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The map label for this gene is kinD [H]

Identifier: 52785286

GI number: 52785286

Start: 1494274

End: 1495785

Strand: Reverse

Name: kinD [H]

Synonym: BLi01521

Alternate gene names: 52785286

Gene position: 1495785-1494274 (Counterclockwise)

Preceding gene: 52785288

Following gene: 52785284

Centisome position: 35.42

GC content: 44.78

Gene sequence:

>1512_bases
ATGCGCAATTTGAAAAGTATATGGAAGAAAATCAGGCTTTATTTGATCTTGGTGATGATCCCCGCCTTCATTATAAGCTT
TTTTGTATACGAACAAGAACGAGAAAATATCACTGAAAAGCACCGTCAGACTGCGACTCTCATGCTCAATATTCACCGCA
ACCAAATCAATTACCTGATCGGCGAAACAGAAGCAAGGCTCAGCTCCCTTGCCACGGCCCTCAACCACCCTGTTAATGAG
CAGCATATCAAACGAATCCTGACGGAAACGTATAAAAAAGAACCGCGTTTTTCGGCTTTATACCTTTTAAATGAAGACGG
CGATGTCATGGTGAGCACGTCTCCCGCCAAAGAAAAAAAGGCGCTTTCTTACAAGAGCATTCTGCAAAAAGCGGAAAAAT
CAAAGAAATCCGTGATCACAGACGATATACATACAGTGTCGGACGGGCTGGAGCTGAATATTTTTACTCCGGTCTTTGAC
AGCGAAGGGAGAACAACAAATTTTCTGCTCGCTTCGATCCGCGTCGATTATCTGAAAAATATCATGAACGTCTTGAGCCC
TGAGCTTTATATCAAAATTCTCAATCAGAAGAATCAGATCGTCTTTACGGCAGGCCATTCTCCTCCTGAGAAGCCGGACG
GCGGTACCGTCGACGCTTTTTTGGACCAGATCGACTGGAAGCTTGAAGTCTATCCGGAACCGGTCCAGCTTGATGAAATC
GTTCACAGTCTTCTGCTGTCATTTTTGAGTATTTTCATTCTGCTGAATATTATGTTCCTCCTGCTCCAGTATGTCCTGCT
GAAGCGGCGGACCAAGCAGGAGCGCGCCCAAAATGAAGCGCAGAAGCTCGAATTAATCGGCACCTTGGCGGCGAGCACCG
CTCATGAAATCAGAAACCCGCTGACAGGCATCAGCGGCTTTATCCAGCTCCTTCAAAAAAAATATCAATCAAAAGAAGAT
CAAATGTATTTCTCAATCATCGACCAGGAAATCCGGAGGATCAACCAGATTGTCAGCGAGTTTCTCGTGCTCGGAAAGCC
GACGGCAGAGCAGTGGCAGCTCAACTCCATGAATGAAATGATTGACGAGATCATGCCGATTATTCATTCTGAGGCAAATT
TATATAATGTGGAAGTGGAATTTCAAGACTGCGGAGAAGATCCGGCTTATGTGTATTGTAAAAAGGATCATATTAAGCAG
GTTGTCTTGAACGTCGCCAAAAATGCTCTTGAATCGATGAAAAACGGCGGAAAGCTGGTCATTCAAATCGAACATGATCA
AGAGAAGGCGCAAATTATTGTGAAGGATATCGGAGAAGGCATTCCACAAGAAATGATGGAAAGTATTTTCCAGCCTTTTG
TTACATCAAAAGAAAAAGGAACCGGACTCGGCCTTGTCGTGTGCAAGCGCATCATTTCCATGTACGGGGGAACCATTCAT
ATCGAAAGCGAACGGCATAAAGGAACGACTGTAACGATTACGCTGCCGACTTCAAAGGAACAGGACGACTGA

Upstream 100 bases:

>100_bases
TGTGTCCTATTTTCACGGTATTGGTTATCTTTTCTATAAATCGGCTCTCACTAGTGATATAATACCTCTATTCCTGTATC
GATTGGGAGAGAGTAAAAAC

Downstream 100 bases:

>100_bases
GGTTTCCCCGTTCCTGTAAAAGAGCCTGCCTTCCTTACGGCAGCTCTTTTTCGTTCATCCGCTATGCCGTATATTTTTCA
ACGGGCAGACAGTCGATGCA

Product: KinD

Products: NA

Alternate protein names: Sensor histidine kinase D [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MRNLKSIWKKIRLYLILVMIPAFIISFFVYEQERENITEKHRQTATLMLNIHRNQINYLIGETEARLSSLATALNHPVNE
QHIKRILTETYKKEPRFSALYLLNEDGDVMVSTSPAKEKKALSYKSILQKAEKSKKSVITDDIHTVSDGLELNIFTPVFD
SEGRTTNFLLASIRVDYLKNIMNVLSPELYIKILNQKNQIVFTAGHSPPEKPDGGTVDAFLDQIDWKLEVYPEPVQLDEI
VHSLLLSFLSIFILLNIMFLLLQYVLLKRRTKQERAQNEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYQSKED
QMYFSIIDQEIRRINQIVSEFLVLGKPTAEQWQLNSMNEMIDEIMPIIHSEANLYNVEVEFQDCGEDPAYVYCKKDHIKQ
VVLNVAKNALESMKNGGKLVIQIEHDQEKAQIIVKDIGEGIPQEMMESIFQPFVTSKEKGTGLGLVVCKRIISMYGGTIH
IESERHKGTTVTITLPTSKEQDD

Sequences:

>Translated_503_residues
MRNLKSIWKKIRLYLILVMIPAFIISFFVYEQERENITEKHRQTATLMLNIHRNQINYLIGETEARLSSLATALNHPVNE
QHIKRILTETYKKEPRFSALYLLNEDGDVMVSTSPAKEKKALSYKSILQKAEKSKKSVITDDIHTVSDGLELNIFTPVFD
SEGRTTNFLLASIRVDYLKNIMNVLSPELYIKILNQKNQIVFTAGHSPPEKPDGGTVDAFLDQIDWKLEVYPEPVQLDEI
VHSLLLSFLSIFILLNIMFLLLQYVLLKRRTKQERAQNEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYQSKED
QMYFSIIDQEIRRINQIVSEFLVLGKPTAEQWQLNSMNEMIDEIMPIIHSEANLYNVEVEFQDCGEDPAYVYCKKDHIKQ
VVLNVAKNALESMKNGGKLVIQIEHDQEKAQIIVKDIGEGIPQEMMESIFQPFVTSKEKGTGLGLVVCKRIISMYGGTIH
IESERHKGTTVTITLPTSKEQDD
>Mature_503_residues
MRNLKSIWKKIRLYLILVMIPAFIISFFVYEQERENITEKHRQTATLMLNIHRNQINYLIGETEARLSSLATALNHPVNE
QHIKRILTETYKKEPRFSALYLLNEDGDVMVSTSPAKEKKALSYKSILQKAEKSKKSVITDDIHTVSDGLELNIFTPVFD
SEGRTTNFLLASIRVDYLKNIMNVLSPELYIKILNQKNQIVFTAGHSPPEKPDGGTVDAFLDQIDWKLEVYPEPVQLDEI
VHSLLLSFLSIFILLNIMFLLLQYVLLKRRTKQERAQNEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYQSKED
QMYFSIIDQEIRRINQIVSEFLVLGKPTAEQWQLNSMNEMIDEIMPIIHSEANLYNVEVEFQDCGEDPAYVYCKKDHIKQ
VVLNVAKNALESMKNGGKLVIQIEHDQEKAQIIVKDIGEGIPQEMMESIFQPFVTSKEKGTGLGLVVCKRIISMYGGTIH
IESERHKGTTVTITLPTSKEQDD

Specific function: Phosphorylates the sporulation-regulatory protein spo0F and, to a minor extent, is responsible for heterogeneous expression of spo0A during logarithmical growth. Also phosphorylates spo0A under biofilm growth conditions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=32.2033898305085, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1790436, Length=261, Percent_Identity=30.2681992337165, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=28.1632653061224, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790300, Length=248, Percent_Identity=27.4193548387097, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=24.0343347639485, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=24.5967741935484, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=28.125, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87081816, Length=244, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786783, Length=222, Percent_Identity=28.8288288288288, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=215, Percent_Identity=26.5116279069767, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786912, Length=255, Percent_Identity=23.5294117647059, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790346, Length=228, Percent_Identity=25.8771929824561, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=22.6851851851852, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57581; Mature: 57581

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNLKSIWKKIRLYLILVMIPAFIISFFVYEQERENITEKHRQTATLMLNIHRNQINYLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHC
GETEARLSSLATALNHPVNEQHIKRILTETYKKEPRFSALYLLNEDGDVMVSTSPAKEKK
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCHHHH
ALSYKSILQKAEKSKKSVITDDIHTVSDGLELNIFTPVFDSEGRTTNFLLASIRVDYLKN
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECEECCCCCCHHHHHHHHHHHHHHH
IMNVLSPELYIKILNQKNQIVFTAGHSPPEKPDGGTVDAFLDQIDWKLEVYPEPVQLDEI
HHHHHCHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCHHHH
VHSLLLSFLSIFILLNIMFLLLQYVLLKRRTKQERAQNEAQKLELIGTLAASTAHEIRNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGISGFIQLLQKKYQSKEDQMYFSIIDQEIRRINQIVSEFLVLGKPTAEQWQLNSMNEM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IDEIMPIIHSEANLYNVEVEFQDCGEDPAYVYCKKDHIKQVVLNVAKNALESMKNGGKLV
HHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCEEE
IQIEHDQEKAQIIVKDIGEGIPQEMMESIFQPFVTSKEKGTGLGLVVCKRIISMYGGTIH
EEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEE
IESERHKGTTVTITLPTSKEQDD
EECCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MRNLKSIWKKIRLYLILVMIPAFIISFFVYEQERENITEKHRQTATLMLNIHRNQINYLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHC
GETEARLSSLATALNHPVNEQHIKRILTETYKKEPRFSALYLLNEDGDVMVSTSPAKEKK
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCHHHH
ALSYKSILQKAEKSKKSVITDDIHTVSDGLELNIFTPVFDSEGRTTNFLLASIRVDYLKN
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECEECCCCCCHHHHHHHHHHHHHHH
IMNVLSPELYIKILNQKNQIVFTAGHSPPEKPDGGTVDAFLDQIDWKLEVYPEPVQLDEI
HHHHHCHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCHHHH
VHSLLLSFLSIFILLNIMFLLLQYVLLKRRTKQERAQNEAQKLELIGTLAASTAHEIRNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGISGFIQLLQKKYQSKEDQMYFSIIDQEIRRINQIVSEFLVLGKPTAEQWQLNSMNEM
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IDEIMPIIHSEANLYNVEVEFQDCGEDPAYVYCKKDHIKQVVLNVAKNALESMKNGGKLV
HHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCEEE
IQIEHDQEKAQIIVKDIGEGIPQEMMESIFQPFVTSKEKGTGLGLVVCKRIISMYGGTIH
EEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEE
IESERHKGTTVTITLPTSKEQDD
EECCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]