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The map label for this gene is dapA [H]

Identifier: 54295154

GI number: 54295154

Start: 2551749

End: 2552621

Strand: Reverse

Name: dapA [H]

Synonym: lpl2234

Alternate gene names: 54295154

Gene position: 2552621-2551749 (Counterclockwise)

Preceding gene: 54295160

Following gene: 54295153

Centisome position: 76.3

GC content: 42.5

Gene sequence:

>873_bases
ATGTTCAGTGGAAGTATAGTAGCCTTGGTAACCCCCATGCGAAATGATAGCGTCGATGTTCATCATTTGCGAGAACTGGT
TGAATTTCATATAGCCAAGGGAACTCATGCCTTGGTCGCAGCTGGCACGACAGGTGAGGCTGGTACTCTATCACATAGCG
AAAAACTTTTGGTTATCAAAACAGTCATTGAACAAGCAAAAGAAAGAGTGCCTGTGATTGCAGGTACTGCTATGAATGCG
ACCAAGGATTGTATTGAACTAACCCAGCAAGCTATGGAATATGGGGCGCATGCTGCTTTAATCATGACACCAGCCTATAT
CAAGCCCACTCAAGAAGGGTTGTATTTGCACTACAGTCATATTGCCCAATCCGTAGCGATACCGATTATTTTATATAATG
TTCCGGGAAGAACAGCCTGTGATATGTTACCCGAAACGGTGGCAAGACTGGCTAAAATTTCGAATATAATAGGAATAAAG
GAAGCAACTGGACAGATGACTCGTTTACAGCAGATTTTGCGGTTATGCGAAGGGAGCATTGATGTTTACAGTGGCGATGA
TTTGACAGCTGCCCAATGGTTGTTGGCCGGGGCTAAAGGTGTTATTTCAGTCACGGCTAATGTGGCTGCTAAATTGATGG
CAAAAATGTGTGATTTGGCAATGGATGATGATCAAGCAGGATGTTTGCGTATTCAAGAGCAATTAATGCCTTTACATGAA
CTTTTGTTCGTGGAGTCGAATCCAATCCCGGTAAAATGGGCTATGAACAAAATGGGATTAATTGGAGGGGAATTAAGATT
ACCGATGACGGAGTTGTCTGAAAAACATCATCAGGCTTTGGAAAAGGTGTTGAAGAATTTAGAGTTGATATAA

Upstream 100 bases:

>100_bases
TAATAGAGATTCCAGTTGACTAAAGTGCTATATAAAAATTTACTCGGGTGTCTGTTTTCCAGTAATATACGATCATGGAT
CATTAATTTTTGAGGGCAAC

Downstream 100 bases:

>100_bases
CTGAGGGTTTTGTTGTGAAAAAATTGAGTTTTATAGTCTTGGCAGCACTGGTACTAACAGCATGTAATTCTCGTTATGCC
AGTAATGGAGAAAATTTATA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIKTVIEQAKERVPVIAGTAMNA
TKDCIELTQQAMEYGAHAALIMTPAYIKPTQEGLYLHYSHIAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIK
EATGQMTRLQQILRLCEGSIDVYSGDDLTAAQWLLAGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
LLFVESNPIPVKWAMNKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI

Sequences:

>Translated_290_residues
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIKTVIEQAKERVPVIAGTAMNA
TKDCIELTQQAMEYGAHAALIMTPAYIKPTQEGLYLHYSHIAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIK
EATGQMTRLQQILRLCEGSIDVYSGDDLTAAQWLLAGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
LLFVESNPIPVKWAMNKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI
>Mature_290_residues
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIKTVIEQAKERVPVIAGTAMNA
TKDCIELTQQAMEYGAHAALIMTPAYIKPTQEGLYLHYSHIAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIK
EATGQMTRLQQILRLCEGSIDVYSGDDLTAAQWLLAGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
LLFVESNPIPVKWAMNKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=261, Percent_Identity=30.2681992337165, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI13540533, Length=299, Percent_Identity=24.0802675585284, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=50.3424657534247, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI87082415, Length=288, Percent_Identity=29.8611111111111, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786463, Length=246, Percent_Identity=28.8617886178862, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789620, Length=287, Percent_Identity=27.5261324041812, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31551; Mature: 31551

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHH
TVIEQAKERVPVIAGTAMNATKDCIELTQQAMEYGAHAALIMTPAYIKPTQEGLYLHYSH
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEHHH
IAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIKEATGQMTRLQQILRLCEGSI
HHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
DVYSGDDLTAAQWLLAGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
EEECCCCHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LLFVESNPIPVKWAMNKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI
HHEECCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFSGSIVALVTPMRNDSVDVHHLRELVEFHIAKGTHALVAAGTTGEAGTLSHSEKLLVIK
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHH
TVIEQAKERVPVIAGTAMNATKDCIELTQQAMEYGAHAALIMTPAYIKPTQEGLYLHYSH
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEHHH
IAQSVAIPIILYNVPGRTACDMLPETVARLAKISNIIGIKEATGQMTRLQQILRLCEGSI
HHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
DVYSGDDLTAAQWLLAGAKGVISVTANVAAKLMAKMCDLAMDDDQAGCLRIQEQLMPLHE
EEECCCCHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LLFVESNPIPVKWAMNKMGLIGGELRLPMTELSEKHHQALEKVLKNLELI
HHEECCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA