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The map label for this gene is ytcB [H]

Identifier: 52784603

GI number: 52784603

Start: 820145

End: 821119

Strand: Reverse

Name: ytcB [H]

Synonym: BLi00804

Alternate gene names: 52784603

Gene position: 821119-820145 (Counterclockwise)

Preceding gene: 52784604

Following gene: 52784602

Centisome position: 19.45

GC content: 48.1

Gene sequence:

>975_bases
ATGAGCGATATGACAGAGTTATCCGGCCAGCATATTTTCATAACTGGCGGAGCAGGCTTTATCGGATCCTCTTTAATAGG
AAAGCTGATAGAGCGCAACAGCGTCACCGTATATGACAATTTTTCAAGAGACTCCCTCCGGTATAAGCCTTACCGGGACC
ATCCTCACTTGAAAGTGCTGCAGGGAGACATTTTGGATTTGAACGCGCTTAAAAAGGCGATCCAGGGGGCCAGCCACATT
GTCCACGCCGCCGGCATCGCTGGGATTGACACGGTCATTCAAAACCCGGTTAAAACGATGCAGGTCAACATGATCGGTTC
AGCCAATCTGCTTGAAGCGGCTGCCGGTTTAACCGAATGCAAAAGGGTTGTCTGTTTCAGTACAAGCGAAGTGTTCGGCC
AAATCGCTTTCAGAGCGCGCGAGACCAGTCATACTGTTTTAGGAGCGGTGGGAGAAGCCCGCTGGACATATGCTGTCAGC
AAACTCGCCGAGGAGCATATGGCATATGCCTATTTTAAAGAACTTGGGCTTCCGACCGTCACCGTCCGCCCTTTTAATGT
TTATGGACCGGAACAAGTCGGCGAAGGCGCCATCAAAACGATGGTTCACAGAGCTCTGTTAGATGAGCCGATCTATATTC
ACGGCGATGGAACGCAAATCCGGGCCTGGTGTTACGTAGATGACATGATCGACGGAATTTTGCGTTGTTTGACGATGAAG
GAAGCCATCGGAGAGTCTTTCAACATCGGCAATGAACGCACTGTGATCACCGTATACGGATTGGCAAGCACGATTATCAG
AGTTCTCGGATCAAAATCACAAATCTTCTTTGGGGAGAAAAAAGAAGCCGATATTGAACTGCGCATCCCTCAGGTCAATA
AAGCAAAAGAGATGCTCGGTTTCAGCGCTAAAGTTGATCTGGAAGAAGGCATCAGAAGAACAGCTGAAAGCATTAAAAAA
AATTTGGATCAATAA

Upstream 100 bases:

>100_bases
TTGGCTGTTTATCAGTCGCTACTTTCGGAATGAAGTTGAACAACTTTCCCGTCGCGGGATTTGTATGTAAAAAAAAACGA
AACAAGCAGGTGAACAATTG

Downstream 100 bases:

>100_bases
GAAAGGAGGCGCTATTGTTGAAACAATGGAAAAGCGAAGGAAAAGGTGAATTCACTCTTTCCCAGCTTGGGGGCTGTGGC
GAAAATGTCGTTATCGAAGA

Product: YtcB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSDMTELSGQHIFITGGAGFIGSSLIGKLIERNSVTVYDNFSRDSLRYKPYRDHPHLKVLQGDILDLNALKKAIQGASHI
VHAAGIAGIDTVIQNPVKTMQVNMIGSANLLEAAAGLTECKRVVCFSTSEVFGQIAFRARETSHTVLGAVGEARWTYAVS
KLAEEHMAYAYFKELGLPTVTVRPFNVYGPEQVGEGAIKTMVHRALLDEPIYIHGDGTQIRAWCYVDDMIDGILRCLTMK
EAIGESFNIGNERTVITVYGLASTIIRVLGSKSQIFFGEKKEADIELRIPQVNKAKEMLGFSAKVDLEEGIRRTAESIKK
NLDQ

Sequences:

>Translated_324_residues
MSDMTELSGQHIFITGGAGFIGSSLIGKLIERNSVTVYDNFSRDSLRYKPYRDHPHLKVLQGDILDLNALKKAIQGASHI
VHAAGIAGIDTVIQNPVKTMQVNMIGSANLLEAAAGLTECKRVVCFSTSEVFGQIAFRARETSHTVLGAVGEARWTYAVS
KLAEEHMAYAYFKELGLPTVTVRPFNVYGPEQVGEGAIKTMVHRALLDEPIYIHGDGTQIRAWCYVDDMIDGILRCLTMK
EAIGESFNIGNERTVITVYGLASTIIRVLGSKSQIFFGEKKEADIELRIPQVNKAKEMLGFSAKVDLEEGIRRTAESIKK
NLDQ
>Mature_323_residues
SDMTELSGQHIFITGGAGFIGSSLIGKLIERNSVTVYDNFSRDSLRYKPYRDHPHLKVLQGDILDLNALKKAIQGASHIV
HAAGIAGIDTVIQNPVKTMQVNMIGSANLLEAAAGLTECKRVVCFSTSEVFGQIAFRARETSHTVLGAVGEARWTYAVSK
LAEEHMAYAYFKELGLPTVTVRPFNVYGPEQVGEGAIKTMVHRALLDEPIYIHGDGTQIRAWCYVDDMIDGILRCLTMKE
AIGESFNIGNERTVITVYGLASTIIRVLGSKSQIFFGEKKEADIELRIPQVNKAKEMLGFSAKVDLEEGIRRTAESIKKN
LDQ

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=326, Percent_Identity=31.9018404907975, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI7657641, Length=333, Percent_Identity=27.027027027027, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI48994969, Length=336, Percent_Identity=28.8690476190476, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788353, Length=339, Percent_Identity=28.6135693215339, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788589, Length=349, Percent_Identity=25.214899713467, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1788365, Length=335, Percent_Identity=22.6865671641791, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17539532, Length=329, Percent_Identity=30.3951367781155, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17568069, Length=322, Percent_Identity=27.0186335403727, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI115532424, Length=334, Percent_Identity=24.251497005988, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21356223, Length=318, Percent_Identity=31.4465408805031, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 35668; Mature: 35536

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMTELSGQHIFITGGAGFIGSSLIGKLIERNSVTVYDNFSRDSLRYKPYRDHPHLKVL
CCCCHHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEE
QGDILDLNALKKAIQGASHIVHAAGIAGIDTVIQNPVKTMQVNMIGSANLLEAAAGLTEC
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCHHHHHHHCHHHH
KRVVCFSTSEVFGQIAFRARETSHTVLGAVGEARWTYAVSKLAEEHMAYAYFKELGLPTV
HHHHEECCHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
TVRPFNVYGPEQVGEGAIKTMVHRALLDEPIYIHGDGTQIRAWCYVDDMIDGILRCLTMK
EEEECCCCCHHHHCCHHHHHHHHHHHHCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHH
EAIGESFNIGNERTVITVYGLASTIIRVLGSKSQIFFGEKKEADIELRIPQVNKAKEMLG
HHHCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCHHHHHHHC
FSAKVDLEEGIRRTAESIKKNLDQ
CCCEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDMTELSGQHIFITGGAGFIGSSLIGKLIERNSVTVYDNFSRDSLRYKPYRDHPHLKVL
CCCHHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEE
QGDILDLNALKKAIQGASHIVHAAGIAGIDTVIQNPVKTMQVNMIGSANLLEAAAGLTEC
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCHHHHHHHCHHHH
KRVVCFSTSEVFGQIAFRARETSHTVLGAVGEARWTYAVSKLAEEHMAYAYFKELGLPTV
HHHHEECCHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
TVRPFNVYGPEQVGEGAIKTMVHRALLDEPIYIHGDGTQIRAWCYVDDMIDGILRCLTMK
EEEECCCCCHHHHCCHHHHHHHHHHHHCCCEEEECCCCEEEEEEEHHHHHHHHHHHHHHH
EAIGESFNIGNERTVITVYGLASTIIRVLGSKSQIFFGEKKEADIELRIPQVNKAKEMLG
HHHCCCCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEECCCCCCCEEEECCCCHHHHHHHC
FSAKVDLEEGIRRTAESIKKNLDQ
CCCEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]