATGAAGATGGTCTCCGCTTCGAATCAGAATTTGTTACTCATAAAGTATTA
GATGCTATCGGTGATCTTTATTTATTGGGTTCCAGTTTAATTGGCGCATTTGAAGGATATAAATCTGGTCACGAATTGAA
TAACAGATTGTTGCGTGAATTAATGATAAGGCAGGATGCTTGGGAATATACCTATTTTGATACAGAAAACTATCTGCCCG
CGGTTCACCCTGAATATTATCCTGTTGAAGCCTGA

Upstream 100 bases:

>100_bases
TTAATTGAAATTAAAAAAATTAGACTAATCAATAAATTGTTGCTAAGATCTTAAGGTTTTTGCGTGCAAAATAAATATAA
GAGAGAAAGGTGAGCACTGA

Downstream 100 bases:

>100_bases
CAGAAATACATCATATCGACGTAGTGAGAATATTCATTTTCACTATTATCATTTTATAGGCATTATCTATACTAAATATA
ATGGCCTAAGCAGTTTCCTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDTMLCTTLHHGKVKIATVEHLL
SALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIREQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGF
EHPVFNDRPQTVSFDFSGTSYVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMIRQDAWEYTYFDTENYLPAVHPEYYPVEA

Sequences:

>Translated_304_residues
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDTMLCTTLHHGKVKIATVEHLL
SALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIREQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGF
EHPVFNDRPQTVSFDFSGTSYVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMIRQDAWEYTYFDTENYLPAVHPEYYPVEA
>Mature_304_residues
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDTMLCTTLHHGKVKIATVEHLL
SALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIREQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGF
EHPVFNDRPQTVSFDFSGTSYVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMIRQDAWEYTYFDTENYLPAVHPEYYPVEA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=294, Percent_Identity=58.5034013605442, Blast_Score=367, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 34167; Mature: 34167

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDT
CCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCCHHHCCE
MLCTTLHHGKVKIATVEHLLSALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIR
EEEEEEECCEEEEHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCEEEEEECCCCC
EQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGFEHPVFNDRPQTVSFDFSGTS
CHHHHHHHHHHHCCEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEEEEECCCHH
YVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEECCCCCEEHHHHHHHHHH
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMIRQDAWEYTYFDTENYLPAVHPEYY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
PVEA
CCCC
>Mature Secondary Structure
MIKQRTPKKVIQATGVGLHSGEKVLLTLRPAPVNTGIVFRRVDLSPVVEIPASYEYVGDT
CCCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCCHHHCCE
MLCTTLHHGKVKIATVEHLLSALAGLGIDNAYIDVNAPEIPIMDGSAAPFVFLIQSAGIR
EEEEEEECCEEEEHHHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCEEEEEECCCCC
EQNAAKRYIRILKPIRVEENGKYVQFLPHKGYKITFTIGFEHPVFNDRPQTVSFDFSGTS
CHHHHHHHHHHHCCEEECCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCEEEEECCCHH
YVKEVCRARTFGFLSDYEKLRECDLAKGGSLDNAIVVDDYRVLNEDGLRFESEFVTHKVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEECCCCCEEHHHHHHHHHH
DAIGDLYLLGSSLIGAFEGYKSGHELNNRLLRELMIRQDAWEYTYFDTENYLPAVHPEYY
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
PVEA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA