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The map label for this gene is lytC [H]

Identifier: 52787488

GI number: 52787488

Start: 3626571

End: 3628058

Strand: Reverse

Name: lytC [H]

Synonym: BLi03808

Alternate gene names: 52787488

Gene position: 3628058-3626571 (Counterclockwise)

Preceding gene: 52787489

Following gene: 52787487

Centisome position: 85.92

GC content: 47.45

Gene sequence:

>1488_bases
TTGAGGGTTTTTCTTAAAGCTGTACCTATGTTGTTGTTAGGGTTCTTTTTGTTTGTGCCTAATGTATTTGCGGCCAACTC
TGTCACAAGATTAGACGGTGCAAACCGATATGAGGTTGCGGTGAACGTTTCCAAGCAGGGGTGGACAAGTGCAAGCACTG
TGATTGTTGCAAATGGAAAGGCATATGCAGACGTCCTTTCAGCGACTCCATTTGCCTATCGAAACAACGCGCCTGTTCTA
TTAACGGAAGCGTCTAAACTGCCAACGGCCACTAAAAACCGAATCAGTCAATTAAAACCTAGCAAAGTGATCGTAATCGG
CGGAACCGTCAGCGTTCAAAACGGTGTCGTAAGCGAGATCAAAAAGCTTGGTGTGTCATCTGTCGAACGCATCGGCGGAG
CGAATCGCTACGAGGTTGCGGCGAATATTGCGAATAAGCTGCCGAGCAATTCGAAAGCTGTCATCGCAAACGGGACGGCC
TATGCTGACAGCCTTGCGATCGGCGCATATGCCGCGAGAAACGGCATCCCGATTCTTTTAACATCGTCGAATTCCATACC
GACAGCGACAAAAAATGCGATGAAGAGCAAAGGAACAACATCGACCATTGTCGTAGGCGGTGAAGTCAGCATCTCCAGCA
GCGTTTACAAACAGCTTGCTTCTCCGACGCGGATCGGCGGCAGCAACCGCTATGAAGTCGCGGCCAATGTCGTCAAGAAA
TATTATTCTTCTGCCAAGAATGCAATCATCAGCAACGGCTATGCGTATGCCGACGGATTAACAGGATCTGTTCTGGCGGC
TAAGCAAAACCGTCCGATGATGTTCACGAATGCATCATCTTTGCCGACACCGACAAGAGAAGTGATCGGTTCCAAAAACA
TGACGACGTTTACTGTGCTTGGCGGAACGGTTTCTCTTCAATCCAATGTCGTGTCACAGCTGAAGAATCCGATCGTCGGC
AAAAAAATCTTCATTGATGCAGGGCACGGAGGTACAGACAGCGGTGCCGTCGGCAACGGTTTATATGAGAAAAGCGTGAA
CCTTGATGTTGCAAAATTAATTAATACGAAACTATCAAACGGCGGTGCTCTGCCAATTATGGCGAGAACGAACGACACTT
ACCTGACGCTCGCACAGCGCGTGTCAAAAGCGCAGTCAAATCATGCGGATTTGTTTGTCAGCATCCATGCAAACTCGGCA
ACGCCAGCTGCTTCCGGAACAGAAACCTACTATTATACAACATATGAATCTGCCAACAGCAAACGGCTGGCAACCGAGAT
TCAAAACCGTCTCTATGTTGCATTGAATACAAAAAACCGCGGTGTAAAGATCGGCAACTTCCATGTCATCAGGGAATCAA
AAATGCCAAGCTGCCTTGTTGAACTTGCGTTTATCAGCAATGTAAGCGATGCGACAAAACTCAAAAGCTCGACTTACAAA
GAAAAAGGCGCTAAAGCGATTTACGACGGAATCGTTGCTTACTATTAA

Upstream 100 bases:

>100_bases
TCTATCAAGCTATTAATAGAGTTTGAACAGGAGGCAGCAGTGCCTCCTCTGTTCATGTTCAGGGGAAAACATAACATTTA
CATTTTTGGAGGTTATTTTT

Downstream 100 bases:

>100_bases
AATATAAACAGAAAACTCGTTTTTCGAAAAATTGCCTATGCTGCCTTTGTTTTGTCTTTATTATATAGTATGATATTTTT
GGTGAAATTAAAGATAAAAC

Product: LytC

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MRVFLKAVPMLLLGFFLFVPNVFAANSVTRLDGANRYEVAVNVSKQGWTSASTVIVANGKAYADVLSATPFAYRNNAPVL
LTEASKLPTATKNRISQLKPSKVIVIGGTVSVQNGVVSEIKKLGVSSVERIGGANRYEVAANIANKLPSNSKAVIANGTA
YADSLAIGAYAARNGIPILLTSSNSIPTATKNAMKSKGTTSTIVVGGEVSISSSVYKQLASPTRIGGSNRYEVAANVVKK
YYSSAKNAIISNGYAYADGLTGSVLAAKQNRPMMFTNASSLPTPTREVIGSKNMTTFTVLGGTVSLQSNVVSQLKNPIVG
KKIFIDAGHGGTDSGAVGNGLYEKSVNLDVAKLINTKLSNGGALPIMARTNDTYLTLAQRVSKAQSNHADLFVSIHANSA
TPAASGTETYYYTTYESANSKRLATEIQNRLYVALNTKNRGVKIGNFHVIRESKMPSCLVELAFISNVSDATKLKSSTYK
EKGAKAIYDGIVAYY

Sequences:

>Translated_495_residues
MRVFLKAVPMLLLGFFLFVPNVFAANSVTRLDGANRYEVAVNVSKQGWTSASTVIVANGKAYADVLSATPFAYRNNAPVL
LTEASKLPTATKNRISQLKPSKVIVIGGTVSVQNGVVSEIKKLGVSSVERIGGANRYEVAANIANKLPSNSKAVIANGTA
YADSLAIGAYAARNGIPILLTSSNSIPTATKNAMKSKGTTSTIVVGGEVSISSSVYKQLASPTRIGGSNRYEVAANVVKK
YYSSAKNAIISNGYAYADGLTGSVLAAKQNRPMMFTNASSLPTPTREVIGSKNMTTFTVLGGTVSLQSNVVSQLKNPIVG
KKIFIDAGHGGTDSGAVGNGLYEKSVNLDVAKLINTKLSNGGALPIMARTNDTYLTLAQRVSKAQSNHADLFVSIHANSA
TPAASGTETYYYTTYESANSKRLATEIQNRLYVALNTKNRGVKIGNFHVIRESKMPSCLVELAFISNVSDATKLKSSTYK
EKGAKAIYDGIVAYY
>Mature_495_residues
MRVFLKAVPMLLLGFFLFVPNVFAANSVTRLDGANRYEVAVNVSKQGWTSASTVIVANGKAYADVLSATPFAYRNNAPVL
LTEASKLPTATKNRISQLKPSKVIVIGGTVSVQNGVVSEIKKLGVSSVERIGGANRYEVAANIANKLPSNSKAVIANGTA
YADSLAIGAYAARNGIPILLTSSNSIPTATKNAMKSKGTTSTIVVGGEVSISSSVYKQLASPTRIGGSNRYEVAANVVKK
YYSSAKNAIISNGYAYADGLTGSVLAAKQNRPMMFTNASSLPTPTREVIGSKNMTTFTVLGGTVSLQSNVVSQLKNPIVG
KKIFIDAGHGGTDSGAVGNGLYEKSVNLDVAKLINTKLSNGGALPIMARTNDTYLTLAQRVSKAQSNHADLFVSIHANSA
TPAASGTETYYYTTYESANSKRLATEIQNRLYVALNTKNRGVKIGNFHVIRESKMPSCLVELAFISNVSDATKLKSSTYK
EKGAKAIYDGIVAYY

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI87082163, Length=225, Percent_Identity=32, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788776, Length=222, Percent_Identity=29.2792792792793, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 52337; Mature: 52337

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFLKAVPMLLLGFFLFVPNVFAANSVTRLDGANRYEVAVNVSKQGWTSASTVIVANGK
CCHHHHHHHHHHHHHHHHHCCHHHCCCEEECCCCCEEEEEEEECCCCCCCCCEEEEECCC
AYADVLSATPFAYRNNAPVLLTEASKLPTATKNRISQLKPSKVIVIGGTVSVQNGVVSEI
HHHHHHHCCCCEECCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEECCEEEECCCHHHHH
KKLGVSSVERIGGANRYEVAANIANKLPSNSKAVIANGTAYADSLAIGAYAARNGIPILL
HHCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEE
TSSNSIPTATKNAMKSKGTTSTIVVGGEVSISSSVYKQLASPTRIGGSNRYEVAANVVKK
ECCCCCCCHHHHHHHCCCCCEEEEECCCEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
YYSSAKNAIISNGYAYADGLTGSVLAAKQNRPMMFTNASSLPTPTREVIGSKNMTTFTVL
HHHHHCCCEEECCEEEECCCCCCEEEECCCCCEEEECCCCCCCCHHHHHCCCCCEEEEEE
GGTVSLQSNVVSQLKNPIVGKKIFIDAGHGGTDSGAVGNGLYEKSVNLDVAKLINTKLSN
CCEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
GGALPIMARTNDTYLTLAQRVSKAQSNHADLFVSIHANSATPAASGTETYYYTTYESANS
CCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCC
KRLATEIQNRLYVALNTKNRGVKIGNFHVIRESKMPSCLVELAFISNVSDATKLKSSTYK
HHHHHHHCCCEEEEEECCCCCEEECEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHH
EKGAKAIYDGIVAYY
HHCCHHHHHHHHHCC
>Mature Secondary Structure
MRVFLKAVPMLLLGFFLFVPNVFAANSVTRLDGANRYEVAVNVSKQGWTSASTVIVANGK
CCHHHHHHHHHHHHHHHHHCCHHHCCCEEECCCCCEEEEEEEECCCCCCCCCEEEEECCC
AYADVLSATPFAYRNNAPVLLTEASKLPTATKNRISQLKPSKVIVIGGTVSVQNGVVSEI
HHHHHHHCCCCEECCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEECCEEEECCCHHHHH
KKLGVSSVERIGGANRYEVAANIANKLPSNSKAVIANGTAYADSLAIGAYAARNGIPILL
HHCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEE
TSSNSIPTATKNAMKSKGTTSTIVVGGEVSISSSVYKQLASPTRIGGSNRYEVAANVVKK
ECCCCCCCHHHHHHHCCCCCEEEEECCCEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
YYSSAKNAIISNGYAYADGLTGSVLAAKQNRPMMFTNASSLPTPTREVIGSKNMTTFTVL
HHHHHCCCEEECCEEEECCCCCCEEEECCCCCEEEECCCCCCCCHHHHHCCCCCEEEEEE
GGTVSLQSNVVSQLKNPIVGKKIFIDAGHGGTDSGAVGNGLYEKSVNLDVAKLINTKLSN
CCEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
GGALPIMARTNDTYLTLAQRVSKAQSNHADLFVSIHANSATPAASGTETYYYTTYESANS
CCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCC
KRLATEIQNRLYVALNTKNRGVKIGNFHVIRESKMPSCLVELAFISNVSDATKLKSSTYK
HHHHHHHCCCEEEEEECCCCCEEECEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHH
EKGAKAIYDGIVAYY
HHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]