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The map label for this gene is dctA [H]

Identifier: 54295091

GI number: 54295091

Start: 2483490

End: 2484782

Strand: Reverse

Name: dctA [H]

Synonym: lpl2171

Alternate gene names: 54295091

Gene position: 2484782-2483490 (Counterclockwise)

Preceding gene: 54295092

Following gene: 54295084

Centisome position: 74.27

GC content: 39.13

Gene sequence:

>1293_bases
ATGAATTTTCTTAAAAAATTATATGTTCAAGTTCTTCTGGGTGTTTTCATTGGTATTTTGCTTGGATATTTTTTGCCTGA
TGTAGGGGTTCAATTAAAAGCTATAACCGATGTTTTTATCAAAATCATTAAGATGCTAATTTCTCCTATTATATTTCTCA
CCCTGGTCTCCGGAATCGCAGCAATGAATGATATGAGGCAAGTTGGGCGCTTGGCAGGTGGGGCATTGCTTTTTTTTACG
TTCATCACAACTCTGGCATTGCTGATAGGTCTTCTGGCGACAGATTATTTTAAGCCTGGTGTTGGTTTAAATGTGAATCC
CAATTCTCTGGATGCCAAGGAAGCGAGTTCTTACCTTGAGGGGGCACATAAGGTAACCAATGTGACTGATTTGCTAATTA
ATATTATCCCGAGAACTTTTATTAGCGCTTTTGTAGATGGTGAACTGCTGCAAGTTATTTTTATTTCAATATTGTTTGCG
ATCGGCCTGATTCTTACAGGCAATGCAGGTAAATCATTGGTTACTGGAATGCAAGCTCTGTCTAATGTCTTTTTTAAAAT
CATTCATTTTGTAATGTATATGGCGCCTGTAGCAGCCTTTGCCGCCATGGCATTCAGTGTCGGGAAATTTGGAGTTGGTC
CTTTGTTTAATTTAATTGGATTATTGGCTTGTTATTATCTAACTTCCATTTTCTTTATCTTGATTATCTTGGGAAGTCTT
TTGCAATGGTATTGCAAAATTAATATTTGGCATTTGTTACGGTATTTAAAGGATGAGCTTTTAATCGTGTGGAGCACCGC
TTCCTCCGAAACCGTACTGCCAAGTTTGATGCAGAAGTTGGAACGATTGGGATGTGAGCAATCTGTAGTCGGTTTGATCC
TGCCATTAGGATATTCTTTTAATTTGGCAGGAACTGCAATCTATTTAACAATGGCTGCCATGTTTATTGCACAGGCTACC
AATACTGATCTAACAGTTTGGCAGGAGTTATCGCTTCTGGGAGTTATGATCATTAGTTCCAAGGGTGCCGCTGGGGTGTC
CGGAAGTGGATTTATTGTGTTGGCGAGCTCATTAGCAACGATAGGACACATTCCTGCTGCAGGCGTCGTTCTTGTTTTGG
GTATCGATAAATTCATGAATGAAGCCAGGTCAATTATTAATATGATGGCTAATGCAATCGCCACGATTATTATTTCCAGG
TGGCAACAATCTTTGGATTACCAGAAAACTCGATTTGAATTGCAAGAAAAAGGACAAGCAGAAACCAAAAGTGTTTATGC
CAGTGAGATGTAA

Upstream 100 bases:

>100_bases
AGCTATTCATGTAATAATGATTTGTCTAGGGAAAGAATTTTTAGTGCTTCATGCTTTGCTTTTGAATAGTTGTTTATAGT
AAACAACCTGGAGAATAAAA

Downstream 100 bases:

>100_bases
GATTTCTACAGGACTCACGAAAAACTCCAAGGTCGAGGCAAAAAATGTTTTTAATTCGGTCATTTAGTTTATCTAAACTC
ACTCATTAAAAACATTTTTT

Product: hypothetical protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNFLKKLYVQVLLGVFIGILLGYFLPDVGVQLKAITDVFIKIIKMLISPIIFLTLVSGIAAMNDMRQVGRLAGGALLFFT
FITTLALLIGLLATDYFKPGVGLNVNPNSLDAKEASSYLEGAHKVTNVTDLLINIIPRTFISAFVDGELLQVIFISILFA
IGLILTGNAGKSLVTGMQALSNVFFKIIHFVMYMAPVAAFAAMAFSVGKFGVGPLFNLIGLLACYYLTSIFFILIILGSL
LQWYCKINIWHLLRYLKDELLIVWSTASSETVLPSLMQKLERLGCEQSVVGLILPLGYSFNLAGTAIYLTMAAMFIAQAT
NTDLTVWQELSLLGVMIISSKGAAGVSGSGFIVLASSLATIGHIPAAGVVLVLGIDKFMNEARSIINMMANAIATIIISR
WQQSLDYQKTRFELQEKGQAETKSVYASEM

Sequences:

>Translated_430_residues
MNFLKKLYVQVLLGVFIGILLGYFLPDVGVQLKAITDVFIKIIKMLISPIIFLTLVSGIAAMNDMRQVGRLAGGALLFFT
FITTLALLIGLLATDYFKPGVGLNVNPNSLDAKEASSYLEGAHKVTNVTDLLINIIPRTFISAFVDGELLQVIFISILFA
IGLILTGNAGKSLVTGMQALSNVFFKIIHFVMYMAPVAAFAAMAFSVGKFGVGPLFNLIGLLACYYLTSIFFILIILGSL
LQWYCKINIWHLLRYLKDELLIVWSTASSETVLPSLMQKLERLGCEQSVVGLILPLGYSFNLAGTAIYLTMAAMFIAQAT
NTDLTVWQELSLLGVMIISSKGAAGVSGSGFIVLASSLATIGHIPAAGVVLVLGIDKFMNEARSIINMMANAIATIIISR
WQQSLDYQKTRFELQEKGQAETKSVYASEM
>Mature_430_residues
MNFLKKLYVQVLLGVFIGILLGYFLPDVGVQLKAITDVFIKIIKMLISPIIFLTLVSGIAAMNDMRQVGRLAGGALLFFT
FITTLALLIGLLATDYFKPGVGLNVNPNSLDAKEASSYLEGAHKVTNVTDLLINIIPRTFISAFVDGELLQVIFISILFA
IGLILTGNAGKSLVTGMQALSNVFFKIIHFVMYMAPVAAFAAMAFSVGKFGVGPLFNLIGLLACYYLTSIFFILIILGSL
LQWYCKINIWHLLRYLKDELLIVWSTASSETVLPSLMQKLERLGCEQSVVGLILPLGYSFNLAGTAIYLTMAAMFIAQAT
NTDLTVWQELSLLGVMIISSKGAAGVSGSGFIVLASSLATIGHIPAAGVVLVLGIDKFMNEARSIINMMANAIATIIISR
WQQSLDYQKTRFELQEKGQAETKSVYASEM

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=419, Percent_Identity=24.8210023866348, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI169790839, Length=463, Percent_Identity=23.3261339092873, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4827012, Length=349, Percent_Identity=23.7822349570201, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI66773030, Length=397, Percent_Identity=22.4181360201511, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI5032093, Length=395, Percent_Identity=24.3037974683544, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI194239697, Length=262, Percent_Identity=27.4809160305344, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI40254478, Length=484, Percent_Identity=22.1074380165289, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI223468566, Length=269, Percent_Identity=24.5353159851301, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=24.5353159851301, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI301601644, Length=158, Percent_Identity=32.2784810126582, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI262359914, Length=374, Percent_Identity=24.0641711229947, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789947, Length=408, Percent_Identity=47.7941176470588, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1790514, Length=411, Percent_Identity=36.4963503649635, Blast_Score=285, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17537407, Length=430, Percent_Identity=22.7906976744186, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71983106, Length=468, Percent_Identity=25.6410256410256, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=468, Percent_Identity=25.6410256410256, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71996953, Length=466, Percent_Identity=24.8927038626609, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=466, Percent_Identity=23.3905579399142, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI193206654, Length=455, Percent_Identity=22.6373626373626, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583025, Length=444, Percent_Identity=22.2972972972973, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17137668, Length=444, Percent_Identity=22.2972972972973, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24583023, Length=444, Percent_Identity=22.2972972972973, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46748; Mature: 46748

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCC
>Mature Secondary Structure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HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA