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The map label for this gene is ladC [H]

Identifier: 54294071

GI number: 54294071

Start: 1265626

End: 1267077

Strand: Reverse

Name: ladC [H]

Synonym: lpl1135

Alternate gene names: 54294071

Gene position: 1267077-1265626 (Counterclockwise)

Preceding gene: 54294072

Following gene: 54294069

Centisome position: 37.87

GC content: 37.19

Gene sequence:

>1452_bases
ATGAAATTTCGTACTAAGTTATTTCTTGGCCTACTTCTCATTGTAATCACTACTAACGGCATATTTCTGTTTTTATCTTA
TCAATATGGTAAAGAAACCGTATATAAAGAAGTAGGCTCATCAGCCCTATCCATAGCTGCGGCAACAGCTGTCCTGATGA
ATCCGGAGGATATTCAGAAATTTAATCTGGATACGTCTGCAAACTCACCTCTTTACAAAGATCTTGAAAAAAAACTTCTT
GAAGTACGTAACGCAAATCGTCGCAAAGATGTGTATGTGAATTTCATATATAGTTTATTTCCCGACTCTAATAATCCCAA
GGTACTTCGCTTTGCCGTAGATCCCGAAGAAAACATTATAGATAGAACTGCATTGGGCACAGTCATGAAACTTAAGACTG
CATCAGGACAGACAATTCATGTAAATTATGAACTCCCTGTCGTTCTGCCCGAATTTGTTGAAGACATCTGGGGTAAATGG
CTAACCGCTTTATATCCAATAAAAGACGCGCAAGGGAAATACATTGGAAATATCCGAGTAGATGTAGACGCCGATTCGGT
TAACCAAAGATTTCATTTCCTGCTGTTTGCTGGTATTGCCGTCTTTATCTCAACATTTTTATTTGCCATGTTTTTAGGTT
GGTTACTTTTTCAGTGGTTTAATAAACCCTTATTAAAAATTACAACCACGCTCAAAAATATTGCCCAAGGTGATCTTGAA
CAGCATCTCGACATTAGGACAAAAGATGAATTCGCGGAAGTGGGTCGAGTAATCAATGAAATGACTGAAGGATTGAGACA
GCGTAACATGCTGCAAGTAAGCTTAACACGTTTTATTTCTCATGCTTTAGCAGAAAAAATTGTGAAATCCGGCGAGTTAC
CGCAAGTATTTAGCGAGAGACGTAAGGTCACTATTATGGTCTGTGATATACGCGATTTCACAACCATTTCGGAGCGTATA
AAACCTGAATTGGTAGTTGATTTTTTAAATCATTTTTTTGAGAAAATGATAGAAGCTATTACCTCGCAACATGGAATATT
GGATAAATATCTTGGAGATGGTTTTTTAGCGATTTTCGGTTCACCTGATGATGACGCCTATCAAGAAGACCATGCTATCC
ATGCCGCATTAAAAATGCGAGAAGCGATGAAATCACTCAATGCCGATTGGGCAAAAATATTAGGCACTGAAATACAAATT
GGTATTGGTATCAATACAGGCAGTGCCATTGTCGGGAATATTGGAACTGATATACATATGGAATACACAGCTATTGGCGA
TACTGTCAATTTGGCGTCACGAATAGAAAATGCCACCAAAAAACTCAATACAGATATTCTAATCAGTGAATATACTTATA
TTGCGACAGATCATACAGCATTTCAATTTATAGAGTTGGGAGAAATTTCTATCAAAGGAAGAGTCCATAAAGTAAAAGTT
TATACGCTTTAA

Upstream 100 bases:

>100_bases
TCGTTCTGGAGATTGGAAAAGATCTCCAGAAATCTGTTGTCTTTACTTCTCACTGCCTTTATCCAATACTTATAATTAAT
CTGCTAATGGTGGATAAATA

Downstream 100 bases:

