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The map label for this gene is uvrB [H]

Identifier: 51599087

GI number: 51599087

Start: 890270

End: 892264

Strand: Direct

Name: uvrB [H]

Synonym: BG0861

Alternate gene names: 51599087

Gene position: 890270-892264 (Clockwise)

Preceding gene: 51599082

Following gene: 51599088

Centisome position: 98.45

GC content: 30.58

Gene sequence:

>1995_bases
ATGATAGATTTTTTTTTGAATTCAGAATATCTTCCTGCTGGTGATCAACCTAAAGCAATAAAAGAGATTGAAAATTCTAT
TTTGCTTGGGAATAAGTATCAAACATTAAAAGGTGTTACAGGAAGTGGAAAGACTTTTACAATTGCGAATATAATTAAAG
ATCTAAACAGGCCAGCTTTAGTTGTCAGTCATAATAAAACATTGGCAGCGCAACTTTATAGGGAATTTAAAGATTTTTTT
CCAAACAATGCTGTTGAATATTTTGTTTCTTATTATGATTATTATCAGCCAGAATCCTATGTGCCTTCAAAAGATTTATT
TATTGAAAAAGAAGCTACTATTAATACTGAGATAGAAATCAAGCGAATAAGGACTGTAACTTCCCTTGCTAAAAGGCGAG
ATGTCATTGTTGTTGCAACTGTATCTTCAATTTATGCTCTTGGATCTCCAGATTTTTTCAAAAAATCAGCACGAGAATTT
TCTGTAGGTCAAAAAATTTCTATTAAAGAAATATCAGATATTTTTGTAGAACTTTATTATGAGAGAACTTTAATGAATCT
AGAGAGAGATAAATTTTCAATTAAAGGAAATATTATTGAAATTTGGCCTAGCAGTGAGCACGGAGAGTTTGCTTATCGAA
TTTGTTTAGATTTTGATGAAATTGTTGAAATATATAGGATTAGTTCATTTTCTAAAAAAAATTTAGGAACCACAAATAGT
TTTACTCTTTTTGCTAAATCTTATTTTGTAATTCCTTATAAAAACGTGTTAGAAGCGATACCTAAAATATCTTATGATTT
AAATCTTCAATGTCAATATTTTAAAGATAATGGCAAGCTTGTAGAAGCTGAGAGGCTTAAGCAGAGAGTAGAGTATGATT
TGGAAATGCTTAGAGAGACAGGATTTTGTTCGGGCATTGAAAATTATTCTAAATATTTGAGTGGAAGTGAAATGGAAAGA
CCTTATTGTCTTTTTGATTTTTTTCCGAAAGATTACTTATTGTTTGTAGACGAATCTCATGTTACATTGCCGCAATTTAG
GGGAATGTATAATGGAGATTATTCTAGAAAATTAAATCTTGTTAACTTTGGATTCAGACTTCCTGCAGCGCTTGAAAACA
GGCCTCTTAAATATGATGAATTTGACGCATTAATTAATCAGGTTGTGTTTGTATCTGCAACTCCAGGTCTTGAAGAGAAT
TTGAAGAGTAGAGTGGTTGTCGATCAAATAATTCGTCCCACAGGTCTTGTTGATCCAGAGATTATTACCAGGCATTCTGA
TGGTCAAATGGAAGATCTTTATAGCGAGATTCAAAAAAGAGTAGCTCTTAAGGAACGGGTTTTAATTACTACTTTGACAA
AGAAAATGTCTGAAGATTTGACTGAATATTTGGTAAGTCTTGGAGTAAGGGCAAAATATTTACATTCAGAACTTGACACT
CTTGAAAGAGTAGAGGTTATTTCGTTGCTTAGAAAATCTGAAATTGATGTTATTGTTGGCATTAACTTACTTAGAGAAGG
CTTAGATATCCCAGAAGTATCTCTTGTTGCAATATTAGATGCTGATAAAGTAGGGTTTTTAAGATCTACTACTTCATTAA
TACAAACAATTGGTAGGGCTGCTAGAAATTCTAACGGACTTGTAATAATGTATTACGACACAATAAGTGTAGCTATGCGG
GAGGCAATTGAGGAAACTAATAGAAGACGTCAAATTCAGGTTGATTATAATAAAAAAAATAATATTACTCCTAAGACAAT
TGTTAAGAAAATTCAAAATATTTTAGAAAAAGAACTTAATAATAAAAATAAAAATATTAACTATGACCTTGAAAAAATTA
TTTCAGGCGAGAGATTGTCTAAAAAAAAGCTTATTAATAAGCTTAAATTTGAGCTAGAAGAAGCTGTTAATGATGAAAGG
TTTGAAGATGCAATTGTTTTAAGAGATAAAATAAAAGAGCTTAGTAGTAAAATTAGTGTGGCTCGCAATAAATAA

Upstream 100 bases:

>100_bases
TAATTAAATTATATTGATTTATAATGAATTATATACTTGATATAGTATTTATTATTAGATAATTTATAAGAATGTATATT
AAATTTTGGTCGTTAAATTA

Downstream 100 bases:

>100_bases
AAGAGAGGTATAATCTTTGGTAAAAAATTTGGGAAAAAAAATTATCGTCAGGGGAGCAAAAGAACATAATTTAAAAAATA
TTGATATAGATATTCCAAAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MIDFFLNSEYLPAGDQPKAIKEIENSILLGNKYQTLKGVTGSGKTFTIANIIKDLNRPALVVSHNKTLAAQLYREFKDFF
PNNAVEYFVSYYDYYQPESYVPSKDLFIEKEATINTEIEIKRIRTVTSLAKRRDVIVVATVSSIYALGSPDFFKKSAREF
SVGQKISIKEISDIFVELYYERTLMNLERDKFSIKGNIIEIWPSSEHGEFAYRICLDFDEIVEIYRISSFSKKNLGTTNS
FTLFAKSYFVIPYKNVLEAIPKISYDLNLQCQYFKDNGKLVEAERLKQRVEYDLEMLRETGFCSGIENYSKYLSGSEMER
PYCLFDFFPKDYLLFVDESHVTLPQFRGMYNGDYSRKLNLVNFGFRLPAALENRPLKYDEFDALINQVVFVSATPGLEEN
LKSRVVVDQIIRPTGLVDPEIITRHSDGQMEDLYSEIQKRVALKERVLITTLTKKMSEDLTEYLVSLGVRAKYLHSELDT
LERVEVISLLRKSEIDVIVGINLLREGLDIPEVSLVAILDADKVGFLRSTTSLIQTIGRAARNSNGLVIMYYDTISVAMR
EAIEETNRRRQIQVDYNKKNNITPKTIVKKIQNILEKELNNKNKNINYDLEKIISGERLSKKKLINKLKFELEEAVNDER
FEDAIVLRDKIKELSSKISVARNK

Sequences:

>Translated_664_residues
MIDFFLNSEYLPAGDQPKAIKEIENSILLGNKYQTLKGVTGSGKTFTIANIIKDLNRPALVVSHNKTLAAQLYREFKDFF
PNNAVEYFVSYYDYYQPESYVPSKDLFIEKEATINTEIEIKRIRTVTSLAKRRDVIVVATVSSIYALGSPDFFKKSAREF
SVGQKISIKEISDIFVELYYERTLMNLERDKFSIKGNIIEIWPSSEHGEFAYRICLDFDEIVEIYRISSFSKKNLGTTNS
FTLFAKSYFVIPYKNVLEAIPKISYDLNLQCQYFKDNGKLVEAERLKQRVEYDLEMLRETGFCSGIENYSKYLSGSEMER
PYCLFDFFPKDYLLFVDESHVTLPQFRGMYNGDYSRKLNLVNFGFRLPAALENRPLKYDEFDALINQVVFVSATPGLEEN
LKSRVVVDQIIRPTGLVDPEIITRHSDGQMEDLYSEIQKRVALKERVLITTLTKKMSEDLTEYLVSLGVRAKYLHSELDT
LERVEVISLLRKSEIDVIVGINLLREGLDIPEVSLVAILDADKVGFLRSTTSLIQTIGRAARNSNGLVIMYYDTISVAMR
EAIEETNRRRQIQVDYNKKNNITPKTIVKKIQNILEKELNNKNKNINYDLEKIISGERLSKKKLINKLKFELEEAVNDER
FEDAIVLRDKIKELSSKISVARNK
>Mature_664_residues
MIDFFLNSEYLPAGDQPKAIKEIENSILLGNKYQTLKGVTGSGKTFTIANIIKDLNRPALVVSHNKTLAAQLYREFKDFF
PNNAVEYFVSYYDYYQPESYVPSKDLFIEKEATINTEIEIKRIRTVTSLAKRRDVIVVATVSSIYALGSPDFFKKSAREF
SVGQKISIKEISDIFVELYYERTLMNLERDKFSIKGNIIEIWPSSEHGEFAYRICLDFDEIVEIYRISSFSKKNLGTTNS
FTLFAKSYFVIPYKNVLEAIPKISYDLNLQCQYFKDNGKLVEAERLKQRVEYDLEMLRETGFCSGIENYSKYLSGSEMER
PYCLFDFFPKDYLLFVDESHVTLPQFRGMYNGDYSRKLNLVNFGFRLPAALENRPLKYDEFDALINQVVFVSATPGLEEN
LKSRVVVDQIIRPTGLVDPEIITRHSDGQMEDLYSEIQKRVALKERVLITTLTKKMSEDLTEYLVSLGVRAKYLHSELDT
LERVEVISLLRKSEIDVIVGINLLREGLDIPEVSLVAILDADKVGFLRSTTSLIQTIGRAARNSNGLVIMYYDTISVAMR
EAIEETNRRRQIQVDYNKKNNITPKTIVKKIQNILEKELNNKNKNINYDLEKIISGERLSKKKLINKLKFELEEAVNDER
FEDAIVLRDKIKELSSKISVARNK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=50.9687034277198, Blast_Score=630, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76631; Mature: 76631

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFFLNSEYLPAGDQPKAIKEIENSILLGNKYQTLKGVTGSGKTFTIANIIKDLNRPAL
CEEEEECCCCCCCCCCCHHHHHHHHCEEECCCCHHHCCCCCCCCEEEHHHHHHHCCCCEE
VVSHNKTLAAQLYREFKDFFPNNAVEYFVSYYDYYQPESYVPSKDLFIEKEATINTEIEI
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEH
KRIRTVTSLAKRRDVIVVATVSSIYALGSPDFFKKSAREFSVGQKISIKEISDIFVELYY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHH
ERTLMNLERDKFSIKGNIIEIWPSSEHGEFAYRICLDFDEIVEIYRISSFSKKNLGTTNS
HHHHHHHHCCCEEECCCEEEECCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCC
FTLFAKSYFVIPYKNVLEAIPKISYDLNLQCQYFKDNGKLVEAERLKQRVEYDLEMLRET
EEEEEEEEEEEEHHHHHHHHCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHC
GFCSGIENYSKYLSGSEMERPYCLFDFFPKDYLLFVDESHVTLPQFRGMYNGDYSRKLNL
CCCCCHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHCCCCCCCCCCEEEE
VNFGFRLPAALENRPLKYDEFDALINQVVFVSATPGLEENLKSRVVVDQIIRPTGLVDPE
EEECCCCCHHHCCCCCCCHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHH
IITRHSDGQMEDLYSEIQKRVALKERVLITTLTKKMSEDLTEYLVSLGVRAKYLHSELDT
HEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LERVEVISLLRKSEIDVIVGINLLREGLDIPEVSLVAILDADKVGFLRSTTSLIQTIGRA
HHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
ARNSNGLVIMYYDTISVAMREAIEETNRRRQIQVDYNKKNNITPKTIVKKIQNILEKELN
HCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
NKNKNINYDLEKIISGERLSKKKLINKLKFELEEAVNDERFEDAIVLRDKIKELSSKISV
CCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ARNK
HCCC
>Mature Secondary Structure
MIDFFLNSEYLPAGDQPKAIKEIENSILLGNKYQTLKGVTGSGKTFTIANIIKDLNRPAL
CEEEEECCCCCCCCCCCHHHHHHHHCEEECCCCHHHCCCCCCCCEEEHHHHHHHCCCCEE
VVSHNKTLAAQLYREFKDFFPNNAVEYFVSYYDYYQPESYVPSKDLFIEKEATINTEIEI
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEH
KRIRTVTSLAKRRDVIVVATVSSIYALGSPDFFKKSAREFSVGQKISIKEISDIFVELYY
HHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHH
ERTLMNLERDKFSIKGNIIEIWPSSEHGEFAYRICLDFDEIVEIYRISSFSKKNLGTTNS
HHHHHHHHCCCEEECCCEEEECCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCC
FTLFAKSYFVIPYKNVLEAIPKISYDLNLQCQYFKDNGKLVEAERLKQRVEYDLEMLRET
EEEEEEEEEEEEHHHHHHHHCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHC
GFCSGIENYSKYLSGSEMERPYCLFDFFPKDYLLFVDESHVTLPQFRGMYNGDYSRKLNL
CCCCCHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHCCCCCCCCCCEEEE
VNFGFRLPAALENRPLKYDEFDALINQVVFVSATPGLEENLKSRVVVDQIIRPTGLVDPE
EEECCCCCHHHCCCCCCCHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHH
IITRHSDGQMEDLYSEIQKRVALKERVLITTLTKKMSEDLTEYLVSLGVRAKYLHSELDT
HEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LERVEVISLLRKSEIDVIVGINLLREGLDIPEVSLVAILDADKVGFLRSTTSLIQTIGRA
HHHHHHHHHHHHCCCCEEEEHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
ARNSNGLVIMYYDTISVAMREAIEETNRRRQIQVDYNKKNNITPKTIVKKIQNILEKELN
HCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
NKNKNINYDLEKIISGERLSKKKLINKLKFELEEAVNDERFEDAIVLRDKIKELSSKISV
CCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ARNK
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]