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The map label for this gene is hisC [H]

Identifier: 54294142

GI number: 54294142

Start: 1348027

End: 1349121

Strand: Reverse

Name: hisC [H]

Synonym: lpl1206

Alternate gene names: 54294142

Gene position: 1349121-1348027 (Counterclockwise)

Preceding gene: 54294143

Following gene: 54294141

Centisome position: 40.32

GC content: 38.26

Gene sequence:

>1095_bases
ATGTCCATACTCAATCTTGTTCGTGCAGATCTATTAAATAGTCAAAATTATGTCCCCGGTGGTGAGAGTGCTCGCTATCG
ATCACATGCCAATGAACTGCCTTGGTCACCAGTTACTATGGGGGAGTACAATTTAAATTATTACCCAAACATTGGCTTAC
AAATAGAGCTGCAAAAGCAATTGGCAAAACGTTATCAAATCAATTCCGATCAAATCATACTGACCCGAGGAAGTGATGAT
GGCATTGATTTGACAACCAGACTTTTTCTAACCGCTGGAAAAGACGCTTTCATGCAATTTCCCCCTACTTTTCCTATGTA
CGCTTTTTATGTTCGGCTACAACAAGCAGAATTGATCGAATGTCCTTTGGATAGAAGGACTAATTTTCGCCTCACCCTGG
ATCAAATTGAAAATAGCTGGAAACCTAACTGCAAAGTTATCATGTTTTGTAGTCCCAATAACCCGACTGGTAATTTGGTG
GATTTAAATTTAATTGCCAAGACATGTGAACTGTATACGAATCAATCTATTATAGTTGTGGACGAGGCGTATATAGAGTT
TGCAAATGCACCAAGCGCTACGTCCTTAATTGGAGAGTTTGAAAATCTGATTGTCTTAAGAACCTTGTCGAAAGCCTTTG
GGCTGGCTGGATTACGTTTAGGCTGCATTATAGCCCAGAGTCCTATTATTCAAGCTTTTAATAAAATCATTGCCCCCTAT
TCCATTGCCACTCCCAGTATGGAGCTGGCTAAAAGAGCTTTGAATAATAGCGATTGGTTCACAAAAACTATTGAGCAAAT
CAAATCATCTCGTGCCTGGGTTATAAAAAAATTTGCCGATAATCCAATCATTGAAAAAATTTATCCTACGGAAACCAATT
TCATTCTCATTCAAACACGATTTTCAAAACAATTAGCCACTTGGCTTGCCCGTTATGGCATCGCAGTAAGAGATTTTCCT
TCGTCCTCTTTATTGCATGATCACCTTCGTATTACGGTGGGTCATGATGAGCAAAATCAATTATTGATTGATGCTTTATC
CTCATTTAACGCTGATGTAGCAGGATTAAATTATGAAAAAGATTTTATTTATTGA

Upstream 100 bases:

>100_bases
CTGTAATTTAGGTCCAGCGGCAATGGCTTTAGCGGAATTAGAGGGTTTGGATGCTCATGCCAATGCCGTTCAAATAAGAC
TCAATACTCTGGGGGATTAA

Downstream 100 bases:

>100_bases
CCGCGATGGCACTTTAGTTGAAGAACCCTTTGATTTTCAAGTAGATTCTCTGGATAAAATTAAATTAACTTCTGGAGTAA
TACCAGCCCTATTGCAATTA

Product: histidinol-phosphate aminotransferase (imidazole acetol-phosphate transaminase)

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEYNLNYYPNIGLQIELQKQLAKRYQINSDQIILTRGSDD
GIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLV
DLNLIAKTCELYTNQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
SIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTRFSKQLATWLARYGIAVRDFP
SSSLLHDHLRITVGHDEQNQLLIDALSSFNADVAGLNYEKDFIY

Sequences:

>Translated_364_residues
MSILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEYNLNYYPNIGLQIELQKQLAKRYQINSDQIILTRGSDD
GIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLV
DLNLIAKTCELYTNQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
SIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTRFSKQLATWLARYGIAVRDFP
SSSLLHDHLRITVGHDEQNQLLIDALSSFNADVAGLNYEKDFIY
>Mature_363_residues
SILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEYNLNYYPNIGLQIELQKQLAKRYQINSDQIILTRGSDDG
IDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIECPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLVD
LNLIAKTCELYTNQSIIVVDEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPYS
IATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTRFSKQLATWLARYGIAVRDFPS
SSLLHDHLRITVGHDEQNQLLIDALSSFNADVAGLNYEKDFIY

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=355, Percent_Identity=34.3661971830986, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1788722, Length=235, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=334, Percent_Identity=29.940119760479, Blast_Score=139, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41283; Mature: 41152

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEYNLNYYPNIGLQIELQKQ
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEEECCCCCEECCCCCEEEEHHHH
LAKRYQINSDQIILTRGSDDGIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIE
HHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCHHHEECCCCCCHHHHHHHHHHHHHHC
CPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLVDLNLIAKTCELYTNQSIIVV
CCCCCCCCEEEEHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHCCCEEEEE
DEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
EHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHCCC
SIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTR
CCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCEEEEEEH
FSKQLATWLARYGIAVRDFPSSSLLHDHLRITVGHDEQNQLLIDALSSFNADVAGLNYEK
HHHHHHHHHHHCCCEEEECCCHHHEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCC
DFIY
CCCC
>Mature Secondary Structure 
SILNLVRADLLNSQNYVPGGESARYRSHANELPWSPVTMGEYNLNYYPNIGLQIELQKQ
CHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCCEEECCCCCEECCCCCEEEEHHHH
LAKRYQINSDQIILTRGSDDGIDLTTRLFLTAGKDAFMQFPPTFPMYAFYVRLQQAELIE
HHHHHCCCCCEEEEECCCCCCCCEEEEEEEECCCHHHEECCCCCCHHHHHHHHHHHHHHC
CPLDRRTNFRLTLDQIENSWKPNCKVIMFCSPNNPTGNLVDLNLIAKTCELYTNQSIIVV
CCCCCCCCEEEEHHHHHCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHCCCEEEEE
DEAYIEFANAPSATSLIGEFENLIVLRTLSKAFGLAGLRLGCIIAQSPIIQAFNKIIAPY
EHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHHHHHHCCC
SIATPSMELAKRALNNSDWFTKTIEQIKSSRAWVIKKFADNPIIEKIYPTETNFILIQTR
CCCCCCHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCEEEEEEH
FSKQLATWLARYGIAVRDFPSSSLLHDHLRITVGHDEQNQLLIDALSSFNADVAGLNYEK
HHHHHHHHHHHCCCEEEECCCHHHEEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCC
DFIY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA