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The map label for this gene is icfA [H]

Identifier: 54294817

GI number: 54294817

Start: 2124195

End: 2125265

Strand: Reverse

Name: icfA [H]

Synonym: lpl1895

Alternate gene names: 54294817

Gene position: 2125265-2124195 (Counterclockwise)

Preceding gene: 54294819

Following gene: 54294810

Centisome position: 63.52

GC content: 37.44

Gene sequence:

>1071_bases
ATGTTAATTAAACTGATGCTCGGATTACTTGAATTTAAAAAAAAACCTTTTATTGGGATGAGAGATTTATTTGAGCAATT
AAGCACCGGGCAGAATCCAGAAACACTATTTATAACGTGCTCTGACTCAAGGATTGTCCCGAGTCTTATAACACAAGCTG
ATCCAGGCGATTTATTCAGCATACGTAATATAGGTAATATCATTCCTCCTTATCCATCAAGCTATAGTGAGGCCGGAGCT
ATTGAGTACGCTTTAAAAGTATTAGAGATAAAAGACATTATCATTTGTGGCCACTCCAATTGTGGTGCAATGAAAGGATT
ATTAAATTCGCATATTGAGGAGCATTTGCCGTGCGTAGCATCGTGGCTAAATCACTCTCAAGCTGTGTTACAAGAGGTGC
ATGAGGAACGAGAAACTGAAACTAATACGCCCGATCGAGAACTTGAGATTGCTACCAAGAAGAATATTCTGCTCCAAATG
GAACATTTGAAAACCTATCCACTGGTCATCGAAAAAACAGCTCATAAGGAGTTAACAATTCATGGTTGGTATTATGAACT
GGAAACGGGAAAGGTATTTATTTATGAACCCGATTTAAAAGAATTTATTAATCTCGAATATGCATTAGACCGGGCCCTTG
AGTCCAGAAAAAACAAAATTGTGTCCGGTCTTTGTATGAATTACCTTCAACAAATGATTCCATTAAAATCAGAAAAGGAA
TATTGCCGGTTAATGGAATTAATTACTAATCTTCAAGAAGATATTCTGCCAATTTGGGAATTTATTAGAGAACCAGCCAA
ACAGCAATTATGGAAGGAGTTAGGGGGCTTTTATGCAAGTCCGGAAGACGAAGAATTTATAGCCATGGTGGAATCGAGTA
CATCAATAAAACTCACTGAATTAGAAGAGTTTAAGAAAAAGGTTTCCTTTGCCAATAATAATACAGCGACAAGCCTATTA
CTCAACTCATCAATTTTTAAAAAACCAACAAAGGATATTGGTAAACTAAATGTTGAGCCAGTCATAAGTCGAGATGCGAG
AGTTGCCTTGTCGGGTGACAGGGGCTCCTAG

Upstream 100 bases:

>100_bases
ACATTTGTTTACGATATTGCAATATTTCTTTACGATTCTTTGTTGTTATGATAATTTGCCTTCATATGATGGATTTTGTA
AAGAAATTATGAGGTTAATT

Downstream 100 bases:

>100_bases
ATGTTTTTCCCGACTGAACATCCAGCCACGGAGTTAGAGAATGCAGTGGCTTAGCAAGCGTAGCCTTGATGCATCACAGC
GTAATCAATGGTTATTCGCC

Product: hypothetical protein

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MLIKLMLGLLEFKKKPFIGMRDLFEQLSTGQNPETLFITCSDSRIVPSLITQADPGDLFSIRNIGNIIPPYPSSYSEAGA
IEYALKVLEIKDIIICGHSNCGAMKGLLNSHIEEHLPCVASWLNHSQAVLQEVHEERETETNTPDRELEIATKKNILLQM
EHLKTYPLVIEKTAHKELTIHGWYYELETGKVFIYEPDLKEFINLEYALDRALESRKNKIVSGLCMNYLQQMIPLKSEKE
YCRLMELITNLQEDILPIWEFIREPAKQQLWKELGGFYASPEDEEFIAMVESSTSIKLTELEEFKKKVSFANNNTATSLL
LNSSIFKKPTKDIGKLNVEPVISRDARVALSGDRGS

Sequences:

>Translated_356_residues
MLIKLMLGLLEFKKKPFIGMRDLFEQLSTGQNPETLFITCSDSRIVPSLITQADPGDLFSIRNIGNIIPPYPSSYSEAGA
IEYALKVLEIKDIIICGHSNCGAMKGLLNSHIEEHLPCVASWLNHSQAVLQEVHEERETETNTPDRELEIATKKNILLQM
EHLKTYPLVIEKTAHKELTIHGWYYELETGKVFIYEPDLKEFINLEYALDRALESRKNKIVSGLCMNYLQQMIPLKSEKE
YCRLMELITNLQEDILPIWEFIREPAKQQLWKELGGFYASPEDEEFIAMVESSTSIKLTELEEFKKKVSFANNNTATSLL
LNSSIFKKPTKDIGKLNVEPVISRDARVALSGDRGS
>Mature_356_residues
MLIKLMLGLLEFKKKPFIGMRDLFEQLSTGQNPETLFITCSDSRIVPSLITQADPGDLFSIRNIGNIIPPYPSSYSEAGA
IEYALKVLEIKDIIICGHSNCGAMKGLLNSHIEEHLPCVASWLNHSQAVLQEVHEERETETNTPDRELEIATKKNILLQM
EHLKTYPLVIEKTAHKELTIHGWYYELETGKVFIYEPDLKEFINLEYALDRALESRKNKIVSGLCMNYLQQMIPLKSEKE
YCRLMELITNLQEDILPIWEFIREPAKQQLWKELGGFYASPEDEEFIAMVESSTSIKLTELEEFKKKVSFANNNTATSLL
LNSSIFKKPTKDIGKLNVEPVISRDARVALSGDRGS

Specific function: Reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation [H]

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm. Note=Associated with carboxysomes [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786534, Length=199, Percent_Identity=38.6934673366834, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786318, Length=182, Percent_Identity=32.4175824175824, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147564, Length=237, Percent_Identity=25.3164556962025, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI115532990, Length=239, Percent_Identity=26.3598326359833, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324292, Length=167, Percent_Identity=29.940119760479, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645213, Length=246, Percent_Identity=26.8292682926829, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 40585; Mature: 40585

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKLMLGLLEFKKKPFIGMRDLFEQLSTGQNPETLFITCSDSRIVPSLITQADPGDLFS
CHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHCCCCCCCEEE
IRNIGNIIPPYPSSYSEAGAIEYALKVLEIKDIIICGHSNCGAMKGLLNSHIEEHLPCVA
HHHCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SWLNHSQAVLQEVHEERETETNTPDRELEIATKKNILLQMEHLKTYPLVIEKTAHKELTI
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHEEHHHHCCCCEEEEECCCCEEEE
HGWYYELETGKVFIYEPDLKEFINLEYALDRALESRKNKIVSGLCMNYLQQMIPLKSEKE
EEEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
YCRLMELITNLQEDILPIWEFIREPAKQQLWKELGGFYASPEDEEFIAMVESSTSIKLTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEHHH
LEEFKKKVSFANNNTATSLLLNSSIFKKPTKDIGKLNVEPVISRDARVALSGDRGS
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCHHCCCCCEEEECCCCCC
>Mature Secondary Structure
MLIKLMLGLLEFKKKPFIGMRDLFEQLSTGQNPETLFITCSDSRIVPSLITQADPGDLFS
CHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHCCCCCCCEEE
IRNIGNIIPPYPSSYSEAGAIEYALKVLEIKDIIICGHSNCGAMKGLLNSHIEEHLPCVA
HHHCCCCCCCCCCCCCCCHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SWLNHSQAVLQEVHEERETETNTPDRELEIATKKNILLQMEHLKTYPLVIEKTAHKELTI
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHEEHHHHCCCCEEEEECCCCEEEE
HGWYYELETGKVFIYEPDLKEFINLEYALDRALESRKNKIVSGLCMNYLQQMIPLKSEKE
EEEEEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
YCRLMELITNLQEDILPIWEFIREPAKQQLWKELGGFYASPEDEEFIAMVESSTSIKLTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEHHH
LEEFKKKVSFANNNTATSLLLNSSIFKKPTKDIGKLNVEPVISRDARVALSGDRGS
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]