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The map label for this gene is pbp-2 [H]

Identifier: 51598970

GI number: 51598970

Start: 756452

End: 758251

Strand: Direct

Name: pbp-2 [H]

Synonym: BG0740

Alternate gene names: 51598970

Gene position: 756452-758251 (Clockwise)

Preceding gene: 51598969

Following gene: 51598971

Centisome position: 83.66

GC content: 30.89

Gene sequence:

>1800_bases
GTGGGTGTTATAACAAATTTTAGATACAAGTTTGCCATATTATTTTTAATAATAATTATGTTGCTTTATTTAGCGATTTT
ATTTCAAATGCAAATTGGTAAGCATTTATTTTACGATAGAGAAGCTAATGTTTTTTTATCAAGATTGGAAAAAATCAATG
CCTCAAGGGGTGAGATCTTAGATTCTAATTCTAATGTTTTGGCAAATAATTTAACTATGTTTATTTTAAAGATAAGCTTG
CAACAGTATTATAATATGCCTGTTGCTACTAGAATTGAGATGATAGACTTTTTATCAAGCACTCTAGATATTGATAAATC
AATCATTTTATCTAAGCTTCAAGAGCCCGGTGGATATCTAAAAGATGTTGAAATAGTTGAACTTACTCCAAAGATGTTGT
TTAAAATTTCTGAAAAAAAGTTTTATTATCCTGCTCTTTTATGGACCTATTCTTTTAAGCGTAACTACTTAGTAGACGAT
TCATATTCGCATTCAATAGGTTATGTTGGACAAATAAATCAAAGAGAACTTAGAACTTTTTATAATATTAGTGGATATGA
TAATACGTCTACAATTGGAAAGTTGGGTATTGAACAAGTTTATGATAATTATATTAGAGGGCAAGAGGGATTAATTAAAT
ACAAAGTAGATTCCAAGGAGAGAAGAATAGACGACGGTACTATTATAAGGAATATGGTGCCGGGTAATGATGTTGTACTT
AATATTAATAAAGATATTCAAGATCTTGCTAAGAATGCTTTAGGCAAAAGGTATGGTGCTATTGTGGTATTAAAACCATC
AACAGGCGCTGTTCTTGCTCTTCATAATTATCCTTATTATTCTATGACAGATGTTTACAATAAATATAATAAAGAAGATT
ATTCTTTTTTAAATAAAGCGATTCAATCTGTTTATCCACCAGCGTCTATTTTTAAATTAGTTGTTGCTGCTGCTATTCTT
GAGGAGAGAGTTATAGACAAAGATCGTAAAATTTATTGTCCTGGACATTTTAAAGTTGGAAATAGAATTTTTCATTGTTG
GAAGCCTGGTGGTCATGGGTATGTTAATTTAGAAGAGGCAATTGCACATTCTTCTAATGTTTATTTTTATACACTTGGAC
TTAAGTATCTTGGGGTTGATAGAATTAGAAAATATGCAAAAGAATTTGGGTTTGGAGAAAAAACGGGAATTGATTTGCCC
AACGAAGTATCTGGTCTTCTTCCTAGTCCTGAGTGGAAAGAAAAAACTTTTAATCAGTCTTGGGTAGGAGGAGATACTGT
AAATTTTTCAATAGGTCAAGGATTTTTGAATGCTACTCCTATTCAGATTGTCAATATGGTTGCTATGATTGCAAACGAAG
GTGTTATATATAAGCCTAGAATTGTAAATAAAATTTTAAAAGGCGGTGGTAATGAAGTTCTTCTTGAAAATAAACCAGAA
ATACTAAGAAAGACAAACCTTATTAGTAAGAACACATTTAAGCTTCTAAAAAAATATATGAGAAGTGTTATAACTTATGG
TACAGCAAGATATGCAGTTCTTACGAAAGCTGTTGAGGTTGGAGGAAAAACAGGTACTGGTCAAACCGGTATAGATGGTT
TTGAAAATAGTTCTTTTATTGGACTTGCTCCTTATAACGGTTCAGCTGATAATCAAATTATTGTTTTTAGTTTAGTTGAG
GCAAAGAGTAATGTGGATTGGTGGCCTGCAAAATCTACAGATTTAATAATGCAAGGTATTTTTGCAAATCAAAGTTATGA
AGATATTCTTAAAGGTTATAGGCCATGGTATATTAGGTAG

Upstream 100 bases:

>100_bases
TTAATCTTGACCTTGTTGTAAATATAATGTTTATCAACTTTTTATATCCAATTCAAAATTATTTTACTAGAAGTTTTTAT
TCTTTTAAAGAGGATTATTA

Downstream 100 bases:

>100_bases
ATTAATGGTTTTTAGAAAAAATTATGATTATTTAGCTTTGATAAGCTTACTTATGGTTTCTTTTGTTGGTATATTGTTAA
TCTATTCTAGCGATTATAAT

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MGVITNFRYKFAILFLIIIMLLYLAILFQMQIGKHLFYDREANVFLSRLEKINASRGEILDSNSNVLANNLTMFILKISL
QQYYNMPVATRIEMIDFLSSTLDIDKSIILSKLQEPGGYLKDVEIVELTPKMLFKISEKKFYYPALLWTYSFKRNYLVDD
SYSHSIGYVGQINQRELRTFYNISGYDNTSTIGKLGIEQVYDNYIRGQEGLIKYKVDSKERRIDDGTIIRNMVPGNDVVL
NINKDIQDLAKNALGKRYGAIVVLKPSTGAVLALHNYPYYSMTDVYNKYNKEDYSFLNKAIQSVYPPASIFKLVVAAAIL
EERVIDKDRKIYCPGHFKVGNRIFHCWKPGGHGYVNLEEAIAHSSNVYFYTLGLKYLGVDRIRKYAKEFGFGEKTGIDLP
NEVSGLLPSPEWKEKTFNQSWVGGDTVNFSIGQGFLNATPIQIVNMVAMIANEGVIYKPRIVNKILKGGGNEVLLENKPE
ILRKTNLISKNTFKLLKKYMRSVITYGTARYAVLTKAVEVGGKTGTGQTGIDGFENSSFIGLAPYNGSADNQIIVFSLVE
AKSNVDWWPAKSTDLIMQGIFANQSYEDILKGYRPWYIR

Sequences:

>Translated_599_residues
MGVITNFRYKFAILFLIIIMLLYLAILFQMQIGKHLFYDREANVFLSRLEKINASRGEILDSNSNVLANNLTMFILKISL
QQYYNMPVATRIEMIDFLSSTLDIDKSIILSKLQEPGGYLKDVEIVELTPKMLFKISEKKFYYPALLWTYSFKRNYLVDD
SYSHSIGYVGQINQRELRTFYNISGYDNTSTIGKLGIEQVYDNYIRGQEGLIKYKVDSKERRIDDGTIIRNMVPGNDVVL
NINKDIQDLAKNALGKRYGAIVVLKPSTGAVLALHNYPYYSMTDVYNKYNKEDYSFLNKAIQSVYPPASIFKLVVAAAIL
EERVIDKDRKIYCPGHFKVGNRIFHCWKPGGHGYVNLEEAIAHSSNVYFYTLGLKYLGVDRIRKYAKEFGFGEKTGIDLP
NEVSGLLPSPEWKEKTFNQSWVGGDTVNFSIGQGFLNATPIQIVNMVAMIANEGVIYKPRIVNKILKGGGNEVLLENKPE
ILRKTNLISKNTFKLLKKYMRSVITYGTARYAVLTKAVEVGGKTGTGQTGIDGFENSSFIGLAPYNGSADNQIIVFSLVE
AKSNVDWWPAKSTDLIMQGIFANQSYEDILKGYRPWYIR
>Mature_598_residues
GVITNFRYKFAILFLIIIMLLYLAILFQMQIGKHLFYDREANVFLSRLEKINASRGEILDSNSNVLANNLTMFILKISLQ
QYYNMPVATRIEMIDFLSSTLDIDKSIILSKLQEPGGYLKDVEIVELTPKMLFKISEKKFYYPALLWTYSFKRNYLVDDS
YSHSIGYVGQINQRELRTFYNISGYDNTSTIGKLGIEQVYDNYIRGQEGLIKYKVDSKERRIDDGTIIRNMVPGNDVVLN
INKDIQDLAKNALGKRYGAIVVLKPSTGAVLALHNYPYYSMTDVYNKYNKEDYSFLNKAIQSVYPPASIFKLVVAAAILE
ERVIDKDRKIYCPGHFKVGNRIFHCWKPGGHGYVNLEEAIAHSSNVYFYTLGLKYLGVDRIRKYAKEFGFGEKTGIDLPN
EVSGLLPSPEWKEKTFNQSWVGGDTVNFSIGQGFLNATPIQIVNMVAMIANEGVIYKPRIVNKILKGGGNEVLLENKPEI
LRKTNLISKNTFKLLKKYMRSVITYGTARYAVLTKAVEVGGKTGTGQTGIDGFENSSFIGLAPYNGSADNQIIVFSLVEA
KSNVDWWPAKSTDLIMQGIFANQSYEDILKGYRPWYIR

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=549, Percent_Identity=29.143897996357, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786272, Length=554, Percent_Identity=22.9241877256318, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 68057; Mature: 67925

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVITNFRYKFAILFLIIIMLLYLAILFQMQIGKHLFYDREANVFLSRLEKINASRGEIL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
DSNSNVLANNLTMFILKISLQQYYNMPVATRIEMIDFLSSTLDIDKSIILSKLQEPGGYL
CCCCCEECCCCEEEHHHEEHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
KDVEIVELTPKMLFKISEKKFYYPALLWTYSFKRNYLVDDSYSHSIGYVGQINQRELRTF
CCCEEEEECHHHHHEECCCCEECCEEEEEEECCCCEEECCCCCCCCCCCCCCCHHHHHHH
YNISGYDNTSTIGKLGIEQVYDNYIRGQEGLIKYKVDSKERRIDDGTIIRNMVPGNDVVL
EECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCEEEECCCCCCEEE
NINKDIQDLAKNALGKRYGAIVVLKPSTGAVLALHNYPYYSMTDVYNKYNKEDYSFLNKA
EECCCHHHHHHHHHHHHHCEEEEEECCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHH
IQSVYPPASIFKLVVAAAILEERVIDKDRKIYCPGHFKVGNRIFHCWKPGGHGYVNLEEA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCEEEEEECCCCCCEEEHHHH
IAHSSNVYFYTLGLKYLGVDRIRKYAKEFGFGEKTGIDLPNEVSGLLPSPEWKEKTFNQS
HHCCCCEEEEEECHHHHCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCHHHHCCCCC
WVGGDTVNFSIGQGFLNATPIQIVNMVAMIANEGVIYKPRIVNKILKGGGNEVLLENKPE
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHCCCCEEEECCCHH
ILRKTNLISKNTFKLLKKYMRSVITYGTARYAVLTKAVEVGGKTGTGQTGIDGFENSSFI
HHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
GLAPYNGSADNQIIVFSLVEAKSNVDWWPAKSTDLIMQGIFANQSYEDILKGYRPWYIR
EEECCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure 
GVITNFRYKFAILFLIIIMLLYLAILFQMQIGKHLFYDREANVFLSRLEKINASRGEIL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEE
DSNSNVLANNLTMFILKISLQQYYNMPVATRIEMIDFLSSTLDIDKSIILSKLQEPGGYL
CCCCCEECCCCEEEHHHEEHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
KDVEIVELTPKMLFKISEKKFYYPALLWTYSFKRNYLVDDSYSHSIGYVGQINQRELRTF
CCCEEEEECHHHHHEECCCCEECCEEEEEEECCCCEEECCCCCCCCCCCCCCCHHHHHHH
YNISGYDNTSTIGKLGIEQVYDNYIRGQEGLIKYKVDSKERRIDDGTIIRNMVPGNDVVL
EECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCEEEECCCCCCEEE
NINKDIQDLAKNALGKRYGAIVVLKPSTGAVLALHNYPYYSMTDVYNKYNKEDYSFLNKA
EECCCHHHHHHHHHHHHHCEEEEEECCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHH
IQSVYPPASIFKLVVAAAILEERVIDKDRKIYCPGHFKVGNRIFHCWKPGGHGYVNLEEA
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCEEEEEECCCCCCEEEHHHH
IAHSSNVYFYTLGLKYLGVDRIRKYAKEFGFGEKTGIDLPNEVSGLLPSPEWKEKTFNQS
HHCCCCEEEEEECHHHHCHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCHHHHCCCCC
WVGGDTVNFSIGQGFLNATPIQIVNMVAMIANEGVIYKPRIVNKILKGGGNEVLLENKPE
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHCCCCEEEECCCHH
ILRKTNLISKNTFKLLKKYMRSVITYGTARYAVLTKAVEVGGKTGTGQTGIDGFENSSFI
HHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
GLAPYNGSADNQIIVFSLVEAKSNVDWWPAKSTDLIMQGIFANQSYEDILKGYRPWYIR
EEECCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]