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The map label for this gene is lonA [H]

Identifier: 52786682

GI number: 52786682

Start: 2834199

End: 2836523

Strand: Reverse

Name: lonA [H]

Synonym: BLi02950

Alternate gene names: 52786682

Gene position: 2836523-2834199 (Counterclockwise)

Preceding gene: 52786683

Following gene: 52786681

Centisome position: 67.17

GC content: 49.42

Gene sequence:

>2325_bases
ATGGCAGATGAAACGAAACGAAACATCCCGCTCCTCCCTTTAAGAGGTTTACTCGTCTATCCGACGATGGTTTTGCACCT
TGACGTCGGGCGTGAAAAGTCGGTTCAGGCACTTGAACAGGCGATGATGAATGACCATATGATCTTTTTGGCAACGCAAA
AGGACATATCCATAGACGAACCGGATGAAGACGAGATTTTTACATTCGGAACCTATACGAAAATCAAGCAGATGCTCAAG
CTGCCGAACGGAACAATCCGCGTTTTGGTGGAGGGGTTGCAGCGCGCCCGCATTCTTGAGTACCATGACTTAGATGAATA
TACGTCTGTAAAAATCGAGCGAATCGATGAAGAGACTGAAAAAGATGTTGAAGATGAAGCACTCATGCGCACATTGCTTG
ACCACTTCGATCAATACATAAAGATTTCGAAAAAAATATCGGCGGAAACATTTGCCGCTGTGACAGATATTGAAGAGCCG
GGAAGAATGGCCGATATTGTCGCCTCCCACCTCCCGCTCAAGCTGAAAGACAAGCAGGAAGTGCTGGAAACGATCGATGT
CAAAGCCAGATTGAACAAAGTAATCGACCTGATTCACAATGAAAAAGAAGTCCTTGAGATTGAAAAGAAGATCGGGCAGC
GCGTCAAGCGTTCAATGGAAAGAACACAAAAGGAGTATTACCTGCGCGAGCAGATGAAAGCCATCCAAAAAGAACTTGGC
GATAAAGAAGGAAAAACGGGTGAGGTCCAAAAGCTGACTGAAAAAATCGAGCAGGCCGGAATGCCTGACAATGTGAAAGA
AACCGCGCTTAAAGAGCTGAACCGGTACGAAAAAATTCCGTCCAGCTCAGCTGAAAGCTCTGTCATCCGCAATTATATCG
AATGGCTTATTTCTCTCCCATGGAACGATGCAACAGAAGACAGGCTGGATTTAAAGCTCGCCAGTCAAATTCTCGATGAA
GAACACCACGGCCTTGAAAAAGTGAAGGAGCGGGTTCTCGAATATTTGGCTGTCCAGAAGCTGACCCGCTCGTTAAAAGG
ACCGATCTTATGCTTGGCCGGCCCTCCGGGTGTTGGAAAAACCTCTCTGGCGAAATCGATCGCCAAATCGCTCGGACGCA
AATTCGTCCGCATTTCCCTTGGCGGCGTGAGGGATGAATCTGAAATCCGCGGTCACCGCCGCACATATGTAGGCGCCATG
CCGGGCCGTATCATTCAGGGGATGAAAAAAGCAGGCAAGAACAATCCCGTATTCCTTTTGGACGAGATTGACAAAATGGC
GTCGGATTTCAGGGGAGATCCCGCTTCAGCGATGCTGGAAGTGCTCGATCCTGAACAAAACCATACGTTCAGCGACCATT
ATATTGAAGAGACATTTGACTTATCAAAGGTTTTGTTTATCGCAACCGCGAACAACCTGGCCACAATCCCCGGCCCGCTC
AGAGACCGCATGGAGATCATCACGATCGCCGGCTATACGGAAGTGGAAAAGGTCGAAATCGTCAAAGACCATCTGCTTCC
AAAACAGCTGAAAGAACACGGTTTGAAAAAATCCAATCTGCAAATACGGGAGCAGGCTGTCCTGGACGTCATTCGCTATT
ATACGAGGGAAGCCGGCGTCAGAAATCTTGAACGCCAAATCGCAGCGATATGCAGAAAAGCGGCGAAGCTGATCGTATCA
GGGGAAAGAAAAAGAATTACGGTCACAGACAAAAACCTTGAAGACTATTTAGGAAAAAGAATGTTCAGGTACGGACAGGC
TGAGCTCGACGATCAGATCGGCGTTGTCACAGGTCTTGCCTACACGACGGTCGGCGGTGATACGCTGTCCATCGAAGTGT
CTCTTTCCCCCGGGAAAGGCAAGCTCATTTTGACCGGAAAGCTCGGCGATGTCATGAGAGAGTCGGCGCAGGCCGCATTC
AGCTATGTCCGTTCAAAGGCGGAAGAGTTGAACATCAGCCCTGATTTTCACGAAAAACACGATATTCACATTCACGTGCC
GGAAGGAGCCGTTCCGAAGGACGGCCCATCCGCGGGGATCACAATGGCGACGGCTCTTGTCTCGGCGCTGACGGGCCGAC
CTGTTTCGCGAAATGTCGGCATGACCGGCGAAATCACGTTAAGAGGCCGCGTTCTTCCGATCGGCGGCTTGAAGGAAAAG
GCGCTCGGCGCACACCGTGCCGGCTTAAAGACTGTCATTATGCCGAAAGATAATGAAAAAGACATTGAGGACATTCCAAA
CAGCGTGCGGGAAGGCTTGACCTTCATTCCCGTCGCTCACCTGGACGAAGTTCTAAAGCATGCGCTAGTAGGAGAAGAGA
AATGA

Upstream 100 bases:

>100_bases
TACAGGAGACCCTTTTTATTTCGCCGGGCTTACAATTGTACAGGAATAAAAAAAGTATATTATAATGGTTCATACTAAAG
TTACGGAGGTGTCAGTCAAA

Downstream 100 bases:

>100_bases
AAGTAACGAAATCAGAGATTGTCATCAGTGCGGTGAAACCCGAGCAGTACCCTGAAGGGGGACTGCCGGAAATCGCCCTT
GCAGGGAGATCTAATGTCGG

Product: LonA

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MADETKRNIPLLPLRGLLVYPTMVLHLDVGREKSVQALEQAMMNDHMIFLATQKDISIDEPDEDEIFTFGTYTKIKQMLK
LPNGTIRVLVEGLQRARILEYHDLDEYTSVKIERIDEETEKDVEDEALMRTLLDHFDQYIKISKKISAETFAAVTDIEEP
GRMADIVASHLPLKLKDKQEVLETIDVKARLNKVIDLIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELG
DKEGKTGEVQKLTEKIEQAGMPDNVKETALKELNRYEKIPSSSAESSVIRNYIEWLISLPWNDATEDRLDLKLASQILDE
EHHGLEKVKERVLEYLAVQKLTRSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGHRRTYVGAM
PGRIIQGMKKAGKNNPVFLLDEIDKMASDFRGDPASAMLEVLDPEQNHTFSDHYIEETFDLSKVLFIATANNLATIPGPL
RDRMEIITIAGYTEVEKVEIVKDHLLPKQLKEHGLKKSNLQIREQAVLDVIRYYTREAGVRNLERQIAAICRKAAKLIVS
GERKRITVTDKNLEDYLGKRMFRYGQAELDDQIGVVTGLAYTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAF
SYVRSKAEELNISPDFHEKHDIHIHVPEGAVPKDGPSAGITMATALVSALTGRPVSRNVGMTGEITLRGRVLPIGGLKEK
ALGAHRAGLKTVIMPKDNEKDIEDIPNSVREGLTFIPVAHLDEVLKHALVGEEK

Sequences:

>Translated_774_residues
MADETKRNIPLLPLRGLLVYPTMVLHLDVGREKSVQALEQAMMNDHMIFLATQKDISIDEPDEDEIFTFGTYTKIKQMLK
LPNGTIRVLVEGLQRARILEYHDLDEYTSVKIERIDEETEKDVEDEALMRTLLDHFDQYIKISKKISAETFAAVTDIEEP
GRMADIVASHLPLKLKDKQEVLETIDVKARLNKVIDLIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELG
DKEGKTGEVQKLTEKIEQAGMPDNVKETALKELNRYEKIPSSSAESSVIRNYIEWLISLPWNDATEDRLDLKLASQILDE
EHHGLEKVKERVLEYLAVQKLTRSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGHRRTYVGAM
PGRIIQGMKKAGKNNPVFLLDEIDKMASDFRGDPASAMLEVLDPEQNHTFSDHYIEETFDLSKVLFIATANNLATIPGPL
RDRMEIITIAGYTEVEKVEIVKDHLLPKQLKEHGLKKSNLQIREQAVLDVIRYYTREAGVRNLERQIAAICRKAAKLIVS
GERKRITVTDKNLEDYLGKRMFRYGQAELDDQIGVVTGLAYTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAF
SYVRSKAEELNISPDFHEKHDIHIHVPEGAVPKDGPSAGITMATALVSALTGRPVSRNVGMTGEITLRGRVLPIGGLKEK
ALGAHRAGLKTVIMPKDNEKDIEDIPNSVREGLTFIPVAHLDEVLKHALVGEEK
>Mature_773_residues
ADETKRNIPLLPLRGLLVYPTMVLHLDVGREKSVQALEQAMMNDHMIFLATQKDISIDEPDEDEIFTFGTYTKIKQMLKL
PNGTIRVLVEGLQRARILEYHDLDEYTSVKIERIDEETEKDVEDEALMRTLLDHFDQYIKISKKISAETFAAVTDIEEPG
RMADIVASHLPLKLKDKQEVLETIDVKARLNKVIDLIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELGD
KEGKTGEVQKLTEKIEQAGMPDNVKETALKELNRYEKIPSSSAESSVIRNYIEWLISLPWNDATEDRLDLKLASQILDEE
HHGLEKVKERVLEYLAVQKLTRSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGHRRTYVGAMP
GRIIQGMKKAGKNNPVFLLDEIDKMASDFRGDPASAMLEVLDPEQNHTFSDHYIEETFDLSKVLFIATANNLATIPGPLR
DRMEIITIAGYTEVEKVEIVKDHLLPKQLKEHGLKKSNLQIREQAVLDVIRYYTREAGVRNLERQIAAICRKAAKLIVSG
ERKRITVTDKNLEDYLGKRMFRYGQAELDDQIGVVTGLAYTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAFS
YVRSKAEELNISPDFHEKHDIHIHVPEGAVPKDGPSAGITMATALVSALTGRPVSRNVGMTGEITLRGRVLPIGGLKEKA
LGAHRAGLKTVIMPKDNEKDIEDIPNSVREGLTFIPVAHLDEVLKHALVGEEK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=779, Percent_Identity=42.2336328626444, Blast_Score=593, Evalue=1e-169,
Organism=Homo sapiens, GI21396489, Length=627, Percent_Identity=43.3811802232855, Blast_Score=546, Evalue=1e-155,
Organism=Escherichia coli, GI1786643, Length=765, Percent_Identity=56.7320261437908, Blast_Score=885, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=688, Percent_Identity=40.843023255814, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17556486, Length=763, Percent_Identity=37.0904325032765, Blast_Score=476, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319449, Length=669, Percent_Identity=40.9566517189836, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221513036, Length=625, Percent_Identity=44.16, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24666867, Length=625, Percent_Identity=44.16, Blast_Score=538, Evalue=1e-153,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86863; Mature: 86732

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADETKRNIPLLPLRGLLVYPTMVLHLDVGREKSVQALEQAMMNDHMIFLATQKDISIDE
CCCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCC
PDEDEIFTFGTYTKIKQMLKLPNGTIRVLVEGLQRARILEYHDLDEYTSVKIERIDEETE
CCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
KDVEDEALMRTLLDHFDQYIKISKKISAETFAAVTDIEEPGRMADIVASHLPLKLKDKQE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEECCHHH
VLETIDVKARLNKVIDLIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DKEGKTGEVQKLTEKIEQAGMPDNVKETALKELNRYEKIPSSSAESSVIRNYIEWLISLP
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
WNDATEDRLDLKLASQILDEEHHGLEKVKERVLEYLAVQKLTRSLKGPILCLAGPPGVGK
CCCCCCHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCH
TSLAKSIAKSLGRKFVRISLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAGKNNPVFLL
HHHHHHHHHHHHHHEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCEEEE
DEIDKMASDFRGDPASAMLEVLDPEQNHTFSDHYIEETFDLSKVLFIATANNLATIPGPL
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCH
RDRMEIITIAGYTEVEKVEIVKDHLLPKQLKEHGLKKSNLQIREQAVLDVIRYYTREAGV
HCCEEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RNLERQIAAICRKAAKLIVSGERKRITVTDKNLEDYLGKRMFRYGQAELDDQIGVVTGLA
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHCCCHHHHHHHH
YTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAFSYVRSKAEELNISPDFHEKH
HEEECCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DIHIHVPEGAVPKDGPSAGITMATALVSALTGRPVSRNVGMTGEITLRGRVLPIGGLKEK
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCHHH
ALGAHRAGLKTVIMPKDNEKDIEDIPNSVREGLTFIPVAHLDEVLKHALVGEEK
HHHHHHCCCEEEEECCCCCCHHHHCCHHHHCCCEECCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ADETKRNIPLLPLRGLLVYPTMVLHLDVGREKSVQALEQAMMNDHMIFLATQKDISIDE
CCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCC
PDEDEIFTFGTYTKIKQMLKLPNGTIRVLVEGLQRARILEYHDLDEYTSVKIERIDEETE
CCCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
KDVEDEALMRTLLDHFDQYIKISKKISAETFAAVTDIEEPGRMADIVASHLPLKLKDKQE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEECCHHH
VLETIDVKARLNKVIDLIHNEKEVLEIEKKIGQRVKRSMERTQKEYYLREQMKAIQKELG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DKEGKTGEVQKLTEKIEQAGMPDNVKETALKELNRYEKIPSSSAESSVIRNYIEWLISLP
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
WNDATEDRLDLKLASQILDEEHHGLEKVKERVLEYLAVQKLTRSLKGPILCLAGPPGVGK
CCCCCCHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCH
TSLAKSIAKSLGRKFVRISLGGVRDESEIRGHRRTYVGAMPGRIIQGMKKAGKNNPVFLL
HHHHHHHHHHHHHHEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCEEEE
DEIDKMASDFRGDPASAMLEVLDPEQNHTFSDHYIEETFDLSKVLFIATANNLATIPGPL
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCH
RDRMEIITIAGYTEVEKVEIVKDHLLPKQLKEHGLKKSNLQIREQAVLDVIRYYTREAGV
HCCEEEEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RNLERQIAAICRKAAKLIVSGERKRITVTDKNLEDYLGKRMFRYGQAELDDQIGVVTGLA
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCHHHCCCHHHHHHHH
YTTVGGDTLSIEVSLSPGKGKLILTGKLGDVMRESAQAAFSYVRSKAEELNISPDFHEKH
HEEECCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DIHIHVPEGAVPKDGPSAGITMATALVSALTGRPVSRNVGMTGEITLRGRVLPIGGLKEK
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCHHH
ALGAHRAGLKTVIMPKDNEKDIEDIPNSVREGLTFIPVAHLDEVLKHALVGEEK
HHHHHHCCCEEEEECCCCCCHHHHCCHHHHCCCEECCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961402; 8969504; 9384377 [H]