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The map label for this gene is manP [H]

Identifier: 54020218

GI number: 54020218

Start: 606952

End: 608934

Strand: Direct

Name: manP [H]

Synonym: mhp490

Alternate gene names: 54020218

Gene position: 606952-608934 (Clockwise)

Preceding gene: 54020217

Following gene: 54020219

Centisome position: 67.99

GC content: 36.01

Gene sequence:

>1983_bases
ATGGAAATTTTTAAAAGAAATTTTGTTTTCCTAAAACAAAATTTAAATTCAAAATCTGAAGTTTTTGAATTTATTGCCAG
CAAGGCTTACAAGCTGAAAATCGCTAAAAACAAAGAAGAAATTATTAATGATCTGGAATTCCGCGAGTCACAGATCTCAA
CCGGTCTTGAAGCAGGATTTGCAATCCCGCATGCTCAAAGTCAGGCCGTTTTGATCCCGAGTTTATTTTTTATCTCGCTT
GAAAATGGAATTGAATGGGAAAATTTTGATAAAACTAAGGCAAAATATCTTTTCTGTATTTTACTACCAAAAAGAGGTTT
TGCAACTAGACAAGTTGAACTGCTTTCAAAAATTGCCAGCATAATCCTTAATCCGGAAATTAGTAAAGTTCTAACATCGG
ATGATCCAGATTTTGTCTTTAAAAATCTGGAAAAACGTTTTCTTGAAAAATTAGTAAATAAAAATAGAGAAAATCAGGAA
AATGTTAAAAATCTAAAAAAAGTTATCGGAATTACTTCTTGCACAGTTGGGATTGCTCATACTTATCTTGCAGCCGAAAA
ATTGGAAAATGCCTTGAAAAATAGTGGCTATTTTCCCAAAATTGAAACGCGCGGCTCGGCTGGTCCAAAAAATATTTTAA
CTAAAAGTGATATAAAAACAGCAGAATTTGTTATAATTTCTTCCGATCTCGAGATTGATACAACTGCTTTTATTGGCAAA
AAAGTTTATTTTTGCACAACAAAAGATGCAATCCATAAATCAGAAAAAATTATTGAACTAGCCCAAAAAGCCCCAATTTT
AAAGGAAAATTTTCGAAAAACAGTCAATGAAGAAGTCAAAACAAGTCAAGGTAATTTCCTAAGACATATAATGGCCGGAA
TCTCTTATATGATTCCTTATATCATTTTTGGTGGAATTATGATTGCTTTATCCCTTGGAATTGGTAAGTCGATTTATGGG
AATAACTCCATAGCTCCCAAAGGTGATTTTCTCTGGTGAATGTTCCAAATTGGTCTGATCTCCTTTCGATTAATGATCGG
CGCTTTAGCTGCTTATATTGCCTATTCAATTTGTGGACGGGCCGGGCTTGCCCCTGGATTTATTGTCTCAACTGTGGCTA
ATTCAAATGATCTTTTCTATGGAATTGGTGGAATCGAGGTCAAAACGCCAATGGGATTTATTGGTGCAGTTTTATTTGGT
TTTTTAGTCGGTTATAGTGTAAAATATCTTAATAGTCTAAAAATACAAAAATCACTTGCGGGTATTATGCCGATTTTTGT
AATTCCGATCGGCGTAAGTCTTTTTTGGTCACTAATGGCAATCTTTATAATTGGTGCGCCGATCGGCTGAATTTTAGACA
AATTTATTGAAGCACTCAAGTCGATTTTTCTTAAAAAAGATAGTCTTGGCCTCGGAATCGCCTTTCTCTTAGGGCTTTTA
CTTGGATCAATGATTGGTTTTGATATGGGAGGTCCTATTAACAAAGTTGCTTATTTAAGCGCTACCGCGCTTGTTGCTAG
TCAAATTTATGAGCCTATGGGAATGGTGGCAGCCGCTATTCCCGTTGCCCCTTTTGGAATGGGTCTTGCAACTCTTATCT
GAAGGAAAAAGTTTTCCCAAAAGGAAAAATCCCTGGGAATTTCAGCATTTGTAATGGGGTTTATCGGGGTTTCAGAAGGA
GCCATTCCCTTTGCGATTGTCGATCCAAAACGGGTAATTAGTGCTAATGTAATCGGATCAGCAATTGCTGGCGGTCTTAG
TGGTATTCTTGCAGTAACTAATTCCGCCGGCCACGGCGGGCCAATTGTTGCTATTTTAGGGGCAATTGGATCAGACAAGC
ACGGACTTGGTCTGGGAATCGCCTTTTTCTTGATTGCAATAATTATTGGTTCGCTAACCACGGCACTAATTTATGGTTTT
AGTAAAAATCGTAGTATAAAAATTTTCACTTTTTGAAAAAAATTATGAAACCGAAACAAATAA

Upstream 100 bases:

>100_bases
AAATTTTTATATTTTTTTAAAAATTTTTTTAATTTCCTTACTTTTTTTAAAAATAGGTGATTATTTAGATAGATAAATAA
TCTAAAGAAAGGAAAATCTT

Downstream 100 bases:

>100_bases
TTATGAAAATTAAAAAAAATAATAATAAAACAGTTTTTTTAGTAGTACTTGTAATTGCACTTGTTTTGATTATTGCCGGA
ATTATAATGCTCATCTTTGG

Product: PTS system, fructose-specific IIABC component

Products: NA

Alternate protein names: EIIBCA-Man; EII-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component [H]

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MEIFKRNFVFLKQNLNSKSEVFEFIASKAYKLKIAKNKEEIINDLEFRESQISTGLEAGFAIPHAQSQAVLIPSLFFISL
ENGIEWENFDKTKAKYLFCILLPKRGFATRQVELLSKIASIILNPEISKVLTSDDPDFVFKNLEKRFLEKLVNKNRENQE
NVKNLKKVIGITSCTVGIAHTYLAAEKLENALKNSGYFPKIETRGSAGPKNILTKSDIKTAEFVIISSDLEIDTTAFIGK
KVYFCTTKDAIHKSEKIIELAQKAPILKENFRKTVNEEVKTSQGNFLRHIMAGISYMIPYIIFGGIMIALSLGIGKSIYG
NNSIAPKGDFLWWMFQIGLISFRLMIGALAAYIAYSICGRAGLAPGFIVSTVANSNDLFYGIGGIEVKTPMGFIGAVLFG
FLVGYSVKYLNSLKIQKSLAGIMPIFVIPIGVSLFWSLMAIFIIGAPIGWILDKFIEALKSIFLKKDSLGLGIAFLLGLL
LGSMIGFDMGGPINKVAYLSATALVASQIYEPMGMVAAAIPVAPFGMGLATLIWRKKFSQKEKSLGISAFVMGFIGVSEG
AIPFAIVDPKRVISANVIGSAIAGGLSGILAVTNSAGHGGPIVAILGAIGSDKHGLGLGIAFFLIAIIIGSLTTALIYGF
SKNRSIKIFTFWKKLWNRNK

Sequences:

>Translated_660_residues
MEIFKRNFVFLKQNLNSKSEVFEFIASKAYKLKIAKNKEEIINDLEFRESQISTGLEAGFAIPHAQSQAVLIPSLFFISL
ENGIEWENFDKTKAKYLFCILLPKRGFATRQVELLSKIASIILNPEISKVLTSDDPDFVFKNLEKRFLEKLVNKNRENQE
NVKNLKKVIGITSCTVGIAHTYLAAEKLENALKNSGYFPKIETRGSAGPKNILTKSDIKTAEFVIISSDLEIDTTAFIGK
KVYFCTTKDAIHKSEKIIELAQKAPILKENFRKTVNEEVKTSQGNFLRHIMAGISYMIPYIIFGGIMIALSLGIGKSIYG
NNSIAPKGDFLW*MFQIGLISFRLMIGALAAYIAYSICGRAGLAPGFIVSTVANSNDLFYGIGGIEVKTPMGFIGAVLFG
FLVGYSVKYLNSLKIQKSLAGIMPIFVIPIGVSLFWSLMAIFIIGAPIG*ILDKFIEALKSIFLKKDSLGLGIAFLLGLL
LGSMIGFDMGGPINKVAYLSATALVASQIYEPMGMVAAAIPVAPFGMGLATLI*RKKFSQKEKSLGISAFVMGFIGVSEG
AIPFAIVDPKRVISANVIGSAIAGGLSGILAVTNSAGHGGPIVAILGAIGSDKHGLGLGIAFFLIAIIIGSLTTALIYGF
SKNRSIKIFTF*KKL*NRNK
>Mature_660_residues
MEIFKRNFVFLKQNLNSKSEVFEFIASKAYKLKIAKNKEEIINDLEFRESQISTGLEAGFAIPHAQSQAVLIPSLFFISL
ENGIEWENFDKTKAKYLFCILLPKRGFATRQVELLSKIASIILNPEISKVLTSDDPDFVFKNLEKRFLEKLVNKNRENQE
NVKNLKKVIGITSCTVGIAHTYLAAEKLENALKNSGYFPKIETRGSAGPKNILTKSDIKTAEFVIISSDLEIDTTAFIGK
KVYFCTTKDAIHKSEKIIELAQKAPILKENFRKTVNEEVKTSQGNFLRHIMAGISYMIPYIIFGGIMIALSLGIGKSIYG
NNSIAPKGDFLW*MFQIGLISFRLMIGALAAYIAYSICGRAGLAPGFIVSTVANSNDLFYGIGGIEVKTPMGFIGAVLFG
FLVGYSVKYLNSLKIQKSLAGIMPIFVIPIGVSLFWSLMAIFIIGAPIG*ILDKFIEALKSIFLKKDSLGLGIAFLLGLL
LGSMIGFDMGGPINKVAYLSATALVASQIYEPMGMVAAAIPVAPFGMGLATLI*RKKFSQKEKSLGISAFVMGFIGVSEG
AIPFAIVDPKRVISANVIGSAIAGGLSGILAVTNSAGHGGPIVAILGAIGSDKHGLGLGIAFFLIAIIIGSLTTALIYGF
SKNRSIKIFTF*KKL*NRNK

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=485, Percent_Identity=36.9072164948454, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1786951, Length=647, Percent_Identity=26.5842349304482, Blast_Score=235, Evalue=6e-63,
Organism=Escherichia coli, GI87082348, Length=479, Percent_Identity=31.9415448851775, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1790386, Length=331, Percent_Identity=37.7643504531722, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1788729, Length=410, Percent_Identity=27.0731707317073, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790387, Length=106, Percent_Identity=39.622641509434, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788730, Length=95, Percent_Identity=41.0526315789474, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 70979; Mature: 70979

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFKRNFVFLKQNLNSKSEVFEFIASKAYKLKIAKNKEEIINDLEFRESQISTGLEAGF
CCCHHHHHHHEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHCCC
AIPHAQSQAVLIPSLFFISLENGIEWENFDKTKAKYLFCILLPKRGFATRQVELLSKIAS
CCCCCCCCEEEEHHEEEEEECCCCCCCCCCCHHHEEEEEEEECCCCCCHHHHHHHHHHHH
IILNPEISKVLTSDDPDFVFKNLEKRFLEKLVNKNRENQENVKNLKKVIGITSCTVGIAH
HHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
TYLAAEKLENALKNSGYFPKIETRGSAGPKNILTKSDIKTAEFVIISSDLEIDTTAFIGK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHCC
KVYFCTTKDAIHKSEKIIELAQKAPILKENFRKTVNEEVKTSQGNFLRHIMAGISYMIPY
EEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IIFGGIMIALSLGIGKSIYGNNSIAPKGDFLWMFQIGLISFRLMIGALAAYIAYSICGRA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLAPGFIVSTVANSNDLFYGIGGIEVKTPMGFIGAVLFGFLVGYSVKYLNSLKIQKSLAG
CCCCCHHHHHCCCCCCEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMPIFVIPIGVSLFWSLMAIFIIGAPIGILDKFIEALKSIFLKKDSLGLGIAFLLGLLLG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
SMIGFDMGGPINKVAYLSATALVASQIYEPMGMVAAAIPVAPFGMGLATLIRKKFSQKEK
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SLGISAFVMGFIGVSEGAIPFAIVDPKRVISANVIGSAIAGGLSGILAVTNSAGHGGPIV
HCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHH
AILGAIGSDKHGLGLGIAFFLIAIIIGSLTTALIYGFSKNRSIKIFTFKKLNRNK
HEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MEIFKRNFVFLKQNLNSKSEVFEFIASKAYKLKIAKNKEEIINDLEFRESQISTGLEAGF
CCCHHHHHHHEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHCCC
AIPHAQSQAVLIPSLFFISLENGIEWENFDKTKAKYLFCILLPKRGFATRQVELLSKIAS
CCCCCCCCEEEEHHEEEEEECCCCCCCCCCCHHHEEEEEEEECCCCCCHHHHHHHHHHHH
IILNPEISKVLTSDDPDFVFKNLEKRFLEKLVNKNRENQENVKNLKKVIGITSCTVGIAH
HHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
TYLAAEKLENALKNSGYFPKIETRGSAGPKNILTKSDIKTAEFVIISSDLEIDTTAFIGK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHCC
KVYFCTTKDAIHKSEKIIELAQKAPILKENFRKTVNEEVKTSQGNFLRHIMAGISYMIPY
EEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IIFGGIMIALSLGIGKSIYGNNSIAPKGDFLWMFQIGLISFRLMIGALAAYIAYSICGRA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLAPGFIVSTVANSNDLFYGIGGIEVKTPMGFIGAVLFGFLVGYSVKYLNSLKIQKSLAG
CCCCCHHHHHCCCCCCEEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMPIFVIPIGVSLFWSLMAIFIIGAPIGILDKFIEALKSIFLKKDSLGLGIAFLLGLLLG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
SMIGFDMGGPINKVAYLSATALVASQIYEPMGMVAAAIPVAPFGMGLATLIRKKFSQKEK
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SLGISAFVMGFIGVSEGAIPFAIVDPKRVISANVIGSAIAGGLSGILAVTNSAGHGGPIV
HCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHH
AILGAIGSDKHGLGLGIAFFLIAIIIGSLTTALIYGFSKNRSIKIFTFKKLNRNK
HEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]