>100_bases
GATTAATTATTTTTAATATAAAACAATTGCATTCTTATTTAGGATATTTAAGCCCAAATCAATTTGAAAAACAGAGTGGT
TTTTTAATTAAAGTTGCTTA

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKFRTKLFLGLLLIVITTNGIFLFLSYQYGKETVYKEVGSSALSIAAATAVLMNPEDIQKFNLDTSANSPLYKDLEKKLL
EVRNANRRKDVYVNFIYSLFPDSNNPKVLRFAVDPEENIIDRTALGTVMKLKTASGQTIHVNYELPVVLPEFVEDIWGKW
LTALYPIKDAQGKYIGNIRVDVDADSVNQRFHFLLFAGIAVFISTFLFAMFLGWLLFQWFNKPLLKITTTLKNIAQGDLE
QHLDIRTKDEFAEVGRVINEMTEGLRQRNMLQVSLTRFISHALAEKIVKSGELPQVFSERRKVTIMVCDIRDFTTISERI
KPELVVDFLNHFFEKMIEAITSQHGILDKYLGDGFLAIFGSPDDDAYQEDHAIHAALKMREAMKSLNADWAKILGTEIQI
GIGINTGSAIVGNIGTDIHMEYTAIGDTVNLASRIENATKKLNTDILISEYTYIATDHTAFQFIELGEISIKGRVHKVKV
YTL

Sequences:

>Translated_483_residues
MKFRTKLFLGLLLIVITTNGIFLFLSYQYGKETVYKEVGSSALSIAAATAVLMNPEDIQKFNLDTSANSPLYKDLEKKLL
EVRNANRRKDVYVNFIYSLFPDSNNPKVLRFAVDPEENIIDRTALGTVMKLKTASGQTIHVNYELPVVLPEFVEDIWGKW
LTALYPIKDAQGKYIGNIRVDVDADSVNQRFHFLLFAGIAVFISTFLFAMFLGWLLFQWFNKPLLKITTTLKNIAQGDLE
QHLDIRTKDEFAEVGRVINEMTEGLRQRNMLQVSLTRFISHALAEKIVKSGELPQVFSERRKVTIMVCDIRDFTTISERI
KPELVVDFLNHFFEKMIEAITSQHGILDKYLGDGFLAIFGSPDDDAYQEDHAIHAALKMREAMKSLNADWAKILGTEIQI
GIGINTGSAIVGNIGTDIHMEYTAIGDTVNLASRIENATKKLNTDILISEYTYIATDHTAFQFIELGEISIKGRVHKVKV
YTL
>Mature_483_residues
MKFRTKLFLGLLLIVITTNGIFLFLSYQYGKETVYKEVGSSALSIAAATAVLMNPEDIQKFNLDTSANSPLYKDLEKKLL
EVRNANRRKDVYVNFIYSLFPDSNNPKVLRFAVDPEENIIDRTALGTVMKLKTASGQTIHVNYELPVVLPEFVEDIWGKW
LTALYPIKDAQGKYIGNIRVDVDADSVNQRFHFLLFAGIAVFISTFLFAMFLGWLLFQWFNKPLLKITTTLKNIAQGDLE
QHLDIRTKDEFAEVGRVINEMTEGLRQRNMLQVSLTRFISHALAEKIVKSGELPQVFSERRKVTIMVCDIRDFTTISERI
KPELVVDFLNHFFEKMIEAITSQHGILDKYLGDGFLAIFGSPDDDAYQEDHAIHAALKMREAMKSLNADWAKILGTEIQI
GIGINTGSAIVGNIGTDIHMEYTAIGDTVNLASRIENATKKLNTDILISEYTYIATDHTAFQFIELGEISIKGRVHKVKV
YTL

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI222080083, Length=202, Percent_Identity=29.7029702970297, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4580422, Length=232, Percent_Identity=28.0172413793103, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI167830411, Length=270, Percent_Identity=26.2962962962963, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17534657, Length=225, Percent_Identity=29.3333333333333, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534649, Length=205, Percent_Identity=27.8048780487805, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561804, Length=226, Percent_Identity=28.3185840707965, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212645052, Length=261, Percent_Identity=28.735632183908, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534659, Length=223, Percent_Identity=27.8026905829596, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17534651, Length=211, Percent_Identity=27.9620853080569, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212659371, Length=182, Percent_Identity=28.021978021978, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534653, Length=228, Percent_Identity=27.1929824561404, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561802, Length=226, Percent_Identity=29.646017699115, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534655, Length=233, Percent_Identity=27.0386266094421, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71982300, Length=267, Percent_Identity=26.9662921348315, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71983004, Length=240, Percent_Identity=26.25, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193207841, Length=225, Percent_Identity=28.4444444444444, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561800, Length=226, Percent_Identity=28.7610619469027, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71995300, Length=195, Percent_Identity=29.2307692307692, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568383, Length=284, Percent_Identity=27.8169014084507, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561810, Length=178, Percent_Identity=28.6516853932584, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71995305, Length=228, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17561794, Length=199, Percent_Identity=29.6482412060301, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193206632, Length=173, Percent_Identity=26.5895953757225, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI62484298, Length=365, Percent_Identity=24.1095890410959, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62484477, Length=365, Percent_Identity=24.1095890410959, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI116008008, Length=365, Percent_Identity=24.1095890410959, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221330468, Length=260, Percent_Identity=27.3076923076923, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221330470, Length=260, Percent_Identity=27.3076923076923, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI161078020, Length=223, Percent_Identity=31.390134529148, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 54684; Mature: 54684

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50885 HAMP ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRTKLFLGLLLIVITTNGIFLFLSYQYGKETVYKEVGSSALSIAAATAVLMNPEDIQK
CCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHEECHHHHHH
FNLDTSANSPLYKDLEKKLLEVRNANRRKDVYVNFIYSLFPDSNNPKVLRFAVDPEENII
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHEEEEHEECCCCCCCEEEEEEECCCHHHH
DRTALGTVMKLKTASGQTIHVNYELPVVLPEFVEDIWGKWLTALYPIKDAQGKYIGNIRV
HHHHHHHHHEEEECCCCEEEEEEECCEECHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
DVDADSVNQRFHFLLFAGIAVFISTFLFAMFLGWLLFQWFNKPLLKITTTLKNIAQGDLE
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHH
QHLDIRTKDEFAEVGRVINEMTEGLRQRNMLQVSLTRFISHALAEKIVKSGELPQVFSER
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
RKVTIMVCDIRDFTTISERIKPELVVDFLNHFFEKMIEAITSQHGILDKYLGDGFLAIFG
CEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEC
SPDDDAYQEDHAIHAALKMREAMKSLNADWAKILGTEIQIGIGINTGSAIVGNIGTDIHM
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEECCCCEEEECCCCCEEE
EYTAIGDTVNLASRIENATKKLNTDILISEYTYIATDHTAFQFIELGEISIKGRVHKVKV
EEEECCCHHHHHHHHHHHHHHCCCCEEEECEEEEEECCCCEEEEEECCEEEECEEEEEEE
YTL
EEC
>Mature Secondary Structure
MKFRTKLFLGLLLIVITTNGIFLFLSYQYGKETVYKEVGSSALSIAAATAVLMNPEDIQK
CCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHEECHHHHHH
FNLDTSANSPLYKDLEKKLLEVRNANRRKDVYVNFIYSLFPDSNNPKVLRFAVDPEENII
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHEEEEHEECCCCCCCEEEEEEECCCHHHH
DRTALGTVMKLKTASGQTIHVNYELPVVLPEFVEDIWGKWLTALYPIKDAQGKYIGNIRV
HHHHHHHHHEEEECCCCEEEEEEECCEECHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
DVDADSVNQRFHFLLFAGIAVFISTFLFAMFLGWLLFQWFNKPLLKITTTLKNIAQGDLE
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHH
QHLDIRTKDEFAEVGRVINEMTEGLRQRNMLQVSLTRFISHALAEKIVKSGELPQVFSER
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
RKVTIMVCDIRDFTTISERIKPELVVDFLNHFFEKMIEAITSQHGILDKYLGDGFLAIFG
CEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEC
SPDDDAYQEDHAIHAALKMREAMKSLNADWAKILGTEIQIGIGINTGSAIVGNIGTDIHM
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEECCCCEEEECCCCCEEE
EYTAIGDTVNLASRIENATKKLNTDILISEYTYIATDHTAFQFIELGEISIKGRVHKVKV
EEEECCCHHHHHHHHHHHHHHCCCCEEEECEEEEEECCCCEEEEEECCEEEECEEEEEEE
YTL
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]