Click here to switch to the map view.

The map label for this gene is apt

Identifier: 54020424

GI number: 54020424

Start: 291165

End: 291680

Strand: Reverse

Name: apt

Synonym: mhp266

Alternate gene names: 54020424

Gene position: 291680-291165 (Counterclockwise)

Preceding gene: 54020425

Following gene: 54020423

Centisome position: 32.67

GC content: 33.53

Gene sequence:

>516_bases
ATGCAAATTAACTTAGAAAAATATATTCGAACCGTCGAAGATTTCCCTAAAAAAGGAATTAGTTTTAAGGACATTTCACC
ATTACTTGCGGATGGAAAAGCACTCAATTATACAATTGTTGAGATGGCCTCACTTGCTAAAGATGTTGATATAATTGTTG
GGCCTGATGCAAGAGGTTTTTTATTTGGCACACCAACAGCCGCTTTTCTTTCAAAACCATTTATAATGATACGAAAAGCT
GGTAAATTACCAGGCGAAGTTGAAGAATTTGCCTATGAATTAGAATATGGTTCAGCAATTCTTGAAGTTCAAGTTGATAT
GATTAAACCCGGACAAAAAGTAGCGATTATTGATGATGTGCTAGCAACTGGAGGAACTGTAAAAGCAATCACCAAAATGA
TCGAAAGAGCTGGAGCAATTGTTGATAAAATCATTTTCTTAATTGAACTTGAACAATTACAAGGTCGTAAAAAGCTTGAA
AATTACGATGTTATTTCCCTAATAAAAATAAGTTAA

Upstream 100 bases:

>100_bases
TATATTTGTCCCGGTTTTGCCGGTTATTTTAAATTGAGGGCAAAAAAAATTAAAAATTTTCAACAAAAGACAAAAAAATA
GTTTATAATATAAGAAAGTT

Downstream 100 bases:

>100_bases
AAAATTTTAATTAAGTTTAAATTTTTAAAGTTTTGACTTTGTTTATAAGTCAAAACTTTTTTTATATAAATAATAAAAAC
TTTAAGGTATAATTTAAATG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MQINLEKYIRTVEDFPKKGISFKDISPLLADGKALNYTIVEMASLAKDVDIIVGPDARGFLFGTPTAAFLSKPFIMIRKA
GKLPGEVEEFAYELEYGSAILEVQVDMIKPGQKVAIIDDVLATGGTVKAITKMIERAGAIVDKIIFLIELEQLQGRKKLE
NYDVISLIKIS

Sequences:

>Translated_171_residues
MQINLEKYIRTVEDFPKKGISFKDISPLLADGKALNYTIVEMASLAKDVDIIVGPDARGFLFGTPTAAFLSKPFIMIRKA
GKLPGEVEEFAYELEYGSAILEVQVDMIKPGQKVAIIDDVLATGGTVKAITKMIERAGAIVDKIIFLIELEQLQGRKKLE
NYDVISLIKIS
>Mature_171_residues
MQINLEKYIRTVEDFPKKGISFKDISPLLADGKALNYTIVEMASLAKDVDIIVGPDARGFLFGTPTAAFLSKPFIMIRKA
GKLPGEVEEFAYELEYGSAILEVQVDMIKPGQKVAIIDDVLATGGTVKAITKMIERAGAIVDKIIFLIELEQLQGRKKLE
NYDVISLIKIS

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=42.9411764705882, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=45.6, Blast_Score=107, Evalue=6e-24,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=45.1219512195122, Blast_Score=137, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17509087, Length=168, Percent_Identity=45.8333333333333, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=167, Percent_Identity=38.3233532934132, Blast_Score=95, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320649, Length=157, Percent_Identity=33.7579617834395, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136334, Length=160, Percent_Identity=45, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_MYCH2 (Q601D6)

Other databases:

- EMBL:   AE017332
- RefSeq:   YP_115779.1
- ProteinModelPortal:   Q601D6
- SMR:   Q601D6
- STRING:   Q601D6
- GeneID:   3105519
- GenomeReviews:   AE017332_GR
- KEGG:   mhy:mhp266
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q601D6
- ProtClustDB:   PRK02304
- BioCyc:   MHYO295358:MHP266-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18849; Mature: 18849

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQINLEKYIRTVEDFPKKGISFKDISPLLADGKALNYTIVEMASLAKDVDIIVGPDARGF
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCEEEECCCCCEE
LFGTPTAAFLSKPFIMIRKAGKLPGEVEEFAYELEYGSAILEVQVDMIKPGQKVAIIDDV
EEECCHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEHHHH
LATGGTVKAITKMIERAGAIVDKIIFLIELEQLQGRKKLENYDVISLIKIS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEEC
>Mature Secondary Structure
MQINLEKYIRTVEDFPKKGISFKDISPLLADGKALNYTIVEMASLAKDVDIIVGPDARGF
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCEEEECCCCCEE
LFGTPTAAFLSKPFIMIRKAGKLPGEVEEFAYELEYGSAILEVQVDMIKPGQKVAIIDDV
EEECCHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEHHHH
LATGGTVKAITKMIERAGAIVDKIIFLIELEQLQGRKKLENYDVISLIKIS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA