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The map label for this gene is pepD [H]

Identifier: 52143001

GI number: 52143001

Start: 2367195

End: 2368664

Strand: Direct

Name: pepD [H]

Synonym: BCZK2240

Alternate gene names: 52143001

Gene position: 2367195-2368664 (Clockwise)

Preceding gene: 52143000

Following gene: 52142996

Centisome position: 44.66

GC content: 33.61

Gene sequence:

>1470_bases
ATGTATTCTACTTTAGAACAATTAACAAAGCACCCTGTATTTTATCATTTTGCAGAAATTTCAAAGATTCCTAGAGGATC
AGGTAATGAAAAAGAAATTAGTGATTTTTTAGTTGGCTTTGCGAAAGAGCGTAATTTAGAAGTGATTCAAGATGAAGCAT
TAAATGTCATTATTAAAAAAGAAGCAACTGCTGGTTATGAAAATGTACCAGCTATTATTATTCAAGGTCATATGGATATG
GTTTGCGAAAAAAATCAAGCAACCGTACATGATTTTGATAAAGATCCAATTGAATTACGAATTATTGGGGACATGTTATA
TGCAAATCAAACAACTTTAGGGGCTGATAATGGTATTGCAGTTGCATATGCATTAGCTTTATTAGATTCAAAAGACATTC
CGCATCCAGCACTAGAAGTAGTTATTACTACTGAAGAAGAAACGACAATGGGCGGAGCTTTCGCTGTTGATTCAAATCAT
TTTGATGGAAAGATTTTTATTAATATTGATTCTGAAGAAGATCATAAATTACTTGTAAGTAGCGCAGGTGGTGCAAAAGC
TGTTGAAACGATTCCAGTAATTTGGGATGAAGCACCAGCGAATATGGATGCATACCGTTTATATGTTGGCGGTCTAAAAG
GCGGACATTCTGGTATGGAAATTGATAAACAACGTGGTAATGCGAACAAAGTATTAGGACGAGTATTACATGATTTATCA
GTAAATATTCAATTTGATATAAGTGAAGTTCACGGTGGATTAAAAACGAATGCAATTCCGCGTGAAAGTGTAGCTACAAT
TTTATTACGTCAAGAAGATGTAGAGAAGGTAGAAGAAAAGTTAGAATCATGGACACGAGTATTACAAGAAGAAATGCGTG
CTGTTGATCCAGATGGTCATGTTACACTTACAAAATTGGATGAGAAAGTAGAAAAAGTATTCGCTAAAGAAACACAAAAG
CAACTTATTTCATCATTATTCTTAATTCCAAATGGCATTCAAAGTATGAGCATGGATATTAAAGGTCTAGTAGAAAGCTC
AACAAATTTAGGTGTTATTGAAACGTTGCAAGATGAAATTAAATTACGTAACGAAGTGAGAAGTTCTGTAAGTAGTTTAA
AACAACATATTGCAGATGAGATTAAATGTATTGCGGAATTAGTTGGCGCAACATTTGAAATAGAGTCAGAGTATCCAGAA
TGGCCATACAATCCGAATTCACAAATTCGTAATTTATTTGAAAAAGTACATCAAGAAAAATACAATAAAGATGTTGAAAT
CTTCGCTGTACACGCTGGGATTGAATGCAGTGTATTCGTTCAAAAGATGCCTGAATTAGATGCAATTTCATTCGGTCCAG
ATATATTCAATGTCCATACTCCAGATGAACATATTAGTATTTCTTCTGTTGTGAATAACTGGGGATTCTTCGTTGATGTA
ATGAAAGGTACGAAAGAATTAGCTAAGTAA

Upstream 100 bases:

>100_bases
AGCGGATATTAAAGTATGAAATAGAAAGTGAAAATAATGAATCATGGTATAATGATAAAAGACTTACATATTATTTTGTT
ATTTTGAGAGGAGCTTAAAA

Downstream 100 bases:

>100_bases
TAATGATGAAATGAAAAATAGCCTATAAAACTTTATAGGCTATTTTTTTGTATAGAGTTTTATTAGAAATTCGTTTTTAT
GTAAGTATTTAATTTTTGCT

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKKEATAGYENVPAIIIQGHMDM
VCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIAVAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNH
FDGKIFINIDSEEDHKLLVSSAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
VNIQFDISEVHGGLKTNAIPRESVATILLRQEDVEKVEEKLESWTRVLQEEMRAVDPDGHVTLTKLDEKVEKVFAKETQK
QLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEIKLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPE
WPYNPNSQIRNLFEKVHQEKYNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
MKGTKELAK

Sequences:

>Translated_489_residues
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKKEATAGYENVPAIIIQGHMDM
VCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIAVAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNH
FDGKIFINIDSEEDHKLLVSSAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
VNIQFDISEVHGGLKTNAIPRESVATILLRQEDVEKVEEKLESWTRVLQEEMRAVDPDGHVTLTKLDEKVEKVFAKETQK
QLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEIKLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPE
WPYNPNSQIRNLFEKVHQEKYNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
MKGTKELAK
>Mature_489_residues
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKKEATAGYENVPAIIIQGHMDM
VCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIAVAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNH
FDGKIFINIDSEEDHKLLVSSAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
VNIQFDISEVHGGLKTNAIPRESVATILLRQEDVEKVEEKLESWTRVLQEEMRAVDPDGHVTLTKLDEKVEKVFAKETQK
QLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEIKLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPE
WPYNPNSQIRNLFEKVHQEKYNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
MKGTKELAK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=480, Percent_Identity=36.4583333333333, Blast_Score=329, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 54445; Mature: 54445

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKK
CCCHHHHHHCCCHHEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCHHEEEEEE
EATAGYENVPAIIIQGHMDMVCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIA
CCCCCCCCCCEEEEECCHHHEECCCCCEEECCCCCCEEEEEEEHHHHCCCCCCCCCCCHH
VAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNHFDGKIFINIDSEEDHKLLVS
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCEEEEEECCCCCCEEEEE
SAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
CCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCEEHHCCCCHHHHHHHHHHHCE
VNIQFDISEVHGGLKTNAIPRESVATILLRQEDVEKVEEKLESWTRVLQEEMRAVDPDGH
EEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VTLTKLDEKVEKVFAKETQKQLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPEWPYNPNSQIRNLFEKVHQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
YNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
CCCCEEEEEEECCCEEEHHHHHCCCCCCEECCCCEEECCCCCHHEEHHHHHHCCHHHHHH
MKGTKELAK
HHHHHHHCC
>Mature Secondary Structure
MYSTLEQLTKHPVFYHFAEISKIPRGSGNEKEISDFLVGFAKERNLEVIQDEALNVIIKK
CCCHHHHHHCCCHHEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCHHEEEEEE
EATAGYENVPAIIIQGHMDMVCEKNQATVHDFDKDPIELRIIGDMLYANQTTLGADNGIA
CCCCCCCCCCEEEEECCHHHEECCCCCEEECCCCCCEEEEEEEHHHHCCCCCCCCCCCHH
VAYALALLDSKDIPHPALEVVITTEEETTMGGAFAVDSNHFDGKIFINIDSEEDHKLLVS
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCEEEEEECCCCCCEEEEE
SAGGAKAVETIPVIWDEAPANMDAYRLYVGGLKGGHSGMEIDKQRGNANKVLGRVLHDLS
CCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCCEEHHCCCCHHHHHHHHHHHCE
VNIQFDISEVHGGLKTNAIPRESVATILLRQEDVEKVEEKLESWTRVLQEEMRAVDPDGH
EEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VTLTKLDEKVEKVFAKETQKQLISSLFLIPNGIQSMSMDIKGLVESSTNLGVIETLQDEI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
KLRNEVRSSVSSLKQHIADEIKCIAELVGATFEIESEYPEWPYNPNSQIRNLFEKVHQEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
YNKDVEIFAVHAGIECSVFVQKMPELDAISFGPDIFNVHTPDEHISISSVVNNWGFFVDV
CCCCEEEEEEECCCEEEHHHHHCCCCCCEECCCCEEECCCCCHHEEHHHHHHCCHHHHHH
MKGTKELAK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]