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The map label for this gene is lonB [H]

Identifier: 52786683

GI number: 52786683

Start: 2836742

End: 2838397

Strand: Reverse

Name: lonB [H]

Synonym: BLi02951

Alternate gene names: 52786683

Gene position: 2838397-2836742 (Counterclockwise)

Preceding gene: 52786684

Following gene: 52786682

Centisome position: 67.22

GC content: 49.88

Gene sequence:

>1656_bases
TTGAGCTGGACGAGCATTGCACTTTTTGTACAACTATTTTTCGGGATCATCATCGGATTATATTTTTGGAATTTGCTCAA
AAATCAAAGAACCCAAAAGGTTACGATAGACAGAGAGTCCAAAAAAGAGATGGAACAGCTCCGGAAAATGAGATCAATCC
ATTTATCAGAACCTTTATCGGAAAAGGTGAGGCCGACGGCTTTTAAAGACATCGTCGGCCAGGAGGACGGCATTAAAGCG
CTGAAAGCCGCCCTTTGCGGACCGAATCCGCAGCATGTCATTATTTACGGCCCTCCAGGTGTGGGAAAAACGGCAGCTGC
AAGGCTTGTCCTTGAAGAAGCGAAAAAGAACAAGCGCTCACCGTTCCAGGAACATTCCGCCTTTGTCGAGCTTGACGCGA
CAACGGCCCGTTTCGACGAGCGGGGAATCGCCGACCCGTTGATCGGTTCGGTCCACGATCCGATTTATCAGGGCGCCGGA
GCGATGGGGCAGGCCGGAATTCCCCAGCCAAAGCAGGGAGCCGTCACGCATGCACACGGTGGAGTATTATTCATCGATGA
AATCGGAGAGCTTCATCCGATTCAAATGAATAAAATGCTGAAGGTGCTCGAAGATCGGAAAGTTTTTTTGGAAAGCGCCT
ATTACAGTGAAGAAAACACGCAAATCCCCAAGCATATTCACGACATTTTTCAAAACGGGCTGCCGGCGGATTTCAGACTG
ATCGGCGCGACGACAAGGATGCCTGATGAAATCCCGCCTGCCATTCGGTCGAGATGTTTGGAAGTGTTCTTCCGCGACCT
TGAAAAGCACGAATTAAAAACGGTCGCCAAAAAAGCGGCAGATAAGATTCAAAAGAAAGTCGCAGAGGAAGGACTCGACC
TGTTGACGCGGTATGCGAGAAACGGCCGCGAAGTCGTCAATATGATGCAAATCGCCGCCGGAATGGCTTTGACTGAAGAG
CGCGACGAGGTGACGGTTGAAGATATCGAATGGGTGATCCATTCGAGCCAGCTGACACCGAAATACGAACAAAAAATCGC
CTCTAAACCGCAGGTCGGCATCGTCAACGGACTTGCCGTCCACGGGCCTAACAGCGGTTCGCTGCTCGAAATTGAGGTCA
CAGTCAATCAGGCGGCTGATAAAGGATCGATTAATATCACAGGCATTGCAGAAGAAGAGAATATCGGCAACCAGTCAAAA
TCGATCCGCCGGAAAAGCATGGCGAAAGGATCGGTCGAAAACGTCATGACTGTATTGCGGACAATGGGAGTCAAAGCTTC
GGATTATGATATTCACGTGAATTTCCCCGGCGGTATCCCGGTTGACGGACCATCTGCAGGGATTGCAATGGCGGCGGGCA
TATTCTCCGCTATTCATAAGATTCCGATAGACCATACTGTCGCCATGACGGGTGAAATCAGCCTGAACGGCCGGGTAAAG
CCGATCGGCGGCGTGATTCCGAAAATCAAAGCGGCCAAGCATGCGGGGGCAAAAACAGTCATTATTCCGCACGAAAATGT
TCAGTCGATTTTAAAGCGGATAGAAGGCATACATATCGTTCCCGTCAAAACCTTGCAGGAAGTACTCGACCTCGTATTGG
TCAACCCTCCTTCAGAAATGCCCGACGGCGTTCAAATGAAAAGAGAATCCGTTTAA

Upstream 100 bases:

>100_bases
AAAGCAAAATAATCCCTTTCTGTACGTTTATTCCCTCCCTGATCAGGAAATACTATCTGACATACTAAAGATACGAAACC
ATTTCAGGAGGGACCATCAG

Downstream 100 bases:

>100_bases
ATCCCCATCGTTTCAGATGGGGATTTTTTTCGGGGCGGTTTCTCCGAAGCCGGGAGCCGGCATGTTTTCTTAGCGGAGGA
CATCTTTTCCTTTTTCAGAA

Product: hypothetical protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MSWTSIALFVQLFFGIIIGLYFWNLLKNQRTQKVTIDRESKKEMEQLRKMRSIHLSEPLSEKVRPTAFKDIVGQEDGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNKRSPFQEHSAFVELDATTARFDERGIADPLIGSVHDPIYQGAG
AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTQIPKHIHDIFQNGLPADFRL
IGATTRMPDEIPPAIRSRCLEVFFRDLEKHELKTVAKKAADKIQKKVAEEGLDLLTRYARNGREVVNMMQIAAGMALTEE
RDEVTVEDIEWVIHSSQLTPKYEQKIASKPQVGIVNGLAVHGPNSGSLLEIEVTVNQAADKGSINITGIAEEENIGNQSK
SIRRKSMAKGSVENVMTVLRTMGVKASDYDIHVNFPGGIPVDGPSAGIAMAAGIFSAIHKIPIDHTVAMTGEISLNGRVK
PIGGVIPKIKAAKHAGAKTVIIPHENVQSILKRIEGIHIVPVKTLQEVLDLVLVNPPSEMPDGVQMKRESV

Sequences:

>Translated_551_residues
MSWTSIALFVQLFFGIIIGLYFWNLLKNQRTQKVTIDRESKKEMEQLRKMRSIHLSEPLSEKVRPTAFKDIVGQEDGIKA
LKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNKRSPFQEHSAFVELDATTARFDERGIADPLIGSVHDPIYQGAG
AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTQIPKHIHDIFQNGLPADFRL
IGATTRMPDEIPPAIRSRCLEVFFRDLEKHELKTVAKKAADKIQKKVAEEGLDLLTRYARNGREVVNMMQIAAGMALTEE
RDEVTVEDIEWVIHSSQLTPKYEQKIASKPQVGIVNGLAVHGPNSGSLLEIEVTVNQAADKGSINITGIAEEENIGNQSK
SIRRKSMAKGSVENVMTVLRTMGVKASDYDIHVNFPGGIPVDGPSAGIAMAAGIFSAIHKIPIDHTVAMTGEISLNGRVK
PIGGVIPKIKAAKHAGAKTVIIPHENVQSILKRIEGIHIVPVKTLQEVLDLVLVNPPSEMPDGVQMKRESV
>Mature_550_residues
SWTSIALFVQLFFGIIIGLYFWNLLKNQRTQKVTIDRESKKEMEQLRKMRSIHLSEPLSEKVRPTAFKDIVGQEDGIKAL
KAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNKRSPFQEHSAFVELDATTARFDERGIADPLIGSVHDPIYQGAGA
MGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTQIPKHIHDIFQNGLPADFRLI
GATTRMPDEIPPAIRSRCLEVFFRDLEKHELKTVAKKAADKIQKKVAEEGLDLLTRYARNGREVVNMMQIAAGMALTEER
DEVTVEDIEWVIHSSQLTPKYEQKIASKPQVGIVNGLAVHGPNSGSLLEIEVTVNQAADKGSINITGIAEEENIGNQSKS
IRRKSMAKGSVENVMTVLRTMGVKASDYDIHVNFPGGIPVDGPSAGIAMAAGIFSAIHKIPIDHTVAMTGEISLNGRVKP
IGGVIPKIKAAKHAGAKTVIIPHENVQSILKRIEGIHIVPVKTLQEVLDLVLVNPPSEMPDGVQMKRESV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=500, Percent_Identity=25.8, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI31377667, Length=208, Percent_Identity=31.7307692307692, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1786643, Length=202, Percent_Identity=39.1089108910891, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17505831, Length=473, Percent_Identity=26.8498942917548, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17556486, Length=115, Percent_Identity=40, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319449, Length=78, Percent_Identity=51.2820512820513, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221513036, Length=506, Percent_Identity=25.6916996047431, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24666867, Length=506, Percent_Identity=25.6916996047431, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 60446; Mature: 60315

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWTSIALFVQLFFGIIIGLYFWNLLKNQRTQKVTIDRESKKEMEQLRKMRSIHLSEPLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHH
EKVRPTAFKDIVGQEDGIKALKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNKRS
HHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCC
PFQEHSAFVELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKQGAVTHAHG
CHHHCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCC
GVLFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTQIPKHIHDIFQNGLPADFRL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEE
IGATTRMPDEIPPAIRSRCLEVFFRDLEKHELKTVAKKAADKIQKKVAEEGLDLLTRYAR
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGREVVNMMQIAAGMALTEERDEVTVEDIEWVIHSSQLTPKYEQKIASKPQVGIVNGLAV
CHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCEEECCEEE
HGPNSGSLLEIEVTVNQAADKGSINITGIAEEENIGNQSKSIRRKSMAKGSVENVMTVLR
ECCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
TMGVKASDYDIHVNFPGGIPVDGPSAGIAMAAGIFSAIHKIPIDHTVAMTGEISLNGRVK
HHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCC
PIGGVIPKIKAAKHAGAKTVIIPHENVQSILKRIEGIHIVPVKTLQEVLDLVLVNPPSEM
CCCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHCCEEEEEHHHHHHHHHHEECCCCCCC
PDGVQMKRESV
CCCHHHHHCCC
>Mature Secondary Structure 
SWTSIALFVQLFFGIIIGLYFWNLLKNQRTQKVTIDRESKKEMEQLRKMRSIHLSEPLS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHH
EKVRPTAFKDIVGQEDGIKALKAALCGPNPQHVIIYGPPGVGKTAAARLVLEEAKKNKRS
HHCCCHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCC
PFQEHSAFVELDATTARFDERGIADPLIGSVHDPIYQGAGAMGQAGIPQPKQGAVTHAHG
CHHHCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCC
GVLFIDEIGELHPIQMNKMLKVLEDRKVFLESAYYSEENTQIPKHIHDIFQNGLPADFRL
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEE
IGATTRMPDEIPPAIRSRCLEVFFRDLEKHELKTVAKKAADKIQKKVAEEGLDLLTRYAR
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGREVVNMMQIAAGMALTEERDEVTVEDIEWVIHSSQLTPKYEQKIASKPQVGIVNGLAV
CHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCCEEECCEEE
HGPNSGSLLEIEVTVNQAADKGSINITGIAEEENIGNQSKSIRRKSMAKGSVENVMTVLR
ECCCCCCEEEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
TMGVKASDYDIHVNFPGGIPVDGPSAGIAMAAGIFSAIHKIPIDHTVAMTGEISLNGRVK
HHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCC
PIGGVIPKIKAAKHAGAKTVIIPHENVQSILKRIEGIHIVPVKTLQEVLDLVLVNPPSEM
CCCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHCCEEEEEHHHHHHHHHHEECCCCCCC
PDGVQMKRESV
CCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]