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The map label for this gene is pdxA [H]

Identifier: 54293304

GI number: 54293304

Start: 406512

End: 407486

Strand: Direct

Name: pdxA [H]

Synonym: lpl0352

Alternate gene names: 54293304

Gene position: 406512-407486 (Clockwise)

Preceding gene: 54293303

Following gene: 54293305

Centisome position: 12.15

GC content: 41.74

Gene sequence:

>975_bases
ATGAACCCACTGCTTATTAGTAGTGGAGAGCCTGCTGGAATTGGCCCGGACTTATGCCTGGCTTTGGCAGAAACCGATTT
GCCCGTAGTGATATTGGGTGATCTGTCTTTATTAGAGGCAAGAGCCAGTGAGTTAAATCTCAGTATTAAATTTATAGAGT
ACAGCTCTCATCAAAGCTTCGAAAAAAAGGCAGGATATTTAACTGTATGGCCTGTTCCATGTGCCGAACCGGTCATTAGT
GGTGAATTAAATCCAAGAAATGCGGCTTATGTTATGGAGCTTTTGACTTTAGGGGCTTCGCTATGTTCCAAAGGGGAGTT
TTCTGCATTAGTGACAGCGCCTGTTCATAAGGCAAACATTAATGCAGCCGGTATCACGTTTACTGGCCACACGGAGTTTT
TTGCTGATTTCTTTGAGGTGGAAACAGTGGTGATGATGCTGGCCTGTTCTCAAATGAAAGTGGCATTAGTCACAACGCAT
CTTCCTCTGCGTATGGTGCCTGATACCATTAGCTCTTTGCTTATCGTAAAGGTAATTCAACAATTACATCATTCATTAAA
ACATGATTTTGGAATTCAAAGTCCCAAAATCAACGTGGCTGGTCTGAATCCGCATGCTGGAGAATCAGGATATTTAGGTC
GAGAAGAAATTGAAATTATTACCCCAGCCTTAAATACTCTAAAAAACCAGGGGATCGATGTGCAAGGGCCGTTACCAGCA
GATACGATGTTTATAACAAACCATATCAATCACTGTGATGCTTATGTGGCAATGTACCATGATCAAGGACTGCCAGTTTT
AAAGTATGCTGGATTTAATGAAGCAGTAAATATAACTCTCGGATTGCCGATAATTCGTACTTCTGTAGATCATGGAACAG
CCATAGAATTAGCTGGTAAGAACAAAGCTAACCCTGGGAGTATGCTTGCGGCGGTTAAGATGGCGAAAGATATGGCTTTA
ACAAGGATAAAATGA

Upstream 100 bases:

>100_bases
GGCAATTTCTACAACAGCGCAAGTTTGTAGAGGCAGTGCAAAACTGGCAACAACATTTGCGCTCTCAAGCTTATATTAAT
ATAGTTGATAAGGATTTAGC

Downstream 100 bases:

>100_bases
AATGTCTCTGATTAGCCTGATAGCAGCCATAGATGAAACAGGAGGATTGGGTATTAACAACCAATTACTCTGCTATTTGC
CAGCTGACTTACAGCATTTT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase 1 [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MNPLLISSGEPAGIGPDLCLALAETDLPVVILGDLSLLEARASELNLSIKFIEYSSHQSFEKKAGYLTVWPVPCAEPVIS
GELNPRNAAYVMELLTLGASLCSKGEFSALVTAPVHKANINAAGITFTGHTEFFADFFEVETVVMMLACSQMKVALVTTH
LPLRMVPDTISSLLIVKVIQQLHHSLKHDFGIQSPKINVAGLNPHAGESGYLGREEIEIITPALNTLKNQGIDVQGPLPA
DTMFITNHINHCDAYVAMYHDQGLPVLKYAGFNEAVNITLGLPIIRTSVDHGTAIELAGKNKANPGSMLAAVKMAKDMAL
TRIK

Sequences:

