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The map label for this gene is deoA

Identifier: 54020133

GI number: 54020133

Start: 342796

End: 344079

Strand: Direct

Name: deoA

Synonym: mhp298

Alternate gene names: 54020133

Gene position: 342796-344079 (Clockwise)

Preceding gene: 54020132

Following gene: 54020134

Centisome position: 38.4

GC content: 32.71

Gene sequence:

>1284_bases
ATGAGTTTATTCGAAATAATTGAAAAAAAATCACAAAAACATAAACTTTCGGCTGAAGAAATTAATTTTATGATCAACGG
ATTTCAAAGCGGCCTAATTACTGACTATCAATTTTCGGCTTTTTTAATGGCCATTTTAATTAACGGTCTTGATGATGATG
AACTTTTTTATTTTACCCGTGAAATTATCGCCTCAGGAAATACAATTAATCTCTCGAAAATTAACGGAATTAAAATTGAT
AAACACTCAACAGGGGGAGTTGGGGATAAAATTTCTTTAATTATTGGACCTATTTTTGCTTCCCTTGGTTATAAAGTAGC
AAAAATGTCAGGACGAGGACTTGGTTTTACAGGTGGAACAATTGATAAATTAGAGTCAATACCTGGGTTTAAAACCCAAT
TAACTGAGGCCAATTTTTTAGAACAAGTTCAAAAAATTGGCCTTGCAATTGTTGCCCAATCAAATGCACTTGTTCCGGCT
GATAAAAAAATTTATGCTCTTCGAGATGTCACCGGGACAGTTTCCTCGATTCCATTAATTGCTAGTTCAATTATGTCTAA
AAAAATTGCAACTGGGGCCGATGTTATCCTTATTGATGTGAAATGTGGTAATGGCGCTTTTATGACTGAACTGCCAAAAG
CCAAAAAATTAGCTAGTAAAATTAAAATGTTAGGGAAAAAATTTGGAAAAAAAACTATCGTTAAAATCACTAACATGGAA
GCACCGCTAGGAAAAATGATTGGAAATAAAAACGAAATTATTGAATCACTTTCGATTCTTCAAGGAAATCAGTCCCAACT
TAGTGAATTTGCAAGCGAGTTAGTTGCTCAAACCTTAACAGAACTTGAAAAAATTAAAATTGAAAAAGCCCGCAAAAAAG
TAAAAGATGTAATTGAATCTGGTCAAGCCTATGAACTTTTTTTGAAAATGGTAAGTGCTCAAGGTGGAAATCTGACATTA
ATTCAGTCCTCAAATTTTTGAATTCCCGCTTATAAAGAGCAAATTTTTGCGCCTCAAAATGGTTATATTAAATGAGAAAA
TGCCTTGATTTTCGGAAAAATTGTTGCTTTTTTAGGTGGGGGGAGAACAAAATTAAACCAAAAAATTGACTATGAGGCTG
GAATCTCCCTTGAGGTTGAAACCGGTGAATATGTCCAAGAAGATCAATTAATTTTTAGTCTATATTCATCTAGTCCAATT
GATCTTAGACAAATCCAGGATTTAATTCCAAAGACTTTTAGTATTAATCCTGAACCTGAATTTGAAAAGATGTTTTTAAA
TTAG

Upstream 100 bases:

>100_bases
ATTTCCGATAATTTAATCACAAAATCTGAACTTGATTCGGTTACAAGACAGGAAAAATTTGTGGAAATGATTGAAATTGC
TCTTGAGGCTATTTAATATT

Downstream 100 bases:

>100_bases
AAAACAAAAATACACTTGATTTTATACTGCTTTTTTAAAATTGAAAAAAATTTTCCTAAAAATTCAAGCTGCATTTTTTT
TTTTTTTTTTTACTAAAATT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSLFEIIEKKSQKHKLSAEEINFMINGFQSGLITDYQFSAFLMAILINGLDDDELFYFTREIIASGNTINLSKINGIKID
KHSTGGVGDKISLIIGPIFASLGYKVAKMSGRGLGFTGGTIDKLESIPGFKTQLTEANFLEQVQKIGLAIVAQSNALVPA
DKKIYALRDVTGTVSSIPLIASSIMSKKIATGADVILIDVKCGNGAFMTELPKAKKLASKIKMLGKKFGKKTIVKITNME
APLGKMIGNKNEIIESLSILQGNQSQLSEFASELVAQTLTELEKIKIEKARKKVKDVIESGQAYELFLKMVSAQGGNLTL
IQSSNFWIPAYKEQIFAPQNGYIKWENALIFGKIVAFLGGGRTKLNQKIDYEAGISLEVETGEYVQEDQLIFSLYSSSPI
DLRQIQDLIPKTFSINPEPEFEKMFLN

Sequences:

>Translated_427_residues
MSLFEIIEKKSQKHKLSAEEINFMINGFQSGLITDYQFSAFLMAILINGLDDDELFYFTREIIASGNTINLSKINGIKID
KHSTGGVGDKISLIIGPIFASLGYKVAKMSGRGLGFTGGTIDKLESIPGFKTQLTEANFLEQVQKIGLAIVAQSNALVPA
DKKIYALRDVTGTVSSIPLIASSIMSKKIATGADVILIDVKCGNGAFMTELPKAKKLASKIKMLGKKFGKKTIVKITNME
APLGKMIGNKNEIIESLSILQGNQSQLSEFASELVAQTLTELEKIKIEKARKKVKDVIESGQAYELFLKMVSAQGGNLTL
IQSSNF*IPAYKEQIFAPQNGYIK*ENALIFGKIVAFLGGGRTKLNQKIDYEAGISLEVETGEYVQEDQLIFSLYSSSPI
DLRQIQDLIPKTFSINPEPEFEKMFLN
>Mature_426_residues
SLFEIIEKKSQKHKLSAEEINFMINGFQSGLITDYQFSAFLMAILINGLDDDELFYFTREIIASGNTINLSKINGIKIDK
HSTGGVGDKISLIIGPIFASLGYKVAKMSGRGLGFTGGTIDKLESIPGFKTQLTEANFLEQVQKIGLAIVAQSNALVPAD
KKIYALRDVTGTVSSIPLIASSIMSKKIATGADVILIDVKCGNGAFMTELPKAKKLASKIKMLGKKFGKKTIVKITNMEA
PLGKMIGNKNEIIESLSILQGNQSQLSEFASELVAQTLTELEKIKIEKARKKVKDVIESGQAYELFLKMVSAQGGNLTLI
QSSNF*IPAYKEQIFAPQNGYIK*ENALIFGKIVAFLGGGRTKLNQKIDYEAGISLEVETGEYVQEDQLIFSLYSSSPID
LRQIQDLIPKTFSINPEPEFEKMFLN

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=410, Percent_Identity=32.6829268292683, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4503445, Length=410, Percent_Identity=32.6829268292683, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI166158922, Length=410, Percent_Identity=32.6829268292683, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1790842, Length=389, Percent_Identity=37.5321336760925, Blast_Score=254, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46557; Mature: 46426

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFEIIEKKSQKHKLSAEEINFMINGFQSGLITDYQFSAFLMAILINGLDDDELFYFTR
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
EIIASGNTINLSKINGIKIDKHSTGGVGDKISLIIGPIFASLGYKVAKMSGRGLGFTGGT
HHHHCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
IDKLESIPGFKTQLTEANFLEQVQKIGLAIVAQSNALVPADKKIYALRDVTGTVSSIPLI
HHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHH
ASSIMSKKIATGADVILIDVKCGNGAFMTELPKAKKLASKIKMLGKKFGKKTIVKITNME
HHHHHHHHHCCCCCEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
APLGKMIGNKNEIIESLSILQGNQSQLSEFASELVAQTLTELEKIKIEKARKKVKDVIES
CCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GQAYELFLKMVSAQGGNLTLIQSSNFIPAYKEQIFAPQNGYIKENALIFGKIVAFLGGGR
CCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCEECCHHHHHHHHHHHCCCC
TKLNQKIDYEAGISLEVETGEYVQEDQLIFSLYSSSPIDLRQIQDLIPKTFSINPEPEFE
HHHCCCCCCCCCCEEEECCCCHHHHHHHHEEECCCCCCCHHHHHHHCCCCEECCCCCCHH
KMFLN
HHCCC
>Mature Secondary Structure 
SLFEIIEKKSQKHKLSAEEINFMINGFQSGLITDYQFSAFLMAILINGLDDDELFYFTR
CHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
EIIASGNTINLSKINGIKIDKHSTGGVGDKISLIIGPIFASLGYKVAKMSGRGLGFTGGT
HHHHCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
IDKLESIPGFKTQLTEANFLEQVQKIGLAIVAQSNALVPADKKIYALRDVTGTVSSIPLI
HHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHH
ASSIMSKKIATGADVILIDVKCGNGAFMTELPKAKKLASKIKMLGKKFGKKTIVKITNME
HHHHHHHHHCCCCCEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCC
APLGKMIGNKNEIIESLSILQGNQSQLSEFASELVAQTLTELEKIKIEKARKKVKDVIES
CCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GQAYELFLKMVSAQGGNLTLIQSSNFIPAYKEQIFAPQNGYIKENALIFGKIVAFLGGGR
CCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCEECCHHHHHHHHHHHCCCC
TKLNQKIDYEAGISLEVETGEYVQEDQLIFSLYSSSPIDLRQIQDLIPKTFSINPEPEFE
HHHCCCCCCCCCCEEEECCCCHHHHHHHHEEECCCCCCCHHHHHHHCCCCEECCCCCCHH
KMFLN
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]