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The map label for this gene is ABC

Identifier: 54020097

GI number: 54020097

Start: 250051

End: 252090

Strand: Direct

Name: ABC

Synonym: mhp222

Alternate gene names: 54020097

Gene position: 250051-252090 (Clockwise)

Preceding gene: 54020096

Following gene: 54020098

Centisome position: 28.01

GC content: 24.71

Gene sequence:

>2040_bases
ATGAAATTATTTTTGCAAAAAGACTTAAGGGATTGCGGACTTGCGGTTCTCCAATCAATTTATTATCATTTTTATGATAA
AAAAATCTCAATAAATGACCTAAAAACAAAGGCATTTTATTCACATGATGGCATAAATATTGCAAATCTTGAACGCGTTG
CCAAGGATTTTGGCATTATTCTTGAATCATATGGCGGATCATTTGAAAATCTACAAGAACTAGAACTCGGAAAACCAACA
ATTATTTTAATTAAAACAGGCGATCTAAATCATTATGTTTTACTAACAAAAATTACAAAAAGGAAATTTGAAATTATCGA
CCCTTTAAAAGGAAAAATAAAAATTACTAAAACTGAAATGCAGAAAATCTTCCAAAACGTCGTGATTTTTGCCCAAAAAG
ATTTTGATTATAAAAAATCAAAAAAAAAAGATAAAAGCTGAAATAATTGGTGGTTTTTCCTTGAGGCAAAAAGTAATTGG
TATTTACTTTTTTTATTTTTTATTACTGCGGTTAGTAATTTTGTCTCCTCATTATTTATGAAAACTGTTATTGATAAAGT
TTTCCCGCAGACTGAATTTTCGCTTTTGGTCAAAGTTTGTATTTTTTTTATCTGGATTGCTTTTTGGCGGATTTTACAGG
ATATTTTTAAAAAAACTTATATTCATAAAATTGAACTTAAAATTGAAAAGGAAATTTTTGATCGATTTTTTAGCGCCTTA
AAAACAGGGGAAAATTTTCAACTTTTAAAATTAGATAATCATGATTATATTCGGCGAATAAATTTAATTCCTAGTTTTGC
TAGTTTTTCTGCTAGCTTTTATTATCATATTTTTAATGAATTAATCACTTTTTTAATTTCATTTTTTATTCTTATTTGAA
TTGATGTAAAAATTTTTGGGCTAATTATTGCTATCAGTATAGTTTATCTTTTAGTTAGTATATTTGTTAGAAAAAATATC
ACAAAAAACCATCGATTTTTAATGGAAGATCAATTAAATAGTCTTACAAGCACTAATGATTTAATTTTTTCAATTGAAAA
TTTAAAGCGGGATGATGTTTATAAAAATTTAAAGCGTCAATTTGATGAAAAATACTACCGTTATAAAAATACTGAATTTA
ACATTTGAAAAAAAGAAAATTATTTGTCAAGTTTTAATAATTTTATTTTTTCAATTTCGCCAATCCTAATTGTTTTAGTG
TCTTCATTTTGAATTTTTGATAAAAAATTATCGATTGGAGAACTTTTGCTTTTTTTAAGTTTTTTTAGTTTTTTTATCAA
TCCACTTTCATCTTTTGTCGATATAGTTACAAATTTACCGATATTTTTAAGAGAATTAGAACTATTAAATTTTGTTTTAA
ATATTGACAAGGAAGCAAAAGGTAAATATCACCAAAAAATTTCTGATATTAAATTAAAAGATTTAAGCGTTAGTTACTAT
AAAAACAAGACACTTTTTTATATTGATAAAATGCGGATTAACGGGAATTTACGAATAATTGGGAAAAATGGAAGTGGGAA
ATCCACTTTTTTAAGACTTTTAAATCAAGATATTGTCTATAATGGCGAGTTTTTAATTAATAATCTTGATCTAAAGTATT
ATGACCAAAACGAACTTCGCAAAAGAATTTGTTATATAAAGTCCCATAATTATTTTCCAAGTATTTCGGTTCTTTCTTTT
ATTACAAACGAAAATCCTGAAAAAATTCAGAATTTAATAAATAATTTTCAGCGTTTTGATATTCAGGAAATGCTTTATGA
ATGACAAATTTCACTTGATGCAAAATTTGTTAATAATGGCTCAAATTTTTCAAGTGGGCAAAAGCAAATAATCGCACTTT
TGCAGTTATTAACACAAGATTTTGACTTAATTTTACTTGATGAGGCTTTTGAAAATATTGATGAAAAAAATTTTGAATTT
TTAAAAAAAGTTATTACAAATTATCAAAAAAATGCTTTTTTTATCGAAATTTCCCACTCAAAAAGATTTATAAACGAGGA
AGGAGAAATACTTGACATCAAAAATATATCAAAACAGTAA

Upstream 100 bases:

>100_bases
CTTTTAAATTTATAGTTTTTCATAATTTTGCTTTTATTTTTCCTATTTTTTTCACTTTTTTCTATAATTTTACTATTTTT
ATCATAATTTCCAACAGAGA

Downstream 100 bases:

>100_bases
AATTTCATTATTAATTAGCATAATTTTGTTAATTTTAATGTCCATTAGTCTTTATTATTTTTTCCAAATAAAAACATATA
AAACAATTAATTTTATACTT

Product: ATP-dependent transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGIILESYGGSFENLQELELGKPT
IILIKTGDLNHYVLLTKITKRKFEIIDPLKGKIKITKTEMQKIFQNVVIFAQKDFDYKKSKKKDKSWNNWWFFLEAKSNW
YLLFLFFITAVSNFVSSLFMKTVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSAL
KTGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILIWIDVKIFGLIIAISIVYLLVSIFVRKNI
TKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFDEKYYRYKNTEFNIWKKENYLSSFNNFIFSISPILIVLV
SSFWIFDKKLSIGELLLFLSFFSFFINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYY
KNKTLFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRICYIKSHNYFPSISVLSF
ITNENPEKIQNLINNFQRFDIQEMLYEWQISLDAKFVNNGSNFSSGQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEF
LKKVITNYQKNAFFIEISHSKRFINEEGEILDIKNISKQ

Sequences:

>Translated_679_residues
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGIILESYGGSFENLQELELGKPT
IILIKTGDLNHYVLLTKITKRKFEIIDPLKGKIKITKTEMQKIFQNVVIFAQKDFDYKKSKKKDKS*NNWWFFLEAKSNW
YLLFLFFITAVSNFVSSLFMKTVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSAL
KTGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILI*IDVKIFGLIIAISIVYLLVSIFVRKNI
TKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFDEKYYRYKNTEFNI*KKENYLSSFNNFIFSISPILIVLV
SSF*IFDKKLSIGELLLFLSFFSFFINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYY
KNKTLFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRICYIKSHNYFPSISVLSF
ITNENPEKIQNLINNFQRFDIQEMLYE*QISLDAKFVNNGSNFSSGQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEF
LKKVITNYQKNAFFIEISHSKRFINEEGEILDIKNISKQ
>Mature_679_residues
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGIILESYGGSFENLQELELGKPT
IILIKTGDLNHYVLLTKITKRKFEIIDPLKGKIKITKTEMQKIFQNVVIFAQKDFDYKKSKKKDKS*NNWWFFLEAKSNW
YLLFLFFITAVSNFVSSLFMKTVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSAL
KTGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILI*IDVKIFGLIIAISIVYLLVSIFVRKNI
TKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFDEKYYRYKNTEFNI*KKENYLSSFNNFIFSISPILIVLV
SSF*IFDKKLSIGELLLFLSFFSFFINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYY
KNKTLFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRICYIKSHNYFPSISVLSF
ITNENPEKIQNLINNFQRFDIQEMLYE*QISLDAKFVNNGSNFSSGQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEF
LKKVITNYQKNAFFIEISHSKRFINEEGEILDIKNISKQ

Specific function: LagD (TC 3.A.1) is involved in processing the signal peptide and probably also in export of the bacteriocin lactococcin G [H]

COG id: COG2274

COG function: function code V; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 peptidase C39 domain [H]

Homologues:

Organism=Homo sapiens, GI157502201, Length=275, Percent_Identity=21.4545454545455, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1787143, Length=560, Percent_Identity=21.4285714285714, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593
- InterPro:   IPR005897
- InterPro:   IPR005074 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran; PF03412 Peptidase_C39 [H]

EC number: NA

Molecular weight: Translated: 79717; Mature: 79717

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50990 PEPTIDASE_C39 ; PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGII
CCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHEECCCCCCHHHHHHHHHHHHHH
LESYGGSFENLQELELGKPTIILIKTGDLNHYVLLTKITKRKFEIIDPLKGKIKITKTEM
HHHCCCCCCCHHHHCCCCCEEEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCEEEEHHHH
QKIFQNVVIFAQKDFDYKKSKKKDKSNNWWFFLEAKSNWYLLFLFFITAVSNFVSSLFMK
HHHHHHHEEEEECCCCHHHHCCCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHH
TVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSALK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHH
TGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILIIDVKIFGLI
CCCCEEEEEECCCHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAISIVYLLVSIFVRKNITKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFD
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHH
EKYYRYKNTEFNIKKENYLSSFNNFIFSISPILIVLVSSFIFDKKLSIGELLLFLSFFSF
HHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYYKNKT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHCCEEEECEEEEECCCE
LFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRIC
EEEEEEEEECCEEEEEECCCCCHHHHHHHHHHCCEECCEEEEEECCEEEECHHHHHHHHH
YIKSHNYFPSISVLSFITNENPEKIQNLINNFQRFDIQEMLYEQISLDAKFVNNGSNFSS
HEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEECCCCCCCC
GQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEFLKKVITNYQKNAFFIEISHSKRFIN
HHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHCC
EEGEILDIKNISKQ
CCCCEEECCCCCCC
>Mature Secondary Structure
MKLFLQKDLRDCGLAVLQSIYYHFYDKKISINDLKTKAFYSHDGINIANLERVAKDFGII
CCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHEECCCCCCHHHHHHHHHHHHHH
LESYGGSFENLQELELGKPTIILIKTGDLNHYVLLTKITKRKFEIIDPLKGKIKITKTEM
HHHCCCCCCCHHHHCCCCCEEEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCEEEEHHHH
QKIFQNVVIFAQKDFDYKKSKKKDKSNNWWFFLEAKSNWYLLFLFFITAVSNFVSSLFMK
HHHHHHHEEEEECCCCHHHHCCCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHH
TVIDKVFPQTEFSLLVKVCIFFIWIAFWRILQDIFKKTYIHKIELKIEKEIFDRFFSALK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHH
TGENFQLLKLDNHDYIRRINLIPSFASFSASFYYHIFNELITFLISFFILIIDVKIFGLI
CCCCEEEEEECCCHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAISIVYLLVSIFVRKNITKNHRFLMEDQLNSLTSTNDLIFSIENLKRDDVYKNLKRQFD
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEHHHCCHHHHHHHHHHHHH
EKYYRYKNTEFNIKKENYLSSFNNFIFSISPILIVLVSSFIFDKKLSIGELLLFLSFFSF
HHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FINPLSSFVDIVTNLPIFLRELELLNFVLNIDKEAKGKYHQKISDIKLKDLSVSYYKNKT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHCCEEEECEEEEECCCE
LFYIDKMRINGNLRIIGKNGSGKSTFLRLLNQDIVYNGEFLINNLDLKYYDQNELRKRIC
EEEEEEEEECCEEEEEECCCCCHHHHHHHHHHCCEECCEEEEEECCEEEECHHHHHHHHH
YIKSHNYFPSISVLSFITNENPEKIQNLINNFQRFDIQEMLYEQISLDAKFVNNGSNFSS
HEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHEECCCCCCCC
GQKQIIALLQLLTQDFDLILLDEAFENIDEKNFEFLKKVITNYQKNAFFIEISHSKRFIN
HHHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHCC
EEGEILDIKNISKQ
CCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7565085 [H]