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The map label for this gene is etfA [H]

Identifier: 52786730

GI number: 52786730

Start: 2880737

End: 2881714

Strand: Reverse

Name: etfA [H]

Synonym: BLi02999

Alternate gene names: 52786730

Gene position: 2881714-2880737 (Counterclockwise)

Preceding gene: 52786731

Following gene: 52786729

Centisome position: 68.24

GC content: 50.61

Gene sequence:

>978_bases
ATGAGCAAAAAAGTTATCGTATTGGGAGAGTTCAGAGACGGTTCGTTGAGGAATGTGACTTTCGAAGCGATAGCCGCAGG
AAAAACGGTTGCCGAAGGGGGAGAGGTGATCGGCGTACTGTTCGGTGAAAGCGTTTCAAGTCATGCGGCAGAACTGATCC
ATTACGGCGCTGACAGAGTGCTTACAGCCGAAAACCCGCTCTTGAAAAACTATACGTCTGACGGCTATGTTCAAGCCTTG
TTGCCGATCATAGAACGCGAGAATCCGGACGTCATCATTTTCGGACATACGTCAATGGGAAAAGACTTGTCGCCGAAGCT
TTCAGCCCGTATGGGAACAGGGCTGATATCGGATGCCGTCGATGTCGAAGTGGCCGGCGGCAACATCGTGTTTACAAGGC
CGATTTACTCGGGCAAAGCGTTTGAACGGATCATTTCCGAAGATGAAACGATTTTTGCAACGATCAGACCGAATAATATC
GCCCCGCTTGACAAAGATGAGACGCGGACAGGAGCGGTCGAAAGCATCGAAGCAGATATTCGGGACATCAGAACGGTCAT
CAAGGACATTGTCAAAAAAACGTCCGAAGGCGTCGATTTGTCTGAAGCGAAAATTATCGTAGCCGGCGGTCGCGGCGTCA
AAAGCGAGGAAGGCTTTAAACCGCTGCAGGAGCTCGCCGATGTATTGGGCGGGGCGGTCGGCGCTTCAAGGGGAGCCTGT
GACGCAGACTACTGCGACTATTCGCTTCAAATCGGCCAGACCGGCAAAGTTGTGACACCTGACTTATATATTGCCTGCGG
CATTTCAGGAGCGATTCAGCACCTCGCAGGGATGTCAAACAGCAAAATCATCGTTGCCATCAACAAAGATCCGGAAGCTG
ATATATTTAAAATTGCCGACTACGGGATCGTCGGCGACTTATTTGAAATCGTTCCGCTGCTCACGGAGGAATTTAAAAAG
CTGAGCGTCAGCACATGA

Upstream 100 bases:

>100_bases
CAGGCGGCAGAACTTGTATCACTGCTGAGAAGCGAAGCAAAGGTCGTATGAAGCCGAAGGGAGAAATAACACGGTCATTA
AAATACAGGGGGAAATGGAC

Downstream 100 bases:

>100_bases
TCAAAAGCCGGCCTGAAATGGCCGGCTTTTGACATAGGCACATTTCCGCCTTCTGCAAAATAACATGGGATATGGACATT
TTCAGAAAGGCTAAAATCCC

Product: EtfA

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSKKVIVLGEFRDGSLRNVTFEAIAAGKTVAEGGEVIGVLFGESVSSHAAELIHYGADRVLTAENPLLKNYTSDGYVQAL
LPIIERENPDVIIFGHTSMGKDLSPKLSARMGTGLISDAVDVEVAGGNIVFTRPIYSGKAFERIISEDETIFATIRPNNI
APLDKDETRTGAVESIEADIRDIRTVIKDIVKKTSEGVDLSEAKIIVAGGRGVKSEEGFKPLQELADVLGGAVGASRGAC
DADYCDYSLQIGQTGKVVTPDLYIACGISGAIQHLAGMSNSKIIVAINKDPEADIFKIADYGIVGDLFEIVPLLTEEFKK
LSVST

Sequences:

