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The map label for this gene is hprK

Identifier: 52787428

GI number: 52787428

Start: 3567326

End: 3568258

Strand: Reverse

Name: hprK

Synonym: BLi03746

Alternate gene names: 52787428

Gene position: 3568258-3567326 (Counterclockwise)

Preceding gene: 52787431

Following gene: 52787427

Centisome position: 84.5

GC content: 49.2

Gene sequence:

>933_bases
GTGCCGAAAGTTCGAACAAAAGATGTGATGGATAAATTTAAGCTTGAGCTCATCAGCGGAGAAGAAGGGATCAACCGCCC
GATTACGATGAGCGATTTATCAAGACCGGGCCTTGAAATGGCTGGTTATTTTACATACTATCCAAAAGAGAGGGTTCAGC
TGCTGGGGAAGACTGAGATTACCTTTTTTGAAAAGCTTCCAGAGGAGGAAAAAAAGCAGCGGATGCTGTCGTTATGCACG
GAAATTACACCGGCTATCATCCTTTCCCGTGATTTGCCGATTCCGCCTGAACTCGTGGAGGCATCCGAAGAAAACGGCGT
GCCTGTGCTTCGTTCCCCATTAAAGACGACGCGCCTGACGAGCCGTCTGACGAATTTTCTTGAAAGCCAGCTGGCTCCGA
CAACTGCGATTCACGGCGTCCTCGTCGACGTTTACGGCGTCGGGGTGCTCATTATCGGAAAGAGCGGGGTTGGAAAAAGC
GAAACGGCTTTGGAGCTTGTCAAAAGAGGCCATCGCCTTGTGGCGGATGACTGCGTTGAGATCAGACAGGAAGACCAGGA
TACATTGATCGGAAGCGCGCCTGAATTAATTGAGCATCTCCTGGAAATCAGAGGTCTTGGCATTATCAATGTCATGACGT
TATTTGGCGCGGGGGCGGTCAGAAGCTTTAAACGAATTACCCTTGTCATGAGCCTGGAGCTTTGGGAGCAAGGAAAGCAG
TACGACCGCTTAGGGCTTGAAGAAGAAACAATGAAAATTATTGATACAGACGTTCCAAAGCTGACAATTCCGGTTCGTCC
GGGAAGAAACCTTGCCGTCATCATCGAAGTGGCCGCAATGAACTTCAGACTGAAGAGAATGGGGCTGAATGCCGCGGAGC
AATTTACCCATAAGCTTGCGGATGTAATTGAAGATGGTGAGCTTGAAGAATAG

Upstream 100 bases:

>100_bases
AGGGGGCCATTTTCAAAAAATGTTTTAGGTTCATTTTGAAAGTGATAGAATAAAGCTGAATGTCTAGTTCTTCATCTGAG
AAGAGGAGGGTGCATCAATC

Downstream 100 bases:

>100_bases
GAGCTGACAATATGAATGAAACGATTGAACCATTAAATCCGATTGCTTTTCAACTGGGGCCGATCGCTGTCCATTGGTAC
GGTATTATCATCGGCCTTGG

Product: HPr kinase/phosphorylase

Products: NA

Alternate protein names: HPrK/P; HPr(Ser) kinase/phosphorylase

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MPKVRTKDVMDKFKLELISGEEGINRPITMSDLSRPGLEMAGYFTYYPKERVQLLGKTEITFFEKLPEEEKKQRMLSLCT
EITPAIILSRDLPIPPELVEASEENGVPVLRSPLKTTRLTSRLTNFLESQLAPTTAIHGVLVDVYGVGVLIIGKSGVGKS
ETALELVKRGHRLVADDCVEIRQEDQDTLIGSAPELIEHLLEIRGLGIINVMTLFGAGAVRSFKRITLVMSLELWEQGKQ
YDRLGLEEETMKIIDTDVPKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTHKLADVIEDGELEE

Sequences:

>Translated_310_residues
MPKVRTKDVMDKFKLELISGEEGINRPITMSDLSRPGLEMAGYFTYYPKERVQLLGKTEITFFEKLPEEEKKQRMLSLCT
EITPAIILSRDLPIPPELVEASEENGVPVLRSPLKTTRLTSRLTNFLESQLAPTTAIHGVLVDVYGVGVLIIGKSGVGKS
ETALELVKRGHRLVADDCVEIRQEDQDTLIGSAPELIEHLLEIRGLGIINVMTLFGAGAVRSFKRITLVMSLELWEQGKQ
YDRLGLEEETMKIIDTDVPKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTHKLADVIEDGELEE
>Mature_309_residues
PKVRTKDVMDKFKLELISGEEGINRPITMSDLSRPGLEMAGYFTYYPKERVQLLGKTEITFFEKLPEEEKKQRMLSLCTE
ITPAIILSRDLPIPPELVEASEENGVPVLRSPLKTTRLTSRLTNFLESQLAPTTAIHGVLVDVYGVGVLIIGKSGVGKSE
TALELVKRGHRLVADDCVEIRQEDQDTLIGSAPELIEHLLEIRGLGIINVMTLFGAGAVRSFKRITLVMSLELWEQGKQY
DRLGLEEETMKIIDTDVPKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTHKLADVIEDGELEE

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRK_BACLD (Q65EF0)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_080831.1
- RefSeq:   YP_093257.1
- HSSP:   Q9S1H5
- ProteinModelPortal:   Q65EF0
- SMR:   Q65EF0
- STRING:   Q65EF0
- EnsemblBacteria:   EBBACT00000056201
- EnsemblBacteria:   EBBACT00000059826
- GeneID:   3027758
- GeneID:   3100944
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi03746
- KEGG:   bli:BL03401
- NMPDR:   fig|279010.5.peg.3810
- eggNOG:   COG1493
- GeneTree:   EBGT00050000001684
- HOGENOM:   HBG566466
- OMA:   IHGVLVD
- ProtClustDB:   PRK05428
- BioCyc:   BLIC279010-1:BLI03746-MONOMER
- BioCyc:   BLIC279010:BL03401-MONOMER
- HAMAP:   MF_01249
- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126
- TIGRFAMs:   TIGR00679

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N

EC number: NA

Molecular weight: Translated: 34664; Mature: 34533

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: ACT_SITE 138-138 ACT_SITE 159-159 ACT_SITE 177-177 ACT_SITE 243-243

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVRTKDVMDKFKLELISGEEGINRPITMSDLSRPGLEMAGYFTYYPKERVQLLGKTEI
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHCCCCCHHHCCEEEECCHHHHHHHCCCHH
TFFEKLPEEEKKQRMLSLCTEITPAIILSRDLPIPPELVEASEENGVPVLRSPLKTTRLT
HHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCCCCCCHHHCCHHHHHHH
SRLTNFLESQLAPTTAIHGVLVDVYGVGVLIIGKSGVGKSETALELVKRGHRLVADDCVE
HHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHH
IRQEDQDTLIGSAPELIEHLLEIRGLGIINVMTLFGAGAVRSFKRITLVMSLELWEQGKQ
HHHCCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCH
YDRLGLEEETMKIIDTDVPKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTHKLA
HHHCCCCHHHHHHHCCCCCEEEEECCCCCCEEEEEEEHHHHHHHHHHCCCHHHHHHHHHH
DVIEDGELEE
HHHCCCCCCC
>Mature Secondary Structure 
PKVRTKDVMDKFKLELISGEEGINRPITMSDLSRPGLEMAGYFTYYPKERVQLLGKTEI
CCCCHHHHHHHHHHHHCCCCCCCCCCEEHHHCCCCCHHHCCEEEECCHHHHHHHCCCHH
TFFEKLPEEEKKQRMLSLCTEITPAIILSRDLPIPPELVEASEENGVPVLRSPLKTTRLT
HHHHHCCHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCCCCCCHHHCCHHHHHHH
SRLTNFLESQLAPTTAIHGVLVDVYGVGVLIIGKSGVGKSETALELVKRGHRLVADDCVE
HHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHH
IRQEDQDTLIGSAPELIEHLLEIRGLGIINVMTLFGAGAVRSFKRITLVMSLELWEQGKQ
HHHCCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCH
YDRLGLEEETMKIIDTDVPKLTIPVRPGRNLAVIIEVAAMNFRLKRMGLNAAEQFTHKLA
HHHCCCCHHHHHHHCCCCCEEEEECCCCCCEEEEEEEHHHHHHHHHHCCCHHHHHHHHHH
DVIEDGELEE
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA