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The map label for this gene is msrA [H]

Identifier: 52145244

GI number: 52145244

Start: 5246469

End: 5247434

Strand: Reverse

Name: msrA [H]

Synonym: BCZK5132

Alternate gene names: 52145244

Gene position: 5247434-5246469 (Counterclockwise)

Preceding gene: 52145245

Following gene: 52145242

Centisome position: 98.99

GC content: 37.58

Gene sequence:

>966_bases
ATGGTTGTAAATGAAAAGGTAGAGTTAGCTACATTTGCTGGAGGATGCTTCTGGTGTATGGTTTCGCCATTTGAAGAGAT
GGAAGGAATTATAAAGGTTGTTTCTGGCTATACAGGTGGTCATAAAGAGAATCCAACATATAAAGAAGTATGTTCAGAAA
CGACGGGACATTATGAGGCAGTACAAATTACATTTGATGCAAATAAAATGCCGTATGAGGAGTTATTAAATATATATTGG
AGACAAATTGATCCGACTGATGTAGGCGGGCAATTCCACGATCGCGGACAGTCTTACGAAACAGTGATTTTTTATCATAA
TGAAGAACAACATAAAAAAGCAGAGGCTTCAAAAGAAGAGCTTGCAAAGAGCGAACGCTTTTCAAAGCCGATTGCGACAA
AAATATTGCCAGCTGCTACGTTTTATCCGGCTGAAGAATATCACCAAGGATATCATAAGAAAAACACATTCCGCTACGAG
TTATACCGTAAGGGCTCAGGGCGAGATGCATTTATTAAGCAACATTGGCCAAAGGATAATGCTCATTTAAAAGAAAAACT
GAATGAGATGCAATTTTATGTAACACAGGAAAATGGTACAGAACCACCATTTCGAAATGAGTATTGGAATCATAAAGAAG
AAGGTCTTTATGTAGATATCGTTTCAGGTGAACCGTTATTTACTTCTATAGATAAATTTGATAGTGGATGTGGTTGGCCT
AGTTTTACGAAGCCGGTTATGTCAGCAAGTGTGAAAGAAAAAATGGATGTGAGTCATAATATGACGCGTACAGAAGTGAG
AAGTAAGGAAGGAGATTCACATCTCGGGCACGTATTTCCAGATGGTCCAGGACCGAATGGACTTCGTTATTGTATAAATT
CAGCAGCTCTTCGATTTATTCCAAAAGAGGAATTAGAAAAAGAAGGCTATGGTGATTTCCTAATGTTGTTTGGAAATAAA
AAATAA

Upstream 100 bases:

>100_bases
GCGAAGAAAAGAAAAAGCATCGATGTTCGATGCTTTTTCTTTTATAACATGATGTTTCTTATGCCATACTGTAAGGAGAA
GATAGAATAGGGGTGAAGTA

Downstream 100 bases:

>100_bases
CCTCGCAGTTAGCGAGGTTATTTTTTTGTTATTTTGCTTTTTTCTTTTTGAACTTGCTTAATACTTCATAAACGATTGGA
ACAATAAGAAGTGTTAATAA

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MVVNEKVELATFAGGCFWCMVSPFEEMEGIIKVVSGYTGGHKENPTYKEVCSETTGHYEAVQITFDANKMPYEELLNIYW
RQIDPTDVGGQFHDRGQSYETVIFYHNEEQHKKAEASKEELAKSERFSKPIATKILPAATFYPAEEYHQGYHKKNTFRYE
LYRKGSGRDAFIKQHWPKDNAHLKEKLNEMQFYVTQENGTEPPFRNEYWNHKEEGLYVDIVSGEPLFTSIDKFDSGCGWP
SFTKPVMSASVKEKMDVSHNMTRTEVRSKEGDSHLGHVFPDGPGPNGLRYCINSAALRFIPKEELEKEGYGDFLMLFGNK
K

Sequences:

>Translated_321_residues
MVVNEKVELATFAGGCFWCMVSPFEEMEGIIKVVSGYTGGHKENPTYKEVCSETTGHYEAVQITFDANKMPYEELLNIYW
RQIDPTDVGGQFHDRGQSYETVIFYHNEEQHKKAEASKEELAKSERFSKPIATKILPAATFYPAEEYHQGYHKKNTFRYE
LYRKGSGRDAFIKQHWPKDNAHLKEKLNEMQFYVTQENGTEPPFRNEYWNHKEEGLYVDIVSGEPLFTSIDKFDSGCGWP
SFTKPVMSASVKEKMDVSHNMTRTEVRSKEGDSHLGHVFPDGPGPNGLRYCINSAALRFIPKEELEKEGYGDFLMLFGNK
K
>Mature_321_residues
MVVNEKVELATFAGGCFWCMVSPFEEMEGIIKVVSGYTGGHKENPTYKEVCSETTGHYEAVQITFDANKMPYEELLNIYW
RQIDPTDVGGQFHDRGQSYETVIFYHNEEQHKKAEASKEELAKSERFSKPIATKILPAATFYPAEEYHQGYHKKNTFRYE
LYRKGSGRDAFIKQHWPKDNAHLKEKLNEMQFYVTQENGTEPPFRNEYWNHKEEGLYVDIVSGEPLFTSIDKFDSGCGWP
SFTKPVMSASVKEKMDVSHNMTRTEVRSKEGDSHLGHVFPDGPGPNGLRYCINSAALRFIPKEELEKEGYGDFLMLFGNK
K

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI117606353, Length=134, Percent_Identity=47.7611940298507, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI301336164, Length=122, Percent_Identity=49.1803278688525, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI301336162, Length=122, Percent_Identity=49.1803278688525, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI73089054, Length=122, Percent_Identity=49.1803278688525, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI37620216, Length=121, Percent_Identity=49.5867768595041, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI6912516, Length=153, Percent_Identity=41.8300653594771, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=41.8300653594771, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI208609993, Length=105, Percent_Identity=40.9523809523809, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788077, Length=125, Percent_Identity=54.4, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1790665, Length=156, Percent_Identity=40.3846153846154, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17553450, Length=131, Percent_Identity=45.0381679389313, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI115532676, Length=131, Percent_Identity=45.0381679389313, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=35.1724137931034, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=33.5443037974684, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319816, Length=147, Percent_Identity=30.6122448979592, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221378664, Length=119, Percent_Identity=47.0588235294118, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553335, Length=119, Percent_Identity=47.0588235294118, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356369, Length=119, Percent_Identity=47.0588235294118, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645799, Length=119, Percent_Identity=47.0588235294118, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221378662, Length=126, Percent_Identity=43.6507936507937, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24645801, Length=130, Percent_Identity=43.0769230769231, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24645804, Length=130, Percent_Identity=43.0769230769231, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24664627, Length=155, Percent_Identity=34.1935483870968, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=155, Percent_Identity=33.5483870967742, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI45553131, Length=143, Percent_Identity=33.5664335664336, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 36939; Mature: 36939

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVNEKVELATFAGGCFWCMVSPFEEMEGIIKVVSGYTGGHKENPTYKEVCSETTGHYEA
CCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEE
VQITFDANKMPYEELLNIYWRQIDPTDVGGQFHDRGQSYETVIFYHNEEQHKKAEASKEE
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEEECCHHHHHHHHHHHH
LAKSERFSKPIATKILPAATFYPAEEYHQGYHKKNTFRYELYRKGSGRDAFIKQHWPKDN
HHHHHHHCCCHHHHHCCCHHCCCHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHCCCCCC
AHLKEKLNEMQFYVTQENGTEPPFRNEYWNHKEEGLYVDIVSGEPLFTSIDKFDSGCGWP
HHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCC
SFTKPVMSASVKEKMDVSHNMTRTEVRSKEGDSHLGHVFPDGPGPNGLRYCINSAALRFI
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
PKEELEKEGYGDFLMLFGNKK
CHHHHHHCCCCCEEEEECCCC
>Mature Secondary Structure
MVVNEKVELATFAGGCFWCMVSPFEEMEGIIKVVSGYTGGHKENPTYKEVCSETTGHYEA
CCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEE
VQITFDANKMPYEELLNIYWRQIDPTDVGGQFHDRGQSYETVIFYHNEEQHKKAEASKEE
EEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEEECCHHHHHHHHHHHH
LAKSERFSKPIATKILPAATFYPAEEYHQGYHKKNTFRYELYRKGSGRDAFIKQHWPKDN
HHHHHHHCCCHHHHHCCCHHCCCHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHCCCCCC
AHLKEKLNEMQFYVTQENGTEPPFRNEYWNHKEEGLYVDIVSGEPLFTSIDKFDSGCGWP
HHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCCC
SFTKPVMSASVKEKMDVSHNMTRTEVRSKEGDSHLGHVFPDGPGPNGLRYCINSAALRFI
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
PKEELEKEGYGDFLMLFGNKK
CHHHHHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]