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The map label for this gene is atpB [H]

Identifier: 52140250

GI number: 52140250

Start: 5112942

End: 5113661

Strand: Reverse

Name: atpB [H]

Synonym: BCZK5011

Alternate gene names: 52140250

Gene position: 5113661-5112942 (Counterclockwise)

Preceding gene: 52140249

Following gene: 52140251

Centisome position: 96.47

GC content: 39.58

Gene sequence:

>720_bases
GTGGAACACGGTAAATTAGTTGAATTTCTAGGTTTAACGTTCGATTTGTCGTCAGTTATGATGGTTACTGTAGCAGCAGT
TATTGTTTTCTTAATCGCTGTTATCGGAACTCGCAGCTTAGCTCTTCGCCCAACAGGAATGCAAAACTTCATGGAATGGG
TGTTTGACTTCGTGAAAGGGATTATCAATAGTACGATGGACTGGAAAACAGGTGGACGTTTCTTAACGCTTGGCGTTACG
CTTATCATGTTTATCATCGTATCGAACTTCCTTGGTTTACCATTCATGTATTCAGCAACTGAAGCTGGCGAACATATTGC
ATGGTGGAGATCACCAACGTCTGATCCAGCAGTTACATTAACATTAGCCGTGATGGTAGTTACCCTCACCCATTATTATG
GAATTAAGATGAAGGGTACGAAAGAATACGTAAAAGGTTATTTCCAACCTATGAAATTCTTATTCCCATTAAAGGTTATT
GAGGAGTTTGCTAACACATTAACGTTAGGTCTTCGTTTATTCGGTAACATTTATGCAGGTGAGATCTTATTAGGATTACT
TGCTAAGTTGGGCGGAGCAACATTCCTTGGAGCATTAGGTGCACTTGTACCGATGTTAGCATGGATGGGATTCAGTGTAT
TCGTTGGATCAATCCAAGCATTTATTTTCGTTATGTTAACGATGGTTTATATGGCTCATAAAGTAAGCCATGACCATTAA

Upstream 100 bases:

>100_bases
ATGTGGGGCTTAGGTGTAGGATTGCTGACAGGATACCTTGTCATGATCATAGATTTTCTTTATTTAGAGTATAAGAGCAG
GGAAGAGAGGTGAATTACTA

Downstream 100 bases:

>100_bases
TATAATTTAAGTAAGAAAAAATTTATTTTTTTATAATACAAAGGAGGACAAATTAAATGAGTTTAGGTGTAATCGCAGCT
GCAATTGCAATTGGTTTATC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MEHGKLVEFLGLTFDLSSVMMVTVAAVIVFLIAVIGTRSLALRPTGMQNFMEWVFDFVKGIINSTMDWKTGGRFLTLGVT
LIMFIIVSNFLGLPFMYSATEAGEHIAWWRSPTSDPAVTLTLAVMVVTLTHYYGIKMKGTKEYVKGYFQPMKFLFPLKVI
EEFANTLTLGLRLFGNIYAGEILLGLLAKLGGATFLGALGALVPMLAWMGFSVFVGSIQAFIFVMLTMVYMAHKVSHDH

Sequences:

>Translated_239_residues
MEHGKLVEFLGLTFDLSSVMMVTVAAVIVFLIAVIGTRSLALRPTGMQNFMEWVFDFVKGIINSTMDWKTGGRFLTLGVT
LIMFIIVSNFLGLPFMYSATEAGEHIAWWRSPTSDPAVTLTLAVMVVTLTHYYGIKMKGTKEYVKGYFQPMKFLFPLKVI
EEFANTLTLGLRLFGNIYAGEILLGLLAKLGGATFLGALGALVPMLAWMGFSVFVGSIQAFIFVMLTMVYMAHKVSHDH
>Mature_239_residues
MEHGKLVEFLGLTFDLSSVMMVTVAAVIVFLIAVIGTRSLALRPTGMQNFMEWVFDFVKGIINSTMDWKTGGRFLTLGVT
LIMFIIVSNFLGLPFMYSATEAGEHIAWWRSPTSDPAVTLTLAVMVVTLTHYYGIKMKGTKEYVKGYFQPMKFLFPLKVI
EEFANTLTLGLRLFGNIYAGEILLGLLAKLGGATFLGALGALVPMLAWMGFSVFVGSIQAFIFVMLTMVYMAHKVSHDH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Escherichia coli, GI1790176, Length=219, Percent_Identity=31.5068493150685, Blast_Score=74, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 26476; Mature: 26476

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHGKLVEFLGLTFDLSSVMMVTVAAVIVFLIAVIGTRSLALRPTGMQNFMEWVFDFVKG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHHH
IINSTMDWKTGGRFLTLGVTLIMFIIVSNFLGLPFMYSATEAGEHIAWWRSPTSDPAVTL
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCEEECCCCCCCHHHHH
TLAVMVVTLTHYYGIKMKGTKEYVKGYFQPMKFLFPLKVIEEFANTLTLGLRLFGNIYAG
HHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EILLGLLAKLGGATFLGALGALVPMLAWMGFSVFVGSIQAFIFVMLTMVYMAHKVSHDH
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEHGKLVEFLGLTFDLSSVMMVTVAAVIVFLIAVIGTRSLALRPTGMQNFMEWVFDFVKG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCHHHHHHHHHHHHHH
IINSTMDWKTGGRFLTLGVTLIMFIIVSNFLGLPFMYSATEAGEHIAWWRSPTSDPAVTL
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCEEECCCCCCCHHHHH
TLAVMVVTLTHYYGIKMKGTKEYVKGYFQPMKFLFPLKVIEEFANTLTLGLRLFGNIYAG
HHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EILLGLLAKLGGATFLGALGALVPMLAWMGFSVFVGSIQAFIFVMLTMVYMAHKVSHDH
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2521483 [H]