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The map label for this gene is ampC [C]

Identifier: 52142831

GI number: 52142831

Start: 2547752

End: 2548918

Strand: Direct

Name: ampC [C]

Synonym: BCZK2409

Alternate gene names: 52142831

Gene position: 2547752-2548918 (Clockwise)

Preceding gene: 52142832

Following gene: 52142830

Centisome position: 48.06

GC content: 40.02

Gene sequence:

>1167_bases
ATGAAAAAGCATTGTCAGATTACATCTACAGGTTTAGTCCTTTTGATGACTGGAAGTTCTTTGTTATATACAACACCAAC
TTCAATTGTAAAAGCAGAGCTCACTCAAAATGTATCTAGTTCGTTACAAACAAGTAATCAAAGCGATCGTACTTCCGTTA
AGAAAGCAATGCGGGATTCACTCCAACTTGGATACCCTGGAATACTCGCTCAAATTTCTAAGGGTGGTAAAAATTGGAGC
TATGCTGCCGGGATAGCGGACCTGAGAACCAAGAAGCCGATGAAAACAGATTTCCGCTTTCGCATTGGCAGTACGACGAA
GACATTCATTGCAACAGTTCTACTTCAATTGGCTGGAGAGAACCGCTTGAATCTAGATGACTCCATCGAAAAATGGTTGC
CTGGCGTTATTCAAGGAAACGGATATGATGCTAACCAGATTACGATTCGGCAAATATTGAATCATACAAGTGGGATTGCT
GAATACTTAAAGTCAAAAGACTATGATATTATGGATACAAAAAAATTGTATACGGCTGAAGAATTAGTAAAGATGGGAAT
TTCTCTTCCACCAGACTTTGCTCCAGGTAAGGGCTGGTCTTATTCAAACACAGGATACGTAATACTGGGTATCCTTATTG
AAAAAGTAACAGGAAACAGCTATGCGGAAGAGGTTGAAAGTCGGATTGTTGAACCGCTCGAATTGTCGAATACATTCCTA
CCTGGTAATTCAACTGTTATTCCAGGTACCAAACATGCCCGTGGATATGAAAGATATGACGGAGAAAGTGAGCTAAAAGA
CGTTACTTATTCTTACCCAGGTAGCTCGGATGGAGATATGATTTCTACTGCTGACGATTTAAACAAATTCTTCTCTTACT
TACTCAGTGGCAAATTACTGAAGGAACAGCAACTAAAACAAATGCTTACTACAGTTCCTACAGGAATTGCTGAAATCGGC
AGATATGGTCTTGGAATCTATGAAACTAAACTTCCAAACGGTGTCTCGATATGGGGACACGCAGGTGCCTCTCCAGGGTT
TTCTACTTTTGCTGGAGGCACACTTGGAGGCAAGCATACATTGGCCATCAATTTGAATGGCCATGAAACTAGTTATAGTC
CTTCTGATCCTTTTAAAAATATTTTACTTGCTGAATTTAGCAAGTAG

Upstream 100 bases:

>100_bases
CTCTTGTCCATTTGTCTTTAATTAAGATGAAAGCTGCGTGACTAGTTTAAAACAGTAAATAATTACCGATAAAATATGAA
TAGAAAAGAGGAACATCTTT

Downstream 100 bases:

>100_bases
TCAAAAAGGAAAGTAAATCTTTTTATAGATAAAAATATACCTTTTTGGTTCAAAAAAATAACCTCTTTTTAAAATTTTTT
TGAAATTAAGGTGGTAAATG

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKKHCQITSTGLVLLMTGSSLLYTTPTSIVKAELTQNVSSSLQTSNQSDRTSVKKAMRDSLQLGYPGILAQISKGGKNWS
YAAGIADLRTKKPMKTDFRFRIGSTTKTFIATVLLQLAGENRLNLDDSIEKWLPGVIQGNGYDANQITIRQILNHTSGIA
EYLKSKDYDIMDTKKLYTAEELVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVESRIVEPLELSNTFL
PGNSTVIPGTKHARGYERYDGESELKDVTYSYPGSSDGDMISTADDLNKFFSYLLSGKLLKEQQLKQMLTTVPTGIAEIG
RYGLGIYETKLPNGVSIWGHAGASPGFSTFAGGTLGGKHTLAINLNGHETSYSPSDPFKNILLAEFSK

Sequences:

>Translated_388_residues
MKKHCQITSTGLVLLMTGSSLLYTTPTSIVKAELTQNVSSSLQTSNQSDRTSVKKAMRDSLQLGYPGILAQISKGGKNWS
YAAGIADLRTKKPMKTDFRFRIGSTTKTFIATVLLQLAGENRLNLDDSIEKWLPGVIQGNGYDANQITIRQILNHTSGIA
EYLKSKDYDIMDTKKLYTAEELVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVESRIVEPLELSNTFL
PGNSTVIPGTKHARGYERYDGESELKDVTYSYPGSSDGDMISTADDLNKFFSYLLSGKLLKEQQLKQMLTTVPTGIAEIG
RYGLGIYETKLPNGVSIWGHAGASPGFSTFAGGTLGGKHTLAINLNGHETSYSPSDPFKNILLAEFSK
>Mature_388_residues
MKKHCQITSTGLVLLMTGSSLLYTTPTSIVKAELTQNVSSSLQTSNQSDRTSVKKAMRDSLQLGYPGILAQISKGGKNWS
YAAGIADLRTKKPMKTDFRFRIGSTTKTFIATVLLQLAGENRLNLDDSIEKWLPGVIQGNGYDANQITIRQILNHTSGIA
EYLKSKDYDIMDTKKLYTAEELVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVESRIVEPLELSNTFL
PGNSTVIPGTKHARGYERYDGESELKDVTYSYPGSSDGDMISTADDLNKFFSYLLSGKLLKEQQLKQMLTTVPTGIAEIG
RYGLGIYETKLPNGVSIWGHAGASPGFSTFAGGTLGGKHTLAINLNGHETSYSPSDPFKNILLAEFSK

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=247, Percent_Identity=24.6963562753036, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082101, Length=213, Percent_Identity=27.2300469483568, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17550934, Length=191, Percent_Identity=30.8900523560209, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115533026, Length=340, Percent_Identity=25.5882352941176, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565630, Length=268, Percent_Identity=26.1194029850746, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 42303; Mature: 42303

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHCQITSTGLVLLMTGSSLLYTTPTSIVKAELTQNVSSSLQTSNQSDRTSVKKAMRDS
CCCCCEEECCCEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LQLGYPGILAQISKGGKNWSYAAGIADLRTKKPMKTDFRFRIGSTTKTFIATVLLQLAGE
HCCCCCHHHHHHHCCCCCCCHHHCHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCC
NRLNLDDSIEKWLPGVIQGNGYDANQITIRQILNHTSGIAEYLKSKDYDIMDTKKLYTAE
CCCCCCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ELVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVESRIVEPLELSNTFL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHCCCCHHHCCEEC
PGNSTVIPGTKHARGYERYDGESELKDVTYSYPGSSDGDMISTADDLNKFFSYLLSGKLL
CCCCEECCCCCCCCCCHHCCCHHHHHHCEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHH
KEQQLKQMLTTVPTGIAEIGRYGLGIYETKLPNGVSIWGHAGASPGFSTFAGGTLGGKHT
HHHHHHHHHHHHCCCHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCHHHCCCCCCCCEE
LAINLNGHETSYSPSDPFKNILLAEFSK
EEEEECCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKKHCQITSTGLVLLMTGSSLLYTTPTSIVKAELTQNVSSSLQTSNQSDRTSVKKAMRDS
CCCCCEEECCCEEEEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LQLGYPGILAQISKGGKNWSYAAGIADLRTKKPMKTDFRFRIGSTTKTFIATVLLQLAGE
HCCCCCHHHHHHHCCCCCCCHHHCHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCC
NRLNLDDSIEKWLPGVIQGNGYDANQITIRQILNHTSGIAEYLKSKDYDIMDTKKLYTAE
CCCCCCHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ELVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVESRIVEPLELSNTFL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHCCCCHHHCCEEC
PGNSTVIPGTKHARGYERYDGESELKDVTYSYPGSSDGDMISTADDLNKFFSYLLSGKLL
CCCCEECCCCCCCCCCHHCCCHHHHHHCEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHH
KEQQLKQMLTTVPTGIAEIGRYGLGIYETKLPNGVSIWGHAGASPGFSTFAGGTLGGKHT
HHHHHHHHHHHHCCCHHHHHHHCCCEEEECCCCCCEEEECCCCCCCCHHHCCCCCCCCEE
LAINLNGHETSYSPSDPFKNILLAEFSK
EEEEECCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]