Click here to switch to the map view.

The map label for this gene is pbuX [H]

Identifier: 52786091

GI number: 52786091

Start: 2293673

End: 2294989

Strand: Reverse

Name: pbuX [H]

Synonym: BLi02347

Alternate gene names: 52786091

Gene position: 2294989-2293673 (Counterclockwise)

Preceding gene: 52786092

Following gene: 52786090

Centisome position: 54.35

GC content: 49.89

Gene sequence:

>1317_bases
ATGAAACTTACAGCCGGTAAAACTGTTTCATTAAGCATTCAGCACGTCCTTGCCATGTATGCAGGAGCCGTTGTCGTACC
GCTGATCGTCGGCGGCGCTCTCGGTCTGACGCCGGCTCAGCTGACATACCTTGTATCTGCCGACATTTTGATGTGCGGTG
TGGCGACGCTGCTGCAAGTTTGGAAAAACCGCTTTTTCGGTATCGGTTTGCCTGTTGTATTGGGGTGTACGTTCACAGCC
GTTTCTCCGATGATTTCGATCGCCTCGACATATGGTATTCCAGCGATCTATGGAAGCATCATAGCAGGTGGTGTGATTGT
CGTCATCATTTCTTTTTTCTTCGGAAAGCTTGTTAAGTTTTTCCCTCCCGTGGTCACAGGATCTGTCGTCACGGTGATCG
GTATCACCTTGATTCCCGTTGCGATGAACAACATGGCCGGCGGTGAAGGCAGCAGCGATTTCGGCGAGCTGTCCAATCTT
GCTTTAGCTTTTTCCGTTTTACTAGTCATCGTCCTTTTATATCGTTTTACATCAGGATTTATCAAGTCAATTTCCATTTT
AATCGGCTTGATCGCAGGAACAGCCGGCGCCGCTCTAATGGGAAAAGTTGATTTTACAGAAGTCGCAAACGCTGGCTGGG
TGCAGATGATTCATCCGTTTTACTTCGGCGCCCCTGTTTTTGAAGTTACCCCGATCTTGACGATGTCCCTCGTGCTGATC
GTCAGCCTTGTCGAGTCCACAGGCGTCTACTTTGCATTGGGCGATTTGACGGACCGCCGCCTGACAGAAAAGGATTTAGG
AAAAGGATATCGCGCCGAAGGGATTGCCGTGCTGTTGGGCGGGGTTTTCAACGCCTTTCCTTATACGGCGTATTCGCAAA
ACGTCGGTCTCGTTCAGCTGACAGGAGTTAAGAAAAACAGCGTGATCGCGCTTGCCGGAGCTTTTCTCATTTTGTTGGGG
CTGTTTCCGAAAGCCGCTGCTTTAACGACGATCATTCCTAAACCTGTGCTCGGCGGCGCTATGGTAGCGATGTTCGGCAT
GGTGATCGCCTACGGGATCAAAATGCTGAGCAGGGTTGATTTCGGCAAGCAGGAGAACTTGTTGATCGTAGCGTGTTCAA
TCGGAATCGGCCTCGGCGTGACGGTTGTACCGCAAATGTTTCAAAACCTTCCTGACGCCGTCAAGCTTTTGACAGAGAAC
GGAATTGTTGCGGGAAGCTTTACCGCCATTCTCTTGAATGCGATCTTTCACATTCATCCGTTTTCTCGTCATGCTGAACA
GCCTGAAGCAGTTTCTGCTGAGAAATCTGCCGTTTAA

Upstream 100 bases:

>100_bases
GCAGGGAGGAACTTGAAAATCTTGGAATCAGAGTCGAATCCCTTGCGCGTATTGCCTCTCTTGCCGGTGGAAAAGTTACC
TTTTTACAGGAGGTTGGGTC

Downstream 100 bases:

>100_bases
AACCTCACGGATTGTGAGGTTTTTTTGTTGTGTTTTCTCATTGCGGATAAGCCATACTACCGGTATGAAGAGGAGGCGTA
ACGAATGGAAACTGTGAATG

Product: PbuX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKLTAGKTVSLSIQHVLAMYAGAVVVPLIVGGALGLTPAQLTYLVSADILMCGVATLLQVWKNRFFGIGLPVVLGCTFTA
VSPMISIASTYGIPAIYGSIIAGGVIVVIISFFFGKLVKFFPPVVTGSVVTVIGITLIPVAMNNMAGGEGSSDFGELSNL
ALAFSVLLVIVLLYRFTSGFIKSISILIGLIAGTAGAALMGKVDFTEVANAGWVQMIHPFYFGAPVFEVTPILTMSLVLI
VSLVESTGVYFALGDLTDRRLTEKDLGKGYRAEGIAVLLGGVFNAFPYTAYSQNVGLVQLTGVKKNSVIALAGAFLILLG
LFPKAAALTTIIPKPVLGGAMVAMFGMVIAYGIKMLSRVDFGKQENLLIVACSIGIGLGVTVVPQMFQNLPDAVKLLTEN
GIVAGSFTAILLNAIFHIHPFSRHAEQPEAVSAEKSAV

Sequences:

>Translated_438_residues
MKLTAGKTVSLSIQHVLAMYAGAVVVPLIVGGALGLTPAQLTYLVSADILMCGVATLLQVWKNRFFGIGLPVVLGCTFTA
VSPMISIASTYGIPAIYGSIIAGGVIVVIISFFFGKLVKFFPPVVTGSVVTVIGITLIPVAMNNMAGGEGSSDFGELSNL
ALAFSVLLVIVLLYRFTSGFIKSISILIGLIAGTAGAALMGKVDFTEVANAGWVQMIHPFYFGAPVFEVTPILTMSLVLI
VSLVESTGVYFALGDLTDRRLTEKDLGKGYRAEGIAVLLGGVFNAFPYTAYSQNVGLVQLTGVKKNSVIALAGAFLILLG
LFPKAAALTTIIPKPVLGGAMVAMFGMVIAYGIKMLSRVDFGKQENLLIVACSIGIGLGVTVVPQMFQNLPDAVKLLTEN
GIVAGSFTAILLNAIFHIHPFSRHAEQPEAVSAEKSAV
>Mature_438_residues
MKLTAGKTVSLSIQHVLAMYAGAVVVPLIVGGALGLTPAQLTYLVSADILMCGVATLLQVWKNRFFGIGLPVVLGCTFTA
VSPMISIASTYGIPAIYGSIIAGGVIVVIISFFFGKLVKFFPPVVTGSVVTVIGITLIPVAMNNMAGGEGSSDFGELSNL
ALAFSVLLVIVLLYRFTSGFIKSISILIGLIAGTAGAALMGKVDFTEVANAGWVQMIHPFYFGAPVFEVTPILTMSLVLI
VSLVESTGVYFALGDLTDRRLTEKDLGKGYRAEGIAVLLGGVFNAFPYTAYSQNVGLVQLTGVKKNSVIALAGAFLILLG
LFPKAAALTTIIPKPVLGGAMVAMFGMVIAYGIKMLSRVDFGKQENLLIVACSIGIGLGVTVVPQMFQNLPDAVKLLTEN
GIVAGSFTAILLNAIFHIHPFSRHAEQPEAVSAEKSAV

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=183, Percent_Identity=30.0546448087432, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI40316845, Length=183, Percent_Identity=30.0546448087432, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI44680145, Length=488, Percent_Identity=22.7459016393443, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI44680143, Length=492, Percent_Identity=22.5609756097561, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI87082181, Length=438, Percent_Identity=40.4109589041096, Blast_Score=335, Evalue=4e-93,
Organism=Escherichia coli, GI1790087, Length=428, Percent_Identity=34.1121495327103, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI87082178, Length=442, Percent_Identity=32.8054298642534, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87081818, Length=459, Percent_Identity=29.8474945533769, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1788843, Length=381, Percent_Identity=31.2335958005249, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17542262, Length=450, Percent_Identity=24.4444444444444, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17558856, Length=199, Percent_Identity=28.643216080402, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17541904, Length=409, Percent_Identity=24.2053789731051, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17542260, Length=186, Percent_Identity=26.3440860215054, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71993493, Length=197, Percent_Identity=26.3959390862944, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356175, Length=456, Percent_Identity=24.1228070175439, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45783; Mature: 45783

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHCCCCCCCCCCHHCCC
>Mature Secondary Structure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CHHCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]