>Translated_325_residues
MSKKVIVLGEFRDGSLRNVTFEAIAAGKTVAEGGEVIGVLFGESVSSHAAELIHYGADRVLTAENPLLKNYTSDGYVQAL
LPIIERENPDVIIFGHTSMGKDLSPKLSARMGTGLISDAVDVEVAGGNIVFTRPIYSGKAFERIISEDETIFATIRPNNI
APLDKDETRTGAVESIEADIRDIRTVIKDIVKKTSEGVDLSEAKIIVAGGRGVKSEEGFKPLQELADVLGGAVGASRGAC
DADYCDYSLQIGQTGKVVTPDLYIACGISGAIQHLAGMSNSKIIVAINKDPEADIFKIADYGIVGDLFEIVPLLTEEFKK
LSVST
>Mature_324_residues
SKKVIVLGEFRDGSLRNVTFEAIAAGKTVAEGGEVIGVLFGESVSSHAAELIHYGADRVLTAENPLLKNYTSDGYVQALL
PIIERENPDVIIFGHTSMGKDLSPKLSARMGTGLISDAVDVEVAGGNIVFTRPIYSGKAFERIISEDETIFATIRPNNIA
PLDKDETRTGAVESIEADIRDIRTVIKDIVKKTSEGVDLSEAKIIVAGGRGVKSEEGFKPLQELADVLGGAVGASRGACD
ADYCDYSLQIGQTGKVVTPDLYIACGISGAIQHLAGMSNSKIIVAINKDPEADIFKIADYGIVGDLFEIVPLLTEEFKKL
SVST

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=321, Percent_Identity=38.9408099688474, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI189181759, Length=267, Percent_Identity=41.5730337078652, Blast_Score=187, Evalue=9e-48,
Organism=Escherichia coli, GI1787990, Length=259, Percent_Identity=31.6602316602317, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786226, Length=275, Percent_Identity=30.5454545454545, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87082157, Length=243, Percent_Identity=27.5720164609054, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506929, Length=314, Percent_Identity=40.4458598726115, Blast_Score=203, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6325261, Length=236, Percent_Identity=44.0677966101695, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI17136898, Length=318, Percent_Identity=41.5094339622642, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24652801, Length=318, Percent_Identity=41.5094339622642, Blast_Score=207, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 34606; Mature: 34475

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKVIVLGEFRDGSLRNVTFEAIAAGKTVAEGGEVIGVLFGESVSSHAAELIHYGADRV
CCCEEEEEEECCCCCCCEEEEEHHHCCCEECCCCCEEEEEECCCHHHHHHHHHHHCCCEE
LTAENPLLKNYTSDGYVQALLPIIERENPDVIIFGHTSMGKDLSPKLSARMGTGLISDAV
EECCCCHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCE
DVEVAGGNIVFTRPIYSGKAFERIISEDETIFATIRPNNIAPLDKDETRTGAVESIEADI
EEEEECCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
RDIRTVIKDIVKKTSEGVDLSEAKIIVAGGRGVKSEEGFKPLQELADVLGGAVGASRGAC
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
DADYCDYSLQIGQTGKVVTPDLYIACGISGAIQHLAGMSNSKIIVAINKDPEADIFKIAD
CCCCCCEEEEECCCCCEECCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEC
YGIVGDLFEIVPLLTEEFKKLSVST
CCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKKVIVLGEFRDGSLRNVTFEAIAAGKTVAEGGEVIGVLFGESVSSHAAELIHYGADRV
CCEEEEEEECCCCCCCEEEEEHHHCCCEECCCCCEEEEEECCCHHHHHHHHHHHCCCEE
LTAENPLLKNYTSDGYVQALLPIIERENPDVIIFGHTSMGKDLSPKLSARMGTGLISDAV
EECCCCHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCCE
DVEVAGGNIVFTRPIYSGKAFERIISEDETIFATIRPNNIAPLDKDETRTGAVESIEADI
EEEEECCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
RDIRTVIKDIVKKTSEGVDLSEAKIIVAGGRGVKSEEGFKPLQELADVLGGAVGASRGAC
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
DADYCDYSLQIGQTGKVVTPDLYIACGISGAIQHLAGMSNSKIIVAINKDPEADIFKIAD
CCCCCCEEEEECCCCCEECCCEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEC
YGIVGDLFEIVPLLTEEFKKLSVST
CCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]