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The map label for this gene is lrgB

Identifier: 52145246

GI number: 52145246

Start: 5248897

End: 5249589

Strand: Reverse

Name: lrgB

Synonym: BCZK5135

Alternate gene names: 52145246

Gene position: 5249589-5248897 (Counterclockwise)

Preceding gene: 52145247

Following gene: 52145245

Centisome position: 99.03

GC content: 37.52

Gene sequence:

>693_bases
ATGGCAAGCACAATGACTCCATATTTCGGAATCGTCGTTTCATTAATCGCATACGGAATCGGAACATTATTGTTTAAGCA
TTCAAAAGGCTTCTTCTTATTTACACCGTTATTCGTAGCAATGGTTTTAGGGATTGTCTTTCTAAAGGTAGGTAACTTCA
CTTTTGAAGAGTATAATACTGGCGGAAAAATGATTAGCTTCTTCTTAGAACCAGCAACTATCGCCTTTGCAATTCCATTA
TATAAACAAGTGGATAAGTTAAAAAAATATTGGTGGCAAATTTTATCAGCTATCGTAGTTGGATCTATTTGCTCAGTAAT
TGTCGTATTCATTGTTGCAAAAGCAATTGGTCTAGATACAGCAGTAATGAATTCAATGTTACCACAAGCAGCAACAACAG
CAATTGCGTTACCAATCTCTGAAAGCATTGGTGGTATACCAGCAATTACATCGTTTGCAGTAATCTTTAACGCAGTTATT
GTATACGCATTAGGAGCATTATTCTTAAAGACATTTAGAGTGAAACATCCAATTGCAAAAGGTTTAGCACTTGGAACAGC
GGGTCACGCATTAGGAGTGGCAGTAGGAATTGAAATGGGTGAAGTAGAGGCAGCTATGGCAAGTATTGCTGTAACGGTAG
TTGGGGTTGTAACTGTAGTTGTCATACCGATGTTTATGCCGTTTATTGGATAG

Upstream 100 bases:

>100_bases
GAAACAGAGGATACAAAAGAATTGAAAGTAGTAAATAAAGGGCGCAAGCACGGAAAAGTTGCGTAACCATTGTAGTATAT
ATTGTTAGGAGGTAATGGAC

Downstream 100 bases:

>100_bases
GAAAACTTACTTAAAAAAATGAGAAAAGCAAGCTATTTGTAGGACAGATTTCTACTGATAGCTTGCTTTTTATGTTACAG
TAGTGGTAAGACCTCTTTTA

Product: antiholin-like protein LrgB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNTGGKMISFFLEPATIAFAIPL
YKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVI
VYALGALFLKTFRVKHPIAKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG

Sequences:

>Translated_230_residues
MASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNTGGKMISFFLEPATIAFAIPL
YKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVI
VYALGALFLKTFRVKHPIAKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG
>Mature_229_residues
ASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNTGGKMISFFLEPATIAFAIPLY
KQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVIV
YALGALFLKTFRVKHPIAKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell

COG id: COG1346

COG function: function code M; Putative effector of murein hydrolase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidB/LrgB family. LrgB subfamily

Homologues:

Organism=Escherichia coli, GI1788464, Length=199, Percent_Identity=36.1809045226131, Blast_Score=136, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LRGB_BACAA (C3P2J6)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002869649.1
- EnsemblBacteria:   EBBACT00000128130
- GeneID:   7851542
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_5719
- GeneTree:   EBGT00050000000862
- ProtClustDB:   PRK04288
- GO:   GO:0019835
- HAMAP:   MF_01142
- InterPro:   IPR007300

Pfam domain/function: PF04172 LrgB

EC number: NA

Molecular weight: Translated: 24350; Mature: 24219

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1c1e031c)-; HASH(0x1bda1698)-; HASH(0x1c57570c)-; HASH(0x1c842cfc)-; HASH(0x1b6c10d4)-; HASH(0x1bb99d28)-; HASH(0x1c607d80)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEHHHHCC
GGKMISFFLEPATIAFAIPLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDT
CHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVIVYALGALFLKTFRVKHPIAK
HHHHHHCCHHHHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG
HHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
ASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNT
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEHHHHCC
GGKMISFFLEPATIAFAIPLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDT
CHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVIVYALGALFLKTFRVKHPIAK
HHHHHHCCHHHHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG
HHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA