Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 51598972

GI number: 51598972

Start: 759739

End: 761487

Strand: Direct

Name: thrS

Synonym: BG0742

Alternate gene names: 51598972

Gene position: 759739-761487 (Clockwise)

Preceding gene: 51598971

Following gene: 51598973

Centisome position: 84.02

GC content: 31.62

Gene sequence:

>1749_bases
GTGAGTAAAGATTTATATAAAGAAGATATTCTTTACAAAAAAAGACATTCAATAGCCCATGTTATGGCAGAAGCTGTGTG
CGATTTATTTCCAAATACGAAAATTGCAATAGGACCCCCTATTAAAGATGGTTTTTATTATGATTTTGAATTCAAAAATC
CAATTACAGAAGATTCTCTTTTGGATATAGAAAATAGAATGAGAGAGATTTTAAAGACTGGGAGTTCTTTTGAAAAAGAG
ATAATAAGCTTAGAACAGGCTCTTGAAATTTTTAAAGATGAACCTTATAAGATCGATTTGATTAAAAATTTTGATTTACA
AAATGAAATTTCTATTTACAAGAGTCATAATTTTATCGATCTTTGCAGGGGTCCCCATGTTGATAATATGAATAAAATTG
ATCCAAAGGCATTTAAGCTTACTGGTATTGCTGGGGCTTATTGGCGAGGTAATGAAAAAAATACAATGCTTACCAGAATT
TATGGAACCTTATGGAATAATGAAAAAGAGCTAAGATCTTATCTTAATTTGAGAGAGGAAATAAAAAAAAGAGACCATAG
AAAGCTTGGGAAAGAGCTTGATTTATTTTCTATTCATGAAGAGATTGGACCAGGGCTTATTTTCTTTCATCCAAATGGAG
CTAAAATAAGAGCTTTAATAGAGGATTTTTGGAGAGAAGAGCACTCTAAAAATGGATATGATATTCTTTTTACTCCTCAT
GTTGGCAAATCTTGGCTTTGGCAAACTTCTGGCCATTTAAACTTTTATAAGGACAGCATGTTTGAAAAAATAGAAATGGA
TAAAAGTGATTATTATCTTAAACCTATGAATTGTCCTTTTCATATTGCAATTTACAATACAGGTAAGCATTCTTATAGAG
ATTTGCCATTTAGATGGGCTGAACTTGGTACTGTATATCGTTATGAAAAGATAGGTGCTTTGCATGGTATGATGAGAGCC
AGAGGTTTTACTCAGGATGATGCTCACATTATATGTACCCATTCTCAAGTTGTAGATGAGATTAAAGAAGTTCTTAGGTT
CGCTATTTATATGTGGAGCAAATTTGGCTTTAACAGCTTAAAGGCATATCTTTCTACAAAGCCTGACAAGTCTGTTGGGA
ATAATTCTGACTGGGAAATGTCTTTAAAGGTCCTTAAAGAGGCTTTAAGTGATTTTGAAGTTCCTTATGAAATTGATAAA
GGGGGAGGTGCTTTTTATGGACCTAAAATTGATCTCAAGATAGTTGATTCGCTTGAGAGAGAGTGGCAGATGAGTACGAT
TCAATTTGATTTTAATCTTCCCGAGAGATTTAATATGACTTATACTTCTGAGGATGGTAAAGAAAAAAGACCATTTATGA
TTCATCGAGCCCTGTTGGGATCTATTGAAAGATTTTTTGGAATTCTTGTAGAACACTATGGTGGAGCATTTCCTTTATGG
TTGTCTCATGTTCAAGCAGTAATCATTCCTGTTAACAATATTGTAGAAGATTATACTATTAAGGTTTTTAATAAATTTAA
AAATGCGGGCATTAGAATAAAACTTGATAATAGTTCCTCAAGAATGAATGCTAAAATTAGAGAATATCAGGCTAAAAAAA
TACCTTATATGTTTATAATTGGTGAGAGAGAAGCAATAGAAGAAAGAATATCTATTAGAACAAGAACAAATGAGCAAATA
AATGGAATTGAACTTGATGAAGCTCTTAAACTTATTTTATTAAAAGTAAGAGATAAGGAGATTTCATAA

Upstream 100 bases:

>100_bases
ATTTAGTAATTATAAATATTTGAGGTACGTGTTTTTGCGTAAAAGTGATGAATGTGAGTTTTAATCGTTTAATAAAAATC
GAAAGATTAAAGGTGTTATT

Downstream 100 bases:

>100_bases
ATTGAATAATTTAATCAAGATTATTACTCCTAATAAAATCACATTAGCTAGGATTATACTTTCCTTTATCATATTAATTT
TATTTTTTTTGGAAAATATA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MSKDLYKEDILYKKRHSIAHVMAEAVCDLFPNTKIAIGPPIKDGFYYDFEFKNPITEDSLLDIENRMREILKTGSSFEKE
IISLEQALEIFKDEPYKIDLIKNFDLQNEISIYKSHNFIDLCRGPHVDNMNKIDPKAFKLTGIAGAYWRGNEKNTMLTRI
YGTLWNNEKELRSYLNLREEIKKRDHRKLGKELDLFSIHEEIGPGLIFFHPNGAKIRALIEDFWREEHSKNGYDILFTPH
VGKSWLWQTSGHLNFYKDSMFEKIEMDKSDYYLKPMNCPFHIAIYNTGKHSYRDLPFRWAELGTVYRYEKIGALHGMMRA
RGFTQDDAHIICTHSQVVDEIKEVLRFAIYMWSKFGFNSLKAYLSTKPDKSVGNNSDWEMSLKVLKEALSDFEVPYEIDK
GGGAFYGPKIDLKIVDSLEREWQMSTIQFDFNLPERFNMTYTSEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPLW
LSHVQAVIIPVNNIVEDYTIKVFNKFKNAGIRIKLDNSSSRMNAKIREYQAKKIPYMFIIGEREAIEERISIRTRTNEQI
NGIELDEALKLILLKVRDKEIS

Sequences:

>Translated_582_residues
MSKDLYKEDILYKKRHSIAHVMAEAVCDLFPNTKIAIGPPIKDGFYYDFEFKNPITEDSLLDIENRMREILKTGSSFEKE
IISLEQALEIFKDEPYKIDLIKNFDLQNEISIYKSHNFIDLCRGPHVDNMNKIDPKAFKLTGIAGAYWRGNEKNTMLTRI
YGTLWNNEKELRSYLNLREEIKKRDHRKLGKELDLFSIHEEIGPGLIFFHPNGAKIRALIEDFWREEHSKNGYDILFTPH
VGKSWLWQTSGHLNFYKDSMFEKIEMDKSDYYLKPMNCPFHIAIYNTGKHSYRDLPFRWAELGTVYRYEKIGALHGMMRA
RGFTQDDAHIICTHSQVVDEIKEVLRFAIYMWSKFGFNSLKAYLSTKPDKSVGNNSDWEMSLKVLKEALSDFEVPYEIDK
GGGAFYGPKIDLKIVDSLEREWQMSTIQFDFNLPERFNMTYTSEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPLW
LSHVQAVIIPVNNIVEDYTIKVFNKFKNAGIRIKLDNSSSRMNAKIREYQAKKIPYMFIIGEREAIEERISIRTRTNEQI
NGIELDEALKLILLKVRDKEIS
>Mature_581_residues
SKDLYKEDILYKKRHSIAHVMAEAVCDLFPNTKIAIGPPIKDGFYYDFEFKNPITEDSLLDIENRMREILKTGSSFEKEI
ISLEQALEIFKDEPYKIDLIKNFDLQNEISIYKSHNFIDLCRGPHVDNMNKIDPKAFKLTGIAGAYWRGNEKNTMLTRIY
GTLWNNEKELRSYLNLREEIKKRDHRKLGKELDLFSIHEEIGPGLIFFHPNGAKIRALIEDFWREEHSKNGYDILFTPHV
GKSWLWQTSGHLNFYKDSMFEKIEMDKSDYYLKPMNCPFHIAIYNTGKHSYRDLPFRWAELGTVYRYEKIGALHGMMRAR
GFTQDDAHIICTHSQVVDEIKEVLRFAIYMWSKFGFNSLKAYLSTKPDKSVGNNSDWEMSLKVLKEALSDFEVPYEIDKG
GGAFYGPKIDLKIVDSLEREWQMSTIQFDFNLPERFNMTYTSEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPLWL
SHVQAVIIPVNNIVEDYTIKVFNKFKNAGIRIKLDNSSSRMNAKIREYQAKKIPYMFIIGEREAIEERISIRTRTNEQIN
GIELDEALKLILLKVRDKEIS

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=545, Percent_Identity=40.9174311926606, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI38202255, Length=546, Percent_Identity=40.1098901098901, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI20070344, Length=577, Percent_Identity=34.8353552859619, Blast_Score=366, Evalue=1e-101,
Organism=Escherichia coli, GI1788013, Length=570, Percent_Identity=41.5789473684211, Blast_Score=495, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71984184, Length=557, Percent_Identity=40.0359066427289, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71984192, Length=557, Percent_Identity=40.0359066427289, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322112, Length=578, Percent_Identity=37.5432525951557, Blast_Score=406, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=37.75, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24583842, Length=569, Percent_Identity=38.8400702987698, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI28574141, Length=569, Percent_Identity=38.8400702987698, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24583839, Length=569, Percent_Identity=38.8400702987698, Blast_Score=430, Evalue=1e-120,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_BORGA (Q660F3)

Other databases:

- EMBL:   CP000013
- RefSeq:   YP_073160.1
- ProteinModelPortal:   Q660F3
- SMR:   Q660F3
- EnsemblBacteria:   EBBORT00000007644
- GeneID:   2957754
- GenomeReviews:   CP000013_GR
- KEGG:   bga:BG0742
- GeneTree:   EBGT00050000007426
- HOGENOM:   HBG352811
- OMA:   FHPKGMV
- ProtClustDB:   PRK12305
- BioCyc:   BGAR290434:BG0742-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 68164; Mature: 68033

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDLYKEDILYKKRHSIAHVMAEAVCDLFPNTKIAIGPPIKDGFYYDFEFKNPITEDSL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCHH
LDIENRMREILKTGSSFEKEIISLEQALEIFKDEPYKIDLIKNFDLQNEISIYKSHNFID
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCEEE
LCRGPHVDNMNKIDPKAFKLTGIAGAYWRGNEKNTMLTRIYGTLWNNEKELRSYLNLREE
CCCCCCCCCCCCCCCCEEEEEECEEEEEECCCCCEEHEEEHHHHHCCHHHHHHHHHHHHH
IKKRDHRKLGKELDLFSIHEEIGPGLIFFHPNGAKIRALIEDFWREEHSKNGYDILFTPH
HHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
VGKSWLWQTSGHLNFYKDSMFEKIEMDKSDYYLKPMNCPFHIAIYNTGKHSYRDLPFRWA
CCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCHHH
ELGTVYRYEKIGALHGMMRARGFTQDDAHIICTHSQVVDEIKEVLRFAIYMWSKFGFNSL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHH
KAYLSTKPDKSVGNNSDWEMSLKVLKEALSDFEVPYEIDKGGGAFYGPKIDLKIVDSLER
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEECCEEEEHHHHHHHH
EWQMSTIQFDFNLPERFNMTYTSEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPLW
HHEEEEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LSHVQAVIIPVNNIVEDYTIKVFNKFKNAGIRIKLDNSSSRMNAKIREYQAKKIPYMFII
HHCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEE
GEREAIEERISIRTRTNEQINGIELDEALKLILLKVRDKEIS
CCHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SKDLYKEDILYKKRHSIAHVMAEAVCDLFPNTKIAIGPPIKDGFYYDFEFKNPITEDSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCHH
LDIENRMREILKTGSSFEKEIISLEQALEIFKDEPYKIDLIKNFDLQNEISIYKSHNFID
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCEEE
LCRGPHVDNMNKIDPKAFKLTGIAGAYWRGNEKNTMLTRIYGTLWNNEKELRSYLNLREE
CCCCCCCCCCCCCCCCEEEEEECEEEEEECCCCCEEHEEEHHHHHCCHHHHHHHHHHHHH
IKKRDHRKLGKELDLFSIHEEIGPGLIFFHPNGAKIRALIEDFWREEHSKNGYDILFTPH
HHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECC
VGKSWLWQTSGHLNFYKDSMFEKIEMDKSDYYLKPMNCPFHIAIYNTGKHSYRDLPFRWA
CCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCHHH
ELGTVYRYEKIGALHGMMRARGFTQDDAHIICTHSQVVDEIKEVLRFAIYMWSKFGFNSL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCHHHH
KAYLSTKPDKSVGNNSDWEMSLKVLKEALSDFEVPYEIDKGGGAFYGPKIDLKIVDSLER
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEECCEEEEHHHHHHHH
EWQMSTIQFDFNLPERFNMTYTSEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPLW
HHEEEEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LSHVQAVIIPVNNIVEDYTIKVFNKFKNAGIRIKLDNSSSRMNAKIREYQAKKIPYMFII
HHCCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEE
GEREAIEERISIRTRTNEQINGIELDEALKLILLKVRDKEIS
CCHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA