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The map label for this gene is pgcA [H]

Identifier: 51893872

GI number: 51893872

Start: 2936886

End: 2938646

Strand: Reverse

Name: pgcA [H]

Synonym: STH2734

Alternate gene names: 51893872

Gene position: 2938646-2936886 (Counterclockwise)

Preceding gene: 51893873

Following gene: 51893871

Centisome position: 82.4

GC content: 72.12

Gene sequence:

>1761_bases
ATGTCCACGGTCATGGAACGCTTCCGGCTCTGGAGCGAGGATCCGTACTTCGATGAGGAGACCCGCCGGGAACTGGCCGG
CGTCGCCGGCGATCCCCGGGAAATCGAGGACCGCTTCTATCAGATGCTCGCGTTCGGCACGGGCGGGCTGCGGGGGGTCA
TCGGCGCGGGCACCAACCGCATCAACCGGTACATGGTTCGCCTGGCCACGCAGGGGCTGGCGGAGGCGCTTCGCGCCACG
GGCCCCGACGCCCTGCGCAGGGGCGTCGTCATCGCCCACGACTCCCGCCGGCGCTCGGCCGAGTTCGCCCGCGAGGCGGC
CTTCACCCTGGCCGCCAACGGGGTCGTCGCGCACCTGTGGGAGGGGCTGCGGCCCACGCCCATGCTCTCCTTCGCCGTGC
GGAAGCTGGGCGCGGCGGCGGGCATCGTCATCACTGCCAGCCACAACCCGCCCGAGTACAACGGGTACAAGGTGTACTGG
GAGGACGGCGGCCAGGTGCCGCCGGACCGGGCCGGTCAGATCCAGGCCGCCATGCAGGCGGTGGGCGACATCCGCTCGAT
CCGGCCGATGGCCGAGGGGGAGGCCCGTACCCGGGGGCTCCTGCGGCCGGTCCCGCCGGAGGTGGACGAGGCTTACTACA
GTCGGCTGCTGGGGCTCGTCTCGGCTTCGCCCACCCAGCGGCACGCGTTGCGCATCCTGTATACGCCGCTGCACGGCACG
GGGCTCGTGCCGGTGCGGACCGTGCTGGAGCGGGCCGGCTTCCCCGTGGAGGTGGTGGCCGAGCAGGCGGAGCCTGACCC
CGGCTTCCCCACCGTGGCCAAGCCGAACCCGGAGGAACCGGAGGTGTACGAGATCGCGCTGCGCCGCGCCGCTTCCGGCC
GTCCCGACCTGATCCTGGCCACGGATCCCGACGCCGACCGGCTCGGCGTGCTGGTCCGGGACCGGGAGGGCGGCTACCGG
GCGCTGACGGGCAACCAGATCGGGGCGATCCTGGCGGAGCAGATCCTGCGCTCCCGGGCAGAGGCGGGGACGCTGCCGGC
CAACGGCGCCGTGATCAAGACCATCGCCACATCCAACCTGGTCGCCTCCCTCTGCCGGGAGTACGGGGTGACCCTGCTGG
AGACGCACACGGGGTTCAAGTTCATCGGCGAGAAGATCAAGGAGTTCGAAGAGACGGGCAGCCACGAGTTCCTCTTCGGC
TTCGAGGAGAGCTACGGCTACCTGGCCGCGACCTTCGTGCGGGACAAGGACGCGGTGATGGCCGCCCTGCTGGTCGCCGA
CGCCGCCGCCCACCACAAGGCGGAGGGGCGCACCCTGCTGGACGCGCTGGAGGCGATCTGGCAGCGCCACGGCTACTTCC
AGGAGGGGCTGCACAACGTCACCCTGCCGGGCCGGGACGGGCAGGCCCGGATCCGGTCCCTGATGGCGGCCCTGCGGGCC
GACCCTCCCCGGGCCTTCGCCGGCGTCCCCGTCGCCTACCGCGACGACTACGCCGCGGGCACCGGCGTGGAAGTGGCCAC
CGGCCGCACTTACCCGCTCCAGCTGGGGCGGGCGGAGGTGCTGCACTACCGCTTCGCCGACGGCGGCTTCGTCATGGTGC
GGCCGTCGGGCACCGAACCGAAGCTGAAGGTGTACGTTTCGGTGGTGGGTGCCGACGCGGCCGATGCCGTCGCCCTGCGG
GACCGGGTGATGGCCGACGCCCTGGCCCGGATGGGGCTCTCGGGAGGGGCCGGTGAACCGGCCGGTGAAAGAATAGAATA
G

Upstream 100 bases:

>100_bases
GGGCCGTGGCGGTACCGACCGGAGCCGCGCCGCCCACCGGGGCGCGGCCGGGTCCGCGCGCCTGCGCGGTTACCGGCGCA
AGACGAGGAGGATCTGGTGC

Downstream 100 bases:

>100_bases
GAATACAGACGTGCGGGCCGCCGGGATTGGACAGCCGTCAGGGCGGCGGCTCGTGCGCAACCGGCTGGAGGGGATGGGGA
TGAGTTCGGGTACCGAGGAC

Product: phosphoglucomutase/phosphomannomutase family protein

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MSTVMERFRLWSEDPYFDEETRRELAGVAGDPREIEDRFYQMLAFGTGGLRGVIGAGTNRINRYMVRLATQGLAEALRAT
GPDALRRGVVIAHDSRRRSAEFAREAAFTLAANGVVAHLWEGLRPTPMLSFAVRKLGAAAGIVITASHNPPEYNGYKVYW
EDGGQVPPDRAGQIQAAMQAVGDIRSIRPMAEGEARTRGLLRPVPPEVDEAYYSRLLGLVSASPTQRHALRILYTPLHGT
GLVPVRTVLERAGFPVEVVAEQAEPDPGFPTVAKPNPEEPEVYEIALRRAASGRPDLILATDPDADRLGVLVRDREGGYR
ALTGNQIGAILAEQILRSRAEAGTLPANGAVIKTIATSNLVASLCREYGVTLLETHTGFKFIGEKIKEFEETGSHEFLFG
FEESYGYLAATFVRDKDAVMAALLVADAAAHHKAEGRTLLDALEAIWQRHGYFQEGLHNVTLPGRDGQARIRSLMAALRA
DPPRAFAGVPVAYRDDYAAGTGVEVATGRTYPLQLGRAEVLHYRFADGGFVMVRPSGTEPKLKVYVSVVGADAADAVALR
DRVMADALARMGLSGGAGEPAGERIE

Sequences:

>Translated_586_residues
MSTVMERFRLWSEDPYFDEETRRELAGVAGDPREIEDRFYQMLAFGTGGLRGVIGAGTNRINRYMVRLATQGLAEALRAT
GPDALRRGVVIAHDSRRRSAEFAREAAFTLAANGVVAHLWEGLRPTPMLSFAVRKLGAAAGIVITASHNPPEYNGYKVYW
EDGGQVPPDRAGQIQAAMQAVGDIRSIRPMAEGEARTRGLLRPVPPEVDEAYYSRLLGLVSASPTQRHALRILYTPLHGT
GLVPVRTVLERAGFPVEVVAEQAEPDPGFPTVAKPNPEEPEVYEIALRRAASGRPDLILATDPDADRLGVLVRDREGGYR
ALTGNQIGAILAEQILRSRAEAGTLPANGAVIKTIATSNLVASLCREYGVTLLETHTGFKFIGEKIKEFEETGSHEFLFG
FEESYGYLAATFVRDKDAVMAALLVADAAAHHKAEGRTLLDALEAIWQRHGYFQEGLHNVTLPGRDGQARIRSLMAALRA
DPPRAFAGVPVAYRDDYAAGTGVEVATGRTYPLQLGRAEVLHYRFADGGFVMVRPSGTEPKLKVYVSVVGADAADAVALR
DRVMADALARMGLSGGAGEPAGERIE
>Mature_585_residues
STVMERFRLWSEDPYFDEETRRELAGVAGDPREIEDRFYQMLAFGTGGLRGVIGAGTNRINRYMVRLATQGLAEALRATG
PDALRRGVVIAHDSRRRSAEFAREAAFTLAANGVVAHLWEGLRPTPMLSFAVRKLGAAAGIVITASHNPPEYNGYKVYWE
DGGQVPPDRAGQIQAAMQAVGDIRSIRPMAEGEARTRGLLRPVPPEVDEAYYSRLLGLVSASPTQRHALRILYTPLHGTG
LVPVRTVLERAGFPVEVVAEQAEPDPGFPTVAKPNPEEPEVYEIALRRAASGRPDLILATDPDADRLGVLVRDREGGYRA
LTGNQIGAILAEQILRSRAEAGTLPANGAVIKTIATSNLVASLCREYGVTLLETHTGFKFIGEKIKEFEETGSHEFLFGF
EESYGYLAATFVRDKDAVMAALLVADAAAHHKAEGRTLLDALEAIWQRHGYFQEGLHNVTLPGRDGQARIRSLMAALRAD
PPRAFAGVPVAYRDDYAAGTGVEVATGRTYPLQLGRAEVLHYRFADGGFVMVRPSGTEPKLKVYVSVVGADAADAVALRD
RVMADALARMGLSGGAGEPAGERIE

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=560, Percent_Identity=30.5357142857143, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI31377548, Length=592, Percent_Identity=30.9121621621622, Blast_Score=254, Evalue=2e-67,
Organism=Escherichia coli, GI1786904, Length=532, Percent_Identity=26.1278195488722, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1788361, Length=353, Percent_Identity=25.4957507082153, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=578, Percent_Identity=29.4117647058824, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71993878, Length=312, Percent_Identity=31.7307692307692, Blast_Score=140, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323934, Length=576, Percent_Identity=32.4652777777778, Blast_Score=236, Evalue=8e-63,
Organism=Drosophila melanogaster, GI20129809, Length=541, Percent_Identity=31.6081330868762, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24651977, Length=467, Percent_Identity=32.762312633833, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24653722, Length=544, Percent_Identity=29.5955882352941, Blast_Score=216, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 63479; Mature: 63348

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVMERFRLWSEDPYFDEETRRELAGVAGDPREIEDRFYQMLAFGTGGLRGVIGAGTNR
CCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCHHH
INRYMVRLATQGLAEALRATGPDALRRGVVIAHDSRRRSAEFAREAAFTLAANGVVAHLW
HHHHHHHHHHHHHHHHHHCCCHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHH
EGLRPTPMLSFAVRKLGAAAGIVITASHNPPEYNGYKVYWEDGGQVPPDRAGQIQAAMQA
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHH
VGDIRSIRPMAEGEARTRGLLRPVPPEVDEAYYSRLLGLVSASPTQRHALRILYTPLHGT
HHHHHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCEEEEEEECCCCC
GLVPVRTVLERAGFPVEVVAEQAEPDPGFPTVAKPNPEEPEVYEIALRRAASGRPDLILA
CCHHHHHHHHHCCCCCEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEE
TDPDADRLGVLVRDREGGYRALTGNQIGAILAEQILRSRAEAGTLPANGAVIKTIATSNL
ECCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHH
VASLCREYGVTLLETHTGFKFIGEKIKEFEETGSHEFLFGFEESYGYLAATFVRDKDAVM
HHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCHHHHH
AALLVADAAAHHKAEGRTLLDALEAIWQRHGYFQEGLHNVTLPGRDGQARIRSLMAALRA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHCCCEECCCCCCCHHHHHHHHHHHHC
DPPRAFAGVPVAYRDDYAAGTGVEVATGRTYPLQLGRAEVLHYRFADGGFVMVRPSGTEP
CCCCHHCCCCEEECCCCCCCCCCEEECCCCCEEECCCEEEEEEEECCCCEEEEECCCCCC
KLKVYVSVVGADAADAVALRDRVMADALARMGLSGGAGEPAGERIE
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STVMERFRLWSEDPYFDEETRRELAGVAGDPREIEDRFYQMLAFGTGGLRGVIGAGTNR
CHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCHHH
INRYMVRLATQGLAEALRATGPDALRRGVVIAHDSRRRSAEFAREAAFTLAANGVVAHLW
HHHHHHHHHHHHHHHHHHCCCHHHHHCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHH
EGLRPTPMLSFAVRKLGAAAGIVITASHNPPEYNGYKVYWEDGGQVPPDRAGQIQAAMQA
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHH
VGDIRSIRPMAEGEARTRGLLRPVPPEVDEAYYSRLLGLVSASPTQRHALRILYTPLHGT
HHHHHHHCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHCEEEEEEECCCCC
GLVPVRTVLERAGFPVEVVAEQAEPDPGFPTVAKPNPEEPEVYEIALRRAASGRPDLILA
CCHHHHHHHHHCCCCCEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEE
TDPDADRLGVLVRDREGGYRALTGNQIGAILAEQILRSRAEAGTLPANGAVIKTIATSNL
ECCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHH
VASLCREYGVTLLETHTGFKFIGEKIKEFEETGSHEFLFGFEESYGYLAATFVRDKDAVM
HHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCHHHHH
AALLVADAAAHHKAEGRTLLDALEAIWQRHGYFQEGLHNVTLPGRDGQARIRSLMAALRA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHCCCEECCCCCCCHHHHHHHHHHHHC
DPPRAFAGVPVAYRDDYAAGTGVEVATGRTYPLQLGRAEVLHYRFADGGFVMVRPSGTEP
CCCCHHCCCCEEECCCCCCCCCCEEECCCCCEEECCCEEEEEEEECCCCEEEEECCCCCC
KLKVYVSVVGADAADAVALRDRVMADALARMGLSGGAGEPAGERIE
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]