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The map label for this gene is lysS [H]

Identifier: 54294664

GI number: 54294664

Start: 1945719

End: 1947209

Strand: Reverse

Name: lysS [H]

Synonym: lpl1741

Alternate gene names: 54294664

Gene position: 1947209-1945719 (Counterclockwise)

Preceding gene: 54294665

Following gene: 54294658

Centisome position: 58.2

GC content: 37.76

Gene sequence:

>1491_bases
ATGAGTGAAGAACATGTACATTTAGATGAAAGTGAAGTTTATCATATTCGCAAACAAAAATTAGCGGAATTGCGCACAAG
CGGGTTTAATTTTCCAAATACCTTTCGCCGCGAACATTTAGCCGATGCTTTGCTGAAGCAATACTCCGAAACTGAGAAAC
AAACATTAGAACAAAAGCATGTGAAAGTATCTGTTGCAGGCCGAATCGTTCTGAGAAGAATTATGGGTAAAGCCAGTTTT
TTTCACATTCAAGATGTATCAGGTCGGATACAAGTTTATCTTCGTTCAAATGATCTTCCTGACGTTTATGAACAGTTTAA
ACATTGGGATTTAGGAGATATTGTTGGTGTACAGGGTGAGTTGTTTAAAACAAACACTGGTGAACTGACCATTAATGCAG
AACATGTTGAGTTATTAACCAAATCTTTAAGGCCGCTTCCTGATAAGTTCCATGGCTTGGCTGATCAGGAATTGAAATAT
CGTAAACGTTATGTTGACTTGATTGCAAATGAAGACAGTCGGAAAACCTTTTTAATACGCTCACATTTAATCAAAGCCTT
CAGAGAGTTTATGGATGATAATCATTTTCTGGAAGTAGAAACACCAATGATGCATCCAATTCCTGGAGGTGCTTTGGCTC
GTCCTTTCGTAACTCATCACAATACATTGGATATGACCATGTATTTGAGGATAGCTCCCGAATTGTACTTAAAACGCTTG
GTTGTTGGTGGTTTTGAGAGAGTATATGAAATTAATAGAAATTTCCGTAATGAAGGAATTTCTACTCGTCATAATCCAGA
GTTCACGATGCTGGAATTTTACCAGGCTTATGCCGATTACAATGATTTGATGAATTTCACTGAACAATTGTTTCATTATC
TATGCGATAAAGTATTAGCTACTCGGCAAATAGAATATCAAGGTCAAGTCATTGATTTCAATAAACCTTTTGAACGGTTG
AGCGTAAAAGAAGCTATATTAAAATATCATCCTGATATTAAGGCGCAGCAGTTAGAAACGGTAGAGGGATGCAGAACACT
TCTGAATGATTTAGATCTGCCTTATAAAGAAACTGATGGCCTGGGTAAACTACAAATTATTCTTTTTGAGGAGACAGTAG
AGCACCAATTATTTCAGCCCACTTTTATTACGGAATACCCTACAGAAATATCTCCTTTAGCGAGACGTTCTGATACCAAT
CCGGAAGTCACCGATCGATTTGAGTTTTTTATTGCTGGTCGTGAGATTGCGAATGGATTTTCTGAATTAAACGATGCAGA
AGATCAAGCTGAGCGCTTTCGAAAGCAAGTTGAAGAAAAGGATGCAGGTGACTTAGAGGCAATGCATTTTGATAGTGATT
ATATTGAAGCATTGGAATATGGCTTGCCGCCTACAGCCGGTGAAGGGATTGGAATCGATCGCTTGGTGATGTTATTTACT
AATTCGCAATCAATCAGAGACGTTATTTTATTTCCGCATTTGAGGCAGTAA

Upstream 100 bases:

>100_bases
ATTTGCGCACCGGTGTTGAAACCAGTAATACTCAGGCAGTATTGGATGGTTCATTAGATCAATTTATTGAAGCCAGTTTA
AAGGCAGGAGTAGGGCAAGC

Downstream 100 bases:

>100_bases
AGTACAGCGATTTTTAGATAGCAATGGTTTGTTTAGAACCATTGCTATGTCAAGCAATACATAAAATACACTTGGTTTAG
ATAAAATTATCTATGTCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSEEHVHLDESEVYHIRKQKLAELRTSGFNFPNTFRREHLADALLKQYSETEKQTLEQKHVKVSVAGRIVLRRIMGKASF
FHIQDVSGRIQVYLRSNDLPDVYEQFKHWDLGDIVGVQGELFKTNTGELTINAEHVELLTKSLRPLPDKFHGLADQELKY
RKRYVDLIANEDSRKTFLIRSHLIKAFREFMDDNHFLEVETPMMHPIPGGALARPFVTHHNTLDMTMYLRIAPELYLKRL
VVGGFERVYEINRNFRNEGISTRHNPEFTMLEFYQAYADYNDLMNFTEQLFHYLCDKVLATRQIEYQGQVIDFNKPFERL
SVKEAILKYHPDIKAQQLETVEGCRTLLNDLDLPYKETDGLGKLQIILFEETVEHQLFQPTFITEYPTEISPLARRSDTN
PEVTDRFEFFIAGREIANGFSELNDAEDQAERFRKQVEEKDAGDLEAMHFDSDYIEALEYGLPPTAGEGIGIDRLVMLFT
NSQSIRDVILFPHLRQ

Sequences:

>Translated_496_residues
MSEEHVHLDESEVYHIRKQKLAELRTSGFNFPNTFRREHLADALLKQYSETEKQTLEQKHVKVSVAGRIVLRRIMGKASF
FHIQDVSGRIQVYLRSNDLPDVYEQFKHWDLGDIVGVQGELFKTNTGELTINAEHVELLTKSLRPLPDKFHGLADQELKY
RKRYVDLIANEDSRKTFLIRSHLIKAFREFMDDNHFLEVETPMMHPIPGGALARPFVTHHNTLDMTMYLRIAPELYLKRL
VVGGFERVYEINRNFRNEGISTRHNPEFTMLEFYQAYADYNDLMNFTEQLFHYLCDKVLATRQIEYQGQVIDFNKPFERL
SVKEAILKYHPDIKAQQLETVEGCRTLLNDLDLPYKETDGLGKLQIILFEETVEHQLFQPTFITEYPTEISPLARRSDTN
PEVTDRFEFFIAGREIANGFSELNDAEDQAERFRKQVEEKDAGDLEAMHFDSDYIEALEYGLPPTAGEGIGIDRLVMLFT
NSQSIRDVILFPHLRQ
>Mature_495_residues
SEEHVHLDESEVYHIRKQKLAELRTSGFNFPNTFRREHLADALLKQYSETEKQTLEQKHVKVSVAGRIVLRRIMGKASFF
HIQDVSGRIQVYLRSNDLPDVYEQFKHWDLGDIVGVQGELFKTNTGELTINAEHVELLTKSLRPLPDKFHGLADQELKYR
KRYVDLIANEDSRKTFLIRSHLIKAFREFMDDNHFLEVETPMMHPIPGGALARPFVTHHNTLDMTMYLRIAPELYLKRLV
VGGFERVYEINRNFRNEGISTRHNPEFTMLEFYQAYADYNDLMNFTEQLFHYLCDKVLATRQIEYQGQVIDFNKPFERLS
VKEAILKYHPDIKAQQLETVEGCRTLLNDLDLPYKETDGLGKLQIILFEETVEHQLFQPTFITEYPTEISPLARRSDTNP
EVTDRFEFFIAGREIANGFSELNDAEDQAERFRKQVEEKDAGDLEAMHFDSDYIEALEYGLPPTAGEGIGIDRLVMLFTN
SQSIRDVILFPHLRQ

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=512, Percent_Identity=41.015625, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI194272210, Length=512, Percent_Identity=41.015625, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI45439306, Length=344, Percent_Identity=25.8720930232558, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI40789249, Length=246, Percent_Identity=25.2032520325203, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1790571, Length=481, Percent_Identity=62.5779625779626, Blast_Score=639, Evalue=0.0,
Organism=Escherichia coli, GI1789256, Length=502, Percent_Identity=60.1593625498008, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI87082379, Length=333, Percent_Identity=34.2342342342342, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788173, Length=252, Percent_Identity=26.1904761904762, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17535925, Length=514, Percent_Identity=40.8560311284047, Blast_Score=354, Evalue=7e-98,
Organism=Caenorhabditis elegans, GI17535927, Length=514, Percent_Identity=40.8560311284047, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI71994340, Length=505, Percent_Identity=40.7920792079208, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17551876, Length=337, Percent_Identity=27.299703264095, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI32566633, Length=267, Percent_Identity=25.8426966292135, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320242, Length=517, Percent_Identity=42.5531914893617, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324256, Length=388, Percent_Identity=35.5670103092784, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323011, Length=350, Percent_Identity=28, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321807, Length=453, Percent_Identity=25.3863134657837, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24640849, Length=516, Percent_Identity=38.953488372093, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24640851, Length=516, Percent_Identity=38.953488372093, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI17136276, Length=466, Percent_Identity=24.6781115879828, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24584738, Length=289, Percent_Identity=28.0276816608997, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 57931; Mature: 57800

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEHVHLDESEVYHIRKQKLAELRTSGFNFPNTFRREHLADALLKQYSETEKQTLEQKH
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKVSVAGRIVLRRIMGKASFFHIQDVSGRIQVYLRSNDLPDVYEQFKHWDLGDIVGVQGE
HHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCHHHHHHHCCCCCHHEECCCCE
LFKTNTGELTINAEHVELLTKSLRPLPDKFHGLADQELKYRKRYVDLIANEDSRKTFLIR
EEECCCCEEEEEHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
SHLIKAFREFMDDNHFLEVETPMMHPIPGGALARPFVTHHNTLDMTMYLRIAPELYLKRL
HHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCEEEEEEEEHHHHHHHHHH
VVGGFERVYEINRNFRNEGISTRHNPEFTMLEFYQAYADYNDLMNFTEQLFHYLCDKVLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
TRQIEYQGQVIDFNKPFERLSVKEAILKYHPDIKAQQLETVEGCRTLLNDLDLPYKETDG
HHEEECCCCEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
LGKLQIILFEETVEHQLFQPTFITEYPTEISPLARRSDTNPEVTDRFEFFIAGREIANGF
CCEEEEEEEHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHEEECHHHHHHH
SELNDAEDQAERFRKQVEEKDAGDLEAMHFDSDYIEALEYGLPPTAGEGIGIDRLVMLFT
HHCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCHHHEEEEEE
NSQSIRDVILFPHLRQ
CCCCHHHEEECCCCCC
>Mature Secondary Structure 
SEEHVHLDESEVYHIRKQKLAELRTSGFNFPNTFRREHLADALLKQYSETEKQTLEQKH
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKVSVAGRIVLRRIMGKASFFHIQDVSGRIQVYLRSNDLPDVYEQFKHWDLGDIVGVQGE
HHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCHHHHHHHCCCCCHHEECCCCE
LFKTNTGELTINAEHVELLTKSLRPLPDKFHGLADQELKYRKRYVDLIANEDSRKTFLIR
EEECCCCEEEEEHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
SHLIKAFREFMDDNHFLEVETPMMHPIPGGALARPFVTHHNTLDMTMYLRIAPELYLKRL
HHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCEEEEEEEEHHHHHHHHHH
VVGGFERVYEINRNFRNEGISTRHNPEFTMLEFYQAYADYNDLMNFTEQLFHYLCDKVLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
TRQIEYQGQVIDFNKPFERLSVKEAILKYHPDIKAQQLETVEGCRTLLNDLDLPYKETDG
HHEEECCCCEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
LGKLQIILFEETVEHQLFQPTFITEYPTEISPLARRSDTNPEVTDRFEFFIAGREIANGF
CCEEEEEEEHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHEEECHHHHHHH
SELNDAEDQAERFRKQVEEKDAGDLEAMHFDSDYIEALEYGLPPTAGEGIGIDRLVMLFT
HHCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCHHHEEEEEE
NSQSIRDVILFPHLRQ
CCCCHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA