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The map label for this gene is lepB [H]

Identifier: 54294756

GI number: 54294756

Start: 2049772

End: 2050527

Strand: Reverse

Name: lepB [H]

Synonym: lpl1833

Alternate gene names: 54294756

Gene position: 2050527-2049772 (Counterclockwise)

Preceding gene: 54294757

Following gene: 54294755

Centisome position: 61.29

GC content: 39.02

Gene sequence:

>756_bases
ATGAATTTTGCTTTAATATTGGTCATATTATCCGCTGTAACAGGATTGATTGCTTTATTGGATTGGTTGATTTGGTCTAA
AAAGCGTTTGCCTGAACAAAAGCCAGGTCGAATCATTGAGTATTCACGTTCTTTTTTTCCTGTATTTTTTATTGTTCTGC
TATTGCGCTCTTTTTTAGTTGAACCTTTTCGTATTCCATCGGGCTCACTCGAGCCTACTCTGTTGGTTGGTGATTTTGTA
GCGGTTAATAAATTTTCTTATGGACTGAGACTTCCAGTATGGGAGAAAAAAATAGTGCCAATTGCTAATCCCAAAACGGG
AGAAATCGCAGTATTTCGCTGGCCACCCGAACCATCTTATGACTATATTAAAAGAGTTATTGGAGTGCCTGGGGATAAAA
TTTCATATCATGATAAAAAACTAACTATTAATGGCAAAGAGGTGAAACAGACCTTTGTTGAGTATACTACCGATGAAAGT
TCTGGCAAGGCTGTGACAAAGTATAAAGAAGATTTAAACGGTGTGGTGCACGACATATTTGTCAGACCTGATGCGCCAGC
TGTAGATTTTGATATAGTTGTTCCTGAGGGGAATTACTTTATGATGGGAGATAATCGGGATGATAGCGCCGATAGCCGGT
TCTGGGGGTTTGTACCTGATAGCTATTTAAGAGGAAAAGCATTTCTGGTCTGGATGAGTTGGAATGGCAAAACAGATAAT
GTACGCTGGTCAAGGATAGGCAGATTAATTCATTGA

Upstream 100 bases:

>100_bases
CATTTACTAATAAGGATGTGCTGACCTTTTCGTCAGCATCTGGACATAAGTCAAATCATGATTAAATTGTCTTTTGTTTA
AAGTTGAGGATATTGAATTT

Downstream 100 bases:

>100_bases
GGGAATAGGGCATGAGAAAACAACAGGGAATGACATTGATTGGCATGCTGTTTACTGCTGTTGTGGTGATAATGGCTGGT
ATACTTGTTATGCGGGCAGC

Product: Signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MNFALILVILSAVTGLIALLDWLIWSKKRLPEQKPGRIIEYSRSFFPVFFIVLLLRSFLVEPFRIPSGSLEPTLLVGDFV
AVNKFSYGLRLPVWEKKIVPIANPKTGEIAVFRWPPEPSYDYIKRVIGVPGDKISYHDKKLTINGKEVKQTFVEYTTDES
SGKAVTKYKEDLNGVVHDIFVRPDAPAVDFDIVVPEGNYFMMGDNRDDSADSRFWGFVPDSYLRGKAFLVWMSWNGKTDN
VRWSRIGRLIH

Sequences:

>Translated_251_residues
MNFALILVILSAVTGLIALLDWLIWSKKRLPEQKPGRIIEYSRSFFPVFFIVLLLRSFLVEPFRIPSGSLEPTLLVGDFV
AVNKFSYGLRLPVWEKKIVPIANPKTGEIAVFRWPPEPSYDYIKRVIGVPGDKISYHDKKLTINGKEVKQTFVEYTTDES
SGKAVTKYKEDLNGVVHDIFVRPDAPAVDFDIVVPEGNYFMMGDNRDDSADSRFWGFVPDSYLRGKAFLVWMSWNGKTDN
VRWSRIGRLIH
>Mature_251_residues
MNFALILVILSAVTGLIALLDWLIWSKKRLPEQKPGRIIEYSRSFFPVFFIVLLLRSFLVEPFRIPSGSLEPTLLVGDFV
AVNKFSYGLRLPVWEKKIVPIANPKTGEIAVFRWPPEPSYDYIKRVIGVPGDKISYHDKKLTINGKEVKQTFVEYTTDES
SGKAVTKYKEDLNGVVHDIFVRPDAPAVDFDIVVPEGNYFMMGDNRDDSADSRFWGFVPDSYLRGKAFLVWMSWNGKTDN
VRWSRIGRLIH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=318, Percent_Identity=38.3647798742138, Blast_Score=195, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 28765; Mature: 28765

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFALILVILSAVTGLIALLDWLIWSKKRLPEQKPGRIIEYSRSFFPVFFIVLLLRSFLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHC
EPFRIPSGSLEPTLLVGDFVAVNKFSYGLRLPVWEKKIVPIANPKTGEIAVFRWPPEPSY
CCEECCCCCCCCEEEEECEEEECCCCCCEECCCCCCCEEECCCCCCCCEEEEECCCCCCH
DYIKRVIGVPGDKISYHDKKLTINGKEVKQTFVEYTTDESSGKAVTKYKEDLNGVVHDIF
HHHHHHHCCCCCCCEECCCEEEECHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEEEE
VRPDAPAVDFDIVVPEGNYFMMGDNRDDSADSRFWGFVPDSYLRGKAFLVWMSWNGKTDN
ECCCCCCCEEEEEEECCCEEEEECCCCCCCCCCEECCCCCHHHCCEEEEEEEECCCCCCC
VRWSRIGRLIH
CHHHHHHHHCC
>Mature Secondary Structure
MNFALILVILSAVTGLIALLDWLIWSKKRLPEQKPGRIIEYSRSFFPVFFIVLLLRSFLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHC
EPFRIPSGSLEPTLLVGDFVAVNKFSYGLRLPVWEKKIVPIANPKTGEIAVFRWPPEPSY
CCEECCCCCCCCEEEEECEEEECCCCCCEECCCCCCCEEECCCCCCCCEEEEECCCCCCH
DYIKRVIGVPGDKISYHDKKLTINGKEVKQTFVEYTTDESSGKAVTKYKEDLNGVVHDIF
HHHHHHHCCCCCCCEECCCEEEECHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEEEE
VRPDAPAVDFDIVVPEGNYFMMGDNRDDSADSRFWGFVPDSYLRGKAFLVWMSWNGKTDN
ECCCCCCCEEEEEEECCCEEEEECCCCCCCCCCEECCCCCHHHCCEEEEEEEECCCCCCC
VRWSRIGRLIH
CHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]