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The map label for this gene is hprT [H]

Identifier: 52783925

GI number: 52783925

Start: 80938

End: 81477

Strand: Direct

Name: hprT [H]

Synonym: BLi00084

Alternate gene names: 52783925

Gene position: 80938-81477 (Clockwise)

Preceding gene: 52783924

Following gene: 52783926

Centisome position: 1.92

GC content: 44.26

Gene sequence:

>540_bases
ATGAAACAGGATATTGAAAATATCTTGATCTCGGAAGAAGAGATCCAAAAGAAAGTCAAGGAGCTGGGCGCGACTCTGAC
AGAAGAGTACAGCGGCAAGTTTCCGCTGGCAATCGGTGTGTTAAAAGGAGCCATGCCGTTTATGGCTGATCTTTTAAAGC
ATATTGATACATATCTGGAAATGGATTTCATGGATGTATCAAGCTACGGCAGTTCCACGGTTTCTTCCGGAGAGGTGAAA
ATCATAAAGGATTTGGACACATCTGTAGAGGGCCGTGACATCTTAATTATTGAGGATATCATCGACAGTGGGCTGACCTT
GAGTTATCTTGTAGAGCTTTTCCGATACCGCAAAGCAAAATCGATTAAGATCGTAACCCTTCTTGATAAACCAAGCGGAC
GAAAAGCGGATATCAAAGCGGATTACGTCGGCTTTGAAGTTCCCGATGCTTTCGTTGTCGGATACGGTCTCGATTATGCT
GAACGCTATCGTAATCTTCCGTACATCGGAGTGCTGAAACCTGCGGTTTATGAGAGCTGA

Upstream 100 bases:

>100_bases
GGTCTGAAAAAAACCATTTTTGAGGAACTTGATGTTACAAACAACGATCGCATTGTATTACAATATAGACAGCATGAAAA
GTGTAGGGGGCTAGCAAAGA

Downstream 100 bases:

>100_bases
TACGGGCTTGTCAGCGAAAGGGATATCTGTTGTATTGGAACGATTTTCTATGATACTATTGAACATAGTTGTGCTTACTG
TGGGAGGAGGTAAGGAATGA

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MKQDIENILISEEEIQKKVKELGATLTEEYSGKFPLAIGVLKGAMPFMADLLKHIDTYLEMDFMDVSSYGSSTVSSGEVK
IIKDLDTSVEGRDILIIEDIIDSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADYVGFEVPDAFVVGYGLDYA
ERYRNLPYIGVLKPAVYES

Sequences:

>Translated_179_residues
MKQDIENILISEEEIQKKVKELGATLTEEYSGKFPLAIGVLKGAMPFMADLLKHIDTYLEMDFMDVSSYGSSTVSSGEVK
IIKDLDTSVEGRDILIIEDIIDSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADYVGFEVPDAFVVGYGLDYA
ERYRNLPYIGVLKPAVYES
>Mature_179_residues
MKQDIENILISEEEIQKKVKELGATLTEEYSGKFPLAIGVLKGAMPFMADLLKHIDTYLEMDFMDVSSYGSSTVSSGEVK
IIKDLDTSVEGRDILIIEDIIDSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADYVGFEVPDAFVVGYGLDYA
ERYRNLPYIGVLKPAVYES

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=180, Percent_Identity=36.6666666666667, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI9910262, Length=180, Percent_Identity=33.8888888888889, Blast_Score=100, Evalue=8e-22,
Organism=Escherichia coli, GI87081689, Length=172, Percent_Identity=50.5813953488372, Blast_Score=179, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17510817, Length=184, Percent_Identity=31.5217391304348, Blast_Score=98, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20048; Mature: 20048

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDIENILISEEEIQKKVKELGATLTEEYSGKFPLAIGVLKGAMPFMADLLKHIDTYLE
CCCCHHHHHCCHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
MDFMDVSSYGSSTVSSGEVKIIKDLDTSVEGRDILIIEDIIDSGLTLSYLVELFRYRKAK
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCC
SIKIVTLLDKPSGRKADIKADYVGFEVPDAFVVGYGLDYAERYRNLPYIGVLKPAVYES
CEEEEEEEECCCCCCCCCEECCCCCCCCCCEEEECCCCHHHHHCCCCEEEEECHHHCCC
>Mature Secondary Structure
MKQDIENILISEEEIQKKVKELGATLTEEYSGKFPLAIGVLKGAMPFMADLLKHIDTYLE
CCCCHHHHHCCHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
MDFMDVSSYGSSTVSSGEVKIIKDLDTSVEGRDILIIEDIIDSGLTLSYLVELFRYRKAK
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCC
SIKIVTLLDKPSGRKADIKADYVGFEVPDAFVVGYGLDYAERYRNLPYIGVLKPAVYES
CEEEEEEEECCCCCCCCCEECCCCCCCCCCEEEECCCCHHHHHCCCCEEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]