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The map label for this gene is uvrC

Identifier: 54020325

GI number: 54020325

Start: 86844

End: 88394

Strand: Reverse

Name: uvrC

Synonym: mhp070

Alternate gene names: 54020325

Gene position: 88394-86844 (Counterclockwise)

Preceding gene: 54020326

Following gene: 54020324

Centisome position: 9.9

GC content: 23.98

Gene sequence:

>1551_bases
ATGGAAAAATTTCAGGAATTAGTTAAAAAATTGATGCTGCCAAACCAGGTAGGAGTTTACCGTTTTTATGATGAAAAAAA
CACCCTTTTATATGTTGGGAAAGCTAAGAATCTAAAATCACGAATGAATCAGTATGCAAAAGGAGCAACTAATTCTTATA
AAACCGAAGTTTTAATTAGAAAAACTAAAGAAATTAAATATGATATTCTCCAAAACGAAACCGAAGCACTAATTTTAGAA
AAAAAAATCATAAGCAAATTCCAACCAATTTATAATATTAAACTTAAAGATGACCAAAATTATCCCTATATAAAATTAGA
ATTAGAAAAAAAACTGAATATTGAACTAGTTTATAAAATTTCACGCAGCAAAAAGTCAAAAAATATCTTTTTTTATGGAC
CTTTTCTTAATAAAAGTAGCGCTTTGGTCCTAAAAAAAATATTAGAAAATATTGTCTTATACAAAAAAGGACAACAAATT
GTACAATCAGAACCAGAAATTTTAAATCAAAAATTTTTTTTATGTAAAAAAATACTACAGGAACAAAAATTAATTAGTTT
TTGCGAACAAAAATTAGAAAAAGCAAAGAAAAATAACCAATTTGAACTCGCCAACGAATATCACAAAGCGCTTATTGCAC
TGAAAAAAACTAAAATTGAACAACAAAATATTGAGCTTAACAACCTAAAAAATATTGATTTTCTTTATTATAGTGAAATT
GGCGAGAATAATTTAGTAATTAGTTTTGCTTTTTATCGCAATGGTGTTTTTTTATCTAATAAAAATTTTATTATTGATAT
TATACTTAATTATACAGAAGTTTTAATTAATTTTTTAAATAATTATTATAAAATTAATATTTATCCCGATGAGTTAGTAG
TTAAAAATTTTTGGCCTAAAAATGCTGAATTTTTAGACCCAAAAATTAATATCAAAATTGGAAAAAGCTTAAAATATAAA
CATATTTTAAACACTTTAGCAAAAAATCACCAAGATTTTATCAGCCATAACTTTGACCAAGAAATTCAGAAAAAAATTAA
AAATCAGAAAATTTTAGGACTTGTTAAGGCCAGTTTAAAAATTGAAAATGTTGAAAAAATCATGGCAATTGACTGCTCAA
ATTTAGAGTCAAACTACCCCACAACTGGAATTATTTTCTATATAAACGGGATATATGAGCGAAATTACAATAGATTTTTC
AATTATAGGGGAACAAAAAAAGGTGATACAAATTATATGAGACAGGGTTTTGAAAAATATATTAAAAATCCAAAGTTTCT
AAAACCTGATTTGATTTTAGTAGATGGAGGAATTCAGCAAATTAATTTAATTATAGAAATTTTAAGAAAAAATCACTTTG
AAATTCCGATTTTTGGAATGGTAAAAAATAAAAGGCATAAAACTGAAAAAATTATTGACTTAAACGGCAAAAAAATTAAC
GTATCTCAAGATGTTCTTAATTTTTTTGCTTTAATTCAAGAAAATGTCGATTTATTTGTTAAGGAAAAAATGAAGAAAAA
ACAAATAAAAAGTTTATTTTCTAAGAGATAA

Upstream 100 bases:

>100_bases
TAATTTATTTTAACTTCAAGGTTTAATTATACCAATTTTTTGTTAAAATTATAATAATTATCAAAAATTTGTTTATATTT
TAAGAACTTAAAATTTTTAT

Downstream 100 bases:

>100_bases
TTCAAATTTCAGCATTTAAATTTTGTTATCTTTTTGAAAAAAATAAGTTAACAAAATTTAATTTTTAAGCTTATTAATAT
TTAAAAAGGTCTTTAAATTC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MEKFQELVKKLMLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIRKTKEIKYDILQNETEALILE
KKIISKFQPIYNIKLKDDQNYPYIKLELEKKLNIELVYKISRSKKSKNIFFYGPFLNKSSALVLKKILENIVLYKKGQQI
VQSEPEILNQKFFLCKKILQEQKLISFCEQKLEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEI
GENNLVISFAFYRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPKNAEFLDPKINIKIGKSLKYK
HILNTLAKNHQDFISHNFDQEIQKKIKNQKILGLVKASLKIENVEKIMAIDCSNLESNYPTTGIIFYINGIYERNYNRFF
NYRGTKKGDTNYMRQGFEKYIKNPKFLKPDLILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKIN
VSQDVLNFFALIQENVDLFVKEKMKKKQIKSLFSKR

