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The map label for this gene is tuaD [H]

Identifier: 52787484

GI number: 52787484

Start: 3621487

End: 3622821

Strand: Reverse

Name: tuaD [H]

Synonym: BLi03804

Alternate gene names: 52787484

Gene position: 3622821-3621487 (Counterclockwise)

Preceding gene: 52787485

Following gene: 52787483

Centisome position: 85.8

GC content: 44.72

Gene sequence:

>1335_bases
ATGTTGAAAAGAATCGCTGTCATTGGAACGGGATATGTCGGGCTGGTGTCTGGAACTTGTTTTGCCGAAGTGGGAAACTC
GGTTGTCTGCTGCGATATTGATGCTGAAAAAATAAGAGGACTCTCAGCCGGAGTGATGCCGATTTATGAAAACGGCCTAA
AAGAACTTGTGGATAAAAACGTAAACGAAAATCGCTTATTTTTCTCTACTGATATTCCAAAAGCGATTGAAGAAGCTGAG
ATTATTTATATTGCAGTCGGTACACCGATGTCGGAAACAGGGGAAGCGGATCTGACATTTGTTAAATCCGTTGCCGAAAT
GATCGGGAAGCACCTGAACGGCTATAAAGTCATCGTCAACAAAAGCACTGTCCCTGTTGGAACAGGAAAGCTCGTACAAG
CCATTATAGAACGCAATTCAAAAGGGGAATTCCCTTTCGACGTCGTGTCGAATCCGGAATTCCTTCGTGAAGGAACAGCT
ATTTACGATACGATGAATATGGAAAGAGCAGTCATCGGCGCGACAAGCGAAAAGGCTGCTGCCATTATTGAAGAGCTTCA
TAAGCCATTTCAAACGAAAATCGTCAAGTCTAACCTTGAAAGTGCAGAAATGATTAAATACGCTGCAAATGCATTTTTGG
CTACAAAGATCTCGTTCATTAATGATATCGCGAATATTTGCGAAAGGGTCGGAGCTGATGTATCCAAGGTGTCTGAAGGC
GTCGGACTCGACAGCAGAATCGGCAGTAAATTTTTAAAAGCCGGAATCGGCTTTGGCGGCTCTTGCTTCCCTAAAGACAC
GATGGCTTTATTGCAAATCGCGAAGTCAGTCGGTTATCCTTTTAAATTGATTGAAGCTGTCATCGAGACGAATCAAAAGC
AGCGCGCCCACATTGTGCAAAAGCTCCTTGATGTGTTCGGCGATTTAAACGGCATGACCATTTCGGTTCTTGGGCTGGCA
TTCAAGCCGAATACTAACGATATGCGCTCGGCGCCGTCTCTGGATGTCATTCCGATGCTGAGAAGCCTCGGTGCTAAAGT
CAAAGCGTTTGATCCGATTGCTGTACCTGAAGCAGAAAAGCTTCTCGGCGATCAAGCCGTTTACAGCGAAGATCTGTATG
AGACGATTCAGGATACGGATGCGTGCGTCATATTGACGGAGTGGCCGGAAGTACAGAACATGGATATTGCCAAACTTAAG
TCTGCTTTGAAAAACCCCGTCTTAATCGATGGAAGAAATATATTTGAAATTGAACAAATGAGAAACGAAGGCATGATCTA
CCATTCAATCGGACGGCCGGAAGTACAGGGAGAAGGAATCCTGACCAACGTATAA

Upstream 100 bases:

>100_bases
GAAAACGAAAAACCCAGATTTTTTCAATAGAAAGAGATAAAGATCATTACCTAAATCAAGCTATTGGATTTGAAGGGTCA
GCTGAAAGAAGGGAATGATA

Downstream 100 bases:

>100_bases
ACAACGGGGGGATAACAATGGAAAAAGTACTAGTGACAGGCGGATGCGGATTTATCGGCTCGCATATTGCTGAACAGCTT
CTAAAAGAAAATTACCGGGT

Product: TuaD

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MLKRIAVIGTGYVGLVSGTCFAEVGNSVVCCDIDAEKIRGLSAGVMPIYENGLKELVDKNVNENRLFFSTDIPKAIEEAE
IIYIAVGTPMSETGEADLTFVKSVAEMIGKHLNGYKVIVNKSTVPVGTGKLVQAIIERNSKGEFPFDVVSNPEFLREGTA
IYDTMNMERAVIGATSEKAAAIIEELHKPFQTKIVKSNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVSEG
VGLDSRIGSKFLKAGIGFGGSCFPKDTMALLQIAKSVGYPFKLIEAVIETNQKQRAHIVQKLLDVFGDLNGMTISVLGLA
FKPNTNDMRSAPSLDVIPMLRSLGAKVKAFDPIAVPEAEKLLGDQAVYSEDLYETIQDTDACVILTEWPEVQNMDIAKLK
SALKNPVLIDGRNIFEIEQMRNEGMIYHSIGRPEVQGEGILTNV

Sequences:

>Translated_444_residues
MLKRIAVIGTGYVGLVSGTCFAEVGNSVVCCDIDAEKIRGLSAGVMPIYENGLKELVDKNVNENRLFFSTDIPKAIEEAE
IIYIAVGTPMSETGEADLTFVKSVAEMIGKHLNGYKVIVNKSTVPVGTGKLVQAIIERNSKGEFPFDVVSNPEFLREGTA
IYDTMNMERAVIGATSEKAAAIIEELHKPFQTKIVKSNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVSEG
VGLDSRIGSKFLKAGIGFGGSCFPKDTMALLQIAKSVGYPFKLIEAVIETNQKQRAHIVQKLLDVFGDLNGMTISVLGLA
FKPNTNDMRSAPSLDVIPMLRSLGAKVKAFDPIAVPEAEKLLGDQAVYSEDLYETIQDTDACVILTEWPEVQNMDIAKLK
SALKNPVLIDGRNIFEIEQMRNEGMIYHSIGRPEVQGEGILTNV
>Mature_444_residues
MLKRIAVIGTGYVGLVSGTCFAEVGNSVVCCDIDAEKIRGLSAGVMPIYENGLKELVDKNVNENRLFFSTDIPKAIEEAE
IIYIAVGTPMSETGEADLTFVKSVAEMIGKHLNGYKVIVNKSTVPVGTGKLVQAIIERNSKGEFPFDVVSNPEFLREGTA
IYDTMNMERAVIGATSEKAAAIIEELHKPFQTKIVKSNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVSEG
VGLDSRIGSKFLKAGIGFGGSCFPKDTMALLQIAKSVGYPFKLIEAVIETNQKQRAHIVQKLLDVFGDLNGMTISVLGLA
FKPNTNDMRSAPSLDVIPMLRSLGAKVKAFDPIAVPEAEKLLGDQAVYSEDLYETIQDTDACVILTEWPEVQNMDIAKLK
SALKNPVLIDGRNIFEIEQMRNEGMIYHSIGRPEVQGEGILTNV

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=464, Percent_Identity=36.2068965517241, Blast_Score=271, Evalue=7e-73,
Organism=Homo sapiens, GI296040438, Length=351, Percent_Identity=36.7521367521368, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI296040443, Length=459, Percent_Identity=32.244008714597, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1788340, Length=355, Percent_Identity=28.7323943661972, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI48994968, Length=354, Percent_Identity=28.8135593220339, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560350, Length=464, Percent_Identity=35.5603448275862, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI17136908, Length=471, Percent_Identity=38.4288747346072, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48251; Mature: 48251

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRIAVIGTGYVGLVSGTCFAEVGNSVVCCDIDAEKIRGLSAGVMPIYENGLKELVDKN
CCCEEEEEECCHHHHHCCHHHHHHCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHCC
VNENRLFFSTDIPKAIEEAEIIYIAVGTPMSETGEADLTFVKSVAEMIGKHLNGYKVIVN
CCCCEEEEECCCCHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
KSTVPVGTGKLVQAIIERNSKGEFPFDVVSNPEFLREGTAIYDTMNMERAVIGATSEKAA
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHEECCCCCHHEECCCCHHHH
AIIEELHKPFQTKIVKSNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVSEG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
VGLDSRIGSKFLKAGIGFGGSCFPKDTMALLQIAKSVGYPFKLIEAVIETNQKQRAHIVQ
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHH
KLLDVFGDLNGMTISVLGLAFKPNTNDMRSAPSLDVIPMLRSLGAKVKAFDPIAVPEAEK
HHHHHHCCCCCCEEEEEEEEECCCCCHHHCCCCCHHHHHHHHCCCCEEECCCCCCCCHHH
LLGDQAVYSEDLYETIQDTDACVILTEWPEVQNMDIAKLKSALKNPVLIDGRNIFEIEQM
HHCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHCCCEEECCCCHHHHHHH
RNEGMIYHSIGRPEVQGEGILTNV
HCCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MLKRIAVIGTGYVGLVSGTCFAEVGNSVVCCDIDAEKIRGLSAGVMPIYENGLKELVDKN
CCCEEEEEECCHHHHHCCHHHHHHCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHCC
VNENRLFFSTDIPKAIEEAEIIYIAVGTPMSETGEADLTFVKSVAEMIGKHLNGYKVIVN
CCCCEEEEECCCCHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
KSTVPVGTGKLVQAIIERNSKGEFPFDVVSNPEFLREGTAIYDTMNMERAVIGATSEKAA
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCHHEECCCCCHHEECCCCHHHH
AIIEELHKPFQTKIVKSNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVSEG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
VGLDSRIGSKFLKAGIGFGGSCFPKDTMALLQIAKSVGYPFKLIEAVIETNQKQRAHIVQ
CCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHH
KLLDVFGDLNGMTISVLGLAFKPNTNDMRSAPSLDVIPMLRSLGAKVKAFDPIAVPEAEK
HHHHHHCCCCCCEEEEEEEEECCCCCHHHCCCCCHHHHHHHHCCCCEEECCCCCCCCHHH
LLGDQAVYSEDLYETIQDTDACVILTEWPEVQNMDIAKLKSALKNPVLIDGRNIFEIEQM
HHCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHCCCEEECCCCHHHHHHH
RNEGMIYHSIGRPEVQGEGILTNV
HCCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]