| Definition | Bacillus licheniformis ATCC 14580, complete genome. |
|---|---|
| Accession | NC_006322 |
| Length | 4,222,645 |
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The map label for this gene is ytbE [H]
Identifier: 52786572
GI number: 52786572
Start: 2723701
End: 2724549
Strand: Reverse
Name: ytbE [H]
Synonym: BLi02838
Alternate gene names: 52786572
Gene position: 2724549-2723701 (Counterclockwise)
Preceding gene: 52786573
Following gene: 52786569
Centisome position: 64.52
GC content: 49.23
Gene sequence:
>849_bases ATGATGACAGCAAAAAATTTGCAAGATCGAATCAAATTGAATAACGGGACAGCTATGCCTTGGTTTGGACTTGGCGTATT TAAAGTAGAAGAAGGGCCCGAACTGGTACAAGCCGTAAAAACGGCGATTAAACACGGCTACCGCAGTATTGATACCGCAG CCATCTACGGTAATGAAGAGGGGGTTGGGCAAGGAATCCGCGAGGGGTTGAAAGAAGCCGGCATTTCAAGAGAAGACCTG TTTGTTACATCAAAGGTCTGGAATGACGATTTAGGCTATGACGAAACGATTGCAGCCTATGAGGCGAGTCTCGAAAAGCT CGGACTTGACTACCTTGATTTATACCTGATCCACTGGCCTGTTGAAGGACGCTACAAAGCGGCGTGGAAAGCGCTTGAAA CACTTTATGAACAAGGACGCGTAAAAGCAATCGGAGTGAGCAATTTTCAGATTCACCATCTGGAAGACTTGCTGAAAGAT GCCGCCGTCAAACCGGCGATCAACCAGGTTGAGTATCATCCGCGGCTGACGCAGAAAGAGCTGCAAGCGTTTTGCCGTGC GCACGGCATCCAGCTGCAAGCATGGTCGCCGCTGATGCAAGGCCAATTGCTCAGCCATCCACTGCTGAAAGATATCGCGG ACAAGTACGGCAAGACACCGGCCCAAGTCATTTTGCGCTGGGATTTGCAAAACGGGGTCGTTACGATTCCGAAGTCGACT AAAGCGGAGCGGATTGCCCAAAACGCGGACATATTTGATTTTGAACTGACCACCGAGGAAATGAAGCAAATTGACGCGCT GAATGAAAACACCCGTGTCGGCCCTGATCCCGATAACTTTGACTTTTAA
Upstream 100 bases:
>100_bases CGCTGGAACGAAATGATCAAAAACAAAATGATCAAAAACAAAATCAAGCTTTAAAGGAAAACTGCGCATGACGCATACAA AATATAAGGAGGCCAATTAA
Downstream 100 bases:
>100_bases CAAAACGGCCCCGTTCGACATTCGAACGGGGCTTTAATTGAATTGTGCGGTTACACCGCCGGACTCCATCATCATCAGTT CTTTTTTCATATCCAATCCG
Product: YtbE
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 282; Mature: 282
Protein sequence:
>282_residues MMTAKNLQDRIKLNNGTAMPWFGLGVFKVEEGPELVQAVKTAIKHGYRSIDTAAIYGNEEGVGQGIREGLKEAGISREDL FVTSKVWNDDLGYDETIAAYEASLEKLGLDYLDLYLIHWPVEGRYKAAWKALETLYEQGRVKAIGVSNFQIHHLEDLLKD AAVKPAINQVEYHPRLTQKELQAFCRAHGIQLQAWSPLMQGQLLSHPLLKDIADKYGKTPAQVILRWDLQNGVVTIPKST KAERIAQNADIFDFELTTEEMKQIDALNENTRVGPDPDNFDF
Sequences:
>Translated_282_residues MMTAKNLQDRIKLNNGTAMPWFGLGVFKVEEGPELVQAVKTAIKHGYRSIDTAAIYGNEEGVGQGIREGLKEAGISREDL FVTSKVWNDDLGYDETIAAYEASLEKLGLDYLDLYLIHWPVEGRYKAAWKALETLYEQGRVKAIGVSNFQIHHLEDLLKD AAVKPAINQVEYHPRLTQKELQAFCRAHGIQLQAWSPLMQGQLLSHPLLKDIADKYGKTPAQVILRWDLQNGVVTIPKST KAERIAQNADIFDFELTTEEMKQIDALNENTRVGPDPDNFDF >Mature_282_residues MMTAKNLQDRIKLNNGTAMPWFGLGVFKVEEGPELVQAVKTAIKHGYRSIDTAAIYGNEEGVGQGIREGLKEAGISREDL FVTSKVWNDDLGYDETIAAYEASLEKLGLDYLDLYLIHWPVEGRYKAAWKALETLYEQGRVKAIGVSNFQIHHLEDLLKD AAVKPAINQVEYHPRLTQKELQAFCRAHGIQLQAWSPLMQGQLLSHPLLKDIADKYGKTPAQVILRWDLQNGVVTIPKST KAERIAQNADIFDFELTTEEMKQIDALNENTRVGPDPDNFDF
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=293, Percent_Identity=42.6621160409556, Blast_Score=234, Evalue=6e-62, Organism=Homo sapiens, GI5174391, Length=293, Percent_Identity=42.6621160409556, Blast_Score=234, Evalue=6e-62, Organism=Homo sapiens, GI310109922, Length=292, Percent_Identity=41.4383561643836, Blast_Score=213, Evalue=1e-55, Organism=Homo sapiens, GI5453543, Length=312, Percent_Identity=39.1025641025641, Blast_Score=210, Evalue=1e-54, Organism=Homo sapiens, GI310109920, Length=312, Percent_Identity=39.1025641025641, Blast_Score=210, Evalue=1e-54, Organism=Homo sapiens, GI45446745, Length=312, Percent_Identity=39.1025641025641, Blast_Score=209, Evalue=2e-54, Organism=Homo sapiens, GI4503285, Length=312, Percent_Identity=39.1025641025641, Blast_Score=209, Evalue=2e-54, Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=40.4761904761905, Blast_Score=208, Evalue=4e-54, Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=40.4682274247492, Blast_Score=204, Evalue=6e-53, Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=38.5906040268456, Blast_Score=201, Evalue=6e-52, Organism=Homo sapiens, GI291291012, Length=278, Percent_Identity=40.2877697841727, Blast_Score=193, Evalue=1e-49, Organism=Homo sapiens, GI93277124, Length=304, Percent_Identity=37.171052631579, Blast_Score=193, Evalue=2e-49, Organism=Homo sapiens, GI24497583, Length=295, Percent_Identity=37.9661016949153, Blast_Score=192, Evalue=2e-49, Organism=Homo sapiens, GI4502049, Length=299, Percent_Identity=40.8026755852843, Blast_Score=190, Evalue=1e-48, Organism=Homo sapiens, GI300116271, Length=280, Percent_Identity=39.2857142857143, Blast_Score=174, Evalue=1e-43, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=37.7697841726619, Blast_Score=173, Evalue=1e-43, Organism=Homo sapiens, GI310109924, Length=169, Percent_Identity=40.2366863905325, Blast_Score=117, Evalue=8e-27, Organism=Homo sapiens, GI310109926, Length=113, Percent_Identity=45.1327433628319, Blast_Score=102, Evalue=5e-22, Organism=Homo sapiens, GI207028673, Length=113, Percent_Identity=45.1327433628319, Blast_Score=101, Evalue=6e-22, Organism=Escherichia coli, GI87082198, Length=274, Percent_Identity=48.9051094890511, Blast_Score=271, Evalue=2e-74, Organism=Escherichia coli, GI1786400, Length=264, Percent_Identity=38.2575757575758, Blast_Score=176, Evalue=2e-45, Organism=Escherichia coli, GI1788081, Length=274, Percent_Identity=33.2116788321168, Blast_Score=128, Evalue=5e-31, Organism=Escherichia coli, GI1787674, Length=276, Percent_Identity=27.8985507246377, Blast_Score=75, Evalue=5e-15, Organism=Escherichia coli, GI1788070, Length=226, Percent_Identity=28.7610619469027, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI87081735, Length=274, Percent_Identity=22.992700729927, Blast_Score=64, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=37.6666666666667, Blast_Score=204, Evalue=4e-53, Organism=Caenorhabditis elegans, GI71998625, Length=270, Percent_Identity=40.3703703703704, Blast_Score=200, Evalue=6e-52, Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=38.7755102040816, Blast_Score=196, Evalue=9e-51, Organism=Caenorhabditis elegans, GI17537075, Length=303, Percent_Identity=37.953795379538, Blast_Score=191, Evalue=4e-49, Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=34.7985347985348, Blast_Score=180, Evalue=7e-46, Organism=Caenorhabditis elegans, GI17561298, Length=272, Percent_Identity=36.3970588235294, Blast_Score=178, Evalue=2e-45, Organism=Caenorhabditis elegans, GI17562292, Length=276, Percent_Identity=34.4202898550725, Blast_Score=176, Evalue=1e-44, Organism=Caenorhabditis elegans, GI17550248, Length=292, Percent_Identity=35.958904109589, Blast_Score=174, Evalue=5e-44, Organism=Caenorhabditis elegans, GI17538386, Length=280, Percent_Identity=36.0714285714286, Blast_Score=169, Evalue=1e-42, Organism=Caenorhabditis elegans, GI17537079, Length=312, Percent_Identity=33.0128205128205, Blast_Score=169, Evalue=1e-42, Organism=Caenorhabditis elegans, GI17566692, Length=285, Percent_Identity=34.0350877192982, Blast_Score=166, Evalue=1e-41, Organism=Caenorhabditis elegans, GI17561300, Length=273, Percent_Identity=36.6300366300366, Blast_Score=166, Evalue=1e-41, Organism=Caenorhabditis elegans, GI17550246, Length=81, Percent_Identity=43.2098765432099, Blast_Score=72, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6321896, Length=317, Percent_Identity=36.9085173501577, Blast_Score=200, Evalue=2e-52, Organism=Saccharomyces cerevisiae, GI6324694, Length=291, Percent_Identity=39.1752577319588, Blast_Score=196, Evalue=4e-51, Organism=Saccharomyces cerevisiae, GI6319625, Length=308, Percent_Identity=38.3116883116883, Blast_Score=191, Evalue=1e-49, Organism=Saccharomyces cerevisiae, GI6320576, Length=299, Percent_Identity=38.1270903010033, Blast_Score=191, Evalue=1e-49, Organism=Saccharomyces cerevisiae, GI6322556, Length=261, Percent_Identity=36.7816091954023, Blast_Score=184, Evalue=2e-47, Organism=Saccharomyces cerevisiae, GI6320079, Length=287, Percent_Identity=35.5400696864112, Blast_Score=147, Evalue=2e-36, Organism=Drosophila melanogaster, GI24663317, Length=298, Percent_Identity=39.5973154362416, Blast_Score=209, Evalue=2e-54, Organism=Drosophila melanogaster, GI24644950, Length=301, Percent_Identity=38.2059800664452, Blast_Score=209, Evalue=2e-54, Organism=Drosophila melanogaster, GI24662789, Length=294, Percent_Identity=39.1156462585034, Blast_Score=203, Evalue=1e-52, Organism=Drosophila melanogaster, GI24657054, Length=302, Percent_Identity=38.4105960264901, Blast_Score=202, Evalue=2e-52, Organism=Drosophila melanogaster, GI221378297, Length=321, Percent_Identity=35.8255451713396, Blast_Score=201, Evalue=3e-52, Organism=Drosophila melanogaster, GI20129731, Length=296, Percent_Identity=36.1486486486487, Blast_Score=188, Evalue=3e-48, Organism=Drosophila melanogaster, GI45553081, Length=298, Percent_Identity=35.5704697986577, Blast_Score=183, Evalue=9e-47, Organism=Drosophila melanogaster, GI24662781, Length=295, Percent_Identity=41.3559322033898, Blast_Score=183, Evalue=1e-46, Organism=Drosophila melanogaster, GI21356425, Length=294, Percent_Identity=35.3741496598639, Blast_Score=181, Evalue=6e-46, Organism=Drosophila melanogaster, GI24662785, Length=291, Percent_Identity=41.2371134020619, Blast_Score=179, Evalue=1e-45, Organism=Drosophila melanogaster, GI281366140, Length=259, Percent_Identity=35.5212355212355, Blast_Score=161, Evalue=4e-40,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 31783; Mature: 31783
Theoretical pI: Translated: 5.08; Mature: 5.08
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.8 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MMTAKNLQDRIKLNNGTAMPWFGLGVFKVEEGPELVQAVKTAIKHGYRSIDTAAIYGNEE CCCHHCCHHHEEECCCCCCCEECCEEEEECCCHHHHHHHHHHHHHCCHHCCCEEEECCCC GVGQGIREGLKEAGISREDLFVTSKVWNDDLGYDETIAAYEASLEKLGLDYLDLYLIHWP HHHHHHHHHHHHCCCCHHHEEEEHHHCCCCCCCCHHHHHHHHHHHHHCCHHEEEEEEECC VEGRYKAAWKALETLYEQGRVKAIGVSNFQIHHLEDLLKDAAVKPAINQVEYHPRLTQKE CCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCHHH LQAFCRAHGIQLQAWSPLMQGQLLSHPLLKDIADKYGKTPAQVILRWDLQNGVVTIPKST HHHHHHHCCCEEEECCHHHHHHHHCCHHHHHHHHHHCCCHHHEEEEEECCCCEEECCCCC KAERIAQNADIFDFELTTEEMKQIDALNENTRVGPDPDNFDF HHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCCC >Mature Secondary Structure MMTAKNLQDRIKLNNGTAMPWFGLGVFKVEEGPELVQAVKTAIKHGYRSIDTAAIYGNEE CCCHHCCHHHEEECCCCCCCEECCEEEEECCCHHHHHHHHHHHHHCCHHCCCEEEECCCC GVGQGIREGLKEAGISREDLFVTSKVWNDDLGYDETIAAYEASLEKLGLDYLDLYLIHWP HHHHHHHHHHHHCCCCHHHEEEEHHHCCCCCCCCHHHHHHHHHHHHHCCHHEEEEEEECC VEGRYKAAWKALETLYEQGRVKAIGVSNFQIHHLEDLLKDAAVKPAINQVEYHPRLTQKE CCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCHHH LQAFCRAHGIQLQAWSPLMQGQLLSHPLLKDIADKYGKTPAQVILRWDLQNGVVTIPKST HHHHHHHCCCEEEECCHHHHHHHHCCHHHHHHHHHHCCCHHHEEEEEECCCCEEECCCCC KAERIAQNADIFDFELTTEEMKQIDALNENTRVGPDPDNFDF HHHHHHCCCCEEEEEECHHHHHHHHHCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]