Sequences:

>Translated_516_residues
MEKFQELVKKLMLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIRKTKEIKYDILQNETEALILE
KKIISKFQPIYNIKLKDDQNYPYIKLELEKKLNIELVYKISRSKKSKNIFFYGPFLNKSSALVLKKILENIVLYKKGQQI
VQSEPEILNQKFFLCKKILQEQKLISFCEQKLEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEI
GENNLVISFAFYRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPKNAEFLDPKINIKIGKSLKYK
HILNTLAKNHQDFISHNFDQEIQKKIKNQKILGLVKASLKIENVEKIMAIDCSNLESNYPTTGIIFYINGIYERNYNRFF
NYRGTKKGDTNYMRQGFEKYIKNPKFLKPDLILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKIN
VSQDVLNFFALIQENVDLFVKEKMKKKQIKSLFSKR
>Mature_516_residues
MEKFQELVKKLMLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIRKTKEIKYDILQNETEALILE
KKIISKFQPIYNIKLKDDQNYPYIKLELEKKLNIELVYKISRSKKSKNIFFYGPFLNKSSALVLKKILENIVLYKKGQQI
VQSEPEILNQKFFLCKKILQEQKLISFCEQKLEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEI
GENNLVISFAFYRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPKNAEFLDPKINIKIGKSLKYK
HILNTLAKNHQDFISHNFDQEIQKKIKNQKILGLVKASLKIENVEKIMAIDCSNLESNYPTTGIIFYINGIYERNYNRFF
NYRGTKKGDTNYMRQGFEKYIKNPKFLKPDLILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKIN
VSQDVLNFFALIQENVDLFVKEKMKKKQIKSLFSKR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=477, Percent_Identity=25.7861635220126, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 61096; Mature: 61096

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFQELVKKLMLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIR
CHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHEEE
KTKEIKYDILQNETEALILEKKIISKFQPIYNIKLKDDQNYPYIKLELEKKLNIELVYKI
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCEEEEEEE
SRSKKSKNIFFYGPFLNKSSALVLKKILENIVLYKKGQQIVQSEPEILNQKFFLCKKILQ
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHH
EQKLISFCEQKLEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
GENNLVISFAFYRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPK
CCCCEEEEEEEEECCEEEECCCEEEEEHHHHHHHHHHHHCCEEEEEEECCHHHHCCCCCC
NAEFLDPKINIKIGKSLKYKHILNTLAKNHQDFISHNFDQEIQKKIKNQKILGLVKASLK
CCCCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHH
IENVEKIMAIDCSNLESNYPTTGIIFYINGIYERNYNRFFNYRGTKKGDTNYMRQGFEKY
HHCHHHEEEEECCCCCCCCCCCEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHH
IKNPKFLKPDLILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKIN
HCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHEEECCCCEEE
VSQDVLNFFALIQENVDLFVKEKMKKKQIKSLFSKR
CHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKFQELVKKLMLPNQVGVYRFYDEKNTLLYVGKAKNLKSRMNQYAKGATNSYKTEVLIR
CHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCCCCCHHHHEEE
KTKEIKYDILQNETEALILEKKIISKFQPIYNIKLKDDQNYPYIKLELEKKLNIELVYKI
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCEEEEEEE
SRSKKSKNIFFYGPFLNKSSALVLKKILENIVLYKKGQQIVQSEPEILNQKFFLCKKILQ
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHH
EQKLISFCEQKLEKAKKNNQFELANEYHKALIALKKTKIEQQNIELNNLKNIDFLYYSEI
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
GENNLVISFAFYRNGVFLSNKNFIIDIILNYTEVLINFLNNYYKINIYPDELVVKNFWPK
CCCCEEEEEEEEECCEEEECCCEEEEEHHHHHHHHHHHHCCEEEEEEECCHHHHCCCCCC
NAEFLDPKINIKIGKSLKYKHILNTLAKNHQDFISHNFDQEIQKKIKNQKILGLVKASLK
CCCCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHH
IENVEKIMAIDCSNLESNYPTTGIIFYINGIYERNYNRFFNYRGTKKGDTNYMRQGFEKY
HHCHHHEEEEECCCCCCCCCCCEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHH
IKNPKFLKPDLILVDGGIQQINLIIEILRKNHFEIPIFGMVKNKRHKTEKIIDLNGKKIN
HCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHEEECCCCEEE
VSQDVLNFFALIQENVDLFVKEKMKKKQIKSLFSKR
CHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9664578 [H]