BacMap

Definition	Legionella pneumophila str. Lens, complete genome.
Accession	NC_006369
Length	3,345,687

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The map label for this gene is fabL [H]

Identifier: 54293350

GI number: 54293350

Start: 447474

End: 448232

Strand: Direct

Name: fabL [H]

Synonym: lpl0399

Alternate gene names: 54293350

Gene position: 447474-448232 (Clockwise)

Preceding gene: 54293347

Following gene: 54293351

Centisome position: 13.37

GC content: 42.29

Gene sequence:

>759_bases
ATGAGTTCATTAGTTTTTTCAGGAAAGGTAGGATTGATAACGGGTGGTGCACGAGGAATTGGTAAAGCGACCGCATTAAA
GTTAGCACAGTCAGGCTGCGATATTGCTATCGTGTATTATAATAGCTCTGATGAGGCTCAAAGTCTGGTCAATGAAATAA
CCGGCATGGGTAGAAAAGCAGTTGCCTTACAAGCCGATGTAGCAGATTGTCAATCTGTCAAAGAAATGTTCTCTCAATTT
AGAGAACACTTTAAGCACTTAAATTTTCTAGTGAGTAATGCAGCGAGTGGGGTATTGAAACCTGCTTTGAAAATGTCGAC
CAAACATTGGCGCTGGTGTTTGGAAACCAATGCTTTGGCTTTGAACCACTTGGTTACGGAAGGTCTTGCCCTAATGCCTA
AAAACAGTCGAGTTATTGCACTATCCAGCTTAGGTGCATCAAGGGCGATTCCAAATTATGCTTTTATTGGTGCCTCTAAA
GCAGCTCTGGAAGCATTGGTTCGTTCGCTAAGTTTGGAGCTCGCTAGTTATGGTATTACTGTGAATACTGTTTCTGCAGG
TGTTGTCGATACGGATGCTTTAAAGCATTTTCCAAACAGAGAACAGTTACTGGATGAATATCAAGCTCATGCTTTGGCAG
ATAGAGCGTTAACACCGGAAGATGTGGCTAATGCTATCTATTTGCTTTGTTTGCCTGAAGCGGCCATGATTAATGCCCAT
ACATTATATGTTGACGCAGGCTATAGTCAGGTTGGGTAG

Upstream 100 bases:

>100_bases
ATAAATTATGAAATTCCGCACGATAGAGTCCCGATATTTCCATTGACAGCACAGCAGATTAGCGGTAGTTTGGTGGGATT
TTATACTATAGGGTTATCGT

Downstream 100 bases:

>100_bases
TAGATGATAAAAGTAAATTTTATGATATAATTTCAAGCTTTGCGAGCTTTGTTGGTTCAGAGGATAAAATATGAATGTAG
CTGAAGTTTACCCTAAGGTT

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSSLVFSGKVGLITGGARGIGKATALKLAQSGCDIAIVYYNSSDEAQSLVNEITGMGRKAVALQADVADCQSVKEMFSQF
REHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALALNHLVTEGLALMPKNSRVIALSSLGASRAIPNYAFIGASK
AALEALVRSLSLELASYGITVNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAH
TLYVDAGYSQVG

Sequences:

>Translated_252_residues
MSSLVFSGKVGLITGGARGIGKATALKLAQSGCDIAIVYYNSSDEAQSLVNEITGMGRKAVALQADVADCQSVKEMFSQF
REHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALALNHLVTEGLALMPKNSRVIALSSLGASRAIPNYAFIGASK
AALEALVRSLSLELASYGITVNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAH
TLYVDAGYSQVG
>Mature_251_residues
SSLVFSGKVGLITGGARGIGKATALKLAQSGCDIAIVYYNSSDEAQSLVNEITGMGRKAVALQADVADCQSVKEMFSQFR
EHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALALNHLVTEGLALMPKNSRVIALSSLGASRAIPNYAFIGASKA
ALEALVRSLSLELASYGITVNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAHT
LYVDAGYSQVG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=251, Percent_Identity=30.6772908366534, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=27.5590551181102, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI7705925, Length=255, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI31542939, Length=244, Percent_Identity=28.2786885245902, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=26.7489711934156, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=26.8, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI109715829, Length=242, Percent_Identity=28.5123966942149, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI209862901, Length=217, Percent_Identity=26.7281105990783, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI19923983, Length=217, Percent_Identity=26.7281105990783, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=29.8969072164948, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=26.6932270916335, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI224922801, Length=170, Percent_Identity=29.4117647058824, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=32.2834645669291, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=31.4516129032258, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI2367175, Length=239, Percent_Identity=34.3096234309623, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=30.952380952381, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=26.9230769230769, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1787545, Length=258, Percent_Identity=29.0697674418605, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789378, Length=231, Percent_Identity=28.1385281385281, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=25.5144032921811, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=27.1317829457364, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=28.0632411067194, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=25.9842519685039, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790717, Length=245, Percent_Identity=25.7142857142857, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787820, Length=237, Percent_Identity=25.7383966244726, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=217, Percent_Identity=29.9539170506912, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=27.7566539923954, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=27.6515151515151, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=253, Percent_Identity=28.4584980237154, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=28.1368821292776, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=25.7692307692308, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=249, Percent_Identity=26.1044176706827, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=241, Percent_Identity=26.1410788381743, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=27.8810408921933, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=27.8195488721804, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=194, Percent_Identity=27.8350515463918, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=25.4681647940075, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=25.1937984496124, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=249, Percent_Identity=25.3012048192771, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=257, Percent_Identity=26.4591439688716, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=261, Percent_Identity=26.8199233716475, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17555612, Length=208, Percent_Identity=27.8846153846154, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=23.9543726235741, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=210, Percent_Identity=28.0952380952381, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=23.7903225806452, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=26.0700389105058, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=198, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=198, Percent_Identity=26.7676767676768, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=265, Percent_Identity=26.7924528301887, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=258, Percent_Identity=24.8062015503876, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=228, Percent_Identity=28.0701754385965, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=30.3149606299213, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24643142, Length=254, Percent_Identity=27.9527559055118, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=28.8, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=28.5140562248996, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=29.5275590551181, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=26.8, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648944, Length=236, Percent_Identity=26.6949152542373, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 26884; Mature: 26753

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLVFSGKVGLITGGARGIGKATALKLAQSGCDIAIVYYNSSDEAQSLVNEITGMGRKA
CCCEEECCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
VALQADVADCQSVKEMFSQFREHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALA
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHEEHHCCHHH
LNHLVTEGLALMPKNSRVIALSSLGASRAIPNYAFIGASKAALEALVRSLSLELASYGIT
HHHHHHCCCEECCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEE
VNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAH
EEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHEEEEEECCCHHHEEEE
TLYVDAGYSQVG
EEEEECCCCCCC
>Mature Secondary Structure 
SSLVFSGKVGLITGGARGIGKATALKLAQSGCDIAIVYYNSSDEAQSLVNEITGMGRKA
CCEEECCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
VALQADVADCQSVKEMFSQFREHFKHLNFLVSNAASGVLKPALKMSTKHWRWCLETNALA
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHEEHHCCHHH
LNHLVTEGLALMPKNSRVIALSSLGASRAIPNYAFIGASKAALEALVRSLSLELASYGIT
HHHHHHCCCEECCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCEE
VNTVSAGVVDTDALKHFPNREQLLDEYQAHALADRALTPEDVANAIYLLCLPEAAMINAH
EEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHEEEEEECCCHHHEEEE
TLYVDAGYSQVG
EEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]