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The map label for this gene is pr1

Identifier: 54020279

GI number: 54020279

Start: 810462

End: 812072

Strand: Direct

Name: pr1

Synonym: mhp643

Alternate gene names: 54020279

Gene position: 810462-812072 (Clockwise)

Preceding gene: 54020278

Following gene: 54020280

Centisome position: 90.78

GC content: 23.71

Gene sequence:

>1611_bases
ATGAAATTATTTCAAAATACTATTCAAATTTTAAAACAAGATAAAAAAAATAATTTCATAATTTTTTTACTACAAATTAT
TTTTTTGACTCTCTTAAATTTACACTTTTATTCCTACTCTTTTATCGTTGGCTTTGTCAAAAAAAAGGTGCCAATTCAAG
ACAAGAATTTTATTTTGTGACTTTTAATTAGTAGCCTTTCTTTTGTTTTTTTTATTATTTTTAAACTTATCTATGTTTAT
CACTCAAATAAGACTACCTTTAAAATTTTTAAAAAAAACACCAATAGATTATCAGAAAATATAAGAAAAAAAACATACGA
AGAAATATTAAAAAATAAGGAAACTTATATATCTTTTTACAATCTGAATTTAGATCTTACAAATTCGCTTAGTATGACAA
TTTATACCCATTTATTTAAGGGTGTTATTTATATTATCTCGAGCACTATATTTATTTTTTTACTAAGCACTAAATCTTGA
ATTTTGATTTTACACTCGACACTTGGCGCTACCATAAGTGTGATTTTATTATTTAAATTTTCACCGTTAATTACAAAATT
ACAAAATAAAATCCAACAACTTTTTCAAAGTTATGCCGGAAAACAAATTAAATTATTCGGGTTATTTAATTTGTTTTACT
TTTTCAATAAAAGAAATGTTTTTACTAAATATCTTAAATCACAATTATTGGAAAAATATTCCCGCGAATTTGGTCTACTG
AAAAATTTTCAATATAAAACTTTTTTACTTAATTCCGGTTTTTTATTTTTTGTTCTTAGTAATTCTATAACTTTGTCGAT
TTTAACATATTATAAAACATTCGATGTTACCTTATTTATTTCCTTGTTTAGTATGAATTTGGTAATGGTAACAGGATTTT
CAAGTTTTTTCACCTATTTATTAACAGCACAAGCATTAAATCCATATGTTAATAAAATTTTCGAAAAAATAGATACTAAA
AATGAAAAAAAAATAGTTTTGCAAGAATTAATTTCAGAAATAAATTTACAAAATTTAAATTTTAGTTACAGCCCCGAAAC
CCGCGTTTTTTCAAATTTAAACCTAAGTTTTGAAAAAAACAAAAAATATGCGATAATTTCACCTTCAGGAAAAGGGAAAT
CATCACTTTTAAAGTTAATTTCCGGAGTTTTAACTAATTATGAAGGTAAAATTTTAATTAATAATTCAACTGAATATAAG
GAATTAGACCCAAAACAGTTAAGAAAACATATTGCACTAACAACAAATGAAAACATAATTTTCGAAGACACTTTGGCAAA
CAACATAACTTTATGAGATAAAAATCCCGATTTAGATTTGCTAAATTCTTTAATAAAAAAGTATAAAATTGATAATTTTT
CAAAACCAGAAACTGAAATTAGCTCAAAAAATTTATCTGAGGGCGAAAAACAAAAAGTTGCATTGGCCAGATTAGAGTAC
AAAAATTTAGATATTTGATGTTTAGATGAAGCTCTTGATAACATTTTCAAGGAAGATGCTTTTGAAATTTACAGTGATTT
ACTTTCAAAACCGAATAAAACAATTTTTATCGCAAGTCACCACATTCCTGAAAAAATAAAACCGATGTTTGACCAAATAA
TTGAAATTTAA

Upstream 100 bases:

>100_bases
TCTAATATAAAAATTATATAATTTTTATATTAGAAAATAGTTTCTTAATTTTATTTTTATATTTTTATGAATTTTTTTAA
CTTTAATATAAAGGAAAATA

Downstream 100 bases:

>100_bases
GGAGGAATTTATGGTAAAATCTACAAAACATTTCAAATTTATCCTTTGAAATTGATTATATTTGATTTTTACGATTTTTT
TTAAAATTTATCTCATTGTT

Product: ABC transporter ATP-binding protein; multidrug resistance protein

Products: ADP; phosphate; thiamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MKLFQNTIQILKQDKKNNFIIFLLQIIFLTLLNLHFYSYSFIVGFVKKKVPIQDKNFILWLLISSLSFVFFIIFKLIYVY
HSNKTTFKIFKKNTNRLSENIRKKTYEEILKNKETYISFYNLNLDLTNSLSMTIYTHLFKGVIYIISSTIFIFLLSTKSW
ILILHSTLGATISVILLFKFSPLITKLQNKIQQLFQSYAGKQIKLFGLFNLFYFFNKRNVFTKYLKSQLLEKYSREFGLL
KNFQYKTFLLNSGFLFFVLSNSITLSILTYYKTFDVTLFISLFSMNLVMVTGFSSFFTYLLTAQALNPYVNKIFEKIDTK
NEKKIVLQELISEINLQNLNFSYSPETRVFSNLNLSFEKNKKYAIISPSGKGKSSLLKLISGVLTNYEGKILINNSTEYK
ELDPKQLRKHIALTTNENIIFEDTLANNITLWDKNPDLDLLNSLIKKYKIDNFSKPETEISSKNLSEGEKQKVALARLEY
KNLDIWCLDEALDNIFKEDAFEIYSDLLSKPNKTIFIASHHIPEKIKPMFDQIIEI

Sequences:

>Translated_536_residues
MKLFQNTIQILKQDKKNNFIIFLLQIIFLTLLNLHFYSYSFIVGFVKKKVPIQDKNFIL*LLISSLSFVFFIIFKLIYVY
HSNKTTFKIFKKNTNRLSENIRKKTYEEILKNKETYISFYNLNLDLTNSLSMTIYTHLFKGVIYIISSTIFIFLLSTKS*
ILILHSTLGATISVILLFKFSPLITKLQNKIQQLFQSYAGKQIKLFGLFNLFYFFNKRNVFTKYLKSQLLEKYSREFGLL
KNFQYKTFLLNSGFLFFVLSNSITLSILTYYKTFDVTLFISLFSMNLVMVTGFSSFFTYLLTAQALNPYVNKIFEKIDTK
NEKKIVLQELISEINLQNLNFSYSPETRVFSNLNLSFEKNKKYAIISPSGKGKSSLLKLISGVLTNYEGKILINNSTEYK
ELDPKQLRKHIALTTNENIIFEDTLANNITL*DKNPDLDLLNSLIKKYKIDNFSKPETEISSKNLSEGEKQKVALARLEY
KNLDI*CLDEALDNIFKEDAFEIYSDLLSKPNKTIFIASHHIPEKIKPMFDQIIEI
>Mature_536_residues
MKLFQNTIQILKQDKKNNFIIFLLQIIFLTLLNLHFYSYSFIVGFVKKKVPIQDKNFIL*LLISSLSFVFFIIFKLIYVY
HSNKTTFKIFKKNTNRLSENIRKKTYEEILKNKETYISFYNLNLDLTNSLSMTIYTHLFKGVIYIISSTIFIFLLSTKS*
ILILHSTLGATISVILLFKFSPLITKLQNKIQQLFQSYAGKQIKLFGLFNLFYFFNKRNVFTKYLKSQLLEKYSREFGLL
KNFQYKTFLLNSGFLFFVLSNSITLSILTYYKTFDVTLFISLFSMNLVMVTGFSSFFTYLLTAQALNPYVNKIFEKIDTK
NEKKIVLQELISEINLQNLNFSYSPETRVFSNLNLSFEKNKKYAIISPSGKGKSSLLKLISGVLTNYEGKILINNSTEYK
ELDPKQLRKHIALTTNENIIFEDTLANNITL*DKNPDLDLLNSLIKKYKIDNFSKPETEISSKNLSEGEKQKVALARLEY
KNLDI*CLDEALDNIFKEDAFEIYSDLLSKPNKTIFIASHHIPEKIKPMFDQIIEI

Specific function: Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG1132

COG function: function code V; ABC-type multidrug transport system, ATPase and permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI9955966, Length=229, Percent_Identity=26.6375545851528, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI45243524, Length=229, Percent_Identity=26.6375545851528, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI42741659, Length=264, Percent_Identity=25.7575757575758, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI171184400, Length=258, Percent_Identity=25.1937984496124, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI9955968, Length=229, Percent_Identity=26.6375545851528, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI9955963, Length=213, Percent_Identity=26.7605633802817, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI4505771, Length=296, Percent_Identity=24.3243243243243, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI9961250, Length=302, Percent_Identity=23.5099337748344, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI255708477, Length=222, Percent_Identity=27.9279279279279, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI9961252, Length=217, Percent_Identity=25.8064516129032, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI148612844, Length=222, Percent_Identity=27.9279279279279, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI21536378, Length=128, Percent_Identity=30.46875, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786253, Length=185, Percent_Identity=30.8108108108108, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787143, Length=229, Percent_Identity=27.5109170305677, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786653, Length=523, Percent_Identity=22.1797323135755, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786654, Length=223, Percent_Identity=25.1121076233184, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558664, Length=469, Percent_Identity=23.454157782516, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17541710, Length=222, Percent_Identity=27.9279279279279, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193208177, Length=332, Percent_Identity=27.1084337349398, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193202349, Length=266, Percent_Identity=25.5639097744361, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115535101, Length=243, Percent_Identity=27.5720164609054, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565938, Length=205, Percent_Identity=27.8048780487805, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567265, Length=321, Percent_Identity=26.1682242990654, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567269, Length=216, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17569145, Length=334, Percent_Identity=25.1497005988024, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71996550, Length=221, Percent_Identity=28.5067873303167, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193209708, Length=199, Percent_Identity=30.6532663316583, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17511077, Length=228, Percent_Identity=26.7543859649123, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71992290, Length=193, Percent_Identity=25.3886010362694, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25146765, Length=483, Percent_Identity=22.7743271221532, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI86564969, Length=483, Percent_Identity=22.7743271221532, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71992070, Length=483, Percent_Identity=22.7743271221532, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71992066, Length=483, Percent_Identity=22.7743271221532, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115534520, Length=334, Percent_Identity=23.9520958083832, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32566680, Length=190, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17569081, Length=268, Percent_Identity=27.6119402985075, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17569143, Length=299, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=323, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=210, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=216, Percent_Identity=29.6296296296296, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324985, Length=301, Percent_Identity=25.9136212624585, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322980, Length=292, Percent_Identity=24.3150684931507, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322640, Length=174, Percent_Identity=31.0344827586207, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24659289, Length=211, Percent_Identity=30.3317535545024, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI23397593, Length=271, Percent_Identity=26.1992619926199, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI85726357, Length=312, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357907, Length=197, Percent_Identity=30.4568527918782, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR011917
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 62005; Mature: 62005

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFQNTIQILKQDKKNNFIIFLLQIIFLTLLNLHFYSYSFIVGFVKKKVPIQDKNFILL
CCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEH
LISSLSFVFFIIFKLIYVYHSNKTTFKIFKKNTNRLSENIRKKTYEEILKNKETYISFYN
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LNLDLTNSLSMTIYTHLFKGVIYIISSTIFIFLLSTKSILILHSTLGATISVILLFKFSP
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHH
LITKLQNKIQQLFQSYAGKQIKLFGLFNLFYFFNKRNVFTKYLKSQLLEKYSREFGLLKN
HHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
FQYKTFLLNSGFLFFVLSNSITLSILTYYKTFDVTLFISLFSMNLVMVTGFSSFFTYLLT
CCEEEEEEECCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHH
AQALNPYVNKIFEKIDTKNEKKIVLQELISEINLQNLNFSYSPETRVFSNLNLSFEKNKK
HHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEECCCE
YAIISPSGKGKSSLLKLISGVLTNYEGKILINNSTEYKELDPKQLRKHIALTTNENIIFE
EEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHEEEECCCCEEEE
DTLANNITLDKNPDLDLLNSLIKKYKIDNFSKPETEISSKNLSEGEKQKVALARLEYKNL
ECCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCC
DICLDEALDNIFKEDAFEIYSDLLSKPNKTIFIASHHIPEKIKPMFDQIIEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKLFQNTIQILKQDKKNNFIIFLLQIIFLTLLNLHFYSYSFIVGFVKKKVPIQDKNFILL
CCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEH
LISSLSFVFFIIFKLIYVYHSNKTTFKIFKKNTNRLSENIRKKTYEEILKNKETYISFYN
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEE
LNLDLTNSLSMTIYTHLFKGVIYIISSTIFIFLLSTKSILILHSTLGATISVILLFKFSP
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHH
LITKLQNKIQQLFQSYAGKQIKLFGLFNLFYFFNKRNVFTKYLKSQLLEKYSREFGLLKN
HHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
FQYKTFLLNSGFLFFVLSNSITLSILTYYKTFDVTLFISLFSMNLVMVTGFSSFFTYLLT
CCEEEEEEECCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHH
AQALNPYVNKIFEKIDTKNEKKIVLQELISEINLQNLNFSYSPETRVFSNLNLSFEKNKK
HHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEECCCE
YAIISPSGKGKSSLLKLISGVLTNYEGKILINNSTEYKELDPKQLRKHIALTTNENIIFE
EEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHEEEECCCCEEEE
DTLANNITLDKNPDLDLLNSLIKKYKIDNFSKPETEISSKNLSEGEKQKVALARLEYKNL
ECCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCC
DICLDEALDNIFKEDAFEIYSDLLSKPNKTIFIASHHIPEKIKPMFDQIIEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; thiamine [Periplasm]; H2O [C]

Specific reaction: ATP + thiamine [Periplasm] + H2O = ADP + phosphate + thiamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA