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The map label for this gene is ytpA [H]

Identifier: 51893935

GI number: 51893935

Start: 3011430

End: 3012275

Strand: Reverse

Name: ytpA [H]

Synonym: STH2797

Alternate gene names: 51893935

Gene position: 3012275-3011430 (Counterclockwise)

Preceding gene: 51893937

Following gene: 51893934

Centisome position: 84.47

GC content: 70.33

Gene sequence:

>846_bases
ATGAGGGAGAGAAGCGGCACCCTGTCGGGCCTCGGCGGGCTGAAACTGTACTACCGCTGCTGGGAGCCCGAGCATGTTCA
GGGCAACCTGGTGCTCGTGCACGGGGCGGGCGAGCATGTGGGGCGATACGAGCACGTCGCGGCCTGGTTCGCCGGCCGGG
GCTTCGCGGTCTGGGCGATGGACCACCGGGGGCACGGGCGGTCCGAAGGCACGCGGATGCACGTGGACCGGTTCTCCGAC
TACCTGGTGGATCTGGCGGCGTTCGTGAAGCTGGCCGCGGAGGCGCACGGCCGGCCGGTGATGATCGGCCACTCCATGGG
CGGGCTCATCGCCTACCGGTATGCCGCGGCGCACCCGGAGACCATCTCGGCCCTGGTGCTCTCGTCGCCATGGTTCCTGA
GCCGGGCGAAGGTGAGCCGGCTGGAGCAGGCGCTGGCGCCGGTCCTGGCGGTGATCTCCCCGCGGTTGCAGGTGAAGTCG
GGCATCCCGCCCGAGATCTGCACCCGGGACGCTGAGCGGATCGCCCTGGACCAGAAGGACCCGCTGCGCTGCCAGACGGC
CACGCCCCGCTGGTTCGTGGAGTGCACCCGCGCCGCCGCGGAGTGCCGCACCCGCGTCGCCTTCCCCGAGGGGCTGCCTG
CGCTCTTCCTGGTGGCCGGCACGGATCATCTGGTGGATCCGGAGGCCACCCGCGCGGTCTTCGATCGCATTGGGCACGGG
GACAAGCGGTTCAAGCTCTATCCGGAGAAGTACCACGAGATCTTCAACGATCCCGGCCGCGAGGAGGTCTTCGCCGAGAT
CCTGGACTGGCTGCGCGCCCACGGACTGGCGCCGCAGGCAGACTGA

Upstream 100 bases:

>100_bases
TCACACATTCGTGCCCCTGTCAGAGAATCCCTGCCAAGAGGAAATGTGCGACAGGTTAACGAATCTGGCTTCCATAACAG
AGCCGAACGGAGGAGAGGCC

Downstream 100 bases:

>100_bases
GCGGGATACGCACAACCACCGCAGAGGAGGCATGCCATGTTCCCGAACGCGATGCGTACCATTGCCGATTTCCAGGCCTT
CCACCGGTGGCTGGATGAGC

Product: lysophospholipase

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MRERSGTLSGLGGLKLYYRCWEPEHVQGNLVLVHGAGEHVGRYEHVAAWFAGRGFAVWAMDHRGHGRSEGTRMHVDRFSD
YLVDLAAFVKLAAEAHGRPVMIGHSMGGLIAYRYAAAHPETISALVLSSPWFLSRAKVSRLEQALAPVLAVISPRLQVKS
GIPPEICTRDAERIALDQKDPLRCQTATPRWFVECTRAAAECRTRVAFPEGLPALFLVAGTDHLVDPEATRAVFDRIGHG
DKRFKLYPEKYHEIFNDPGREEVFAEILDWLRAHGLAPQAD

Sequences:

>Translated_281_residues
MRERSGTLSGLGGLKLYYRCWEPEHVQGNLVLVHGAGEHVGRYEHVAAWFAGRGFAVWAMDHRGHGRSEGTRMHVDRFSD
YLVDLAAFVKLAAEAHGRPVMIGHSMGGLIAYRYAAAHPETISALVLSSPWFLSRAKVSRLEQALAPVLAVISPRLQVKS
GIPPEICTRDAERIALDQKDPLRCQTATPRWFVECTRAAAECRTRVAFPEGLPALFLVAGTDHLVDPEATRAVFDRIGHG
DKRFKLYPEKYHEIFNDPGREEVFAEILDWLRAHGLAPQAD
>Mature_281_residues
MRERSGTLSGLGGLKLYYRCWEPEHVQGNLVLVHGAGEHVGRYEHVAAWFAGRGFAVWAMDHRGHGRSEGTRMHVDRFSD
YLVDLAAFVKLAAEAHGRPVMIGHSMGGLIAYRYAAAHPETISALVLSSPWFLSRAKVSRLEQALAPVLAVISPRLQVKS
GIPPEICTRDAERIALDQKDPLRCQTATPRWFVECTRAAAECRTRVAFPEGLPALFLVAGTDHLVDPEATRAVFDRIGHG
DKRFKLYPEKYHEIFNDPGREEVFAEILDWLRAHGLAPQAD

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=267, Percent_Identity=32.9588014981273, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI6005786, Length=267, Percent_Identity=32.9588014981273, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1787678, Length=262, Percent_Identity=25.9541984732824, Blast_Score=77, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 31311; Mature: 31311

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRERSGTLSGLGGLKLYYRCWEPEHVQGNLVLVHGAGEHVGRYEHVAAWFAGRGFAVWAM
CCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEE
DHRGHGRSEGTRMHVDRFSDYLVDLAAFVKLAAEAHGRPVMIGHSMGGLIAYRYAAAHPE
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCH
TISALVLSSPWFLSRAKVSRLEQALAPVLAVISPRLQVKSGIPPEICTRDAERIALDQKD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHCCCHHHHCCCCCC
PLRCQTATPRWFVECTRAAAECRTRVAFPEGLPALFLVAGTDHLVDPEATRAVFDRIGHG
CCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCC
DKRFKLYPEKYHEIFNDPGREEVFAEILDWLRAHGLAPQAD
CCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRERSGTLSGLGGLKLYYRCWEPEHVQGNLVLVHGAGEHVGRYEHVAAWFAGRGFAVWAM
CCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEE
DHRGHGRSEGTRMHVDRFSDYLVDLAAFVKLAAEAHGRPVMIGHSMGGLIAYRYAAAHPE
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCH
TISALVLSSPWFLSRAKVSRLEQALAPVLAVISPRLQVKSGIPPEICTRDAERIALDQKD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHCCCHHHHCCCCCC
PLRCQTATPRWFVECTRAAAECRTRVAFPEGLPALFLVAGTDHLVDPEATRAVFDRIGHG
CCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCC
DKRFKLYPEKYHEIFNDPGREEVFAEILDWLRAHGLAPQAD
CCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]