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The map label for this gene is ccmA

Identifier: 54296877

GI number: 54296877

Start: 1025169

End: 1025771

Strand: Direct

Name: ccmA

Synonym: lpp0918

Alternate gene names: 54296877

Gene position: 1025169-1025771 (Clockwise)

Preceding gene: 54296874

Following gene: 54296878

Centisome position: 29.26

GC content: 36.48

Gene sequence:

>603_bases
ATGCTTGATGTGATTGAACTTGATTTTGACTATCATGACCAGCCATTGTTGCAACAAATTTCTTTTCATCTTCCTGCTGG
AGGCTTATTGCATTTAAAAGGTTCCAATGGAGCAGGAAAAACGACTTTACTTAAATTAATCGCAGGTTTGCTTAATCCTG
AAAAGGGAGAAATTCTCTTCGAAAGGCAATCTATAAAAAAAGATCTATGCACCTATCAAAAGCAATTATGTTTTGTGGGG
CATAGATCAGGGATCAATCCCTATCTTACGCTAAGAGAAAATTGTTTATATGACATACATTTTTCTCCTGGTGCAGTGGG
CATTACAGAATTATGCAGATTATTCAGTTTAGAACACCTTATTGATTATCCATGTGGATTACTATCCTCAGGACAAAAAA
GGCAAGTTGCTTTATTAAGATTATGGATGTCAAAAGCAAAATTATGGTTGCTTGATGAGCCTTTGGTTGCTCTTGATGAG
TTATCATTGCTTACAATTATCACAAAAATCCAGGAGCACAGGGCAAAAGGTGGTGCTGTATTATTGACCTCTCATCAGGA
TTTGCCTTTAAACAAGGCGGATTATGAGGAGTATCATCTATGA

Upstream 100 bases:

>100_bases
ACTTCGCAAGCAAAAATTAAATAACTTTTCACGAAGGCATTGGGGATTTTTCTTATGTCCTGTTATAGTTAGCCGAGTGT
ATCTAAAAATAAAGTGTTTT

Downstream 100 bases:

>100_bases
ATTCCCCATTTCAATTATTCGGAAAACAGTTCAGGCGTGAAATATTAATCCAGGTGCGGCAAATCAGATATTTAGTTAAT
TCGTGTTTATTTTTTTTAAT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MLDVIELDFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEILFERQSIKKDLCTYQKQLCFVG
HRSGINPYLTLRENCLYDIHFSPGAVGITELCRLFSLEHLIDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDE
LSLLTIITKIQEHRAKGGAVLLTSHQDLPLNKADYEEYHL

Sequences:

>Translated_200_residues
MLDVIELDFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEILFERQSIKKDLCTYQKQLCFVG
HRSGINPYLTLRENCLYDIHFSPGAVGITELCRLFSLEHLIDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDE
LSLLTIITKIQEHRAKGGAVLLTSHQDLPLNKADYEEYHL
>Mature_200_residues
MLDVIELDFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEILFERQSIKKDLCTYQKQLCFVG
HRSGINPYLTLRENCLYDIHFSPGAVGITELCRLFSLEHLIDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDE
LSLLTIITKIQEHRAKGGAVLLTSHQDLPLNKADYEEYHL

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI11967969, Length=186, Percent_Identity=26.3440860215054, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI153792144, Length=179, Percent_Identity=26.2569832402235, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082064, Length=194, Percent_Identity=39.6907216494845, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI87081709, Length=162, Percent_Identity=31.4814814814815, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788761, Length=153, Percent_Identity=33.9869281045752, Blast_Score=78, Evalue=3e-16,
Organism=Escherichia coli, GI1786563, Length=198, Percent_Identity=30.8080808080808, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081834, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1787370, Length=154, Percent_Identity=30.5194805194805, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786698, Length=191, Percent_Identity=28.7958115183246, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786319, Length=174, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI87081791, Length=165, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789593, Length=184, Percent_Identity=26.6304347826087, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081782, Length=204, Percent_Identity=25, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1788897, Length=197, Percent_Identity=28.9340101522843, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786398, Length=181, Percent_Identity=28.7292817679558, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1790467, Length=178, Percent_Identity=26.4044943820225, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789873, Length=193, Percent_Identity=27.979274611399, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789586, Length=216, Percent_Identity=25.462962962963, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1787143, Length=209, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI48995001, Length=181, Percent_Identity=25.9668508287293, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788165, Length=195, Percent_Identity=27.1794871794872, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787547, Length=172, Percent_Identity=28.4883720930233, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789891, Length=196, Percent_Identity=27.0408163265306, Blast_Score=61, Evalue=4e-11,
Organism=Escherichia coli, GI1786345, Length=182, Percent_Identity=26.3736263736264, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1788210, Length=182, Percent_Identity=29.1208791208791, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193208177, Length=207, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19920532, Length=170, Percent_Identity=27.0588235294118, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24580930, Length=170, Percent_Identity=27.0588235294118, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_LEGPA (Q5X6P7)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_123246.1
- ProteinModelPortal:   Q5X6P7
- SMR:   Q5X6P7
- STRING:   Q5X6P7
- GeneID:   3119608
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp0918
- LegioList:   lpp0918
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   RENCLYD
- ProtClustDB:   PRK13540
- BioCyc:   LPNE297246:LPP0918-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 22558; Mature: 22558

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVIELDFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEILF
CCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
ERQSIKKDLCTYQKQLCFVGHRSGINPYLTLRENCLYDIHFSPGAVGITELCRLFSLEHL
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHH
IDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDELSLLTIITKIQEHRAKGGAV
HHCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEE
LLTSHQDLPLNKADYEEYHL
EEECCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MLDVIELDFDYHDQPLLQQISFHLPAGGLLHLKGSNGAGKTTLLKLIAGLLNPEKGEILF
CCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
ERQSIKKDLCTYQKQLCFVGHRSGINPYLTLRENCLYDIHFSPGAVGITELCRLFSLEHL
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEECCCCCCCHHHHHHHHHHHHH
IDYPCGLLSSGQKRQVALLRLWMSKAKLWLLDEPLVALDELSLLTIITKIQEHRAKGGAV
HHCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEE
LLTSHQDLPLNKADYEEYHL
EEECCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA