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The map label for this gene is rnc [H]

Identifier: 52141634

GI number: 52141634

Start: 3745730

End: 3746467

Strand: Reverse

Name: rnc [H]

Synonym: BCZK3608

Alternate gene names: 52141634

Gene position: 3746467-3745730 (Counterclockwise)

Preceding gene: 52141635

Following gene: 52141633

Centisome position: 70.68

GC content: 37.94

Gene sequence:

>738_bases
ATGCCGTACCGTAAATATAGAGAAAAAAAATACGAAACAAAATATCGTGAAGCGTTTAAAGTATTTCAAGAAAAGATAGG
TATTACGTTTACAGATGAAAAATTATTGATTCAAGCATTTACGCATTCATCGTATGTGAATGAGCATCGAAAAAAACCAC
ATGAAGACAATGAGCGTCTCGAATTTCTTGGAGATGCAGTATTGGAGCTTACTGTATCGCAGTATCTGTTTCAAAAATAT
CCGACAATGAGCGAAGGAGAGTTAACAAAACTACGTGCAGCAATTGTGTGTGAACCATCTCTTGTTCGTTTTGCAAACGA
GTTGTCATTTGGTGGCCTTGTTTTATTAGGCAAAGGTGAGGAAATGACGGGTGGACGCGAACGACCAGCTTTATTAGCGG
ATGTCTTTGAAGCGTTTATTGGTGCCCTTTATCTTGATCAAGGGCTAGAAACAGTATGGGGCTTCTTAAAAGAAATTGTA
TACCCTAAAATTAATGAAGGTGCTTTTTCTCATGTGATGGATTATAAGAGTCAATTACAAGAGTTGATTCAGCGTGATGG
TAGTGGCAATATTGAGTATCAAATTTTGCAAGAAAAAGGCCCAGCCCACAATCGAGAATTTGTGTCACGTGTTACGTTAA
ATAACGTGGCTTTAGGACTTGGTAGTGGCAAGTCGAAAAAAGAAGCAGAACAACAAGCTGCTGCAGAAGCGTTGAAAAAG
TTAAAAGAACAACTATAA

Upstream 100 bases:

>100_bases
ACTGTTGGCGATGCTGTGACTTACATAGAGAGTCATCTATAATGCTTGAATGAAGTCCCGTTTTTTAGCGGGGCTTCTCG
GCTTATATCTGGAGGGACCT

Downstream 100 bases:

>100_bases
GGAATCCCCCTTTGAATGAGGGGGATTCCTTGTGCATAGAATGAAACTTTCTTTTCGTTTGTAAATGAAAGGAAAGGAAA
TCCGTATAAATATTGTTTTT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MPYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERLEFLGDAVLELTVSQYLFQKY
PTMSEGELTKLRAAIVCEPSLVRFANELSFGGLVLLGKGEEMTGGRERPALLADVFEAFIGALYLDQGLETVWGFLKEIV
YPKINEGAFSHVMDYKSQLQELIQRDGSGNIEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKK
LKEQL

Sequences:

>Translated_245_residues
MPYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERLEFLGDAVLELTVSQYLFQKY
PTMSEGELTKLRAAIVCEPSLVRFANELSFGGLVLLGKGEEMTGGRERPALLADVFEAFIGALYLDQGLETVWGFLKEIV
YPKINEGAFSHVMDYKSQLQELIQRDGSGNIEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKK
LKEQL
>Mature_244_residues
PYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERLEFLGDAVLELTVSQYLFQKYP
TMSEGELTKLRAAIVCEPSLVRFANELSFGGLVLLGKGEEMTGGRERPALLADVFEAFIGALYLDQGLETVWGFLKEIVY
PKINEGAFSHVMDYKSQLQELIQRDGSGNIEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKKL
KEQL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=225, Percent_Identity=35.1111111111111, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI155030236, Length=225, Percent_Identity=35.1111111111111, Blast_Score=117, Evalue=9e-27,
Organism=Escherichia coli, GI1788920, Length=223, Percent_Identity=35.4260089686099, Blast_Score=124, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17506883, Length=244, Percent_Identity=32.7868852459016, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193202651, Length=244, Percent_Identity=32.7868852459016, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17552834, Length=266, Percent_Identity=27.8195488721804, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323895, Length=220, Percent_Identity=28.1818181818182, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=31.0043668122271, Blast_Score=104, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27949; Mature: 27818

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EFLGDAVLELTVSQYLFQKYPTMSEGELTKLRAAIVCEPSLVRFANELSFGGLVLLGKGE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCC
EMTGGRERPALLADVFEAFIGALYLDQGLETVWGFLKEIVYPKINEGAFSHVMDYKSQLQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ELIQRDGSGNIEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKK
HHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHH
LKEQL
HHHCC
>Mature Secondary Structure 
PYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERL
CCHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EFLGDAVLELTVSQYLFQKYPTMSEGELTKLRAAIVCEPSLVRFANELSFGGLVLLGKGE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCC
EMTGGRERPALLADVFEAFIGALYLDQGLETVWGFLKEIVYPKINEGAFSHVMDYKSQLQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ELIQRDGSGNIEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKK
HHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHH
LKEQL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA