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The map label for this gene is pyrD [H]

Identifier: 54294708

GI number: 54294708

Start: 1997474

End: 1998475

Strand: Reverse

Name: pyrD [H]

Synonym: lpl1785

Alternate gene names: 54294708

Gene position: 1998475-1997474 (Counterclockwise)

Preceding gene: 54294709

Following gene: 54294707

Centisome position: 59.73

GC content: 38.62

Gene sequence:

>1002_bases
ATGTATTCACTGCTGCGCCCTTTACTTTTCAGATTGGATGCAGAAAAAGCCCATTCATTAACATTATCCTTATTACATTA
CCTCCCTGGTTTTTATTTTCGAAAAATGGCCGGTCAACCTGTTCATGCTATGGGTCTTGTATTCCCTCATCAAGTTGGAC
TGGCAGCTGGTTTAGATAAAAATGGCGAACATTTGGATGCATTGGCCAAATTGGGATTTTCATTCATTGAATTGGGGACA
GTAACACCTAAGGGACAAACAGGTAATCCCAAACCAAGGCTTTTTCGTATTGCAGAGGCCAATGCGATTATCAACAGGAT
GGGTTTTAACAATTCCGGAGTTGATGTACTGGTAGAAAATGTAAAAAGTGCAAATTATAAAGGAATATTGGGGATAAATA
TTGGAAAAAATAAAGAGACTAATTTAAATCAAGCTGCTGATGACTATCTTTATTGCTTCCGTAAAGTATATGATCATGCT
TCCTATGTCACTATCAATATTTCCTCCCCCAATACCCCAGATTTACGCCAGTTACAACAAGGAGATTATTTTGCTGAATT
ACTCGCCCAGTTACAAAAAGAACAGATAAAATTAGCAGATCAATATGGACGCCATGTGCCTTTAGTGGTGAAAGTATCAC
CGGATGAAACAGATGAAACACTAAAACAAATGACAGATATCATTTTACAGTATGGAATCGAGGGTATTATTGCAACAAAT
ACCACCTGTTCTCGGGAAATGGTAAAAAATTTGCCTTGCTCTGAAGAACAGGGCGGATTAAGTGGTAGGCCACTAATGGA
ATTATCTACTCGCTGCTTGCGCTTGTTGAAACAATACGTTGGTAATGATGTGACATTGATAGGAGTGGGTGGTATTGACA
GTTTGGAGAGTGCCAAAGACAAGATCAATGCAGGAGCTTCGTTATTACAAGTATACAGTGGTTTAGTTTATAAGGGACCG
GAGTTGATTCACGATATTGTTTCAGGTTTAAATGCTGTCTGA

Upstream 100 bases:

>100_bases
TCGCTTCCTATTAATCGTCAGTACGAAAATCATCACGAAAAATGTTATCATACCTCAATTGCTTTTTATTAATGATTCTC
CCTGCTTTAGGAGTAATTTT

Downstream 100 bases:

>100_bases
TCCTGGTGGTGAGGAAATTGATGTATATTACTAAGGAATTGGCTGTTCGCATGGAAGGATGTATCAAGCAGAGTCATATT
GAGGTGACAAAGCGGTACTC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKMAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGT
VTPKGQTGNPKPRLFRIAEANAIINRMGFNNSGVDVLVENVKSANYKGILGINIGKNKETNLNQAADDYLYCFRKVYDHA
SYVTINISSPNTPDLRQLQQGDYFAELLAQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGP
ELIHDIVSGLNAV

Sequences:

>Translated_333_residues
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKMAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGT
VTPKGQTGNPKPRLFRIAEANAIINRMGFNNSGVDVLVENVKSANYKGILGINIGKNKETNLNQAADDYLYCFRKVYDHA
SYVTINISSPNTPDLRQLQQGDYFAELLAQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGP
ELIHDIVSGLNAV
>Mature_333_residues
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKMAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGT
VTPKGQTGNPKPRLFRIAEANAIINRMGFNNSGVDVLVENVKSANYKGILGINIGKNKETNLNQAADDYLYCFRKVYDHA
SYVTINISSPNTPDLRQLQQGDYFAELLAQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGP
ELIHDIVSGLNAV

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=333, Percent_Identity=40.2402402402402, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1787177, Length=332, Percent_Identity=50.9036144578313, Blast_Score=342, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17509475, Length=331, Percent_Identity=37.7643504531722, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI281361352, Length=339, Percent_Identity=39.2330383480826, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI17137316, Length=339, Percent_Identity=39.2330383480826, Blast_Score=229, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36580; Mature: 36580

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKMAGQPVHAMGLVFPHQVGLAAGLDK
CHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
NGEHLDALAKLGFSFIELGTVTPKGQTGNPKPRLFRIAEANAIINRMGFNNSGVDVLVEN
CCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHH
VKSANYKGILGINIGKNKETNLNQAADDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQ
HHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHC
GDYFAELLAQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECC
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKD
CHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
KINAGASLLQVYSGLVYKGPELIHDIVSGLNAV
HHHCCHHHHHHHHCHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MYSLLRPLLFRLDAEKAHSLTLSLLHYLPGFYFRKMAGQPVHAMGLVFPHQVGLAAGLDK
CHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
NGEHLDALAKLGFSFIELGTVTPKGQTGNPKPRLFRIAEANAIINRMGFNNSGVDVLVEN
CCHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHH
VKSANYKGILGINIGKNKETNLNQAADDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQ
HHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHC
GDYFAELLAQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATN
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECC
TTCSREMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKD
CHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHH
KINAGASLLQVYSGLVYKGPELIHDIVSGLNAV
HHHCCHHHHHHHHCHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA