Click here to switch to the map view.

The map label for this gene is adh [H]

Identifier: 54294955

GI number: 54294955

Start: 2278869

End: 2279909

Strand: Reverse

Name: adh [H]

Synonym: lpl2034

Alternate gene names: 54294955

Gene position: 2279909-2278869 (Counterclockwise)

Preceding gene: 54294956

Following gene: 54294954

Centisome position: 68.14

GC content: 40.44

Gene sequence:

>1041_bases
GTGAAAGCATTTATTTACCAAGGACCAGGAAAAAAAGCTATTGAAGAGCGGCCCACTCCAATTATTACAAACCCAACAGA
TGCCATCATTAAAGTCACTAAAACTACGATTTGCGGCACAGATTTACATATCCTTAAAGGGGATGTTGTGACTTGTGTAC
CTGGTCGTATTCTGGGTCATGAAGGAATTGGTGTAGTGGATAAAGTGGGGCAGGGCGTTACTGAGTTTCAGAAAGGAGAT
CTCGTCTTAATCTCTTGCATCACTTCTTGCAGTAAGTGTGAGTATTGTCGGAAAGGAATGTATTCACACTGCGCTAAAGG
CGGTTGGATTCTTGGAAATACTATTGATGGGACACAAGCTGAGTATGTTCGTATCCCTTATGCTGATACCAGTCTATATA
AAATTCCGGAAGGAATTGATGAAGACGTACTGGTAATGCTAAGTGATATATTACCAACAGGATTTGAATGTGGTGTACAA
AATGGCAAAGTACAGCCAGGTAATACCGTGGCTATAGTCGGTGCTGGACCAATTGGTTTGTCTACGCTACTCACAGCCCA
ATTTTATTCACCTGCTGAAATTATAGTGATTGATTTAGATGATAATCGTCTTGAAGTAGCAAAACGTTTTGGCGCAACTG
CAACTGTAAACAGTAGTGACGGTAAAGCAGTTGACAAGATTATGCAAATGACGAATGGGCGTGGAGTTGATACGGCTATA
GAGGCGGTTGGCATTCCAGCCACGTTTGTTATGTGTGAAGATATTGTGGCGCCAGGTGGTACTATTGCCAATATCGGCGT
GCATGGGGTCAAAGCTGATTTACATTTAGAAAGGTTATGGTCTCAAAATATTTCTATTACTACACGACTTGTTGATACTG
TAACAACACCAATGTTGCTAAAAACTGTCAGTGCAAAAAAAATTAATCCTATGCTGTTAATTAGTCATCGATTTAAATTT
GCTAAAATCTTGGATGCCTACGAAACCTTTGCACATGCGGCAGATACTCATGCTCTCAAGGTAATAATTAATGTATCGTG
A

Upstream 100 bases:

>100_bases
ATTCAATCCTAACTTTTTCTAACCACAATAATCTACTTGTGAGAATGCTTAACATAATCTCTCCTAAAATTATTCTAGAA
TATCTTTAAGGAAAACCACA

Downstream 100 bases:

>100_bases
CTTATAGAGTATCAATGGCTATATGATTACTGTTGGGCTCTAAAAATCATACCGCAGGATCACAATTAAGCAGTAGTTAC
CGTGCACTAGTGAAGCGGTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKAFIYQGPGKKAIEERPTPIITNPTDAIIKVTKTTICGTDLHILKGDVVTCVPGRILGHEGIGVVDKVGQGVTEFQKGD
LVLISCITSCSKCEYCRKGMYSHCAKGGWILGNTIDGTQAEYVRIPYADTSLYKIPEGIDEDVLVMLSDILPTGFECGVQ
NGKVQPGNTVAIVGAGPIGLSTLLTAQFYSPAEIIVIDLDDNRLEVAKRFGATATVNSSDGKAVDKIMQMTNGRGVDTAI
EAVGIPATFVMCEDIVAPGGTIANIGVHGVKADLHLERLWSQNISITTRLVDTVTTPMLLKTVSAKKINPMLLISHRFKF
AKILDAYETFAHAADTHALKVIINVS

Sequences:

>Translated_346_residues
MKAFIYQGPGKKAIEERPTPIITNPTDAIIKVTKTTICGTDLHILKGDVVTCVPGRILGHEGIGVVDKVGQGVTEFQKGD
LVLISCITSCSKCEYCRKGMYSHCAKGGWILGNTIDGTQAEYVRIPYADTSLYKIPEGIDEDVLVMLSDILPTGFECGVQ
NGKVQPGNTVAIVGAGPIGLSTLLTAQFYSPAEIIVIDLDDNRLEVAKRFGATATVNSSDGKAVDKIMQMTNGRGVDTAI
EAVGIPATFVMCEDIVAPGGTIANIGVHGVKADLHLERLWSQNISITTRLVDTVTTPMLLKTVSAKKINPMLLISHRFKF
AKILDAYETFAHAADTHALKVIINVS
>Mature_346_residues
MKAFIYQGPGKKAIEERPTPIITNPTDAIIKVTKTTICGTDLHILKGDVVTCVPGRILGHEGIGVVDKVGQGVTEFQKGD
LVLISCITSCSKCEYCRKGMYSHCAKGGWILGNTIDGTQAEYVRIPYADTSLYKIPEGIDEDVLVMLSDILPTGFECGVQ
NGKVQPGNTVAIVGAGPIGLSTLLTAQFYSPAEIIVIDLDDNRLEVAKRFGATATVNSSDGKAVDKIMQMTNGRGVDTAI
EAVGIPATFVMCEDIVAPGGTIANIGVHGVKADLHLERLWSQNISITTRLVDTVTTPMLLKTVSAKKINPMLLISHRFKF
AKILDAYETFAHAADTHALKVIINVS

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=330, Percent_Identity=29.3939393939394, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4501929, Length=330, Percent_Identity=30, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI156627571, Length=336, Percent_Identity=26.4880952380952, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4501933, Length=330, Percent_Identity=28.7878787878788, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI71565154, Length=330, Percent_Identity=28.1818181818182, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI262073058, Length=329, Percent_Identity=28.8753799392097, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI71743840, Length=329, Percent_Identity=28.8753799392097, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=26.2569832402235, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI156523966, Length=358, Percent_Identity=26.2569832402235, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI71565152, Length=331, Percent_Identity=27.190332326284, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786825, Length=279, Percent_Identity=35.1254480286738, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1787863, Length=351, Percent_Identity=28.7749287749288, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1790045, Length=326, Percent_Identity=29.4478527607362, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082125, Length=351, Percent_Identity=27.9202279202279, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788073, Length=334, Percent_Identity=27.8443113772455, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788075, Length=339, Percent_Identity=25.3687315634218, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788407, Length=348, Percent_Identity=26.1494252873563, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI87081918, Length=268, Percent_Identity=33.5820895522388, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790718, Length=342, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=25.5255255255255, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786552, Length=239, Percent_Identity=33.4728033472803, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=26.5486725663717, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=333, Percent_Identity=29.4294294294294, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71997431, Length=333, Percent_Identity=29.1291291291291, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=207, Percent_Identity=31.8840579710145, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17565904, Length=357, Percent_Identity=27.4509803921569, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71988145, Length=181, Percent_Identity=32.0441988950276, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=348, Percent_Identity=28.448275862069, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=348, Percent_Identity=28.448275862069, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=343, Percent_Identity=25.9475218658892, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=241, Percent_Identity=30.7053941908714, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=300, Percent_Identity=28, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=299, Percent_Identity=25.4180602006689, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=271, Percent_Identity=29.1512915129151, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=266, Percent_Identity=29.3233082706767, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=280, Percent_Identity=28.9285714285714, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=264, Percent_Identity=26.8939393939394, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137530, Length=340, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17737897, Length=340, Percent_Identity=29.4117647058824, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17737895, Length=331, Percent_Identity=29.0030211480363, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37042; Mature: 37042

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFIYQGPGKKAIEERPTPIITNPTDAIIKVTKTTICGTDLHILKGDVVTCVPGRILGH
CCEEEEECCCCHHHHHCCCCEEECCCCCEEEEEEEEECCCCEEEECCCEEEECCCEEECC
EGIGVVDKVGQGVTEFQKGDLVLISCITSCSKCEYCRKGMYSHCAKGGWILGNTIDGTQA
CCCCHHHHHCCCHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
EYVRIPYADTSLYKIPEGIDEDVLVMLSDILPTGFECGVQNGKVQPGNTVAIVGAGPIGL
CEEEEECCCCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCH
STLLTAQFYSPAEIIVIDLDDNRLEVAKRFGATATVNSSDGKAVDKIMQMTNGRGVDTAI
HHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCHHHH
EAVGIPATFVMCEDIVAPGGTIANIGVHGVKADLHLERLWSQNISITTRLVDTVTTPMLL
HHCCCCHHEEEHHHHHCCCCCEEECCCEEEEHHHHHHHHHCCCCEEEEHHHHHHCCHHHH
KTVSAKKINPMLLISHRFKFAKILDAYETFAHAADTHALKVIINVS
HHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
>Mature Secondary Structure
MKAFIYQGPGKKAIEERPTPIITNPTDAIIKVTKTTICGTDLHILKGDVVTCVPGRILGH
CCEEEEECCCCHHHHHCCCCEEECCCCCEEEEEEEEECCCCEEEECCCEEEECCCEEECC
EGIGVVDKVGQGVTEFQKGDLVLISCITSCSKCEYCRKGMYSHCAKGGWILGNTIDGTQA
CCCCHHHHHCCCHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
EYVRIPYADTSLYKIPEGIDEDVLVMLSDILPTGFECGVQNGKVQPGNTVAIVGAGPIGL
CEEEEECCCCCCEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCH
STLLTAQFYSPAEIIVIDLDDNRLEVAKRFGATATVNSSDGKAVDKIMQMTNGRGVDTAI
HHHHHHHCCCCCEEEEEEECCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCHHHH
EAVGIPATFVMCEDIVAPGGTIANIGVHGVKADLHLERLWSQNISITTRLVDTVTTPMLL
HHCCCCHHEEEHHHHHCCCCCEEECCCEEEEHHHHHHHHHCCCCEEEEHHHHHHCCHHHH
KTVSAKKINPMLLISHRFKFAKILDAYETFAHAADTHALKVIINVS
HHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]