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The map label for this gene is flp [H]

Identifier: 52142924

GI number: 52142924

Start: 2449711

End: 2451156

Strand: Direct

Name: flp [H]

Synonym: BCZK2316

Alternate gene names: 52142924

Gene position: 2449711-2451156 (Clockwise)

Preceding gene: 52142926

Following gene: 52142923

Centisome position: 46.21

GC content: 30.43

Gene sequence:

>1446_bases
ATGAAGAATGCGATCTATAAAGTCTTTCTAATTTGTATTCTTTGTAATGTATTTATGCTATGTATCACACATCCAAAAGT
TTACGCTGAGCAAAATGTTAAAGTTACATTAGATAAGTATATTGAAAAATTTATAAAGGAACAGAATATTCCAGGAGCTG
CTGTTGCAATTGTACATAATAAAGAAGTATTCTTCACAAAAACGATGGGGGTTACTGGAGAATCTGAAAAAAAGGTAATT
AGTAAAACGCCATTTGCAATCGGCTCAATAAGTAAATCTTTAACAGCTTTAGCTATAGTGAAATTAATAGAAGATAAAAA
AATAAAATTAGAGGATCCAGTTCAACGATATCTCCCCTGGTTTAAACTAAAAAATCCTCAAATATCCTCAACTATAACAA
TCCAACATCTACTAACTCATACAAGCGGAATCAACACATATGAGGGCTTAGCATTATCAGATAAGCAATCCAAAAGTTCT
ACAGCATTAAAAGAAAATGTAATGAAGCTTTCAAATGTAAAAGTAACTGTTCCACCAGGTGAAAAATATCAATATAGTAA
TGCAAATTATATTGTTTTAGGTGCACTGATTGAAGAAGTCACAAATGAAACATATTCATCATATATGGAAAAGTATATTT
TTCAGCCGTTAAATATGAATGGCGCGGCAGCAAGTAAAGAAACTGCATATAAAAAAGGTTATTTAACAGGTTATCAGTCT
TGGTTTGGCATTCCAAGAAAAAGTGTAGTGTCCTATGATAATGCCGGGGCACCGTATGGCTATATTACAGCAAATTTAGA
AGATATGATTCAATATATTATGTTTTTGAATCGTCCAGAGGATGCTCAATTATTAAAGCAAGAAAATATGCATCTTTATC
TATCACCACTTTATAAAATAAATTCAGAAAAAAGTTATGGTTTTGGATTAAGAACAACAAATATAAATGAAAGTGAAACG
ATGATTTGGCATTCAGGATCAACGCCCGATGCTCGTGCAGAAATATTTACTTTAAATAAAAGTGGCTGGAGTGGAGTAAT
TTTAACAAATAAAAATCATGTATTAGAAGAAACAGCACTATCAGTATTGAAAAAGGGTATTATTAGTATTTTGAATGGAG
AAGAACCGGTTGATATCCCTAAAAAAATACCATTAACACAAATTATTTTGTTGGTAGTTACACTCATACTTTTCATAATA
TCAATTATGTTAATTAAAAAGTATAAACATATGAAAACTGTAAAAAAGGTAATTTGGTTATTCATAGGGAGTCTATCCCT
ACTATTATCTATTATTTTCATCCCACTGCTTACTTATAGTACGAGTTCACCTTGGCGTACGATTAAAATATTTGCGTCAG
ACGTAGCTTTATTTACAAGTATTAGTGTAACTTTATTAGCTGTTAACGGACTAATATCAATTTTTATAGCTTTAAGAAGG
AAGTAA

Upstream 100 bases:

>100_bases
CAATGGTGGAACGCATTATTAATAATGACTAGTTTGACACTCTCTGTAGTAGTATATATTAGCTTAGTAAGTTATAAAAA
AAGAAAGCATCTAAAGTATA

Downstream 100 bases:

>100_bases
GTAGAAGGGGAAAGAATGAAAGAAGTATAAGTTAAGTGTTAGAAACAGTTGACTCTCACACAATGTCATTGTTTAAGATG
AAGTTGAACTTCGAAGTAGA

Product: penicillin-binding protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKNAIYKVFLICILCNVFMLCITHPKVYAEQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVI
SKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSS
TALKENVMKLSNVKVTVPPGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQS
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINESET
MIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFII
SIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFASDVALFTSISVTLLAVNGLISIFIALRR
K

Sequences:

>Translated_481_residues
MKNAIYKVFLICILCNVFMLCITHPKVYAEQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVI
SKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSS
TALKENVMKLSNVKVTVPPGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQS
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINESET
MIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFII
SIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFASDVALFTSISVTLLAVNGLISIFIALRR
K
>Mature_481_residues
MKNAIYKVFLICILCNVFMLCITHPKVYAEQNVKVTLDKYIEKFIKEQNIPGAAVAIVHNKEVFFTKTMGVTGESEKKVI
SKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPWFKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSS
TALKENVMKLSNVKVTVPPGEKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQS
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKINSEKSYGFGLRTTNINESET
MIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETALSVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFII
SIMLIKKYKHMKTVKKVIWLFIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFASDVALFTSISVTLLAVNGLISIFIALRR
K

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=280, Percent_Identity=27.8571428571429, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17550934, Length=259, Percent_Identity=28.1853281853282, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115533026, Length=376, Percent_Identity=23.4042553191489, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 54101; Mature: 54101

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNAIYKVFLICILCNVFMLCITHPKVYAEQNVKVTLDKYIEKFIKEQNIPGAAVAIVHN
CCCHHHHHHHHHHHHHHHHHHHCCCHHEECCCCEEEHHHHHHHHHHHCCCCCEEEEEEEC
KEVFFTKTMGVTGESEKKVISKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPW
CEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC
FKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTVPPG
EEECCCCCCHHEEHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCEEECCCC
EKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQS
CCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHH
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKI
HHCCCCHHHCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEHEEE
NSEKSYGFGLRTTNINESETMIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETAL
CCCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHH
SVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVIWL
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFASDVALFTSISVTLLAVNGLISIFIALRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure
MKNAIYKVFLICILCNVFMLCITHPKVYAEQNVKVTLDKYIEKFIKEQNIPGAAVAIVHN
CCCHHHHHHHHHHHHHHHHHHHCCCHHEECCCCEEEHHHHHHHHHHHCCCCCEEEEEEEC
KEVFFTKTMGVTGESEKKVISKTPFAIGSISKSLTALAIVKLIEDKKIKLEDPVQRYLPW
CEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCC
FKLKNPQISSTITIQHLLTHTSGINTYEGLALSDKQSKSSTALKENVMKLSNVKVTVPPG
EEECCCCCCHHEEHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCEEECCCC
EKYQYSNANYIVLGALIEEVTNETYSSYMEKYIFQPLNMNGAAASKETAYKKGYLTGYQS
CCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCHHH
WFGIPRKSVVSYDNAGAPYGYITANLEDMIQYIMFLNRPEDAQLLKQENMHLYLSPLYKI
HHCCCCHHHCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEEHEEE
NSEKSYGFGLRTTNINESETMIWHSGSTPDARAEIFTLNKSGWSGVILTNKNHVLEETAL
CCCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHH
SVLKKGIISILNGEEPVDIPKKIPLTQIILLVVTLILFIISIMLIKKYKHMKTVKKVIWL
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIGSLSLLLSIIFIPLLTYSTSSPWRTIKIFASDVALFTSISVTLLAVNGLISIFIALRR
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA