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The map label for this gene is pepQ [H]

Identifier: 52141612

GI number: 52141612

Start: 3775357

End: 3776427

Strand: Direct

Name: pepQ [H]

Synonym: BCZK3635

Alternate gene names: 52141612

Gene position: 3775357-3776427 (Clockwise)

Preceding gene: 52141613

Following gene: 52141611

Centisome position: 71.22

GC content: 34.73

Gene sequence:

>1071_bases
ATGACTTTAAAAATTAATAAAATCCAAAATCAACTACAGAACTATGAAATTGACGGGTTACTCATTACAAAAAAAGAAAA
TCGCCAATATGCGACAGGCTTTACAGGTAGTGCTGGTGTTGTCTTAATCTCTGCGGATGCAGCTGTTTTTATAACTGATT
TCCGCTATGTAGACCAAGCGAATTCACAAATAAAAAATGCTGAAATTATTATGCATAAAGGAAATTTAGAAAAAGAAATT
GCAAATCAAGTATCGAAATTAAACATTCAAAAACTTGGAATTGAAGAAAATAATATGACATTGCAACAATATAAAAACTT
ACAAAAATATGTACATACGGAAATGGTTCAAGTGTGTGAAATCATTGAAAACATTCGTCTTATTAAAGACACTCATGAAA
TAGAAACAATGAAAATCGCAGCTAATATTGCGGACGAAGCATTTCACCACATCATTACGTTTCTAAAACCAGGAATAAGT
GAAAATGATGTACGAGATGAGTTAGAATTTTTCATGCGAAAAAAAGGGGCTACGTCCTCTTCATTCCAAATCATTGTAGC
TTCTGGCGTTCGTTCTTCACTTCCTCATGGAGTTGCATCAAATAAAATAATTGAACGAGGCGACATCGTTACATTAGATT
TCGGTGCACTTTACGACGGATATTGTTCCGATATAACACGTACTGTAGCAATCGGGGAACCACCAGAAGAGTTCAAAAAA
ATATACAGTGTTGTACGCGAAGCATTAAAACGCGGGACTGAAGCAATTAAGCCTGGAGAAACTGCGAAACGTATCGATGA
TATAACGAGAAACTATATTATAGAACATGGATACGGTCAATATTTTGGACATTCTACTGGTCATGGTCTTGGATTAGAAA
TTCATGAACCACTTCGCCTATCCCAAGAAAGTAAGGCTATTTTAGAAGAAGGTATGGTCGTTACCATTGAACCAGGTATT
TACATACCAAACTGGGGCGGTTGTAGAATTGAAGATGATATCGTCATTACAGAAGATGGATATGAAGTTATTACAAAATC
AAATAGAGATCTAATTATAATCCCTTGTTAA

Upstream 100 bases:

>100_bases
TTTACTTCAACTTAAATATATGTAGTTCTTATCCTTTCTTCAAATATACACTTTGGCACACTATTTGCTTTATTCAATAC
TGTGAATAGGGGGAATTAAT

Downstream 100 bases:

>100_bases
TATTTTGAAATTCCCAACAGGATTTTTTCTCTGCACATAGAATTCCTTCTCTGGAGTATTTGTTTAAAGAGGGGGAATTG
TAATTGAACTTTGTAATCGA

Product: proline dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MTLKINKIQNQLQNYEIDGLLITKKENRQYATGFTGSAGVVLISADAAVFITDFRYVDQANSQIKNAEIIMHKGNLEKEI
ANQVSKLNIQKLGIEENNMTLQQYKNLQKYVHTEMVQVCEIIENIRLIKDTHEIETMKIAANIADEAFHHIITFLKPGIS
ENDVRDELEFFMRKKGATSSSFQIIVASGVRSSLPHGVASNKIIERGDIVTLDFGALYDGYCSDITRTVAIGEPPEEFKK
IYSVVREALKRGTEAIKPGETAKRIDDITRNYIIEHGYGQYFGHSTGHGLGLEIHEPLRLSQESKAILEEGMVVTIEPGI
YIPNWGGCRIEDDIVITEDGYEVITKSNRDLIIIPC

Sequences:

>Translated_356_residues
MTLKINKIQNQLQNYEIDGLLITKKENRQYATGFTGSAGVVLISADAAVFITDFRYVDQANSQIKNAEIIMHKGNLEKEI
ANQVSKLNIQKLGIEENNMTLQQYKNLQKYVHTEMVQVCEIIENIRLIKDTHEIETMKIAANIADEAFHHIITFLKPGIS
ENDVRDELEFFMRKKGATSSSFQIIVASGVRSSLPHGVASNKIIERGDIVTLDFGALYDGYCSDITRTVAIGEPPEEFKK
IYSVVREALKRGTEAIKPGETAKRIDDITRNYIIEHGYGQYFGHSTGHGLGLEIHEPLRLSQESKAILEEGMVVTIEPGI
YIPNWGGCRIEDDIVITEDGYEVITKSNRDLIIIPC
>Mature_355_residues
TLKINKIQNQLQNYEIDGLLITKKENRQYATGFTGSAGVVLISADAAVFITDFRYVDQANSQIKNAEIIMHKGNLEKEIA
NQVSKLNIQKLGIEENNMTLQQYKNLQKYVHTEMVQVCEIIENIRLIKDTHEIETMKIAANIADEAFHHIITFLKPGISE
NDVRDELEFFMRKKGATSSSFQIIVASGVRSSLPHGVASNKIIERGDIVTLDFGALYDGYCSDITRTVAIGEPPEEFKKI
YSVVREALKRGTEAIKPGETAKRIDDITRNYIIEHGYGQYFGHSTGHGLGLEIHEPLRLSQESKAILEEGMVVTIEPGIY
IPNWGGCRIEDDIVITEDGYEVITKSNRDLIIIPC

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=256, Percent_Identity=31.25, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI260593665, Length=293, Percent_Identity=26.6211604095563, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI149589008, Length=293, Percent_Identity=26.6211604095563, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI93141226, Length=250, Percent_Identity=27.6, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI264681563, Length=227, Percent_Identity=29.0748898678414, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI164420681, Length=245, Percent_Identity=21.6326530612245, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI40385867, Length=185, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788728, Length=360, Percent_Identity=37.2222222222222, Blast_Score=259, Evalue=1e-70,
Organism=Escherichia coli, GI1789275, Length=261, Percent_Identity=30.6513409961686, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786364, Length=229, Percent_Identity=26.2008733624454, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71989583, Length=281, Percent_Identity=27.0462633451957, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17508215, Length=296, Percent_Identity=26.0135135135135, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=230, Percent_Identity=28.2608695652174, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321118, Length=283, Percent_Identity=26.1484098939929, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323273, Length=254, Percent_Identity=25.1968503937008, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19920384, Length=261, Percent_Identity=28.3524904214559, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357079, Length=321, Percent_Identity=29.595015576324, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=22.8571428571429, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39990; Mature: 39859

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKINKIQNQLQNYEIDGLLITKKENRQYATGFTGSAGVVLISADAAVFITDFRYVDQA
CEEEHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCEEEEECCCEEEEEHHHHHHHH
NSQIKNAEIIMHKGNLEKEIANQVSKLNIQKLGIEENNMTLQQYKNLQKYVHTEMVQVCE
CCCCCCCEEEEECCCCHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
IIENIRLIKDTHEIETMKIAANIADEAFHHIITFLKPGISENDVRDELEFFMRKKGATSS
HHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
SFQIIVASGVRSSLPHGVASNKIIERGDIVTLDFGALYDGYCSDITRTVAIGEPPEEFKK
CEEEEEECCCHHHCCCCCCCCCEEECCCEEEEEHHHHHCHHHHHHHEEEECCCCHHHHHH
IYSVVREALKRGTEAIKPGETAKRIDDITRNYIIEHGYGQYFGHSTGHGLGLEIHEPLRL
HHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHEEECCCCHHCCCCCCCCCCEEECCCHHC
SQESKAILEEGMVVTIEPGIYIPNWGGCRIEDDIVITEDGYEVITKSNRDLIIIPC
CHHHHHHHHCCCEEEECCCEEECCCCCCEEECCEEEECCCCEEEECCCCCEEEEEC
>Mature Secondary Structure 
TLKINKIQNQLQNYEIDGLLITKKENRQYATGFTGSAGVVLISADAAVFITDFRYVDQA
EEEHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCEEEEECCCEEEEEHHHHHHHH
NSQIKNAEIIMHKGNLEKEIANQVSKLNIQKLGIEENNMTLQQYKNLQKYVHTEMVQVCE
CCCCCCCEEEEECCCCHHHHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
IIENIRLIKDTHEIETMKIAANIADEAFHHIITFLKPGISENDVRDELEFFMRKKGATSS
HHHHHHHHHCCHHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
SFQIIVASGVRSSLPHGVASNKIIERGDIVTLDFGALYDGYCSDITRTVAIGEPPEEFKK
CEEEEEECCCHHHCCCCCCCCCEEECCCEEEEEHHHHHCHHHHHHHEEEECCCCHHHHHH
IYSVVREALKRGTEAIKPGETAKRIDDITRNYIIEHGYGQYFGHSTGHGLGLEIHEPLRL
HHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHEEECCCCHHCCCCCCCCCCEEECCCHHC
SQESKAILEEGMVVTIEPGIYIPNWGGCRIEDDIVITEDGYEVITKSNRDLIIIPC
CHHHHHHHHCCCEEEECCCEEECCCCCCEEECCEEEECCCCEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]