>Translated_324_residues
MNPLLISSGEPAGIGPDLCLALAETDLPVVILGDLSLLEARASELNLSIKFIEYSSHQSFEKKAGYLTVWPVPCAEPVIS
GELNPRNAAYVMELLTLGASLCSKGEFSALVTAPVHKANINAAGITFTGHTEFFADFFEVETVVMMLACSQMKVALVTTH
LPLRMVPDTISSLLIVKVIQQLHHSLKHDFGIQSPKINVAGLNPHAGESGYLGREEIEIITPALNTLKNQGIDVQGPLPA
DTMFITNHINHCDAYVAMYHDQGLPVLKYAGFNEAVNITLGLPIIRTSVDHGTAIELAGKNKANPGSMLAAVKMAKDMAL
TRIK
>Mature_324_residues
MNPLLISSGEPAGIGPDLCLALAETDLPVVILGDLSLLEARASELNLSIKFIEYSSHQSFEKKAGYLTVWPVPCAEPVIS
GELNPRNAAYVMELLTLGASLCSKGEFSALVTAPVHKANINAAGITFTGHTEFFADFFEVETVVMMLACSQMKVALVTTH
LPLRMVPDTISSLLIVKVIQQLHHSLKHDFGIQSPKINVAGLNPHAGESGYLGREEIEIITPALNTLKNQGIDVQGPLPA
DTMFITNHINHCDAYVAMYHDQGLPVLKYAGFNEAVNITLGLPIIRTSVDHGTAIELAGKNKANPGSMLAAVKMAKDMAL
TRIK

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=318, Percent_Identity=53.1446540880503, Blast_Score=332, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 34818; Mature: 34818

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPLLISSGEPAGIGPDLCLALAETDLPVVILGDLSLLEARASELNLSIKFIEYSSHQSF
CCCEEECCCCCCCCCHHHHHEECCCCCCEEEECCHHHHHHHHHHCEEEEEEEEECCCCCH
EKKAGYLTVWPVPCAEPVISGELNPRNAAYVMELLTLGASLCSKGEFSALVTAPVHKANI
HHCCCEEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCC
NAAGITFTGHTEFFADFFEVETVVMMLACSQMKVALVTTHLPLRMVPDTISSLLIVKVIQ
CEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECHHHHHHHHHHHHHH
QLHHSLKHDFGIQSPKINVAGLNPHAGESGYLGREEIEIITPALNTLKNQGIDVQGPLPA
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHEEEHHHHHHHHHCCCCCCCCCCC
DTMFITNHINHCDAYVAMYHDQGLPVLKYAGFNEAVNITLGLPIIRTSVDHGTAIELAGK
CEEEEECCCCHHHEEEEEEECCCCCEEEECCCCCEEEEEECCEEEEECCCCCCEEEECCC
NKANPGSMLAAVKMAKDMALTRIK
CCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPLLISSGEPAGIGPDLCLALAETDLPVVILGDLSLLEARASELNLSIKFIEYSSHQSF
CCCEEECCCCCCCCCHHHHHEECCCCCCEEEECCHHHHHHHHHHCEEEEEEEEECCCCCH
EKKAGYLTVWPVPCAEPVISGELNPRNAAYVMELLTLGASLCSKGEFSALVTAPVHKANI
HHCCCEEEEECCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCC
NAAGITFTGHTEFFADFFEVETVVMMLACSQMKVALVTTHLPLRMVPDTISSLLIVKVIQ
CEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECHHHHHHHHHHHHHH
QLHHSLKHDFGIQSPKINVAGLNPHAGESGYLGREEIEIITPALNTLKNQGIDVQGPLPA
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHEEEHHHHHHHHHCCCCCCCCCCC
DTMFITNHINHCDAYVAMYHDQGLPVLKYAGFNEAVNITLGLPIIRTSVDHGTAIELAGK
CEEEEECCCCHHHEEEEEEECCCCCEEEECCCCCEEEEEECCEEEEECCCCCCEEEECCC
NKANPGSMLAAVKMAKDMALTRIK
CCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]