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The map label for this gene is sfcA [H]

Identifier: 54294179

GI number: 54294179

Start: 1386317

End: 1388032

Strand: Reverse

Name: sfcA [H]

Synonym: lpl1243

Alternate gene names: 54294179

Gene position: 1388032-1386317 (Counterclockwise)

Preceding gene: 54294184

Following gene: 54294175

Centisome position: 41.49

GC content: 40.38

Gene sequence:

>1716_bases
ATGCTTGATTTTAGTTTGAATCGTGATCCCCAAACGGGCGAGTTATACATAGAAACCTCATTATGTGGGAAGCCTTTATT
GACTACGCCGCAATTAAATAAAGGAACAGCATTTACTCAGGAAGAAAGAAAAGATTTCGGTCTTTTAGGCAAGTTACCAC
ACCGCGTAGAAACTCTTGATGAACAAGTAAAACGTGCCTATCTTCAATATTCAAGTTACACGACGCGTTTGCAGCAACAT
ATTTATTTAAATAATTTACATGATAAAAACCAAATAGTATTTTACAAACTGCTAAGTCGTCATTTGGGGGAAATGCTTCC
CATCATCTATACACCAATCGTTGGTGCTGCAGCCAAGAGGTTTAGTCATGAATACAGACAGCCACGAGGATTGTATATTG
CTCATTCGGATAAAAACCAGCTTGAGGAAATAATTAATAACCGTTCGAATCCAGACATAGACCTTGTTGTAGTGACCGAT
GGTGAGGGAGTCCTAGGCATTGGCGATCAAGGGATAGGAGGAATGGATATACCTGTTGCCAAACTAATGGTTTACAGCTT
ATGTGGTGGCATTGATCCAACTCGCACATTACCCATATTTCTTGATGTAGGAACTAACAACCAAGAATTATTAAATGACC
CTATGTATCTGGGTTGCCGTCACCCCAGAATAAAAAGCTCAGAATACGACGATTTTATCAAAACTTTTGTCAATAAAATT
CATAAGCAATTTCCAAACGCTTTTTTACATTGGGAAGACTTTGGTCGGGGCAATGCTCGACGAATCCTGGATCAATTTCA
AGATGAATTGTGTACTTTTAATGATGATATTCAGGGAACTGGTGCAGTAACTCTGGCAGCAATTTTGGCAGCATGTGATG
TAACTGGATTACCCTTACATGAACACAGAATCGTTGTGTTTGGAGCTGGCTCAGCAGGTACTGGTATTAGCGACCAAATT
GTTGATGCAATGGTGAAAAACAGATTGAGCTTAACTGATGCTTATGACAGATTCTGGTTAATAGACAAACAGGGTTTATT
ACTTGCGACTGACCAAGAGCTTACTGATGCTCAAAAACCCTATGCACGGAATCCTATAGATATACAATCCTGGGAAATTA
ATAATAAACAACATCCTTCGTTTACTGACACCATCAGGCATGTCAAACCTACCATTTTAATTGGCTGTTCAGCGCAAACG
GGTGCATTCTCACAAGATATTGTGGAAACTATGTCGACAGCCTGCGAGCGACCAATCATTTTCCCTTTATCAAATCCTGA
TGAAAAATGTGAAGCACAGCCCTCAGATATATTGGCATGGAGTAAAGGACGGGCATTAATTGCTACTGGAACTGCTTTTG
CCCCTATTGAATATCAGAACCGAATGGTGCAAATAGCTCAATGCAACAATGCCTTGGTATTCCCTGGAATCGGATTGGGC
GTTTTGGCGGTAAGCGCCTCTCGTTTAACTAAAGATATGATATTGGCTGCCGCCCAGACCTTAAGTAAATTTGCGCCAAG
TAAAAAGGACAGCTTTTTGCCACTGTTACCCTCATTAGACAATGCGCAAATTGTAGCCAAAGAAATAGCTATTGCAGTAG
CTCAGTGTGCAATAGACTCAGGTTATGCTCAAAAAAATCAAGACAAGGAGCTACCTCGATTAATTGATGAACTCTTTTGG
GAGCCTAGATATCTGCCTTTTAGAAAAAGGGGATAG

Upstream 100 bases:

>100_bases
TATCACTAAGTACTTATTCATACCCGCCCTCTTGATGTAAACTACAAAAAGTCGATATTATCACCAGTCAGCAAGTAACG
CTATCTTATGAGAATACCAT

Downstream 100 bases:

>100_bases
AGCGAATAAAATAAAGCTCTATGACTATATTATTGAAAAATAAATTTTCTTAATTCTTAGTCTGAGGGGTTGGTGAAATT
AATCGTTACATTTTTTATAG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 3 [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLDEQVKRAYLQYSSYTTRLQQH
IYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKRFSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTD
GEGVLGIGDQGIGGMDIPVAKLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNKI
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLHEHRIVVFGAGSAGTGISDQI
VDAMVKNRLSLTDAYDRFWLIDKQGLLLATDQELTDAQKPYARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQT
GAFSQDIVETMSTACERPIIFPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDSGYAQKNQDKELPRLIDELFW
EPRYLPFRKRG

Sequences:

>Translated_571_residues
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLDEQVKRAYLQYSSYTTRLQQH
IYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKRFSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTD
GEGVLGIGDQGIGGMDIPVAKLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNKI
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLHEHRIVVFGAGSAGTGISDQI
VDAMVKNRLSLTDAYDRFWLIDKQGLLLATDQELTDAQKPYARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQT
GAFSQDIVETMSTACERPIIFPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDSGYAQKNQDKELPRLIDELFW
EPRYLPFRKRG
>Mature_571_residues
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLDEQVKRAYLQYSSYTTRLQQH
IYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKRFSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTD
GEGVLGIGDQGIGGMDIPVAKLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNKI
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLHEHRIVVFGAGSAGTGISDQI
VDAMVKNRLSLTDAYDRFWLIDKQGLLLATDQELTDAQKPYARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQT
GAFSQDIVETMSTACERPIIFPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDSGYAQKNQDKELPRLIDELFW
EPRYLPFRKRG

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505145, Length=547, Percent_Identity=37.2943327239488, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI4505143, Length=525, Percent_Identity=36.5714285714286, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI62420882, Length=550, Percent_Identity=36.7272727272727, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI62420880, Length=550, Percent_Identity=36.7272727272727, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI239049447, Length=550, Percent_Identity=36.7272727272727, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI270265879, Length=458, Percent_Identity=39.9563318777293, Blast_Score=350, Evalue=1e-96,
Organism=Escherichia coli, GI87081919, Length=564, Percent_Identity=45.0354609929078, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17537199, Length=518, Percent_Identity=35.9073359073359, Blast_Score=335, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6322823, Length=578, Percent_Identity=42.2145328719723, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI21356279, Length=546, Percent_Identity=36.996336996337, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI281362674, Length=546, Percent_Identity=36.996336996337, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI281362672, Length=546, Percent_Identity=36.996336996337, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24646388, Length=537, Percent_Identity=35.9404096834264, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24646386, Length=537, Percent_Identity=35.9404096834264, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI78707242, Length=522, Percent_Identity=34.2911877394636, Blast_Score=331, Evalue=1e-90,
Organism=Drosophila melanogaster, GI78707238, Length=522, Percent_Identity=34.2911877394636, Blast_Score=331, Evalue=1e-90,
Organism=Drosophila melanogaster, GI78707232, Length=513, Percent_Identity=32.3586744639376, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI281363505, Length=511, Percent_Identity=32.4853228962818, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI78707236, Length=511, Percent_Identity=32.4853228962818, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI78707240, Length=513, Percent_Identity=34.1130604288499, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI281363503, Length=507, Percent_Identity=32.3471400394477, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI19922384, Length=548, Percent_Identity=27.9197080291971, Blast_Score=241, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 63707; Mature: 63707

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLD
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHH
EQVKRAYLQYSSYTTRLQQHIYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTDGEGVLGIGDQGIGGMDIPVA
HHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCHHH
KLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNKI
HHHHHHHHCCCCCCCEEEEEEEECCCCHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHH
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLH
HHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
EHRIVVFGAGSAGTGISDQIVDAMVKNRLSLTDAYDRFWLIDKQGLLLATDQELTDAQKP
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHCCEEEEEECCCEEEECCCHHHHCCCC
YARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQTGAFSQDIVETMSTACERPII
CCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEE
FPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
EECCCCCHHHCCCCCCEEEECCCCEEEEECCEECCCHHHCCEEEEEECCCEEEECCCCHH
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
GYAQKNQDKELPRLIDELFWEPRYLPFRKRG
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MLDFSLNRDPQTGELYIETSLCGKPLLTTPQLNKGTAFTQEERKDFGLLGKLPHRVETLD
CCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHH
EQVKRAYLQYSSYTTRLQQHIYLNNLHDKNQIVFYKLLSRHLGEMLPIIYTPIVGAAAKR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSHEYRQPRGLYIAHSDKNQLEEIINNRSNPDIDLVVVTDGEGVLGIGDQGIGGMDIPVA
HHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCHHH
KLMVYSLCGGIDPTRTLPIFLDVGTNNQELLNDPMYLGCRHPRIKSSEYDDFIKTFVNKI
HHHHHHHHCCCCCCCEEEEEEEECCCCHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHH
HKQFPNAFLHWEDFGRGNARRILDQFQDELCTFNDDIQGTGAVTLAAILAACDVTGLPLH
HHHCCCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
EHRIVVFGAGSAGTGISDQIVDAMVKNRLSLTDAYDRFWLIDKQGLLLATDQELTDAQKP
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHCCEEEEEECCCEEEECCCHHHHCCCC
YARNPIDIQSWEINNKQHPSFTDTIRHVKPTILIGCSAQTGAFSQDIVETMSTACERPII
CCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEE
FPLSNPDEKCEAQPSDILAWSKGRALIATGTAFAPIEYQNRMVQIAQCNNALVFPGIGLG
EECCCCCHHHCCCCCCEEEECCCCEEEEECCEECCCHHHCCEEEEEECCCEEEECCCCHH
VLAVSASRLTKDMILAAAQTLSKFAPSKKDSFLPLLPSLDNAQIVAKEIAIAVAQCAIDS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
GYAQKNQDKELPRLIDELFWEPRYLPFRKRG
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]