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The map label for this gene is ribA [H]

Identifier: 52786212

GI number: 52786212

Start: 2406044

End: 2407261

Strand: Reverse

Name: ribA [H]

Synonym: BLi02473

Alternate gene names: 52786212

Gene position: 2407261-2406044 (Counterclockwise)

Preceding gene: 52786213

Following gene: 52786211

Centisome position: 57.01

GC content: 51.07

Gene sequence:

>1218_bases
ATGAAAGGAGGCTGTGCGTCTATGTTTCACACAATTGAAGAAGCGATTCGCGATTTGAAGCAGGGAAAAGTCATCATCGT
AGTCGATGACGAGAACAGGGAAAACGAAGGCGATTTCGTTGCGCTGGCGGAATACGCAACACCCGATGTAATCAACTTTA
TGGCTTCGCACGGAAGGGGGTTGATCTGCGCGCCGCTCAATGAAGAGATCGCTTCCCGGCTTGAGCTCCAACCGATGGTG
GACGAAAATACCGATTCTCACCACACAGCATTTACGGTCAGTGTCGATCACCGCGATACAAAGACGGGGATTAGCGCTCA
GGAGCGGTCGCTGACCGTCATGTCGCTGATCGCTGATCACGCGCATCCGGGTGATTTTAAAAGGCCGGGGCACATTTTCC
CCCTGATCGCGAAAAAAGGCGGCGTTTTAAAAAGAGCCGGACATACGGAGGCGGCCGTTGACCTTGCAGAAGCGTGCGGG
TCCGCGCCGGCCGGCGTCATCTGCGAAATCATGAATGAAGACGGCACGATGGCAAGGGTGCCTGAACTCAAAAAAATAGC
CGATCAGCACGGCTTGAAAATGATCACGATTAAAGATTTGATCGAATACCGCTACAGCAAGGGAACGCTGATCAACCGGG
AAGTGAAAATTACGCTGCCTTCCGAATTCGGTACCTTCAAGGTTTACGGCTATACAAACGAAATCGATGACAAAGAACAT
ATAGCACTCGTCAAAGGCGACATACCTTTCGGTGACGAGCCTGTGCTTGTCCGGGTACACTCAGAATGCCTGACGGGCGA
TGTTTTCGGCTCTTACCGCTGCGACTGCGGCCCGCAGCTTGCCGCTGCGCTCGCGCAAATCGAACAAGCGGGCCGGGGCG
TACTCCTGTATTTGAGACAGGAAGGAAGGGGAATCGGCTTAATCAATAAACTGAAAGCTTATAAGCTGCAGGAAGAAGGA
TACGACACCGTACAGGCTAACGAAAAGCTCGGTTTTCTTCCAGACCTTCGCAACTACGGGATCGGCGCCCAAATCTTAAG
GGACCTCGGCGTGAAGCAAATGAAGCTGTTAACGAACAACCCGCGAAAAATTGCAGGTCTCGAAGGTTACGGCCTGACGA
TCGCAGACAGGGTGCCGCTGCAGATGGAGACAAAAAAAGATAATGAAAAGTATCTAAAAACGAAAAAATCAAAATTGGGG
CATATGCTTCATTTTTAA

Upstream 100 bases:

>100_bases
TATGATCGGCAAATACATTTACCGCTTTCTCCACCAAACAAAACAAGAAAAACAGGCACAGGCATTGACTGAAGCATTCT
TTAAAGAAAACGGGTTTTAA

Downstream 100 bases:

>100_bases
ACTAAAATCAATCACAAAAAAGGACGGGATTCATATGAATAAAATAGAAGGTCATGTAATTGGAACAGATTTGAAAATTG
GGATCGTTGTGTCAAGGTTC

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKGGCASMFHTIEEAIRDLKQGKVIIVVDDENRENEGDFVALAEYATPDVINFMASHGRGLICAPLNEEIASRLELQPMV
DENTDSHHTAFTVSVDHRDTKTGISAQERSLTVMSLIADHAHPGDFKRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACG
SAPAGVICEIMNEDGTMARVPELKKIADQHGLKMITIKDLIEYRYSKGTLINREVKITLPSEFGTFKVYGYTNEIDDKEH
IALVKGDIPFGDEPVLVRVHSECLTGDVFGSYRCDCGPQLAAALAQIEQAGRGVLLYLRQEGRGIGLINKLKAYKLQEEG
YDTVQANEKLGFLPDLRNYGIGAQILRDLGVKQMKLLTNNPRKIAGLEGYGLTIADRVPLQMETKKDNEKYLKTKKSKLG
HMLHF

Sequences:

>Translated_405_residues
MKGGCASMFHTIEEAIRDLKQGKVIIVVDDENRENEGDFVALAEYATPDVINFMASHGRGLICAPLNEEIASRLELQPMV
DENTDSHHTAFTVSVDHRDTKTGISAQERSLTVMSLIADHAHPGDFKRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACG
SAPAGVICEIMNEDGTMARVPELKKIADQHGLKMITIKDLIEYRYSKGTLINREVKITLPSEFGTFKVYGYTNEIDDKEH
IALVKGDIPFGDEPVLVRVHSECLTGDVFGSYRCDCGPQLAAALAQIEQAGRGVLLYLRQEGRGIGLINKLKAYKLQEEG
YDTVQANEKLGFLPDLRNYGIGAQILRDLGVKQMKLLTNNPRKIAGLEGYGLTIADRVPLQMETKKDNEKYLKTKKSKLG
HMLHF
>Mature_405_residues
MKGGCASMFHTIEEAIRDLKQGKVIIVVDDENRENEGDFVALAEYATPDVINFMASHGRGLICAPLNEEIASRLELQPMV
DENTDSHHTAFTVSVDHRDTKTGISAQERSLTVMSLIADHAHPGDFKRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACG
SAPAGVICEIMNEDGTMARVPELKKIADQHGLKMITIKDLIEYRYSKGTLINREVKITLPSEFGTFKVYGYTNEIDDKEH
IALVKGDIPFGDEPVLVRVHSECLTGDVFGSYRCDCGPQLAAALAQIEQAGRGVLLYLRQEGRGIGLINKLKAYKLQEEG
YDTVQANEKLGFLPDLRNYGIGAQILRDLGVKQMKLLTNNPRKIAGLEGYGLTIADRVPLQMETKKDNEKYLKTKKSKLG
HMLHF

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=51.5463917525773, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1789420, Length=199, Percent_Identity=45.2261306532663, Blast_Score=191, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=42.2330097087379, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=44.7058823529412, Blast_Score=124, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44683; Mature: 44683

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGGCASMFHTIEEAIRDLKQGKVIIVVDDENRENEGDFVALAEYATPDVINFMASHGRG
CCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCE
LICAPLNEEIASRLELQPMVDENTDSHHTAFTVSVDHRDTKTGISAQERSLTVMSLIADH
EEEECCCHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHC
AHPGDFKRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSAPAGVICEIMNEDGTMARV
CCCCCCCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECC
PELKKIADQHGLKMITIKDLIEYRYSKGTLINREVKITLPSEFGTFKVYGYTNEIDDKEH
CHHHHHHHHHCEEEEEHHHHHHHHCCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCE
IALVKGDIPFGDEPVLVRVHSECLTGDVFGSYRCDCGPQLAAALAQIEQAGRGVLLYLRQ
EEEEECCCCCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEE
EGRGIGLINKLKAYKLQEEGYDTVQANEKLGFLPDLRNYGIGAQILRDLGVKQMKLLTNN
CCCCCCHHHHHHHHEECCCCCCEEECCCCCCCCCCHHHCCCHHHHHHHCCHHHHHHHCCC
PRKIAGLEGYGLTIADRVPLQMETKKDNEKYLKTKKSKLGHMLHF
CCEEECCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGGCASMFHTIEEAIRDLKQGKVIIVVDDENRENEGDFVALAEYATPDVINFMASHGRG
CCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCE
LICAPLNEEIASRLELQPMVDENTDSHHTAFTVSVDHRDTKTGISAQERSLTVMSLIADH
EEEECCCHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHC
AHPGDFKRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSAPAGVICEIMNEDGTMARV
CCCCCCCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEECC
PELKKIADQHGLKMITIKDLIEYRYSKGTLINREVKITLPSEFGTFKVYGYTNEIDDKEH
CHHHHHHHHHCEEEEEHHHHHHHHCCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCE
IALVKGDIPFGDEPVLVRVHSECLTGDVFGSYRCDCGPQLAAALAQIEQAGRGVLLYLRQ
EEEEECCCCCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEE
EGRGIGLINKLKAYKLQEEGYDTVQANEKLGFLPDLRNYGIGAQILRDLGVKQMKLLTNN
CCCCCCHHHHHHHHEECCCCCCEEECCCCCCCCCCHHHCCCHHHHHHHCCHHHHHHHCCC
PRKIAGLEGYGLTIADRVPLQMETKKDNEKYLKTKKSKLGHMLHF
CCEEECCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA