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The map label for this gene is mdh [H]

Identifier: 54295096

GI number: 54295096

Start: 2490028

End: 2491188

Strand: Reverse

Name: mdh [H]

Synonym: lpl2176

Alternate gene names: 54295096

Gene position: 2491188-2490028 (Counterclockwise)

Preceding gene: 54295097

Following gene: 54295095

Centisome position: 74.46

GC content: 43.93

Gene sequence:

>1161_bases
ATGAAAAACCAATCATTAATTGTCAATTGGAATTACCCGACACGAATCCTGGTTGGGGCTGGGCGAATCAATGAACTAGC
GAAAGTATGTCGTGACTTAGGTATGAATGCTCCTCTGTTAGTCACAGACCCGGGATTGGCTTCGTCGTTAATGGTGAGTA
AAGTTATACAACAGGCTCAGGCATCCGGTTTGCGAACGGGGTTATTTTGCCAAATTAAAACAAATCCTACCGGTGACAAT
GTGATGAATGGAGTCTATGCTTTTAAAGCTGGGCAGCATGATGGTGTGATTGCTTTCGGAGGTGGCTCGGCTTTGGATGC
CGGCAAAGCCATCGCTTTAATGGTTGGCCAGGATCGACCTTTATGGGATTTCGAGGACGTGGGTGATAACTGGACTCGAG
TGAATATTTCAGCCATGGCCCCAGTTCTTGCCATTCCAACAACAGCAGGAACTGGTTCAGAGGTCGGGCGAGCTTCTGTA
ATTACCGATGCTGAAAAGCAGGTTAAAAAAATCATTTTTCATCCTAAAATGTTGCCTGCTATGGTTATTCTCGATCCAGA
GTTAACTGTCGGGCTTCCCAAATCACTTACTGCAGCTACAGGTATGGATGCTCTTTCCCATTGTCTTGAAGCTTATTGTT
CCAATTATTATCATCCTATGGCAGAAGGTATTGCGTTGGAAGGAATAAGATTAATCAAGGGGAATTTAATTCAAGCTTAC
AAGGATGGTAGTGACCTGGAGGCAAGAACCCATATGCTGGTTGCTTCAGCAATGGGGGCTACCGCCTTTCAGCGTGGTCT
TGGAGCGATGCACGCCTTGGCTCATCCATTAGGTGCAATTTATGATGTCCATCACGGGCGGCTTAATGCGGTTTTGATGC
CTTATGTTTTATTGGCTAATCGTAGTGAAATTGAAAACAAGATAGAGCGTCTGGCAAATTGTTTATCAATAGCAAATGGA
TTTGATGGTTTTTTGGAGTGGATAGAGCAGATGAGATTAGAGTTAGGAATCGAAAATACATTAAGTCAGTTAGGTATTGA
TCATTCGCAGATAGACAGACTGGCAAAAATGGCCACTGAGGATGCGGCAGCAGCTTCCAATCCTGTTCTTTTTACATTAG
AGCAATACAAAGAACTATTGAGCAAAGCCATTGGTGAGTGA

Upstream 100 bases:

>100_bases
AAAACCCAAAATAAAATTATAAAAAAGACCTAATCTTTCCTGCGGAAAGGTACTTGCTATCAGTTACAATGGTCTTTTTC
GAATCAAAGGAAGATCATAG

Downstream 100 bases:

>100_bases
TCGTTGTAAAGGAAAAGGTGCAGAAACGGGTTGTTTACCAGGTATAAATCAGATGGAAAGGACTTGTATATTGAAATTAA
GTCTAATCCAGACAATAAAA

Product: hypothetical protein

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKNQSLIVNWNYPTRILVGAGRINELAKVCRDLGMNAPLLVTDPGLASSLMVSKVIQQAQASGLRTGLFCQIKTNPTGDN
VMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRPLWDFEDVGDNWTRVNISAMAPVLAIPTTAGTGSEVGRASV
ITDAEKQVKKIIFHPKMLPAMVILDPELTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKGNLIQAY
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLANRSEIENKIERLANCLSIANG
FDGFLEWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATEDAAAASNPVLFTLEQYKELLSKAIGE

Sequences:

>Translated_386_residues
MKNQSLIVNWNYPTRILVGAGRINELAKVCRDLGMNAPLLVTDPGLASSLMVSKVIQQAQASGLRTGLFCQIKTNPTGDN
VMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRPLWDFEDVGDNWTRVNISAMAPVLAIPTTAGTGSEVGRASV
ITDAEKQVKKIIFHPKMLPAMVILDPELTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKGNLIQAY
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLANRSEIENKIERLANCLSIANG
FDGFLEWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATEDAAAASNPVLFTLEQYKELLSKAIGE
>Mature_386_residues
MKNQSLIVNWNYPTRILVGAGRINELAKVCRDLGMNAPLLVTDPGLASSLMVSKVIQQAQASGLRTGLFCQIKTNPTGDN
VMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRPLWDFEDVGDNWTRVNISAMAPVLAIPTTAGTGSEVGRASV
ITDAEKQVKKIIFHPKMLPAMVILDPELTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKGNLIQAY
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLANRSEIENKIERLANCLSIANG
FDGFLEWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATEDAAAASNPVLFTLEQYKELLSKAIGE

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=307, Percent_Identity=26.0586319218241, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI48994951, Length=371, Percent_Identity=33.1536388140162, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI87082107, Length=384, Percent_Identity=32.8125, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=32, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1787493, Length=383, Percent_Identity=28.7206266318538, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789386, Length=372, Percent_Identity=26.6129032258064, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=284, Percent_Identity=27.8169014084507, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321181, Length=391, Percent_Identity=36.3171355498721, Blast_Score=226, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24657991, Length=391, Percent_Identity=22.7621483375959, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 41465; Mature: 41465

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQSLIVNWNYPTRILVGAGRINELAKVCRDLGMNAPLLVTDPGLASSLMVSKVIQQAQ
CCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHH
ASGLRTGLFCQIKTNPTGDNVMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRP
HCCCCCCEEEEEECCCCCCHHHCCHHEEECCCCCCEEEECCCCCCCCCCEEEEEECCCCC
LWDFEDVGDNWTRVNISAMAPVLAIPTTAGTGSEVGRASVITDAEKQVKKIIFHPKMLPA
CCCHHHCCCCEEEEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
MVILDPELTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKGNLIQAY
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHCCCHHHHCCHHHHH
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLAN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
RSEIENKIERLANCLSIANGFDGFLEWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHH
DAAAASNPVLFTLEQYKELLSKAIGE
HHHCCCCCEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNQSLIVNWNYPTRILVGAGRINELAKVCRDLGMNAPLLVTDPGLASSLMVSKVIQQAQ
CCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHH
ASGLRTGLFCQIKTNPTGDNVMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRP
HCCCCCCEEEEEECCCCCCHHHCCHHEEECCCCCCEEEECCCCCCCCCCEEEEEECCCCC
LWDFEDVGDNWTRVNISAMAPVLAIPTTAGTGSEVGRASVITDAEKQVKKIIFHPKMLPA
CCCHHHCCCCEEEEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCE
MVILDPELTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKGNLIQAY
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHCCCHHHHCCHHHHH
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLAN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
RSEIENKIERLANCLSIANGFDGFLEWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHH
DAAAASNPVLFTLEQYKELLSKAIGE
HHHCCCCCEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]