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The map label for this gene is pmbA [H]

Identifier: 54294658

GI number: 54294658

Start: 1937249

End: 1938607

Strand: Reverse

Name: pmbA [H]

Synonym: lpl1735

Alternate gene names: 54294658

Gene position: 1938607-1937249 (Counterclockwise)

Preceding gene: 54294664

Following gene: 54294653

Centisome position: 57.94

GC content: 40.62

Gene sequence:

>1359_bases
ATGCAAATTAAACCGCAAAATAACAATAGTGAAGTATATAAGTCAACAACAGATTTAAATCGAGTGATAAAAGATGTCTT
AGAACTTGCCAAAAAAGAAGGTGCCACTGATGCAGCAGTAGCTGTAAATTATGATCGAGGTTTTTCAGTCGATGTGAGAA
TGGGGGAAGTGGAGACAGTCGCTTTTAGCGAAGATAAAGGAGTTGGTTTAACTGTATACATAGGCCGGCGCAAAGGGGGA
GCAAGCAGTACAGACACATCTCTTGAAGCACTGCAATCTTTGGTTAAAGCAGCCTGTGAAATAGCAAAGGTTAGTGCTGA
AGATCCTTGCTTTGGATTAGCTGATAAGGAATTGATGACAAAGAATCATCCAGATCTTGATTTGTATCATTCCTGGGATA
TTACCCCACAACAAGCTATCGATTTGGCTTTAAAATGCGAATCACATGCCTTGTCTTTAGATAAACGGATTACTAATTCA
GATGGTGTTAATGTTTCTTCCTATGAATCACATCACGGTTATGCCAATACTCATGGTGGGGAGGGGTTTATTCATAGTAC
TCGACATAGTGTAAGTTGCTCGGTAATCGCCAAAGAAGGTGATGAAATGCAAAGAGACTACGATTATACGACTGCCAGAA
ATGCGGAAAATTTAGTCTCAGCTGATTTGATAGCAGCTAAAGCTGTTGAAAGGGCATTAAGTCGTCTGGGATCAAAACAA
ATTAAAACACAAATGACTCCGGTTATTTTTTCTTCAAGAGTTTCCAGTGGATTATTGGGTAGCTTTGTGAGCGCCATTAG
TGGTTCAAATTTATACAGAAAGAATTCCTTTTTGCTTGATTCCATTGGACAACAATTGTTTCCGGAGTTTGTTCATATTT
ACGAACAGCCACATCTAAAAGGTGCTTTGGGGAGCGCCCCTTTTGATGGGGAAGGGGTGCCTACGCGACCCAATGTATTA
GTTGAAAAGGGGCGTTTGCTTCAATATGTTCTTGGCAGTTATTCGGCGCGAAAAATGGGTTTAAAGACAACAGCAAATAG
TGATGGCGTTCATAATTTAACCATTGATCCTACTTGCGGGGATCTTGGTGACCTTTTGAAAATGATGCGGAATGGGTTGC
TGGTTACAGAACTAATGGGCCAGGGTGTGAATGGTATTACCGGAGATTATTCACGTGGGGCAAGTGGATACTGGGTTGAG
GATGGGGTCATACAATATCCGGTTGATCAAATTACTATTGCAGGAAACCTTAAAGAAATGTACCGGATGATATTGGCAAT
AGGCAGTGACATTAATCCGAATATTTCCATGCGCTGTGGCTCTATTTTAATAGAAAATATGATGGTTGCAGGGAAATGA

Upstream 100 bases:

>100_bases
GCAAGAACCATAAATTCAACTTGTTTGCAGGATAAACATTGGTTTGCGAAGACATGTTATTGTATCCTTATGTACATCAT
TCAACACCACGGAATCTCAT

Downstream 100 bases:

>100_bases
AATGCCCCAAACCATCGAGGTTAACCACTTGCTCTGTAATCTTGATGATAGTTCTCTGTAACATTTTTTAGCGATATACC
TGGCTGCTTGCAGCCAGCTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MQIKPQNNNSEVYKSTTDLNRVIKDVLELAKKEGATDAAVAVNYDRGFSVDVRMGEVETVAFSEDKGVGLTVYIGRRKGG
ASSTDTSLEALQSLVKAACEIAKVSAEDPCFGLADKELMTKNHPDLDLYHSWDITPQQAIDLALKCESHALSLDKRITNS
DGVNVSSYESHHGYANTHGGEGFIHSTRHSVSCSVIAKEGDEMQRDYDYTTARNAENLVSADLIAAKAVERALSRLGSKQ
IKTQMTPVIFSSRVSSGLLGSFVSAISGSNLYRKNSFLLDSIGQQLFPEFVHIYEQPHLKGALGSAPFDGEGVPTRPNVL
VEKGRLLQYVLGSYSARKMGLKTTANSDGVHNLTIDPTCGDLGDLLKMMRNGLLVTELMGQGVNGITGDYSRGASGYWVE
DGVIQYPVDQITIAGNLKEMYRMILAIGSDINPNISMRCGSILIENMMVAGK

Sequences:

>Translated_452_residues
MQIKPQNNNSEVYKSTTDLNRVIKDVLELAKKEGATDAAVAVNYDRGFSVDVRMGEVETVAFSEDKGVGLTVYIGRRKGG
ASSTDTSLEALQSLVKAACEIAKVSAEDPCFGLADKELMTKNHPDLDLYHSWDITPQQAIDLALKCESHALSLDKRITNS
DGVNVSSYESHHGYANTHGGEGFIHSTRHSVSCSVIAKEGDEMQRDYDYTTARNAENLVSADLIAAKAVERALSRLGSKQ
IKTQMTPVIFSSRVSSGLLGSFVSAISGSNLYRKNSFLLDSIGQQLFPEFVHIYEQPHLKGALGSAPFDGEGVPTRPNVL
VEKGRLLQYVLGSYSARKMGLKTTANSDGVHNLTIDPTCGDLGDLLKMMRNGLLVTELMGQGVNGITGDYSRGASGYWVE
DGVIQYPVDQITIAGNLKEMYRMILAIGSDINPNISMRCGSILIENMMVAGK
>Mature_452_residues
MQIKPQNNNSEVYKSTTDLNRVIKDVLELAKKEGATDAAVAVNYDRGFSVDVRMGEVETVAFSEDKGVGLTVYIGRRKGG
ASSTDTSLEALQSLVKAACEIAKVSAEDPCFGLADKELMTKNHPDLDLYHSWDITPQQAIDLALKCESHALSLDKRITNS
DGVNVSSYESHHGYANTHGGEGFIHSTRHSVSCSVIAKEGDEMQRDYDYTTARNAENLVSADLIAAKAVERALSRLGSKQ
IKTQMTPVIFSSRVSSGLLGSFVSAISGSNLYRKNSFLLDSIGQQLFPEFVHIYEQPHLKGALGSAPFDGEGVPTRPNVL
VEKGRLLQYVLGSYSARKMGLKTTANSDGVHNLTIDPTCGDLGDLLKMMRNGLLVTELMGQGVNGITGDYSRGASGYWVE
DGVIQYPVDQITIAGNLKEMYRMILAIGSDINPNISMRCGSILIENMMVAGK

Specific function: May facilitate the secretion of the peptide antibiotic microcin B17 (MccB17) by completing its maturation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA) [H]

COG id: COG0312

COG function: function code R; Predicted Zn-dependent proteases and their inactivated homologs

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase U62 family [H]

Homologues:

Organism=Escherichia coli, GI1790682, Length=447, Percent_Identity=47.8747203579418, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1789640, Length=397, Percent_Identity=23.9294710327456, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002510 [H]

Pfam domain/function: PF01523 PmbA_TldD [H]

EC number: NA

Molecular weight: Translated: 48988; Mature: 48988

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKPQNNNSEVYKSTTDLNRVIKDVLELAKKEGATDAAVAVNYDRGFSVDVRMGEVETV
CCCCCCCCCCHHEECHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCEEEE
AFSEDKGVGLTVYIGRRKGGASSTDTSLEALQSLVKAACEIAKVSAEDPCFGLADKELMT
EECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
KNHPDLDLYHSWDITPQQAIDLALKCESHALSLDKRITNSDGVNVSSYESHHGYANTHGG
CCCCCCEEEECCCCCHHHHHHHHEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
EGFIHSTRHSVSCSVIAKEGDEMQRDYDYTTARNAENLVSADLIAAKAVERALSRLGSKQ
CCCEECCCCCEEEEEEECCCHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHH
IKTQMTPVIFSSRVSSGLLGSFVSAISGSNLYRKNSFLLDSIGQQLFPEFVHIYEQPHLK
HHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCC
GALGSAPFDGEGVPTRPNVLVEKGRLLQYVLGSYSARKMGLKTTANSDGVHNLTIDPTCG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCEECCCCCCCEEEEECCCCC
DLGDLLKMMRNGLLVTELMGQGVNGITGDYSRGASGYWVEDGVIQYPVDQITIAGNLKEM
CHHHHHHHHHCCEEHHHHHCCCCCCCCCCCCCCCCCEEECCCEEECCCCEEEEECCHHHH
YRMILAIGSDINPNISMRCGSILIENMMVAGK
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQIKPQNNNSEVYKSTTDLNRVIKDVLELAKKEGATDAAVAVNYDRGFSVDVRMGEVETV
CCCCCCCCCCHHEECHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCEEEE
AFSEDKGVGLTVYIGRRKGGASSTDTSLEALQSLVKAACEIAKVSAEDPCFGLADKELMT
EECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
KNHPDLDLYHSWDITPQQAIDLALKCESHALSLDKRITNSDGVNVSSYESHHGYANTHGG
CCCCCCEEEECCCCCHHHHHHHHEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
EGFIHSTRHSVSCSVIAKEGDEMQRDYDYTTARNAENLVSADLIAAKAVERALSRLGSKQ
CCCEECCCCCEEEEEEECCCHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHH
IKTQMTPVIFSSRVSSGLLGSFVSAISGSNLYRKNSFLLDSIGQQLFPEFVHIYEQPHLK
HHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCC
GALGSAPFDGEGVPTRPNVLVEKGRLLQYVLGSYSARKMGLKTTANSDGVHNLTIDPTCG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCEECCCCCCCEEEEECCCCC
DLGDLLKMMRNGLLVTELMGQGVNGITGDYSRGASGYWVEDGVIQYPVDQITIAGNLKEM
CHHHHHHHHHCCEEHHHHHCCCCCCCCCCCCCCCCCEEECCCEEECCCCEEEEECCHHHH
YRMILAIGSDINPNISMRCGSILIENMMVAGK
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]